Clinical trials: Pulmonary Disease, Chronic Obstructive (COPD)
Chronic Obstructive Pulmonary Disease
Clinical Trial Assessing the Value of an Antibiotic Protocol Guided by Serum Procalcitonin in Acute Exacerbations of Chronic Obstructive Pulmonary Disease in Intensive Care
Investigators propose to conduct a prospective, randomized, controlled, multicenter assessing the interests of an antibiotic protocol guided by serum procalcitonin (PCT) on morbidity and mortality in patients with chronic…
- Trial name
- BPCTréa (NCT02521636)
- Testing
- Antibiotic therapy randomization, Serum PCT dosage
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Caen
Chronic Obstructive Pulmonary Disease, COPD
Mindfulness Based Stress Reduction in COPD
The objective of this study is to test the efficacy of a Mindfulness Based Stress Reduction program in COPD on quality of life, dyspnea, daily physical activity and mindfulness during daily life.
- Trial name
- NCT01058499
- Testing
- Mindfulness Based Stress Reduction Program (MBSR)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Pulmonary Disease, Chronic Obstructive
Safety And Tolerability Study In Patients With Chronic Obstructive Pulmonary Disease
GSK233705 is a high-affinity specific muscarinic receptor (mAChR) antagonist which is being developed for once daily treatment of chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT00376714
- Testing
- GSK233705
- Where
- 5 sites in Belgium, Sweden
- Volunteers
- 45 people
- Sponsor
- GlaxoSmithKline
Cardiovascular Diseases, Heart Diseases
Chinese Community Smoking Cessation Project
The study has two objectives/aims: Aim 1: To test the efficacy of the intervention among adult smokers with cardiovascular disease, pulmonary disease and diabetes mellitus related illnesses (later modified to Chinese adults with…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Lung Diseases, Diabetes Mellitus
- Trial name
- NCT00139516
- Testing
- self-help, nicotine replacement therapy, smoking cessation
- Sponsor
- University of California, San Francisco
Lung Diseases, Lung Diseases, Obstructive
Effects of Chronic Ozone Exposure on Lung Function
To determine the effects of chronic ozone exposure on lung function in young men and women.
- Conditions
- Lung Diseases, Lung Diseases, Obstructive, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT00006306
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Chronic Obstructive Lung Disease, Chronic Obstructive Pulmonary Disease
Mapping and Characterization of Alveolar Cells During Smoking and Chronic Obstructive Disease
To evaluate the regenerative capacities of mesenchymal cells composing the microenvironment of alveolar type 2 cells in a population of patients, undergoing thoracic surgery for suspected cancer, who are smokers with and without…
- Trial name
- CoStemCells (NCT05227547)
- Testing
- Thoracic resection surgery
- Where
- 4 sites in France
- Volunteers
- 186 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
COPD
Dose of Corticosteroids in COPD
COPD (chronic obstructive pulmonary disease) is a long-lasting lung disease usually caused by long-term smoking. COPD can get worse, making people sick enough to need hospitalization.
- Trial name
- DOSE (NCT01742338)
- Testing
- Low Dose Corticosteroids, High Dose Corticosteroids
- Where
- 2 sites in United States
- Volunteers
- 89 people
- Sponsor
- Rutgers, The State University of New Jersey
COPD
High Intensity Interval Training and Technologies in COPD
Trials in COPD have shown that HIIT leads to the same positive outcomes as constant load training but causes less breathlessness and leg discomfort during training.
- Trial name
- NCT05343949
- Testing
- HIIT exercise program ABC, HIIT exercise program CAB, HIIT exercise program BCA
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Chronic Obstructive Pulmonary Disease
Combined Effects of Global Posture Re-education and Active Cycle of Breathing Technique in COPD
The randomized controlled trial will involve 30 participants, with Group A receiving GPRM and ACBT, while Group B follows the conventional COPD model that includes ACBT only.Assessments of heart rate, physical fitness, and…
- Trial name
- NCT06308289
- Testing
- Global Posture Re-education, Active Cycle of Breathing Technique
- Where
- Pakistan
- Volunteers
- 68 people
- Sponsor
- Riphah International University
Pulmonary Disease, Chronic Obstructive
Training of Inhalation Technique in Hospitalized Chronic Obstructive Pulmonary Disease (COPD) Patients - a Pilot Study
Inhalation drugs are essential in the treatment of COPD, in controlling symptoms and preventing exacerbations. The aim of this pilot study is to collect data necessary for the planning of future efficacy trials.
- Trial name
- NCT03691324
- Testing
- Inhalation technique training and discharge service
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- Oslo University College
Pulmonary Disease, Chronic Obstructive
Efficacy and Safety of the Addition of Fluticasone Propionate/Salmeterol (250/50mcg) Twice-daily to 2 Doses of Umeclidinium Bromide Inhalation Powder (62.5 or 125mcg) Once-daily Over 12 Weeks.
The purpose of this 12 week study is to evaluate the effects of the addition of umeclidinium bromide (62.5mcg) once-daily to fluticasone propionate (250/50mcg) twice-daily and umeclidinium bromide (125mcg) once-daily to…
- Trial name
- NCT01772147
- Testing
- Umeclidinium bromide 62.5mcg, Umeclidinium bromide 125mcg, Fluticasone propionate 250mcg/Salmeterol 50mcg
- Where
- 55 sites in United States, Chile and 3 more
- Volunteers
- 608 people
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease, Emphysema
LVR in Severe Emphysema Using Bronchoscopic Autologous Blood Instillation in Combination With Intra-bronchial Valves
A single arm pilot study of lung volume reduction in severe emphysema using bronchoscopic autologous blood instillation in combination with intra-bronchial valves.
- Trial name
- BLOOD-VALVES (NCT03010449)
- Testing
- Intra-bronchial valve and blood
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Pulmonary Disease, Chronic Obstructive, Rehabilitation
A Trial to Study the Effects of Pulmonary Rehabilitation Program on Exercise Capacity and Quality of Life in Patients With Severe Form of Chronic Obstructive Pulmonary Disease (COPD)
This study is a randomized parallel group controlled trial which aims to study the effects of pulmonary rehabilitation intervention on exercise capacity and quality of life in patients with severe COPD as compared to standard…
- Trial name
- RehabCOPD (NCT02512549)
- Testing
- Pulmonary Rehabilitation
- Where
- India
- Volunteers
- 80 people
- Sponsor
- All India Institute of Medical Sciences
Chronic Obstructive Pulmonary Disease
Integrating Care After Exacerbation of COPD
This clinical trial is designed to determine whether an intervention that provides information to primary care providers about gaps in care for their patients recently discharged from hospital for COPD can reduce hospital…
- Trial name
- InCasE (NCT02021955)
- Testing
- guideline treatment recommendations
- Where
- 2 sites in United States
- Volunteers
- 717 people
- Sponsor
- VA Office of Research and Development
COPD
Responses to Live Attenuated Influenza Virus (LAIV) in Chronic Obstructive Pulmonary Disease (COPD)
This study will determine the functional status of the nasal immune environment with LAIV exposure in COPD persons with frequent exacerbations (defined as individuals with two or more episodes of worsening in COPD symptoms…
- Trial name
- NCT04901455
- Testing
- LAIV
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Chronic Obstructive Pulmonary Disease, Oxygen/Therapeutic Use
Correction of Exercise-induced Desaturation by Acute Oxygen Supply and Exercise Responses in COPD
In the literature, the effects of acute oxygen administration on exercise tolerance and related symptoms have often appeared to be contradictory.
- Trial name
- RePox-1 (NCT02055885)
- Where
- 2 sites in France
- Volunteers
- 255 people
- Sponsor
- 5 Santé
Chronic Obstructive Pulmonary Disease
A Comprehensive Care Programme for Patients With Chronic Obstructive Pulmonary Disease
Objective: Chronic obstructive pulmonary disease (COPD) is a disease with significant morbidity and incurs heavy utilization of healthcare resources.
- Trial name
- NCT01108835
- Testing
- Comprehensive care programme
- Where
- Hong Kong
- Volunteers
- 180 people
- Sponsor
- Chinese University of Hong Kong
Pulmonary Disease, Chronic Obstructive
A 24-Week Study to Evaluate the Safety and Efficacy of ADVAIR DISKUS® Inhaler 250/50mcg Plus SPIRIVA HANDIHALER® Inhaler Versus SPIRIVA HANDIHALER® Inhaler Plus Placebo DISKUS® Inhaler in Subjects With Chronic Obstructive Pulmonary Disease (COPD).
The purpose of the study is to determine the efficacy and safety of the combination of ADVAIR DISKUS® 250/50mcg (FLUTICASONE PROPIONATE/SALMETEROL COMBINATION PRODUCT) plus SPIRIVA® HANDIHALER® inhaler 18mcg (TIOTROPIUM) compared…
- Trial name
- ADC111114 (NCT00784550)
- Testing
- Tiotropium Bromide, Fluticasone Propionate/Salmeterol
- Where
- 35 sites in United States
- Volunteers
- 342 people
- Sponsor
- GlaxoSmithKline
COPD, Interstitial Lung Disease
Effects of an Oxymizer on Endurance Time in Patients With Chronic Lung Diseases
The Oxymizer pendant® is a special oxygen cannula that can be used to supply high flow long term oxygen therapy. It is compatible with a wide variety of oxygen sources.
- Trial name
- NCT01713413
- Testing
- Oxymizer, conventional nasal cannula
- Where
- Germany
- Volunteers
- 67 people
- Sponsor
- Schön Klinik Berchtesgadener Land
Chronic Obstructive Pulmonary Disease (COPD), Respiratory Muscle Dysfunction
Multimodal Assessment of NMES Effects on Respiratory and Peripheral Muscles in COPD
The goal of this clinical trial is to learn if targeted neuromuscular electrical stimulation (NMES) can treat respiratory and peripheral muscle weakness in patients with chronic obstructive pulmonary disease (COPD).
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Respiratory Muscle Dysfunction, Muscle Weakness
- Trial name
- NMES in COPD (NCT07910006)
- Testing
- Neuromuscular Electric Stimulation, Exercise
- Where
- Indonesia
- Volunteers
- 45 people
- Sponsor
- Universitas Padjadjaran
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