Clinical trials: Pulmonary Complications
Pulmonary Complication, Dyspnea
Incentive Spirometry in Non-critically Ill Hospitalized Patients With Acute Respiratory Failure
To evaluate the use of Incentive Spirometry in Non-critically Ill Hospitalized Patients With Shortness of Breath.
- Conditions
- Pulmonary Complication, Dyspnea, Pneumonia, COPD
- Trial name
- NCT02873000
- Testing
- Incentive Spirometry
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Jewish Hospital, Cincinnati, Ohio
Lung Neoplasm, Lung Cancer
Lung Ultrasound to Assess Aeration Loss After Lung Resection Surgery
The purpose of this prospective observational study is to assess perioperative changes in lung aeration after lung resection surgery using lung ultrasound, and to explore their relationship with oxygenation, inflammatory…
- Conditions
- Lung Neoplasm, Lung Cancer, Lung Resection Surgery, Thoracic Surgery
- Trial name
- THORUS (NCT04677309)
- Testing
- Perioperative lung ultrasound assessment
- Where
- Spain
- Volunteers
- 32 people
- Sponsor
- Ana Broseta Lleó
Vascular Surgical Procedures, COVID-19
Outcomes of Vascular Surgery in COVID-19 Infection: National Cohort Study
There is an urgent need to understand the outcomes of COVID-19 infected patients who undergo surgery, specially vascular surgery.
- Conditions
- Vascular Surgical Procedures, COVID-19, Postoperative Complications
- Trial name
- Covid-VAS (NCT04333693)
- Testing
- Vascular surgery
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Vascular Investigation Network Spanish Society for Angiology and Vascular Surgery
Mechanical Ventilation Complication
Effect of Intermittent Versus Continuous Subglottic Secretion Drainage on Tracheal Mucosa Damages
Endotracheal tubes with subglottic secretion drainage (incorporating a suction port above the cuff) have been shown to reduce the incidence of ventilator-associated pneumonia.
- Trial name
- ASPIRE (NCT01555229)
- Testing
- Intermittent subglottic secretion drainage, Continuous subglottic secretion drainage
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Rennes University Hospital
Lymphoma, Non-Hodgkin, Lymphoma, Follicular
A Study Of PF-05082566 As A Single Agent And In Combination With Rituximab
A study of PF-05082566, a 4-1BB agonist monoclonal antibody (mAb), in patients with solid tumors or b-cell lymphomas, and in combination with rituximab in patients with CD20 positive Non-Hodgkin's Lymphoma (NHL).
- Conditions
- Lymphoma, Non-Hodgkin, Lymphoma, Follicular, Lymphoma, Large B-Cell, Diffuse, Carcinoma, Non-Small-Cell Lung
- Trial name
- NCT01307267
- Testing
- PF-05082566, rituximab
- Where
- 42 sites in United States, Australia and 3 more
- Volunteers
- 190 people
- Sponsor
- Pfizer
Ovarian Carcinoma, Fallopian Tube Carcinoma
NM32-2668 in Adult Patients With Selected Advanced Solid Tumors
This is a first-in-human, open-label, multi-center, Phase 1, dose-escalation study with expansion cohorts to evaluate NM32-2668 for safety and immunogenicity, to determine the maximal tolerated dose and recommended Phase 2 dose…
- Conditions
- Ovarian Carcinoma, Fallopian Tube Carcinoma, Peritoneal Carcinoma, Endometrial Cancer
- Trial name
- NCT06299163
- Testing
- NM32-2668
- Where
- 11 sites in United States
- Volunteers
- 11 people
- Sponsor
- Numab Therapeutics AG
Premature Birth
Preterm Lung Function and Exercise Response Measured by OEP
This study will explore lung function and respiratory health in school-aged children who were born prematurely at <32 weeks gestation.
- Trial name
- NCT04239287
- Testing
- Lung function + exercise tests
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Postoperative Pulmonary Complications (PPCs), Feasibility Studies
PROtective Ventilation With FLOW-Controlled Ventilation
The investigators want to investigate in patients undergoing robot-assisted laparoscopic surgery (a minimally invasive procedure) how applicable flow-controlled ventilation is, and whether it might also be safer than the current…
- Conditions
- Postoperative Pulmonary Complications (PPCs), Feasibility Studies, Pilot Study
- Trial name
- PROFLOW (NCT06703814)
- Testing
- Intraoperative flow-controlled ventilation strategy, Intraoperative pressure-controlled ventilation strategy
- Where
- 3 sites in Austria, Germany and 1 more
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cantonal Hospital of St. Gallen
Postoperative Pain, Lung Cancer
Postoperative Pain Management on Patients Undergoing Lung Tumor Resection
Multimodal analgesia (MMA) is an essential part of Enhanced Recovery After Surgery (ERAS) protocol. The principle of MMA is to manage pain with analgesics of multiple classes acting on distinct target sites through different…
- Conditions
- Postoperative Pain, Lung Cancer, Lung Tumor
- Trial name
- NCT06397807
- Testing
- Dinalbuphine sebacate, Analgesic injectables, Enteral analgesics
- Volunteers
- 400 people
- Sponsor
- China Medical University Hospital
Lung Tumor, Bone Tumor
Preliminary Study of Microwave Tumoral Ablation Performances for the Treatment of Pulmonary, Renal and Bone Neoplasia.
The aims of this work were to assess the feasibility, efficacy, short-term outcome and safety of microwave ablation in the treatment of malignant bone, lung and renal tumors.
- Conditions
- Lung Tumor, Bone Tumor, Renal Tumor
- Trial name
- TherMO (NCT02862288)
- Testing
- Microwave ablation with Acculis Accu2i pMTA Applicator
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Lung Cancer, Breast Cancer
Plasma Metabolic Biomarkers for Multi-Cancer Diagnosis
The aim of this observational study is to comprehensively analyze the metabolites in plasma samples from multi-cancer patients using advanced mass spectrometry detection technology, in conjunction with metabolomics approaches.
- Conditions
- Lung Cancer, Breast Cancer, Colorectal Cancer, Thyroid Cancer
- Trial name
- NCT06363123
- Where
- 4 sites in China
- Volunteers
- 2,700 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital
Pulmonary Disease, Chronic Obstructive
Development and Validation of the GLORI-COPD Score
The objective of this study is to evaluate the diagnostic accuracy of the GLORI-COPD score in ambulatory care, to enable the screening of COPD patients at risk of complications, requiring early management
- Trial name
- GLORI-COPD (NCT04027296)
- Where
- France
- Volunteers
- 462 people
- Sponsor
- University of Paris 5 - Rene Descartes
Prostate Cancer, Breast Cancer
Collection of Blood From Patients With Cancer, Other Tumors, or Tumor Predisposition Syndromes for Genetic Analysis
Background: Some genes may be associated with a greater chance of side effects during cancer treatment. These genes may also make certain treatments less effective.
- Conditions
- Prostate Cancer, Breast Cancer, Lung Cancer, Ovarian Cancer
- Trial name
- NCT01441089
- Where
- United States
- Volunteers
- 1,100 people
- Sponsor
- National Cancer Institute (NCI)
Mechanical Ventilation Complication
National Approach to Standardize and Improve Mechanical Ventilation
This is a pre-post implementation cohort study. This is a data driven quality improvement project which aims to improve the care of mechanically ventilated patients through the implementation of a bundle of evidence based…
- Trial name
- NASAM (NCT03790150)
- Testing
- Evidence-based practices
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 27,966 people
- Sponsor
- King Abdullah International Medical Research Center
Postoperative Pulmonary Complications, Positive End-expiratory Pressure
Individualized PEEP Titration on Postoperative Pulmonary Complications
This study aims to investigate the effectiveness and safety of implementing a personalized positive end-expiratory pressure (PEEP) management strategy guided by esophageal pressure (Pes), as well as its potential to reduce the…
- Conditions
- Postoperative Pulmonary Complications, Positive End-expiratory Pressure, Elderly, Laparoscopic Surgery
- Trial name
- NCT06150079
- Testing
- Pes-Guided PEEP titration
- Where
- 4 sites in China
- Volunteers
- 240 people
- Sponsor
- Shanghai Zhongshan Hospital
Lung Resection Surgery, Anesthesia General
Effect of Oxygen Administration in the Non-dependent Lung on Postoperative Complications After Lung Surgery
The purpose of this study is to analyze the effectiveness of apneic oxygenation and CPAP applied to the non-dependent lung during pulmonary resection surgery in reducing inflammatory response, ischemia-reperfusion injury, and…
- Trial name
- NCT07461779
- Testing
- Medicinal gas - oxygen (Nippon Gases 200 bar), CPAP, Oxygen therapy according to standard clinical practice
- Where
- Spain
- Volunteers
- 177 people
- Sponsor
- Francisco Andres de la Gala
Vascular Access Complication, Apheresis Related Complication
Vascular Access Complications for Therapeutic Apheresis in Nephrology
The aim of this study is to describe vascular access complications which are used for therapeutic apheresis in Nephrology.
- Trial name
- VACTANE (NCT05894317)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Tumors, Ovarian Cancer
Phase I Study of ZN-c3 and Bevacizumab ± Pembrolizumab in Metastatic CCNE1 Amplified and TP53 Mutant Solid Tumors
Primary Objectives are to determine the maximum tolerated dose (MTD)/recommended phase 2 dose (RP2D) of ZN-c3 and ZN-c3 and bevacizumab or ZN-c3 and bevacizumab plus pembrolizumab in metastatic CCNE1 amplified and TP53 mutant…
- Conditions
- Tumors, Ovarian Cancer, Breast Cancer, Lung Cancer
- Trial name
- NCT05431582
- Testing
- ZN-c3, Bevacizumab, Pembrolizumab
- Sponsor
- M.D. Anderson Cancer Center
Pneumonia
Efficiency of the Imaging Strategy for the Management of Pneumonia
For patients with suspected pneumonia presenting to the emergency room, the imaging strategy most often involves a frontal and lateral chest x-ray despite poor diagnostic input.
- Trial name
- EFFI-PNEUMO (NCT05140408)
- Where
- France
- Volunteers
- 2,240 people
- Sponsor
- University Hospital, Strasbourg, France
Respiratory Virus Infection, Stroke
Respiratory Virus Infections in Acutely Hospitalized Adult Patients With Pulmonary and Extrapulmonary Complications
Respiratory virus infections are one of the major causes of hospitalizations, and outbreaks of respiratory virus infection have led to severe economic loss.
- Conditions
- Respiratory Virus Infection, Stroke, Lung Disease, Acute Coronary Syndrome
- Trial name
- NCT03816059
- Testing
- Respiratory virus testing
- Where
- Hong Kong
- Volunteers
- 200 people
- Sponsor
- The University of Hong Kong