Clinical trials: Pulmonary Disease, Chronic Obstructive (COPD)
Chronic Obstructive Pulmonary Disease (COPD)
Patients With Chronic Obstructive Pulmonary Disease at Altitude - Effect of Nocturnal Oxygen on Exercise Performance
The purpose of this study is to investigate the effect of nocturnal oxygen therapy during a stay at moderate altitude on exercise performance of patients with chronic obstructive lung disease.
- Trial name
- NCT02143609
- Testing
- oxygen
- Where
- Switzerland
- Volunteers
- 32 people
- Sponsor
- University of Zurich
COPD (Chronic Obstructive Pulmonary Disease), COPD
Balance Training Following Pulmonary Rehabilitation on Balance in People With Chronic Obstructive Pulmonary Disease (COPD)
This study aims to see if a co-designed balance training programme called Sport4Steadiness (S4S), is acceptable to people with COPD and if the study procedures, including recruitment and the collection of outcomes, is feasible.
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), COPD, Balance Exercise, Falls, Intervention
- Trial name
- B-PuRe (NCT07750821)
- Testing
- Sport4Steadiness
- Where
- 3 sites in United Kingdom
- Volunteers
- 77 people
- Sponsor
- Samantha Harrison
Chronic Obstructive Pulmonary Disease, Non Invasive Ventilation
Interfaces of Non-invasive Ventilation on Performance in Patients With Chronic Obstructive Pulmonary Disease
The purpose of this study is to determine wether the interface (facial or nasal mask) influences performance in patients with chronic obstructive pulmonary disease exercising with non-invasive ventilation.
- Conditions
- Chronic Obstructive Pulmonary Disease, Non Invasive Ventilation, Exercise, Aerobic
- Trial name
- Exercise-NIV (NCT02796599)
- Testing
- Non invasive ventilation during exercise with facial or nasal mask.
- Where
- France
- Volunteers
- 21 people
- Sponsor
- ADIR Association
COPD, Copd Bronchitis
Muco-ciliary Cleansing of Lungs in COPD With and Without a Salt Particle Inhaler
Cross-over trial of the effect of a salt particle inhaler on pulmonary muco-ciliary cleansing in COPD patients as measured by lung scintigraphy.
- Trial name
- NCT03927365
- Testing
- Inhalation from a salt particle inhaler with or without content
- Where
- Denmark
- Volunteers
- 35 people
- Sponsor
- Liita Care ApS
COPD Chronic Obstructive Pulmonary Disease
Digital Follow-up Program for People with Chronic Obstructive Pulmonary Disease in Primary Healthcare
Chronic Obstructive Pulmonary Disease (COPD), characterized by non-reversible airflow obstruction, contributes to high mortality and morbidity rates worldwide, including Norway.
- Trial name
- NCT06401512
- Testing
- Guided self-determination (GSD) follow-up approach by primary care nurses.
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- Western Norway University of Applied Sciences
Emphysema, COPD
Fissure Closure With the AeriSeal System for CONVERTing Collateral Ventilation Status (CONVERT)
This is a prospective, open-label, multi-center, single-arm study to be conducted at up to 20 investigational sites. The Study plans to enroll up to 140 subjects with severe emphysema and collateral ventilation in the target…
- Conditions
- Emphysema, COPD, Severe Emphysema
- Trial name
- CONVERT (NCT04559464)
- Testing
- AeriSeal, Zephyr Valves
- Where
- 14 sites in Australia, France and 5 more
- Volunteers
- 102 people
- Sponsor
- Pulmonx Corporation
Chronic Obstructive Pulmonary Disease
Smartphone-based Self-management in COPD Patients: A Needs Assessment Survey
COPD patients often experience multiple symptoms (e.g. dyspnea, cough, and deteriorating quality of life) and have imposed a substantial economic and social burden on health care.
- Trial name
- NCT05151198
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- The University of Hong Kong
Chronic Obstructive Pulmonary Disease
Efficacy of Interval Aerobic Training Versus Laser Puncture Therapy on Restless Leg Syndrome in Copd Patient
DETERMINE HOW TO IMPROVE THE QUALITY OF LIFE FOR PATIENTS WITH COPD BY DECREASING TINTENSITY OF THE RESTLESS SYNDROME
- Trial name
- NCT06955000
- Testing
- traidmail, laser puncture therapy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Pharos University in Alexandria
Pulmonary Disease, Chronic Obstructive
Simvastatin Therapy for Moderate and Severe COPD
To determine the effect of daily administration of 40 mgms simvastatin taken for at least 12 months (range 12-36 months) on the frequency of exacerbations of chronic obstructive lung disease (COPD) in patients with moderate to…
- Trial name
- STATCOPE (NCT01061671)
- Testing
- simvastatin
- Where
- 51 sites in United States, Canada
- Volunteers
- 885 people
- Sponsor
- University of Minnesota
Chronic Obstructive Pulmonary Disease
Comparison of a Serum PRO-CT Guided Treatment and the Recommended Antibiotic Treatment for COPD
Exacerbations of chronic obstructive pulmonary disease (COPD) are the first cause of admission to Pulmonary Department in Italy and worldwide.
- Trial name
- NCT01125098
- Testing
- PRO-CT values
- Where
- Italy
- Volunteers
- 183 people
- Sponsor
- University of Modena and Reggio Emilia
COPD, Mechanical Ventilation
Doxapram Administration on Diaphragmatic Excursion in Mechanically Ventilated Patients With Chronic Obstructive Pulmonary Disease Undergoing Spontaneous Breathing Trial
Researchers aim to evaluate the impact of doxapram administration on diaphragmatic excursion in chronic obstructive pulmonary disease (COPD) patients undergoing spontaneous breathing trial
- Conditions
- COPD, Mechanical Ventilation, Weaning From Mechanical Ventilation
- Trial name
- NCT07022704
- Testing
- Doxapram
- Where
- Egypt
- Volunteers
- 35 people
- Sponsor
- Cairo University
COPD, Chronic Obstructive Pulmonary Disease
Melodica Orchestra for Dyspnea: Safety and Feasibility Pilot
This project seeks to pilot-test the feasibility of using a melodica training program to teach pursed lip breathing for Veterans with chronic obstructive pulmonary disease (COPD) with moderate to severe dyspnea (shortness of…
- Conditions
- COPD, Chronic Obstructive Pulmonary Disease, Dyspnea, Breathlessness
- Trial name
- MELODY (NCT03653104)
- Testing
- Melodica Intervention, Pulmonary Health Education
- Where
- United States
- Sponsor
- VA Quality Enhancement Research Intiative
Asthma, Chronic Obstructive Pulmonary Disease
Study of the Metabolism of Two Magnesium Supplements in Healthy Volunteers
The present study is part of a project titled 'Magnesium in asthma and chronic obstructive pulmonary disease'. The hypothesis of the main project is that daily magnesium supplement will benefit patients with asthma and chronic…
- Trial name
- NCT01113138
- Testing
- Mablet (Magnesium-supplement), Magnesium Sulfate
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Diaphragm Electrical Activity, COPD (Chronic Obstructive Pulmonary Disease)
Effect of Electrical Diaphragmatic Stimulation on Chronic Obstructive Pulmonary Disease
Respiratory muscle dysfunction is a common consequence of chronic obstructive pulmonary disease (COPD). This technique consists of placing electrodes on the skin at locations near the motor points of the diaphragm, transmitting…
- Trial name
- NCT07020299
- Testing
- Device : Digital electrical muscle stimulator is applied to induce diaphragm contraction.
- Where
- Egypt
- Volunteers
- 128 people
- Sponsor
- Mansoura University Hospital
Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus
Evaluate Safety of Technosphere® Insulin (TI) in Diabetic Subjects With Moderate Obstructive Pulmonary Disease
Examine the effects of TI in combination with an anti-diabetic regimen including inhaled insulin versus anti-diabetic treatment without inhaled insulin on lung function \& pulmonary safety
- Conditions
- Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Moderate Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT00642616
- Testing
- Technosphere® Insulin, Usual Care
- Where
- 21 sites in United States, Russia and 1 more
- Volunteers
- 34 people
- Sponsor
- Mannkind Corporation
COPD (Chronic Obstructive Pulmonary Disease)
Real-World Effectiveness of a Triple Combination BDP/FF/GB Extrafine in a Single Pressurised Metered Dose Inhaler in Brazilian COPD Patients
This multicenter, retrospective-prospective, cohort study aims to evaluate the effectiveness and safety of Extra-fine Beclometasone Diproprionate/Formoterol Fumarate/Glycopyrronium Bromide (EF-BDP/FF/GB) therapy in adults with…
- Trial name
- RETRIBUTE (NCT07406048)
- Testing
- BDP/FF/GB (100ug/6ug/12.5ug)
- Where
- Brazil
- Volunteers
- 396 people
- Sponsor
- Chiesi Farmaceutica Ltda.
Chronic Obstructive Pulmonary Disease
The Effect of Respiratory Muscle Strength and Functional Capacity on Posture and Balance
As a result of the study, inspiratory muscle strength, posture and physical performance evaluations of individuals with Chronic Obstructive Pulmonary Disease will be made, suggestions will be made to help individual postural…
- Trial name
- NCT05005533
- Testing
- Observational
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Abant Izzet Baysal University
Cystic Fibrosis, Chronic Obstructive Pulmonary Disease
A Phase 1 Study to Characterize the Effect of GS-5737 Enhancement of Mucociliary Clearance (MCC) in Healthy Subjects
This is a randomized, double-blind, cross-over, vehicle-controlled study to determine whether GS-5737 in 2.8% saline accelerates mucociliary clearance (MCC) in healthy subjects, compared to vehicle of 2.8% saline alone.
- Trial name
- NCT01793649
- Testing
- GS-5737
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Gilead Sciences
Chronic Obstructive Pulmonary Disease (COPD)
A Phase 1b Study of PUR1800 in Patients With COPD
This is a randomised, placebo-controlled, double-blind 3-way crossover study in which PUR1800, or placebo is dosed daily for 14 consecutive days in adult subjects with stable COPD over three discrete TPs.
- Trial name
- NCT04759807
- Testing
- PUR1800 250 ug, PUR1800 500 ug
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- Pulmatrix Inc.
Study is Being Conducted in Healthy Volunteers
A Study to Assess How Much Drug Reaches the Blood When Given From Symbicort pMDI With Spacer Compared to That of Symbicort pMDI Without Spacer in Healthy Volunteers
This study will be conducted to establish the relative bioavailability of budesonide and formoterol delivered via Symbicort pressurized metered-dose inhaler (pMDI) with and without a spacer device.
- Trial name
- NCT02934607
- Testing
- Symbicort pMDI with spacer device, Symbicort pMDI without spacer device
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
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