Clinical trials: Pulmonary Disease, Obstructive
Asthma in Children
Impact of Modified Specific Carbohydrate Diet on Bronchial Asthma Control in Children
The aim of this study will explore if the specific carbohydrate diet has an effect on asthma control in children and if it will affect the frequency, severity, and duration of asthma and thus provide it as a potential…
- Trial name
- NCT05728385
- Testing
- Modified Specific carbohydrate diet for 3 months
- Volunteers
- 60 people
- Sponsor
- Tanta University
Healthy Participants
A Study to Assess the Pharmacokinetics of AZD6793 When Administered Alone and in Combination With Itraconazole in Healthy Participants.
The study will evaluate the pharmacokinetics (PK) of AZD6793 when administered alone and in combination with itraconazole in healthy adult participants.
- Trial name
- NCT06494644
- Testing
- AZD6793, Itraconazole, AZD6793+ Itraconazole
- Where
- Germany
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Asthma
Study Of Fluticasone Propionate/Salmeterol In Asthmatic Subjects
The aim of the present study is to investigate whether the effects of salmeterol in combination with fluticasone propionate on blood markers of airway inflammation are maintained after chronic dosing and whether the effect is…
- Trial name
- NCT00517634
- Testing
- FP, SFC
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 23 people
- Sponsor
- GlaxoSmithKline
Pulmonary Disease, Oropharyngeal Disease
Role of Helicobacter Pylori and Its Toxins in Lung and Digestive System Diseases
This study will examine bacteria and toxins in the mouth, lung and digestive system that may be the cause of various diseases or symptoms. H.
- Conditions
- Pulmonary Disease, Oropharyngeal Disease, Lymphangioleiomyomatosis, Pulmonary Fibrosis
- Trial name
- NCT00366509
- Where
- United States
- Volunteers
- 157 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Asthma
DESOLO - SiT Peri-Launch: A Comparison of Symbicort Single Inhaler Therapy and Conventional Best Practice for the Treatment of Persistent Asthma in Adults
The purpose of this study is to determine whether Symbicort dosed according to the Symbicort Maintenance and Reliever Therapy (SMART) concept is superior to standard asthma treatment according to the local German treatment…
- Trial name
- NCT00252863
- Testing
- Symbicort, used twice daily (b.i.d) and as needed (prn), Budesonide Turbuhaler 200 µg, Fluticasone Discus 250 µg
- Where
- 169 sites in Germany
- Volunteers
- 1,600 people
- Sponsor
- AstraZeneca
Pulmonary Disease, Chronic Obstructive
A Study to Evaluate the Effectiveness and Safety of CNTO6785 in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease
The purpose of the study is to evaluate the effect of CNTO6785 compared with placebo in participants with moderate to severe Chronic Obstructive Pulmonary Disease.
- Trial name
- NCT01966549
- Testing
- CNTO 6785
- Where
- 44 sites in Czechia, Germany and 6 more
- Volunteers
- 187 people
- Sponsor
- Janssen Research & Development, LLC
Allergic Asthma
Study on the Role of Treatment With Vitamin E on Asthmatic Responses in Allergic Asthmatics
Asthma is a common respiratory disease of unknown etiology which currently affects approximately 7.5 % of the adult population ( ). Asthma is an inflammatory disorder of the airways.
- Trial name
- NCT00581048
- Testing
- Natural source d-α-tocopheryl acetate
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Vanderbilt University
COPD (Chronic Obstructive Pulmonary Disease)
The Study of Chronic Obstructive Pulmonary Disease (COPD) Participants Treated With Dupilumab (STRIDE) Registry
The STRIDE Registry will evaluate the real-world effectiveness and safety of dupilumab in participants with COPD. The primary objective is to describe characteristics of participants newly initiated with dupilumab for COPD.
- Trial name
- STRIDE (NCT07612878)
- Testing
- Cohort 1: Dupilumab, Cohort 2: usual care only
- Where
- 7 sites in United States
- Volunteers
- 350 people
- Sponsor
- Sanofi
Lung Diseases, Obstructive, Chronic Obstructive Pulmonary Disease
Effect of Maternal Smoking On Neonatal Lung Function
To determine factors, including maternal cigarette smoking and acute respiratory illness, influencing infant lung function at birth and up to five years of age.
- Trial name
- NCT00005285
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Pulmonary Disease, Chronic Obstructive
Safety, Blood Levels and Effects of GW642444
GW642444 (the study medicine) is a new experimental medicine for treating asthma and chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT00469040
- Testing
- GW642444M for 14 days
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Asthma
BREATHE: An Efficacy-implementation With Listening Sessions
Listening sessions: The research team will collect qualitative data from the listening sessions (focus groups) using a semi-structured iterative focus group guide.
- Trial name
- NCT05045690
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Columbia University
Hypoxemia, Anoxia
Reproducibility of 6 Minute Walk Tests for Oxygen Desaturation
This trial will test the hypothesis that the 6 minute walk test (6MWT) is not reproducible as a measure for oxygen desaturation.
- Conditions
- Hypoxemia, Anoxia, Chronic Obstructive Pulmonary Disease
- Trial name
- 6MWT (NCT00740220)
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Wake Forest University Health Sciences
Pulmonary Disease, Chronic Obstructive
Pharmacokinetics, Safety and Tolerability of Twice-Daily Aclidinium Bromide/Formoterol Fumarate Fixed Dose Combination in Chinese Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease
A Phase IIa, open-label, repeat-dose trial to investigate the pharmacokinetics (PK), safety and tolerability of single and multiple twice daily doses of inhaled Aclidinium Bromide/Formoterol Fumarate 400/12 μg in 20 Chinese male…
- Trial name
- NCT03276078
- Testing
- Aclidinium Bromide/Formoterol Fumarate 400/12μg BID
- Where
- China
- Volunteers
- 20 people
- Sponsor
- AstraZeneca
Asthma
Evaluation of Negative Inspiratory Flow in Children With Acute Asthma
There are different inhalers used for the treatment of asthma and they work differently and require different technique for the optimal drug delivery to the lungs. One of the inhalers is the Dry Powder Inhaler (DPI).
- Trial name
- NCT05762978
- Testing
- In-Check Dial, Inhaler Device
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Winthrop University Hospital
Allergic Rhinitis, Asthma
Integrating Targeted MedlinePlus Health Prescriptions Into Clinic Practice Workflow
The specific aim of this proposed project is to implement a standard process for integrating MedlinePlus health information prescriptions into the clinic workflow.
- Conditions
- Allergic Rhinitis, Asthma, Back Pain, Benign Prostatic Hypertrophy
- Trial name
- NCT00634608
- Testing
- Health Information Prescription
- Where
- United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Chronic Obstructive Pulmonary Disease
Dietary Intervention Increasing Omega-3 Intake
This Dietary Intervention is being done to evaluate the feasibility of a food voucher program and dietary counseling to increase consumption of healthy fatty acids (omega-3) in individuals with Chronic Obstructive Pulmonary…
- Trial name
- NCT03806868
- Testing
- voucher for ordering foods (ONLY omega-3 rich foods), voucher for ordering foods in general (any type of foods)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Asthma
Immune Interactions in Severe Asthma
This research study is being done to learn more about severe asthma by comparing people with severe asthma to those with milder forms of asthma and people without asthma, at baseline and over time.
- Trial name
- NCT02566668
- Testing
- 1 year Observational Follow-up
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Asthma
The Effect of Allergen Inhalation on Sputum Myeloid and Plasmacytoid Dendritic Cells in Mild Atopic Asthmatics
Summary: A picture is emerging of dendritic cells migrating through the blood to the airways following allergen inhalation in atopic asthmatics.
- Trial name
- NCT00625989
- Testing
- Aeroallergen
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Hamilton Health Sciences Corporation
COPD, Early-Onset
SPIROMICS Study of Early COPD Progression (SOURCE)
This is an observational study of 1000 participants to further define the nature of early chronic obstructive pulmonary disease (COPD) in younger, at-risk individuals.
- Trial name
- SOURCE (NCT05033990)
- Where
- 14 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Pulmonary Disease, Chronic Obstructive
Study to Evaluate Efficacy and Safety of Inhaled BEA 2180 BR in COPD Patients
Study to investigate the dose-dependent bronchodilator effect and the safety of single inhalation doses of BEA 2180 inhaled via Respimat® compared to placebo in patients with stable Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- NCT02242279
- Testing
- BEA 2180 BR, Tiotropium
- Volunteers
- 37 people
- Sponsor
- Boehringer Ingelheim