Clinical trials: Pulmonary Disease, Chronic Obstructive (COPD)
Respiratory Disorders
A Study to Test if the Vaccine is Working Well in Chronic Obstructive Pulmonary Disease (COPD) Patients Aged 40 to 80 Years Old to Reduce Episodes of Worsening Symptoms and to Gather Further Information on Safety and Immune Response.
The purpose of this study is to test if the vaccine is working well in COPD patients aged 40 to 80 years old to reduce episodes of worsening symptoms ("exacerbations") and to gather further information on safety and immune…
- Trial name
- NCT03281876
- Testing
- NTHi Mcat investigational vaccine (GSK3277511A)
- Where
- 67 sites in United States, Belgium and 6 more
- Volunteers
- 606 people
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease
Inspiratory Muscle Activation Patterns in Patients With Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease that causes obstructed airflow from the lung, characterized by chronic cough, dyspnea, and sputum production.
- Trial name
- NCT03522376
- Testing
- Loaded inspiratory muscle test
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Chronic Obstructive Lung Disease
Evaluation of Breathe NIOV System on Work of Breathing in Chronic Obstructive Lung Disease Patients
The Breathe Ventilator is a lightweight, wearable ventilator that has received U.S. FDA clearance for use in patients with respiratory difficulty.
- Trial name
- NCT01596023
- Testing
- Breathe NIOV Ventilator
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Breathe Technologies, Inc.
Infection, Heart Failure
Hospital-Level Care at Home for Acutely Ill Adults
The investigators propose a home hospital model of care that substitutes for treatment in an acute care hospital. Limited studies of the home hospital model have demonstrated that a sizeable proportion of acute care can be…
- Conditions
- Infection, Heart Failure, COPD, Asthma
- Trial name
- NCT03203759
- Testing
- Home hospitalization, Traditional inpatient hospitalization
- Where
- 2 sites in United States
- Volunteers
- 91 people
- Sponsor
- Brigham and Women's Hospital
COPD (With - Without Rehabilitation)
Effects of Structural Integration on Chest Wall Expansion Among COPD Patients
The present study aims to investigate the effects of the 10-Series of Structural Integration on chest wall expansion in patients with stable COPD using a randomized controlled trial design.
- Trial name
- NCT07752420
- Testing
- Structural Integration with Conventional Pulmonary Rehabilitation, Pulmonary Rehabilitation only
- Where
- Pakistan
- Volunteers
- 52 people
- Sponsor
- Green International University
Chronic Obstructive Pulmonary Disease
Physical Activity Counseling During Pulmonary Rehabilitation
This randomized controlled trial will assess the effect of adding intensive physical activity counseling to an outpatient pulmonary rehabilitation program.
- Trial name
- PAC (NCT00948623)
- Testing
- physical activity counseling program
- Where
- Belgium
- Volunteers
- 70 people
- Sponsor
- KU Leuven
Chronic Obstructive Pulmonary Disease, Physical Activity
Physical Activity Coaching in Chronic Obstructive Pulmonary Disease (COPD)
This study is designed to explore a new approach to help people with chronic obstructive pulmonary disease (COPD) become more physically active.
- Conditions
- Chronic Obstructive Pulmonary Disease, Physical Activity, Health Behavior
- Trial name
- PACC (NCT01349608)
- Testing
- Telephonic health coaching
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Chronic Obstructive Pulmonary Disease, Asthma
Respiratory Registry for Lung Health: a Prospective, Observational Study on Adult Patients With Asthma or COPD
The database will contain a wide range of demographic, clinical, radiological, laboratory, functional, microbiological, treatment, and clinical outcomes data on adults with chronic obstructive pulmonary disease (COPD) and asthma…
- Trial name
- NCT05826613
- Where
- 4 sites in Italy
- Volunteers
- 500 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Severe Chronic Obstructive Pulmonary Disease
Evaluation of Benefit of Nebulized Bronchodilators at Home in Severe Chronic Obstructive Pulmonary Disease and Very Severe Steady State
Design studies of nebulization in COPD does not respond adequately to the clinically relevant question: the intervention of administering nebulized bronchodilators at home it is likely to make a profit, compared to the standard…
- Trial name
- Nebuadom (NCT02103374)
- Testing
- Atrovent + Bricanyl or Atrovent + Ventoline
- Where
- 13 sites in France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Tours
Pulmonary Disease, Chronic Obstructive
Depemokimab as an Extended Treatment Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation (ENDURA-2)
Depemokimab is being developed as a treatment for individuals with moderate to severe COPD. The aim of this study is to assess the efficacy and safety of depemokimab compared as an add-on medicine in participants with…
- Trial name
- ENDURA-2 (NCT06961214)
- Testing
- Depemokimab
- Where
- 193 sites in United States, Argentina and 14 more
- Volunteers
- 961 people
- Sponsor
- GlaxoSmithKline
Asthma
The Efficacy of Fluticasone Furoate/Vilanterol Versus (vs) Fluticasone Furoate on Asthma
The objective of this study is to evaluate fluticasone furoate/vilanterol compared with fluticasone furoate alone in subjects with asthma that is uncontrolled on low to mid dose inhaled corticosteroid (ICS) or low dose ICS/ long…
- Trial name
- NCT03363191
- Testing
- Fluticasone Furoate/Vilanterol, Fluticasone Furoate, Salbutamol/Albuterol
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease (COPD)
Time Course of Respiratory Oscillometry Parameters During Nasal High-Flow Therapy in Stable Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) can affect the small airways and alter respiratory mechanics. Nasal high-flow therapy delivers warmed and humidified gas through nasal cannulas and may change airway resistance.
- Trial name
- NHFlOscillo (NCT07750613)
- Testing
- Heated Humidified Nasal High-Flow Therapy
- Where
- France
- Volunteers
- 20 people
- Sponsor
- ADIR Association
Pulmonary Disease, Chronic Obstructive, Healthy
Low Load, High-repetitive Elastic Band Resistance Training in COPD
Recent work have shown that low load, high-repetitive single limb resistance training, if compared to a control, can increase limb muscle function and functional exercise capacity in patients with chronic obstructive pulmonary…
- Trial name
- NCT02283580
- Testing
- Single limb, Two limb
- Where
- 2 sites in Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Laval University
Chronic Respiratory Disease, Asthma
Remote Monitoring of Respiratory Health
Recently, interest in ways to monitor and care for patients remotely has significantly increased due to concerns for infection control as well as a way to increase access to regular clinic visits that may be limited for…
- Conditions
- Chronic Respiratory Disease, Asthma, Copd
- Trial name
- NCT04739943
- Testing
- Mobile Monitoring
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Stanford University
Chronic Respiratory Disease, COPD
Chronic Respiratory Disease Burden in Bangladesh
Chronic Respiratory Disease (CRD), particularly asthma and chronic obstructive pulmonary disorders (COPD) are leading causes of mortality and reduced quality of life due to its wide-reported association with other…
- Trial name
- NCT04851808
- Where
- Bangladesh
- Volunteers
- 981 people, healthy volunteers welcome
- Sponsor
- Child Health Research Foundation, Bangladesh
Chronic Obstructive Pulmonary Disease
GECo: Implementation and Effectiveness of COPD Case-Finding in Low and Middle Income Countries
This study will test how well short questionnaires, with and without a simple breathing test called 'peak flow', can identify people with COPD compared to the gold-standard diagnostic test called spirometry.
- Trial name
- GECo1 (NCT03365713)
- Where
- 3 sites in Nepal, Peru and 1 more
- Volunteers
- 10,709 people, healthy volunteers welcome
- Sponsor
- University College, London
Pulmonary Disease, Chronic Obstructive
Pharmacokinetic Study in Elderly Patients With Chronic Obstructive Bronchitis (COPD)
Study to evaluate the pharmacokinetics of tiotropium following 14 days of administration (18µg once per day) in elderly COPD patients.
- Trial name
- NCT02172326
- Testing
- Tiotropium inhalation capsules for oral inhalation
- Volunteers
- 29 people
- Sponsor
- Boehringer Ingelheim
COPD, COPD Exacerbation Acute
The Reducing REVISITS Study: A Cluster RCT
This type II hybrid effectiveness-implementation trial will concurrently study the comparative effectiveness of virtual vs. in-person COPD care transition programs implemented via virtual mentored implementation approaches with…
- Trial name
- REVISITS (NCT05568043)
- Testing
- COPD Transitions of Care Intervention Bundle: Virtual Interventions, COPD Transitions of Care Intervention Bundle: In-Person Interventions
- Where
- United States
- Volunteers
- 384 people
- Sponsor
- University of Chicago
Coronary Artery Disease, Chronic Obstructive Pulmonary Disease
ComparisoN of ticAgrelor vs. Clopidogrel in endoTHeliAl Function of COPD patieNts
This is an investigator-initiated, prospective, single-centre, randomised, phase II, open-label study, testing the superiority of ticagrelor, as compared to clopidogrel, in modulating on-P2Y12 treatment platelet reactivity…
- Trial name
- NATHAN-NEVER (NCT02519608)
- Testing
- Aspirin 100 mg, Ticagrelor, Clopidogrel
- Where
- Italy
- Volunteers
- 44 people
- Sponsor
- University Hospital of Ferrara
Pulmonary Disease, Chronic Obstructive
A Phase 1 (Ph1), Single Dose (SD), GSK961081 Absorption, Distribution, Metabolism, and Excretion (ADME) Study in Healthy Subjects
Batefenterol (GSK961081) is a bifunctional bronchodilator that is being developed for the treatment of Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- NCT02663089
- Testing
- [14C]-GSK961081 solution for IV infusion, [14C]-GSK961081 oral solution, GSK961081 dry powder for inhalation
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Theravance Biopharma
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