Clinical trials: Pulmonary Disease, Chronic Obstructive (COPD)
COPD, Exacerbation
A Pilot Safety Study of Inhaled Dry Powder Mannitol in Acute Exacerbations of COPD
COPD is a major cause of ill health and death in Australia with 40,000 hospital admissions, and a national cost of $898,000,000 annually.
- Trial name
- NCT00446667
- Testing
- mannitol
- Where
- 2 sites in Australia
- Sponsor
- Syntara
COPD (Chronic Obstructive Pulmonary Disease), Intersitital Lung Disease
MoblO2 to Maintain Oxygenation
Many patients with chronic lung disease (e.g., chronic obstructive pulmonary disease (COPD) or interstitial lung disease (ILD)) require supplemental oxygen (O2) at some point during their disease course.
- Trial name
- SSeifert (NCT07704567)
- Testing
- MoblO2 controls O2 flow, MoblO2 does not control flow
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Minnesota HealthSolutions
COPD (Chronic Obstructive Pulmonary Disease)
Singing Intervention for Chronic Obstructive Pulmonary Disease (COPD)
Why is this study being done? Chronic Obstructive Pulmonary Disease (COPD) causes airflow blockage creating breathing issues, distress, and lower well-being. COPD also causes hyperinflation of the lungs.
- Trial name
- EMPOWER (NCT07563283)
- Testing
- singing intervention for COPD
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Kansas Medical Center
Chronic Obstructive Pulmonary Disease
Evaluation of a Combined Strategy Addressed to Practitioners and Chronic Obstructive Pulmonary Disease (COPD) Patients to Improve Clinical Control and Quality of Life
Main objective: Evaluate the effectiveness of a combined strategy addressed to health care workers and patients, in relation to improving clinical control and patient's quality of life.It includes a feed-back about the health…
- Trial name
- NCT00922545
- Testing
- Implementation of Clinical Practice Guidelines (GPC) and Health Education Program
- Where
- Spain
- Volunteers
- 801 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Chronic Obstructive Pulmonary Disease
Characteristics That Identify Exacerbation Risk Following Colds in COPD Patients
Respiratory virus infections are a common cause of COPD exacerbations and antiviral therapies have potential as treatments for exacerbations.
- Trial name
- NCT01376830
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- Imperial College London
Pulmonary Hypertension
Frespaciguat (MK-5475) in Participants With Pulmonary Hypertension Associated With Chronic Obstructive Pulmonary Disease (PH-COPD) (MK-5475-006)
The primary objectives of this study are to assess the safety/tolerability and efficacy (by evaluating changes in pulmonary vascular resistance [PVR] and pulmonary blood volume [PBV]) of frespaciguat in participants with…
- Trial name
- NCT04370873
- Testing
- Frespaciguat
- Where
- 9 sites in United States, Israel and 1 more
- Volunteers
- 22 people
- Sponsor
- Merck Sharp & Dohme LLC
Pulmonary Disease, Chronic Obstructive, Pulmonary Emphysema
PROCHYMAL™ (Human Adult Stem Cells) for the Treatment of Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
The objective of the present study is to establish the safety and efficacy of multiple administrations of Prochymal™(ex-vivo cultured human adult mesenchymal stem cells) in participants with moderate to severe chronic obstructive…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Pulmonary Emphysema, Chronic Bronchitis
- Trial name
- NCT00683722
- Testing
- Prochymal™
- Where
- 6 sites in United States
- Volunteers
- 62 people
- Sponsor
- Mesoblast, Inc.
Pulmonary Disease, Chronic Obstructive
Measurements of Diaphragmatic Mobility on COPD Patients
To determine whether the COPD impairs the diaphragmatic mobility (DM), and verify improvements after an inpatient pulmonary rehabilitation (PR).
- Trial name
- NCT02838953
- Testing
- Pulmonary Rehabilitation
- Where
- Italy
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Casa Di Cura Villa Serena SpA
Respiratory Disease Undergoing Elective Bronchoscopy., Chronic Obstructive Pulmonary Disease
Safety and Benefits of Using Laryngeal Mask Airway to Keep Airway Potency During Fiber-optic Bronchoscopy
Bronchoscopy is a method of diagnosis and treatment of common respiratory diseases and lung recognized for many years. Since the action takes place in the airways and in light of the use of sedation, when performing, the…
- Trial name
- NCT02698007
- Testing
- Laryngeal Mask Airway (LMA)
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Rabin Medical Center
Pulmonary Disease, Chronic Obstructive
Efficacy and Safety of Tiotropium and Atrovent in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
To compare the bronchodilator efficacy and safety of tiotropium inhalation capsules (18 µg once daily) and Atrovent® MDI (2 puffs of 20µg q.i.d.) among Filipino patients with COPD
- Trial name
- NCT02172469
- Testing
- Tiotropium inhalation powder capsule, Ipratropium Bromide Metered Dose Inhaler
- Volunteers
- 215 people
- Sponsor
- Boehringer Ingelheim
Pulmonary Disease, Chronic Obstructive
A Randomized Study, Comparing Fluticasone Furoate/Umeclidinium/Vilanterol (FF/UMEC/VI) Single Inhaler Triple Therapy, Versus Multiple Inhaler Therapy (Budesonide/Formoterol Plus Tiotropium) in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
The primary purpose of this study is to evaluate lung function and health related quality of life (HRQoL) after 84 days of treatment with a single inhaler triple therapy combination of FF/UMEC/VI [100/62.5/25 microgram (mcg)]…
- Trial name
- NCT03478683
- Testing
- budesonide/formoterol, albuterol/salbutamol, FF/UMEC/VI
- Where
- 57 sites in United States, Czechia and 2 more
- Volunteers
- 729 people
- Sponsor
- GlaxoSmithKline
COPD, Obesity &Amp; Overweight
The Impact of a Weight Reduction Intervention on Clinical Outcomes in Patients With Obesity and COPD
Obesity and COPD are increasingly common and often coexist, worsening health outcomes such as reduced lung function, exercise capacity, and increased systemic inflammation.
- Trial name
- NCT07159594
- Testing
- Energy restriction
- Volunteers
- 70 people
- Sponsor
- Sahlgrenska University Hospital
COPD Chronic Obstructive Pulmonary Disease
Effectiveness of TNI vs. BiPAP in Chronic Global Insufficiency in COPD Patients
The purpose of this trial ist to investigate the difference of the efficacy of two systems for breath support in patients with COPD.
- Trial name
- TIBICO (NCT02007772)
- Testing
- nHF, BiPAP
- Where
- 14 sites in Germany
- Volunteers
- 105 people
- Sponsor
- University of Leipzig
COPD, Chronic Obstructive Pulmonary Disease
Evaluating the Safety and Efficacy of dNerva Lung Denervation System in Patients With COPD
The dNerva Lung Denervation System is one-time treatment intended to improve breathing in Chronic Obstructive Pulmonary Disease (COPD) patients on standard medical care.
- Trial name
- AIRFLOW-4 (NCT07051707)
- Testing
- Targeted Lung Denervation (TLD)
- Where
- 10 sites in United States
- Volunteers
- 200 people
- Sponsor
- Nuvaira, Inc.
COPD, Chronic Bronchitis
Metered Cryospray for the Treatment of Patients With Chronic Obstructive Pulmonary Disease With Chronic Bronchitis
To evaluate the relationship between airway structure and function in patients with chronic bronchitis treated with metered cryospray (MCS).
- Trial name
- NCT03892694
- Testing
- RejuvenAir System
- Where
- 2 sites in Netherlands, United Kingdom
- Volunteers
- 32 people
- Sponsor
- CSA Medical, Inc.
COPD
Adverse Health Effects of Mainstream and Secondhand Hookah Smoke in NYC Hookah Bars
The primary purpose of this study is to examine the health effects of mainstream and secondhand hookah (i.e. water pipe) smoke on pulmonary and cardiovascular functions as well as serum levels of inflammatory biomarkers.
- Trial name
- NCT02638194
- Testing
- Active smoking of Tobacco Hookah for 2 hours, Exposure to tobacco hookah second hand smoke, Visit a win bar
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Pulmonary Disease, Chronic Obstructive
Effects of SIMEOX on Static Hyperinflation in Patients With COPD
This study will investigate the effects on the SIMEOX technology on static hyperinflation in patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT04157972
- Testing
- SIMEOX, PEP
- Where
- Belgium
- Volunteers
- 25 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
COPD, Breathlessness
Reducing Breathlessness With Dronabinol in COPD Patients
This clinical trial examines whether Dronabinol, which contains the synthetic psychoactive compound tetrahydrocannabinol (THC), can alleviate severe breathlessness in patients with severe and very severe chronic obstructive…
- Conditions
- COPD, Breathlessness, Cannabis
- Trial name
- BONG (NCT06473701)
- Testing
- Dronabinol 2.5mg Capsule
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Vejle Hospital
Diabetes Mellitus, Congestive Heart Failure
Homing in on Health: Study of a Home Delivered Chronic Disease Self Management Program
The purpose of the study is to determine the effectiveness of a home-delivered variant of the chronic disease self management program in improving health outcomes in patients with chronic conditions.
- Conditions
- Diabetes Mellitus, Congestive Heart Failure, Arthritis, COPD
- Trial name
- NCT00263939
- Testing
- Homing in on Health
- Where
- United States
- Volunteers
- 415 people
- Sponsor
- Agency for Healthcare Research and Quality (AHRQ)
Hypertension, Diabetes Mellitus, Type 2
ENCOMPASS: Expansion Study C
Some patients living with multiple long-term health conditions have difficulty accessing the services they need, despite available primary care and community resources.
- Conditions
- Hypertension, Diabetes Mellitus, Type 2, Chronic Kidney Diseases, Ischemic Heart Disease
- Trial name
- NCT04791267
- Testing
- Community Health Navigator Program
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- University of Calgary
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