Clinical trials: Pulmonary Disease, Chronic Obstructive (COPD)
Respiratory Diseases
Time of Exercise Re-training With Chronic Obstructive Pulmonary Disease (COPD)
Pulmonary rehabilitation (PR) is an effective intervention for reducing hospital readmissions, secondary events, and mortality in patients with respiratory pathologies.
- Trial name
- CHRONOBIO (NCT06366113)
- Testing
- Pulmonary rehabilitation
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Michaël RACODON
Chronic Obstructive Pulmonary Disease, Optical Coherence Tomography
Research of Endobronchial Optical Coherence Tomography in Pre-COPD
The pre-stage of Chronic Obstructive Pulmonary Disease (Pre-COPD) is challenging to diagnose. However, identifying Pre-COPD is a crucial step in the prevention and management of COPD.
- Conditions
- Chronic Obstructive Pulmonary Disease, Optical Coherence Tomography, Pulmonary Function
- Trial name
- EBOCTIPCOPD (NCT06436482)
- Testing
- Optical Coherence Tomography
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sichuan Provincial People's Hospital
Chronic Obstructive Pulmonary Disease, COPD
The HERO-study: Effects of Roflumilast in Patients With COPD (Chronic Obstructive Pulmonary Disease) (BY217/M2-121)
The purpose of this trial is to study the effects of roflumilast on lung function parameters indicative of hyperinflation in patients with COPD.
- Trial name
- NCT00108823
- Testing
- Roflumilast
- Where
- 16 sites in United States, Canada and 5 more
- Volunteers
- 550 people
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease
Oral Cyclosporine in Chronic Obstructive Pulmonary Disease
This is a randomized, double-blinded, placebo-controlled trial of oral Cyclosporine A (CsA) in patients with advanced stage chronic obstructive pulmonary disease.
- Trial name
- NCT00974142
- Testing
- Cyclosporine
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Michael Donahoe
Pulmonary Disease, Chronic Obstructive
Increase Level of Physical Activity and Decrease Use of Health Care for People With COPD
This study evaluates the effects of the COPD Web (KOLwebben), an interactive web-based tool directed towards people with chronic obstructive pulmonary disease (COPD).
- Trial name
- COPD (NCT03746873)
- Testing
- COPD Web
- Where
- Sweden
- Volunteers
- 146 people
- Sponsor
- Umeå University
COPD
The Improving Care in Chronic Obstructive Lung Disease Study A Cluster Randomized Trial
Background The Swiss health ministry launched a national quality program "QualiCCare" in 2011 to improve healthcare for patients with COPD.
- Trial name
- CAROL (NCT01921556)
- Testing
- active comparator, QualiCCare education
- Where
- Switzerland
- Volunteers
- 216 people
- Sponsor
- University of Zurich
Chronic Obstructive Pulmonary Disease, Cardiovascular Disease
Interaction in Chronic Obstructive Pulmonary Disease Experiment
The final purpose of this study is to determine whether bronchodilation and cigarette smoking in Chronic Obstructive Pulmonary Disease (COPD) patients interact, resulting in an increase of cardiovascular disease.
- Conditions
- Chronic Obstructive Pulmonary Disease, Cardiovascular Disease, Smoking, Bronchodilation
- Trial name
- ICE (NCT00981851)
- Testing
- Tiotropium (Spiriva) + Salbutamol (Ventolin)
- Where
- 2 sites in Netherlands
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Chronic Obstructive Pulmonary Disease
Foster® pMDI (CHF 1535) Versus Symbicort® Turbohaler in COPD Patient (FORSYYN)
Primary Objective To demonstrate that CHF 1535 pMDI is non-inferior to Symbicort® Turbohaler® in terms of pulmonary function (change from baseline in pre-dose morning FEV1 at Week 24) in patients with COPD.
- Trial name
- FORSYYN (NCT03888131)
- Where
- 53 sites in China
- Volunteers
- 750 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Pulmonary Disease, Chronic Obstructive, Osteoporosis
Chronic Obstructive Pulmonary Disease (COPD) and Osteoporosis
The main objective is to study important factors in the patho-physiology of osteoporosis in patients with COPD. Therefore, the investigators will study biological markers in plasma and urine and correlate them to markers of bone…
- Trial name
- NCT01067248
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Catharina Ziekenhuis Eindhoven
Chronic Obstructive Pulmonary Disease
Efficacy, Safety, and Tolerability of NVA237 Compared to Tiotropium in Patients With Chronic Obstructive Pulmonary Disease (COPD)
This study compared the efficacy and safety of NVA237 with tiotropium in patients with moderate to severe COPD. Tiotropium belongs to the same drug class as NVA237.
- Trial name
- GLOW5 (NCT01613326)
- Testing
- NVA237, Tiotropium, salbutamol/albuterol
- Where
- 77 sites in Canada, Croatia and 13 more
- Volunteers
- 657 people
- Sponsor
- Novartis Pharmaceuticals
Chronic Obstructive Pulmonary Disease
Safety and Tolerability QAT370 Compared to Tiotropium in Patients With Chronic Obstructive Pulmonary Disease
This study will assess the safety and tolerability of QAT370 compared to tiotropium in patients with COPD.
- Trial name
- NCT00532350
- Testing
- QAT370, Tiotropium
- Where
- 3 sites in Germany
- Volunteers
- 22 people
- Sponsor
- Novartis
Pulmonary Arterial Hypertension, Chronic Obstructive Pulmonary Disease
Impact of Inhaled Treprostinil Sodium on Ventilation Perfusion Matching
The purpose of this study is to see how inhaled treprostinil sodium (Tyvaso) affects the amount of air and blood that reach the alveoli, or tiy air sacs, in the lungs of patients with Group 1 Pulmonary Arterial Hypertension with…
- Trial name
- NCT01494896
- Where
- 3 sites in United States
- Volunteers
- 9 people
- Sponsor
- University of Florida
COPD
Immunological Basis for Mepolizumab Activity in COPD
The current literature suggests that the mode of action of mepolizumab is to bind with Interleukin (IL)-5 and block the interaction of IL-5 with the IL-5Ra receptor on eosinophils.
- Trial name
- NCT05320939
- Testing
- Mepolizumab 100 MG
- Volunteers
- 30 people
- Sponsor
- Temple University
COPD, Healthy Adult
Shear Wave Elastography of Intercostal Muscles for the Non-invasive Assessment of the Work of BreathinG
Quantifying respiratory effort is a key step in physiological and clinical research on exercise tolerance, mechanisms of fatigability, and ventilatory impairment.
- Trial name
- SWING (NCT07371754)
- Testing
- Intercostal muscle shear wave elastography (SWE) during standardized inspiratory loading
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Groupe Hospitalier du Havre
Covid19
Comorbidities and Risk Score in COVID-19 Patients
Retrospective multi-center cohort study. Consecutive patients hospitalized for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) up to October 2020 will be included.
- Trial name
- Comorbidities (NCT04670094)
- Where
- 5 sites in Italy
- Volunteers
- 4,555 people
- Sponsor
- University of Milano Bicocca
Chronic Obstructive Pulmonary Disease
Is COPD a Risk Factor for Cardiovascular Disease?
Patients with chronic obstructive pulmonary disease suffer from significant cardiovascular morbidity and mortality. This study wants to determine whether chronic obstructive pulmonary disease might be a risk factor for coronary…
- Trial name
- NCT02162095
- Where
- Switzerland
- Volunteers
- 162 people
- Sponsor
- University of Zurich
Chronic Obstructive Pulmonary Disease
Evaluation in Individuals with COPD and Asymptomatic Individuals
The literature does not provide sufficient information on the evaluation of frailty, handgrip strength, physical activity, kinesiophobia, and fatigue in elderly individuals with Chronic Obstructive Pulmonary Disease and…
- Trial name
- NCT06077357
- Testing
- MMSE Test, PASE Test, The PRISMA-7 Frailty Scale
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Chronic Obstructive Pulmonary Disease
A Scintigraphy Study of PT010 in COPD Patients
This study is a single treatment period, single dose gamma scintigraphy study investigating the deposition in the lungs of a Budesonide, Glycopyrronium and Formoterol Fumarate Metered Dose Inhaler (BGF-MDI).
- Trial name
- RD708/34000 (NCT03906045)
- Testing
- BGF-MDI
- Where
- 2 sites in United Kingdom
- Volunteers
- 18 people
- Sponsor
- AstraZeneca
Asthma, Chronic Obstructive Pulmonary Disease
Macrolides to Prevent Exacerbations of Asthma and Chronic Obstructive Pulmonary Disease
The purpose of this study is to determine whether macrolide therapy is effective in treating patients hospitalized with asthma exacerbations or chronic obstructive pulmonary disease (COPD)exacerbations.
- Trial name
- NCT00181272
- Testing
- azithromycin
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Johns Hopkins University
Chronic Obstructive Pulmonary Disease
Effects of Diaphragm and Abdominal Muscle Training on PFT and Dyspnea Among COPD Obstructive Pulmonary Disease Patients.
It will be a randomized control trial at Services Hospital Lahore through convenience sampling technique which will be allocated through simple random sampling through sealed opaque enveloped in to Group A and Group B .
- Trial name
- NCT05587829
- Testing
- • Diaphragmatic breathing technique, basic breathing technique
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Riphah International University
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