Clinical trials: Pulmonary Artery Hypertension
Pulmonary Artery Hypertension
Sotatercept in Pulmonary Arterial Hypertension
The goal of this clinical trial is to determine whether sotatercept is effective in improving diffusing capacity in patients with pulmonary arterial hypertension.
- Trial name
- NCT07140484
- Testing
- Sotatercept
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- University of Alberta
Idiopathic Pulmonary Arterial Hypertension
Virtual Reality in Patients With Pulmonary Hypertension: A Randomized Controlled Trial
The goal of this research is to investigate the effectiveness of exercise administered via immersive virtual reality in patients with pulmonary hypertension, thereby contributing to the existing literature on this subject.
- Trial name
- NCT07558460
- Testing
- Virtual Reality Group
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Istanbul University - Cerrahpasa
Hypertension in Pregnancy
Pulmonary Artery Doppler And Neonatal Outcome In Hypertensive Disorders Of Pregnancy
To correlate fetal Pulmonary artery Doppler parameters with neonatal outcome in patients diagnosed with hypertensive disorders of pregnancy.
- Trial name
- NCT05793125
- Testing
- Ultrasonography
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Cairo University
Pulmonary Arterial Hypertension
3D Echo Evaluation of the Ventricles in Sclero Associated Severe PAH
The aim of the study is to document the left and right ventricular function in patients with sclerodermia associated pulmonal arterial hypertension via 3D echocardiography.
- Trial name
- EVA3D (NCT02207868)
- Where
- Austria
- Volunteers
- 6 people
- Sponsor
- Regina Steringer-Mascherbauer
Pulmonary Artery Hypertension
Vascular Subphenotypes of Lung Disease in HIV & COPD
This study is looking for high blood pressure in the lungs (Pulmonary artery hypertension PAH) in HIV and COPD patients.
- Trial name
- VAST (NCT01581086)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pittsburgh
Pulmonary Arterial Hypertension, Chronic Thromboembolic Pulmonary Hypertension
Home-based Inspiratory Muscle Training in Pulmonary Hypertension
The main objective of this study is to determine whether an 8-week inspiratory muscle training (IMT) programme, delivered at home through telerehabilitation, improves ventilatory efficiency (VE/VCO2 slope) compared with a sham…
- Trial name
- SLOPE-PH (NCT07917416)
- Testing
- Inspiratory muscle training
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Universidad Complutense de Madrid
Pulmonary Arterial Hypertension
Utility of At-home Monitoring of Exercise Capacity by App-based 6-minute Walk Test
Evaluate for accuracy and reproducibility of data collected via the participant-operated Walk.Talk.Track. (WTT) app combined with Apple Watch during in-clinic, technician proctored 6MWT's.
- Trial name
- DynAMITE (NCT03893500)
- Testing
- Home-based 6 minute walk test
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Stanford University
Pulmonary Arterial Hypertension (PAH)
Open-Label Study of IKT-001 in Pulmonary Arterial Hypertension (PAH)
This is a multicenter, open-label extension (OLE), single-arm study designed to assess the long-term safety and tolerability of oral IKT-001 administered once daily.
- Trial name
- NCT07632898
- Testing
- IKT-001
- Volunteers
- 484 people
- Sponsor
- Inhibikase Therapeutics
Pulmonary Arterial Hypertension (PAH)
ALlogeneic Cardiosphere-derived Stem Cells (CDCs) for Pulmonary Hypertension therApy
Pulmonary Arterial Hypertension or PAH is a progressive condition for which there is no cure. Even with substantial pharmacologic advances in the modern treatment era, survival still remains unacceptably poor, as reported in…
- Trial name
- ALPHA (NCT03145298)
- Testing
- Allogeneic Human Cardiosphere-Derived Stem Cells
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Cedars-Sinai Medical Center
Pulmonary Arterial Hypertension
Drug Interaction Between Ritonavir And Sitaxsentan
The study is to assess if sitaxsentan and ritonavir will affect the blood levels of each other when coadministered.
- Trial name
- NCT01251848
- Testing
- Sitaxentan, Ritonavir, Sitaxsentan
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pfizer
Pulmonary Arterial Hypertension
Exercise Capacity Respiratory Muscle Strength Dyspnea and Physical Activity in Pediatric Pulmonary Arterial Hypertension
The primary aim of this study was to evaluate exercise capacity, respiratory muscle strength, pulmonary function, dyspnea and physical activity levels in pediatric PAH patients and compare them with healthy controls.
- Trial name
- NCT05124015
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Gazi University
Pulmonary Arterial Hypertension
Subcutaneous Elafin in Healthy Subjects
A multiple-ascending-dose (MAD), randomized, placebo-controlled, blinded trial to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of Elafin in healthy adult subjects.
- Trial name
- NCT03522935
- Testing
- Elafin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Roham T. Zamanian
Pulmonary Arterial Hypertension
Fluoxetine in Pulmonary Arterial Hypertension (PAH) Trial
This protocol describes an open-label phase 2 clinical trial of fluoxetine in PAH looking at change in pulmonary vascular resistance (PVR) as the primary endpoint.
- Trial name
- PAH (NCT03638908)
- Testing
- Fluoxetine
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Pulmonary Arterial Hypertension
Bosentan and Pulmonary Endothelial Function
6 months therapy of Bosentan, an endothelin antagonist, will lead to improvement in pulmonary microvascular endothelial function.
- Trial name
- PARBO (NCT01721564)
- Testing
- Bosentan
- Volunteers
- 8 people
- Sponsor
- Prof David S Celermajer
Pulmonary Arterial Hypertension
A Multi-Center, Open-Label, Multiple Dose, Dose Finding Study Exploring the Safety and Tolerability of Beraprost Sodium Modified Release in PAH Patients
This study is an international, open-label, multi-center, Phase II, multiple dose, dose-finding study to investigate the safety, tolerability and pharmacokinetic characteristics of BPS-MR tablets in male and female patients with…
- Trial name
- NCT00781885
- Testing
- Beraprost sodium modified release
- Where
- 6 sites in United States, Belgium and 1 more
- Volunteers
- 19 people
- Sponsor
- Lung Biotechnology PBC
Pulmonary Arterial Hypertension
Efficacy and Safety of Seralutinib in Adult Subjects With PAH (PROSERA)
The primary objective of the study is to determine the effect of seralutinib on improving exercise capacity in subjects with WHO Group 1 PAH who are FC II or III.
- Trial name
- NCT05934526
- Testing
- Seralutinib, Generic Dry Powder Inhaler
- Where
- 166 sites in United States, Argentina and 29 more
- Volunteers
- 390 people
- Sponsor
- GB002, Inc.
Pulmonary Hypertension
Evaluation of the Strength of Handgrip in Patients With Pulmonary Artery Hypertension
Our study aims to investigate the changes in muscle strength and muscle mass in PAH patients compared to healthy individuals and determine its effects on prognosis.
- Trial name
- NCT05447390
- Testing
- Handgrip strength test
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Gazi University
Idiopathic Pulmonary Arterial Hypertension, Heritable Pulmonary Arterial Hypertension
Right Ventricle Lipid in Pulmonary Arterial Hypertension (PAH)
The investigators propose to study the relationship between right ventricle (RV) steatosis and RV function, exercise capacity, and outcomes in humans with pulmonary arterial hypertension (PAH) and to identify potential drivers of…
- Conditions
- Idiopathic Pulmonary Arterial Hypertension, Heritable Pulmonary Arterial Hypertension, Pulmonary Arterial Hypertension Associated With Connective Tissue Disease
- Trial name
- NCT05462574
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Vanderbilt University Medical Center
Pulmonary Arterial Hypertension, Randomized Controlled Trial
Efficacy and Safety Evaluation of Tolvaptan in the Treatment of Patients With RHF Caused by PAH
Efficacy and safety evaluation of tolvaptan in the treatment of patients with right heart failure caused by pulmonary arterial hypertension
- Trial name
- NCT05569655
- Testing
- Tolvaptan, Furosemide
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chinese Pulmonary Vascular Disease Research Group
Congenital Heart Disease
Reversibility by Sildenafil of Exercise-Induced Abnormal Right Ventricular Pressure Response in ASD and VSD-Operated Patients
The purpose of this study is to determine whether oral sildenafil citrate reduces the abnormal right ventricular pressure response during exercise in adolescent and adult patients with specific types of congenital heart defects.
- Trial name
- NCT00772135
- Testing
- sildenafil citrate
- Where
- Norway
- Volunteers
- 15 people
- Sponsor
- Oslo University Hospital