Clinical trials: Pulmonary Arterial Hypertension
Pulmonary Arterial Hypertension
Effect of BIA 5-1058 400 mg on Warfarin Pharmacokinetics
The purpose of this study is: To investigate CYP2C9 inhibition by BIA 5-1058 through the assessment of its effect on the Pharmacokinetic (PK) of S-warfarin, a substrate of CYP2C9.
- Trial name
- NCT04994119
- Testing
- BIA 5-1058, Warfarin
- Where
- Germany
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Chronic Thromboembolic Pulmonary Hypertension, CTEPH
TrEatment Approach in the Multimodal Era Registry
The goal of this observational patient registry is to learn how expert centers treat patients with chronic thromboembolic pulmonary hypertension (CTEPH).
- Trial name
- TEAM (NCT05629052)
- Testing
- Pulmonary endarterectomy, Balloon pulmonary angioplasty, Pulmonary hypertension (PH)-specific medication
- Where
- 25 sites in United States, Argentina and 18 more
- Volunteers
- 1,000 people
- Sponsor
- International CTEPH Association
Congenital Diaphragmatic Hernia
Fetal Endotracheal Occlusion (FETO) in the Resolution of Pulmonary Hypertension in Fetuses With Severe CDH
Congenital diaphragmatic hernia (CDH) occurs when the diaphragm fails to fully fuse and leaves a portal through which abdominal structures can migrate into the thorax.
- Trial name
- NCT03980717
- Testing
- Goldbal Detachable Balloon and delivery microcatheter
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Michael A Belfort
Pulmonary Hypertension Outcome Assessment
Zürich Pulmonary Hypertension Outcome Assessment Cohort
PH is a serious disease with a dismal prognosis and impaired quality of life when left untreated. Reliable patient centered and prognostically relevant outcome measures are highly warranted in the field of PH.
- Trial name
- ZHPHCohort (NCT02249806)
- Testing
- PH target therapy according to physician
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Chronic Fatigue Syndrome
Use of Xyrem to Improve Sleep in Chronic Fatigue Syndrome
Chronic fatigue syndrome is a disabling illness for which there is no specific treatment. As a group, CFS patients have disturbed sleep with frequent arousals and the sense of not having slept upon awakening.
- Trial name
- NCT00498485
- Testing
- Sodium Oxybate
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Pulmonary Hypertension, Interstitial Lung Disease
A Phase 3 Trial of Inhaled Mosliciguat in PH-ILD (PHrontier)
A Phase 3, Multicenter, Randomized, Double-Blind Placebo-Controlled Trial to Evaluate the Safety and Efficacy of Inhaled Mosliciguat in Participants with Pulmonary Hypertension Associated with Interstitial Lung Disease
- Conditions
- Pulmonary Hypertension, Interstitial Lung Disease, Vascular Diseases, Cardiovascular Diseases
- Trial name
- NCT07816185
- Testing
- Mosliciguat, Dry Powder Inhaler
- Where
- 3 sites in United States
- Volunteers
- 376 people
- Sponsor
- Pulmovant, Inc.
Hypertension, COVID-19
ARB, ACEi, DRi Effects on COVID-19 Course Disease
It is supposed to monitor hypertensive patients who are infected or have clinical manifestations of COVID-19 for 1 month after the onset of the disease. Three groups will be considered: 1. receiving ACE inhibitors 2.
- Trial name
- BIRCOV (NCT04364984)
- Testing
- Angiotensin converting enzyme inhibitor, Angiotensin Receptor Blockers, Direct renin inhibitor
- Where
- Ukraine
- Volunteers
- 112 people
- Sponsor
- Medical Practice Prof D. Ivanov
Pulmonary Arterial Hypertension, Pulmonary Hypertension, Interstitial Lung Disease
An Expanded Access Study to Assess Treprostinil Palmitil Inhalation Powder (TPIP) for Participants With Pulmonary Arterial Hypertension (PAH) and Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
The purpose of this study is to provide continued access to TPIP for participants who have successfully completed the open-label extension (OLE) studies of INS1009-203 for PAH or INS1009-212 for PH-ILD.
- Trial name
- NCT06939647
- Testing
- Treprostinil Palmitil
- Sponsor
- Insmed Incorporated
Pulmonary Rehabilitation, Physical Activities
Feasibility of Integrating Street Racket Into Ambulatory Pulmonary Rehabilitation
This study looks at whether Street Racket is a feasable activity that can be added to pulmonary rehabilitation for people with chronic lung disease.
- Conditions
- Pulmonary Rehabilitation, Physical Activities, Exercise Therapy
- Trial name
- APRacket (NCT07430943)
- Testing
- Street Racket
- Where
- 2 sites in Switzerland
- Volunteers
- 12 people
- Sponsor
- Mona Lichtblau
Asthma, Hypertension
World Trade Center Adolescent Health Study
The proposed study builds upon preliminary studies in self-selected populations to identify opportunities for early identification of World Trade Center-related health consequences in adolescents.
- Conditions
- Asthma, Hypertension, Cardiovascular Risk Factor, Insulin Resistance
- Trial name
- NCT02068183
- Where
- United States
- Volunteers
- 402 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Systemic Sclerosis
Investigation of Coronary and Pulmonary Circulatory Parameters in Systemic Sclerosis
Aim: Determination of frequency and nature of coronary involvement (including epicardial and microvascular) among scleroderma patients referred for right heart catheterization.
- Trial name
- NCT00843102
- Where
- Hungary
- Volunteers
- 120 people
- Sponsor
- University of Pecs
Chronic Thromboembolic Pulmonary Hypertension
The Role of Matrix Metalloproteinase 2 and 9 Enzymes in Developing Chronic Thromboembolic Pulmonary Hypertension
Chronic thromboembolic pulmonary hypertension is an occlusive disease in pulmonary artery.Matrix metalloproteinase enzymes play a substantial role of extracellular matrix remodeling.
- Trial name
- NCT04773028
- Testing
- matrix metalloproteinase enzymes 2 and 9
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- AHMET ZENGIN
Pulmonary Arterial Hypertension
Clinical Study to Evaluate the Effects of Macitentan on Exercise Capacity in Subjects With Eisenmenger Syndrome
Clinical study to assess the efficacy, safety, and tolerability of macitentan in subjects with Eisenmenger Syndrome.
- Trial name
- MAESTRO (NCT01743001)
- Testing
- Macitentan 10 mg
- Where
- 55 sites in United States, Austria and 19 more
- Volunteers
- 226 people
- Sponsor
- Actelion
Pulmonary Arterial Hypertension
A Study to Investigate Safe and Tolerable Dose of GMA301 Injection in Healthy Volunteers
This study is a single-centre, randomized, double-blind, placebo-controlled, dose escalation study to assess the safety, tolerability and PK of GMA301 Injection in healthy subjects.
- Trial name
- NCT04505137
- Testing
- GMA301 Injection
- Where
- Australia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Gmax Biopharm Australia Pty Ltd.
Oesophageal Cancer, Non Small Cell Lung Cancer
Cardiopulmonary Toxicity of Thoracic Radiotherapy
Radiotherapy improves locoregional control and survival of thoracic tumour patients. However, the associated exposure of normal tissues, often leads to side effects and possibly even reduces survival.
- Trial name
- CLARIFY (NCT03978377)
- Where
- 3 sites in Belgium, Netherlands and 1 more
- Volunteers
- 320 people
- Sponsor
- University Medical Center Groningen
Pulmonary Hypertension
CTEPH DIAGNOSIS Europe - MRI
Phase III diagnostic trial to demonstrate that functional lung MRI can replace VQ-SPECT in a diagnostic strategy for patients with suspected CTEPH where positive findings are verified with catheter pulmonary angiography (CPA), or…
- Trial name
- NCT02791282
- Testing
- Index test: functional dynamic contrast enhanced (DCE)-MRI
- Where
- Germany
- Volunteers
- 1,080 people
- Sponsor
- Hannover Medical School
Hypertension, Pulmonary
Pulmonary Hypertension: Assessment of Cell Therapy
The primary objective is to establish the safety of autologous progenitor cell-based gene therapy of heNOS in patients with severe Pulmonary Arterial Hypertension(PAH) refractory to conventional treatment.
- Trial name
- PHACeT (NCT00469027)
- Testing
- eNOS transfected EPCs will be delivered via a PA line
- Where
- 2 sites in Canada
- Volunteers
- 7 people
- Sponsor
- Northern Therapeutics
Pulmonary Hypertension
Dapagliflozin in Mangement of Pulmonary Hypertension Patients
Effect of SGLT2 (Dapagliflozin)on prognosis of patient with pulmonary Hypertension and Effect on RV function By speckle tract echocardiography at Assiut University Hospital.
- Trial name
- NCT06612086
- Testing
- Dapagliflozin (Forxiga)
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Assiut University
Pulmonary Arterial Hypertension, Idiopathic Pulmonary Fibrosis
Pulmonary Arterial Hypertension Secondary to Idiopathic Pulmonary Fibrosis and Treatment With Bosentan
Pulmonary Arterial Hypertension (PAH) in the setting of Idiopathic Pulmonary Fibrosis(IPF)is a risk factor for morbidity and mortality in the peri-lung transplant(LT) setting.
- Trial name
- NCT00625469
- Testing
- bosentan
- Where
- 2 sites in United States
- Sponsor
- Rajan Saggar
Infection, Heart Failure
Rural Home Hospital: Proof of Concept
This study examines the implications of providing hospital-level care in rural homes.
- Conditions
- Infection, Heart Failure, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT04531280
- Testing
- Home hospital care
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Brigham and Women's Hospital
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