Clinical trials: Pulmonary Coin Lesion
Pulmonary Nodule, Multiple, Pulmonary Nodule, Solitary
Utility of CAML as Diagnostic for Early Stage Lung Cancer
Primary Objective Determine the prevalence of CAMLS in patients with pulmonary nodules. Secondary Objectives Determine the positive and negative predictive value of CAMLS in patients with pulmonary nodules who undergo biopsy.
- Trial name
- NCT03992183
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Fox Chase Cancer Center
Tumor
Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors
This is a study to assess the combination of PXD101 and 5-Fluorouracil (5-FU)in patients with advanced solid tumors. The primary goal of the study is to understand the safety, anti-tumor activity, and how the study drug behaves…
- Trial name
- NCT00413322
- Testing
- belinostat, 5-Fluorouracil (5-FU)
- Where
- 3 sites in United States
- Volunteers
- 35 people
- Sponsor
- Valerio Therapeutics
Lung Cancer
Ultrathin Bronchoscopy for Solitary Pulmonary Nodules
The evaluation of solitary pulmonary nodules (SPN) requires a balance between procedure-related morbidity and diagnostic yield, particularly in areas where tuberculosis is endemic.
- Trial name
- Babyscope (NCT02490059)
- Testing
- bronchoscopy
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University of Zurich
Lung Diseases, Interstitial, Pulmonary Nodule, Solitary
Chest Tube After a Video-assisted Thoracoscopic Surgery Pulmonary Wedge Resection
After performing VATS pulmonary wedge resections, a chest tube is routinely left in the pleural cavity to drain possible air leaks and fluid accumulations.
- Trial name
- NOTUBE (NCT00841750)
- Testing
- Do not leave a chest tube in the pleural cavity., Do leave a chest tube in the pleural cavity.
- Where
- 3 sites in Colombia
- Volunteers
- 100 people
- Sponsor
- Fundación Oftalmológica de Santander Clínica Carlos Ardila Lulle
Pulmonary Nodule, Solitary, Lung; Node
The Early Diagnosis of Pulmonary Nodule Based on Multi-dimension Messages
The researchers are aimed to investigate the early diagnosis of pulmonary nodule based on DNA, RNA, protein, metabolites through analyzing the serum, plasma, urine, faeces, peripheral blood mononuclear cell (PBMC), exhaled breath…
- Trial name
- NCT04005677
- Testing
- The serum, plasma, urine, faeces, peripheral blood mononuclear cell (PBMC), exhaled breath condensate and the clinical characteristics are collected.
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Pulmonary Nodule, Solitary, Pulmonary Nodule, Multiple
Nitrous Oxide for Identifying the Intersegmental Plane in Segmentectomy: A Randomized Controlled Trial
Lung cancer is currently one of the most common malignant tumors in the world. In recent years, with the popularity of high-resolution CT, more and more early-stage lung cancers have been found.
- Conditions
- Pulmonary Nodule, Solitary, Pulmonary Nodule, Multiple, Lung Cancer
- Trial name
- NCT04302350
- Testing
- nitrous oxide
- Where
- 2 sites in China
- Volunteers
- 81 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Solitary Pulmonary Nodule, Bronchial Neoplasms
ThoHSpEkt Thoracoscopic Ectomy of Radioactively Marked Pulmonary Nodules With Free-hand SPECT
Title ThoHSpEkt Study Design Pilot Study concerning the technical operative methods and a phase II study concerning the radiopharmaceutical (therapeutic-explorative study with an approved drug in a new indication) Location…
- Trial name
- ThoHSpEkt (NCT02050724)
- Testing
- Radioactive labelling of pulmonary nodules, CT guided radioactive labelling, Electromagnetic guided bronchoscopic radioactive labelling
- Where
- Switzerland
- Volunteers
- 11 people
- Sponsor
- Cantonal Hospital of St. Gallen
Lung Cancer (Diagnosis), Nodule, Solitary Pulmonary
Non-Invasive Malignancy Classifiers Using Blood-Biomarkers for Lung Nodule Evaluation
The goal of the NIMBLE study is to evaluate blood-based biomarkers for lung cancer risk prediction in patients referred with a lung nodule.
- Trial name
- NIMBLE (NCT07623473)
- Testing
- Blood tests
- Where
- Denmark
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Herlev and Gentofte Hospital
Lung Neoplasms, Pulmonary Nodule, Solitary
LungVision AI-Augmented Fluoroscopic Navigation for Intraoperative Pulmonary Nodule Localization
This prospective single-center pilot study evaluates the clinical feasibility, localization accuracy, and safety of the LungVision system-an AI-augmented fluoroscopic navigation platform-for real-time intraoperative localization…
- Conditions
- Lung Neoplasms, Pulmonary Nodule, Solitary, Carcinoma, Non-Small-Cell Lung
- Trial name
- NCT07682012
- Testing
- LungVision System, Preoperative Dual Localization
- Where
- Taiwan
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Tri-Service General Hospital (TSGH)
Lung Cancer, Solitary Pulmonary Nodule
Liquid Biopsy With PET/CT Versus PET/CT Alone in Diagnosis of Small Lung Nodules
The purpose of this study is to determine if a liquid biopsy, a method of detecting cancer from a blood draw, combined with a PET/CT scan, a type of radiological scan, is better at determining whether a lung nodule is cancerous…
- Conditions
- Lung Cancer, Solitary Pulmonary Nodule, Multiple Pulmonary Nodules
- Trial name
- NCT05066776
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Palo Alto Veterans Institute for Research
Lung Cancer, Pulmonary Nodule, Solitary
Assessment of a Radiomics-based Computer-Aided Diagnosis Tool for Pulmonary nodulES
This is a pragmatic clinical trial that will study the effect of a radiomics-based computer-aided diagnosis (CAD) tool on clinicians' management of pulmonary nodules (PNs) compared to usual care.
- Trial name
- ARCADES (NCT05968898)
- Testing
- Optellum Virtual Nodule Clinic
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Pulmonary Nodule, Solitary, Pulmonary Nodule, Multiple
Clinical Evaluation of Primary Sampling Scatter Correction for Chest Tomosynthesis
This is a study that will evaluate the utility of a scatter reduction technique in reducing dose and increasing the sensitivity of stationary digital chest tomosynthesis (s-DCT) in the detection of lung lesions.
- Trial name
- NCT04076696
- Testing
- Scatter corrected s-DCT
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Incidental Lung Nodule
Lung Nodule Characterization by Artificial Intelligence Techniques
Management of incidental lung nodule is difficult and mainly based on simple morphometric characteristics such as maximum size and shape.
- Trial name
- CARANOD-IA (NCT03843164)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Pulmonary Nodule, Solitary
Circulating Tumor DNA Methylation Test to Differentiate Benign and Malignant Pulmonary Nodules
Current state-of-the-art lung cancer early screening utilizes low-dose CT scan to identify lung nodules smaller than 3 cm in diameter.
- Trial name
- NCT03181490
- Testing
- Circulating Tumor DNA Methylation Test
- Where
- 14 sites in China
- Volunteers
- 1,490 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Nodule Solitary Pulmonary, Non-small Cell Carcinoma
Nodify XL2 Classifier Clinical Utility Study in Low to Moderate Risk Lung Nodules
This study evaluates the how addition of the Nodify XL2 test result impacts the clinical management of newly identified solid lung nodules assessed as low to moderate risk of cancer.
- Trial name
- ALTITUDE (NCT04171492)
- Where
- 25 sites in United States, Canada
- Volunteers
- 2,000 people
- Sponsor
- Biodesix, Inc.
Solitary Pulmonary Nodule, Multiple Pulmonary Nodules
Evaluation of Lung Nodule Detection With Artificial Intelligence Assisted Computed Tomography in North China
Lung cancer is one of the leading cause of cancer related death in China. Lung cancer screening with low-dose computed tomography was considered as a better approach than radiography.
- Trial name
- NCT03487952
- Testing
- Questionnaire Administration
- Volunteers
- 5,000 people
- Sponsor
- Peking University People's Hospital
Pulmonary Neoplasms, Solitary Pulmonary Nodules
Diagnosis of Lung Lesions by Endobronchial Ultrasound With an Alternative Guide Sheath
The purpose of this study is to examine the usefulness of a balloon covered sheath as a guide sheath in endobronchial ultrasound guided transbronchial biopsy and bronchial brushing cytology for diagnosis of peripheral lung lesions
- Trial name
- NCT00922155
- Testing
- guide sheath
- Where
- Taiwan
- Volunteers
- 180 people
- Sponsor
- Chang Gung Memorial Hospital
Solitary Pulmonary Nodule, Multiple Pulmonary Nodules
Multiparametric Lung MRI With Diffusion-Weighted Imaging in Lung-RADS 4 Lesion Characterization
This study evaluates whether multiparametric chest magnetic resonance imaging (MRI) with diffusion-weighted imaging (DWI), performed without any contrast material, can distinguish malignant from benign lung lesions that were…
- Conditions
- Solitary Pulmonary Nodule, Multiple Pulmonary Nodules, Lung Neoplasms, Lung Cancer Screening
- Trial name
- NCT07768046
- Testing
- Multiparametric chest MRI with diffusion-weighted imaging
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Florida