Clinical trials: Pulmonary Complications
Cystic Fibrosis, Gastrointestinal System Disease
CFTR Modulators and Gastrointestinal Complications
To elucidate the similarities and distinctions in non-pulmonary manifestations of cystic fibrosis (CF) including distal intestinal obstruction syndrome (DIOS) incidence and pancreatic enzyme replacement therapy (PERT) use between…
- Conditions
- Cystic Fibrosis, Gastrointestinal System Disease, Distal Intestinal Obstruction Syndrome, Pancreatic Enzyme Abnormality
- Trial name
- CFTR-MAGIC (NCT05253859)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 47,023 people
- Sponsor
- Nottingham University Hospitals NHS Trust
COVID-19, Endothelial Function
Diagnostics of Coronavirus Disease 2019 Cardiovascular Complications
Aim of this prospective, observational, multi-centered, randomized study is to detect cardiovascular complications in patients after coronavirus infection.
- Conditions
- COVID-19, Endothelial Function, Diastolic Dysfunction, Oxygen Consumption
- Trial name
- NCT05608603
- Testing
- Portable cardiac monitor "CardioQvark", Cardiorespiratory stress test, Analysis of exhaled air using the Compact PTR-MS proton mass spectrometer
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Atherosclerosis, Chronic Kidney Diseases
The ILERVAS Project: Assessing the Prevalence of Subclinical Vascular Disease and Hidden Kidney Disease
BACKGROUND AND OBJECTIVES: Cardiovascular disease is the leading cause of death despite huge primary and secondary prevention policies with a strong economic burden.
- Conditions
- Atherosclerosis, Chronic Kidney Diseases, Metabolic Syndrome, PreDiabetes
- Trial name
- ILERVAS (NCT03228459)
- Testing
- Dried blood spot test, Urine test, Artery ultrasound
- Where
- 3 sites in Spain
- Volunteers
- 16,660 people
- Sponsor
- Institut de Recerca Biomèdica de Lleida
Post Opeative Pulmonary Complication
The Effect of Acapella and Incentive Spirometry on Blood Gases and Peak Expiratory Flow Rate After Coronary Artery Bypass Graft.
The goal of this clinical trial is to learn if whether the Acapella and Incentive Spirometry have effect on Blood Gas and Peak Expiratory Flow Rate among patients undergoing Coronary Artery Bypass Graft Surgery.
- Trial name
- NCT07337746
- Testing
- Incentive Spirometry therapy, Acapella therapy
- Where
- 2 sites in Iraq
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Metastatic Malignant Neoplasm in the Lung, Metastatic Melanoma
Aerosolized Aldesleukin in Treating Patients With Lung Metastases
This phase I/II trial studies the side effects and best dose of aerosolized aldesleukin and to see how well it works in treating patients with cancer that has spread from the original tumor to the lungs.
- Conditions
- Metastatic Malignant Neoplasm in the Lung, Metastatic Melanoma, Metastatic Osteosarcoma, Metastatic Renal Cell Cancer
- Trial name
- NCT01590069
- Testing
- Aerosolized Aldesleukin, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- M.D. Anderson Cancer Center
Postoperative Pulmonary Atelectasis
Effectiveness of Oscillation on Postoperative Pulmonary Complications After Elective Postcardiac Surgery
Our study aims to evaluate the effectiveness of continuous high-frequency oscillation therapy in reducing PPCs in patients following elective cardiac surgery.
- Trial name
- NCT06902220
- Testing
- continuous high-frequency oscillation therapy
- Volunteers
- 470 people
- Sponsor
- Southeast University, China
Breast Cancer, Head and Neck Squamous Cell Carcinoma
A Study to Evaluate ONM-100, an Intraoperative Fluorescence Imaging Agent for the Detection of Cancer
This study is to evaluate diagnostic performance, safety and timing of post-dose imaging of ONM-100, an intraoperative fluorescence imaging agent for the detection of cancer in patients with solid tumors undergoing routine…
- Conditions
- Breast Cancer, Head and Neck Squamous Cell Carcinoma, Colorectal Cancer, Prostate Cancer
- Trial name
- NCT03735680
- Testing
- ONM-100
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- OncoNano Medicine, Inc.
Neoplasms, Carcinoma, Non Small Cell Lung
A Study Of PF-06263507 In Patients With Advanced Solid Tumors
To assess the safety and tolerability at increasing dose levels of PF-06263507 in patients with advanced solid tumors in order to determine the maximum tolerated dose and select the recommended Phase 2 dose.
- Conditions
- Neoplasms, Carcinoma, Non Small Cell Lung, Breast Neoplasms, Ovarian Neoplasms
- Trial name
- NCT01891669
- Testing
- PF-06263507
- Where
- 4 sites in United States
- Volunteers
- 26 people
- Sponsor
- Pfizer
Respiratory Distress Syndrome (RDS), Newborn
Noninvasive High Frequency Oscillatory Ventilation Versus Nasal Intermittent Mandatory Ventilation for Respiratory Distress Syndrome in Preterm Neonates
The goal of this clinical trial is to learn if nasal high frequency oscillatory ventilation (nHFOV) works no worse than nasal intermittent mandatory ventilation (NIMV) as early breathing support.
- Conditions
- Respiratory Distress Syndrome (RDS), Newborn, Premature Birth
- Trial name
- NOV-RDS (NCT07837141)
- Testing
- Noninvasive High Frequency Oscillatory Ventilation, Nasal Intermittent Mandatory Ventilation
- Where
- Pakistan
- Volunteers
- 158 people
- Sponsor
- Aga Khan University
COVID, Pregnancy Complications, Infectious
International Lung UltraSound Analysis (ILUSA) Study
Currently there is a great need for an accurately and rapid assessment of patients suspected for Covid-19. Like CT, Lung Ultrasound (LUS) examination can potentially help with the initial triage of patients but also help track…
- Conditions
- COVID, Pregnancy Complications, Infectious, Pregnancy Related, Pregnancy, High Risk
- Trial name
- ILUSA (NCT04353141)
- Testing
- standardized Lung Ultrasound (LUS) examination
- Where
- 7 sites in Belgium, Italy and 1 more
- Volunteers
- 1,850 people
- Sponsor
- KU Leuven
Non-small Cell Lung Cancer, Renal Cell Carcinoma
Pre-Incisional Ketorolac for Patients Undergoing Surgery for Non-Small Cell Lung Cancer and Renal Cell Carcinoma
This is a pilot study of biomarker evaluation and safety of pre-incisional ketorolac for patients undergoing surgical resection for non-small cell lung cancer and renal cell carcinoma.
- Trial name
- NCT04495894
- Testing
- Preoperative Ketorolac
- Where
- 4 sites in United States
- Volunteers
- 68 people
- Sponsor
- Emory University
SARS CoV 2 Infection, Multisystem Inflammatory Disease, Pediatric, COVID-19 Related
Incidence of MIS-C and Other Complications Following SARS-CoV-2 Infection
Multisystem inflammatory syndrome in children (MIS-C) is a rare severe complication to SARS-CoV-2 infection in children. It has been reported to occur in approximately one of 3,000 to 4,000 unvaccinated children during the…
- Conditions
- SARS CoV 2 Infection, Multisystem Inflammatory Disease, Pediatric, COVID-19 Related, Multisystem Inflammatory Syndrome in Children, COVID-19 Pandemic
- Trial name
- NCT05186597
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cancer
TTX-080 HLA-G Antagonist in Subjects With Advanced Cancers
TTX-080-001 is a Phase 1, open label, dose escalation and dose expansion clinical study to determine the safety, tolerability, and recommended Phase 2 dose of TTX-080 monotherapy (HLA-G inhibitor) and in combination with either…
- Trial name
- NCT04485013
- Testing
- TTX-080, pembrolizumab, cetuximab
- Where
- 41 sites in United States
- Volunteers
- 240 people
- Sponsor
- Tizona Therapeutics, Inc
Advanced Solid Tumors With Alterations of FGFR1, 2 and or 3, Squamous Lung Cancer With FGFR1 Amplification
A Dose Escalation Study in Adult Patients With Advanced Solid Malignancies
The study will determine the maximum tolerated dose and thus the recommended phase II dose and schedule of the compound and characterize the safety.
- Conditions
- Advanced Solid Tumors With Alterations of FGFR1, 2 and or 3, Squamous Lung Cancer With FGFR1 Amplification, Bladder Cancer With FGFR3 Mutation or Fusion, Advanced Solid Tumors With FGFR1 Amplication
- Trial name
- NCT01004224
- Testing
- BGJ398
- Where
- 50 sites in United States, Australia and 12 more
- Volunteers
- 208 people
- Sponsor
- Novartis Pharmaceuticals
Breast Cancer, Ovarian Cancer
Dermatological Effects and Quality of Life in Oncology Patients
This is a monocentric, low-risk interventional study designed to characterize established treatment-related dermatologic toxicity in patients receiving systemic anticancer therapies.
- Conditions
- Breast Cancer, Ovarian Cancer, NSCLC (Non-small Cell Lung Cancer), Melanoma (Skin Cancer)
- Trial name
- ReGenera (NCT07869186)
- Testing
- skin barrier assessment
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- European Institute of Oncology
Coronary Artery Disease, Postoperative Pulmonary Complications
Flow-Controlled vs. Pressure-Controlled Ventilation in CABG: Effects on Lung Aeration and Diaphragm Function
Pulmonary atelectasis and loss of lung aeration are common complications following cardiac surgery with cardiopulmonary bypass (CPB) and are associated with impaired oxygenation and prolonged mechanical ventilation.
- Conditions
- Coronary Artery Disease, Postoperative Pulmonary Complications, Pulmonary Atelectasis, Postoperative, Diaphragm Dysfunction
- Trial name
- FCV-PCV-DTI-LU (NCT07800741)
- Testing
- Flow-Controlled Ventilation, Pressure-Controlled Ventilation (PCV)
- Where
- Turkey (Türkiye)
- Volunteers
- 154 people
- Sponsor
- Koşuyolu Kartal Heart Training and Research Hospital
Acute Respiratory Distress Syndrome, Mechanical Ventilation Complication
Early Diagnosis of ARDS in Mechanically Ventilated Patient Using LUS Score in Comparison With CT
The aim of this study is to assess accuracy of Lung ultrasound score for early diagnosis of acute respiratory distress syndrome in patients who expected to be mechanically ventilated more than 24 hour in comparison with computed…
- Conditions
- Acute Respiratory Distress Syndrome, Mechanical Ventilation Complication, Computed Tomography
- Trial name
- NCT06971042
- Testing
- Lung Ultrasound
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Tanta University
Drug Use, Alcohol Use
Specialized Community Disease Management to Reduce Substance Use and Hospital Readmissions
This study will assess Specialized Community Disease Management (SCDM), an intervention which employs various evidence-based strategies to engage substance using co-morbid patients while in the hospital and follow them into the…
- Conditions
- Drug Use, Alcohol Use, Congestive Heart Failure, Pneumonia
- Trial name
- NCT02059005
- Testing
- Specialized Community Disease Management, Treatment As Usual
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Treatment Research Institute
B-Cell Neoplasm, Estrogen Receptor Negative
18F-FSPG PET/CT for Cancer Patients on Therapy
The goal of this phase 2 study trial is to evaluate the utility of the radiolabel 18F-FSPG used before and after treatment to diagnose, predict, and evaluate response to therapy in patients with a wide variety of metastatic…
- Conditions
- B-Cell Neoplasm, Estrogen Receptor Negative, HER2/Neu Negative, Metastatic Renal Cell Cancer
- Trial name
- NCT02599194
- Testing
- 18F-FSPG, 18F-FDG
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Andrei Iagaru
Essential Hypertension, Liver Cancer
A Multicentre Study on Features of the Gut Microbiota of Patients With Critical Chronic Diseases in China
The human gut microbiome has been associated with many health factors but variability between studies limits the exploration of effects between them.
- Conditions
- Essential Hypertension, Liver Cancer, Nasopharyngeal Cancer, Pancreatic Cancer
- Trial name
- NCT05638269
- Testing
- no intervention
- Where
- 50 sites in China
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital