Clinical trials: Pulmonary Disease, Chronic Obstructive (COPD)
Pulmonary Disease, Chronic Obstructive
Characteristics and Treatment Patterns of Patients With Chronic Obstructive Pulmonary Disease (COPD), Initiating Tio+Olo or Other Maintenance Therapies in the US and the UK: A Retrospective Claims Database Study
The primary objectives of the study are to use US and UK data to describe the characteristics of Chronic Obstructive Pulmonary Disease (COPD) patients according to various demographic, lifestyle, clinical, and medication use.
- Trial name
- NCT04926233
- Testing
- Tiotropium bromide + Olodaterol, Sp(t)iolto® Respimat®
- Where
- United States
- Volunteers
- 1,371,146 people
- Sponsor
- Boehringer Ingelheim
Atrial Fibrillation, Coronary Heart Disease
EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
Health inequality and genetic disparity are a significant issue in the United Kingdom (UK). This study focuses on diseases that are associated with significant morbidity and mortality in the UK, and specifically examines the…
- Conditions
- Atrial Fibrillation, Coronary Heart Disease, Cardiovascular Diseases, Heart Failure
- Trial name
- EMPOWER (NCT03987633)
- Where
- United Kingdom
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- Future Genetics Limited
COPD
Exploring the Anti-ageing Effects of Metformin in COPD
Prospective, multicentre, double-blind, placebo-controlled, randomised, prospective clinical trial comparing the effect of metformin 850 mg twice daily with placebo in COPD patients with evidence of emphysema (by CT scan or…
- Trial name
- AMICO (NCT06999343)
- Testing
- Metformin 850Mg Tab
- Volunteers
- 212 people
- Sponsor
- Fundación Instituto de Investigación Sanitaria de Navarra
Chronic Obstructive Pulmonary Disease
Characterization of Aerosol Generation and Transport in the Human Lung of Subjects With Chronic Obstructive Pulmonary Disease (COPD)
This study is aiming at evaluating the characteristics of particle emission in subjects with different stages of chronic obstructive pulmonary disease (COPD) compared with healthy smokers.
- Trial name
- NCT01088633
- Testing
- Exhaled particle analysis
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fraunhofer-Institute of Toxicology and Experimental Medicine
Chronic Obstructive Pulmonary Disease, Hypercapnia
Physiological and Clinical Changes in NHF Therapy
The study explores the changes in pressure, volume and in hypercapnia in patients with COPD and ILD. The investigators will use different application forms.
- Conditions
- Chronic Obstructive Pulmonary Disease, Hypercapnia, Interstitital Lung Disease
- Trial name
- ATMOFLOW (NCT02504814)
- Testing
- Nasal Highflow (NHF)
- Where
- Germany
- Volunteers
- 64 people
- Sponsor
- University of Leipzig
Effects of Obesity on COPD Mechanically Ventilated Patients
The Effect of Obesity in COPD Mechanically Ventilated Patients
Study the relationship between the body mass index and duration of mechanical ventilation \& complications in mechanically ventilated COPD patients.
- Trial name
- NCT06048549
- Volunteers
- 200 people
- Sponsor
- Assiut University
Pulmonary Disease, Chronic Obstructive, COPD Exacerbation
Mechanisms of COPD Exacerbation Recurrence
Chronic obstructive pulmonary disease (COPD) is a common smoking-related lung disease. Patients with COPD are at increased risk of readmission to hospitals within the following 30 days.
- Conditions
- Pulmonary Disease, Chronic Obstructive, COPD Exacerbation, Patient Readmission, Recurrence
- Trial name
- NCT04024735
- Testing
- Spirometry, Forced Oscillation Technique, Step-counter, sputum and blood samples
- Where
- United Kingdom
- Volunteers
- 166 people
- Sponsor
- University College, London
Asthma, Chronic Obstructive Pulmonary Disease
A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Dose in Healthy Volunteers, Repeat Doses in Asthmatic Patients and of Single Dose in COPD Patients of CHF6366
CHF6366 is a novel bifunctional compound displaying both muscarinic receptor antagonist and β2-adrenergic receptor agonist properties (MABA), with the potential to deliver optimal bronchodilation after inhalation dosing via two…
- Trial name
- NCT03378648
- Testing
- CHF6366, umeclidinium bromide and vilanterol trifenatate
- Where
- United Kingdom
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Chiesi Farmaceutici S.p.A.
COPD
Has Pulmonary Rehabilitation a Positive Impact on Sleep Quality in Patients Suffering From COPD ?
The purpose of our study is to assess the impact of pulmonary rehabilitation on objective sleep quality in COPD patients.
- Trial name
- NCT03314558
- Testing
- pulmonary rehabilitation
- Where
- Belgium
- Volunteers
- 31 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Chronic Obstructive Pulmonary Disease
Mitochondrial Derived Reactive Oxygen Species on Cardiovascular Health in Chronic Obstructive Pulmonary Disease (COPD)
Cardiovascular health is a critical problem in patients with chronic obstructive pulmonary disease (COPD). Existing literature suggests oxidative stress from the mitochondria c driving some of the poor health outcomes in COPD.
- Trial name
- NCT05605548
- Testing
- MitoQ
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Virginia Commonwealth University
Smoking Cessation, COPD
Effectiveness of Spirometry as a Motivational Tool to Quit Smoking
The aim of the study is to asses the efficacy of the spirometry and a minimal smoking cessation counselling intervention to quit smoking after a year in patients older than 40 years, smokers of more than 10 packs-year and without…
- Trial name
- ESPIMOAT (NCT01821885)
- Testing
- Spirometry and a brief advice to quit smoking, Brief advice to quit smoking
- Where
- Spain
- Volunteers
- 335 people
- Sponsor
- Basque Health Service
COPD, Heart Failure
Technology Assisted Nudging to Increase Physical Activity Among Hospitalised Medical Patients
Primary Objective To investigate if patients hospitalised for older adults with a decreased level of physical function, either related to a chronic condition e.g., COPD, Congestive heart failure, renal failure; infections…
- Conditions
- COPD, Heart Failure, Parkinson Disease, Arthritis
- Trial name
- SENS4ME (NCT06336252)
- Testing
- Digital nudging intervention target to change behavior
- Where
- Denmark
- Volunteers
- 130 people
- Sponsor
- Bispebjerg Hospital
COPD, Chest Wall Disease
Comparison of Pressure Support and Pressure Control Ventilation in Chronic Respiratory Failure
This study is looking at whether there is a difference in outcomes using two different types of breathing support in those patients who have chronic respiratory failure (patients who under-breathe).
- Conditions
- COPD, Chest Wall Disease, Neuromuscular Disease, Obesity Hypoventilation
- Trial name
- NCT00994552
- Testing
- Pressure support ventilation, Pressure control ventilation
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Chronic Obstructive Pulmonary Disease, Heart Failure
PATient Navigator to rEduce Readmissions
Staying out of the hospital is valued by patients and their caregivers. Their interests converge with those of hospitals now that high 30-day readmission rates for some conditions place hospitals at risk for financial penalties…
- Conditions
- Chronic Obstructive Pulmonary Disease, Heart Failure, Sickle Cell Disease, Myocardial Infarction
- Trial name
- PArTNER (NCT02114515)
- Testing
- Hospital usual care, Navigator intervention, Peer-led telephone support line
- Where
- United States
- Volunteers
- 1,029 people
- Sponsor
- University of Illinois Chicago
Chronic Obstructive Pulmonary Disease
The Effect of OMT on Patients With COPD: Correlating Pulmonary Function Tests With Biochemical Alterations
This project proposes to test the hypothesis that osteopathic manipulative treatment (OMT) given to patients with moderate to severe chronic obstructive pulmonary disease (COPD) enrolled in a 12-week pulmonary rehabilitation…
- Trial name
- NCT01582958
- Testing
- Osteopathic Manipulative Treatment (OMT)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Michigan State University
Chronic Obstructive Pulmonary Disease
Integrating Care After Exacerbation of COPD
This clinical trial is designed to determine whether an intervention that provides information to primary care providers about gaps in care for their patients recently discharged from hospital for COPD can reduce hospital…
- Trial name
- InCasE (NCT02021955)
- Testing
- guideline treatment recommendations
- Where
- 2 sites in United States
- Volunteers
- 717 people
- Sponsor
- VA Office of Research and Development
Chronic Obstructive Pulmonary Disease, Cardiovascular Disease
Selenium Supplementation in Chronic Obstructive Pulmonary Disease (COPD) Patients
Does an oral selenium supplement increase blood levels of antioxidants in patients with established, smoking-related lung disease? Members of our study group recently discovered that elevated levels of the anti-oxidant GPx-1 may…
- Trial name
- NCT00186706
- Testing
- Selenium
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- St. Joseph's Health Care London
COPD
Qui Gong Programme vs Short Form Sun Style Tai Chi in COPD Patients
This was a Randomized control Trial. Purposive sampling was done to obtained Sample (n=78) which were randomly allocated to Group A (n=39) and Group B (n=39).
- Trial name
- NCT04357678
- Testing
- Qi Gong Programme, Short Form Sun Style Tai Chi
- Where
- Pakistan
- Volunteers
- 78 people
- Sponsor
- Riphah International University
Chronic Obstructive Pulmonary Disease
A Study to Assess the Total Systemic Exposure Bioequivalence of of Budesonide, Glycopyrronium, and Formoterol Delivered by BGF MDI With Next-Generation Propellant Compared With BGF MDI With HFA Propellant
The study will evaluate bioequivalence, pharmacokinetics, safety, and tolerability of Budesonide, Glycopyrronium and Formoterol (BGF) metered dose inhaler (MDI) formulated with hydrofluoroolefin (HFO) [Test] and hydrofluoroalkane…
- Trial name
- NCT05569421
- Testing
- Treatment A: BGF MDI HFO, Treatment B: BGF MDI HFA
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Respiratory Virus Infection, Stroke
Respiratory Virus Infections in Acutely Hospitalized Adult Patients With Pulmonary and Extrapulmonary Complications
Respiratory virus infections are one of the major causes of hospitalizations, and outbreaks of respiratory virus infection have led to severe economic loss.
- Conditions
- Respiratory Virus Infection, Stroke, Lung Disease, Acute Coronary Syndrome
- Trial name
- NCT03816059
- Testing
- Respiratory virus testing
- Where
- Hong Kong
- Volunteers
- 200 people
- Sponsor
- The University of Hong Kong
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