Clinical trials: Pulmonary Disease (COPD), Chronic Obstructive
Chronic Obstructive Pulmonary Disease
A Multi-center,Prospective, OS to Evaluate the Effectiveness of 'NAC' Nebulizer Therapy in COPD (NEWEST)
To evaluate the effect of Mucomyst nebulizer therapy on improvement in symptoms and quality of life in COPD patients with difficulty of expectoration.
- Trial name
- NCT05102305
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Boryung Pharmaceutical Co., Ltd
COPD (Chronic Obstructive Pulmonary Disease)
Effectiveness of DITM Versus IMT in COPD Patients
The goal of this clinical trial is to learn if digital inhaled therapy management (DITM) and inspiratory muscle training (IMT), alone or in combination, can improve outcomes in adults aged 40 years and older with symptomatic…
- Trial name
- NCT06958666
- Testing
- Digital Inhaled Therapy Management, Inspiratory Muscle Training
- Where
- 9 sites in China
- Volunteers
- 410 people
- Sponsor
- Sir Run Run Shaw Hospital
Chronic Obstructive Pulmonary Disease (COPD)
Pedometer-based Behavioural Intervention for Individuals With COPD to Stay Active After Rehabilitation
The STAR-study (STay Active after Rehabilitation) investigates in a randomized controlled trial (RCT) the additional effect of a pedometer-based behavior change intervention (BCI) during in-patient pulmonary rehabilitation (PR)…
- Trial name
- STAR (NCT02966561)
- Testing
- Pedometer-based activity promotion, Short patient education and exercise, Pulmonary rehabilitation (Standard care)
- Where
- Germany
- Volunteers
- 418 people
- Sponsor
- University of Erlangen-Nürnberg
Respiratory Tract Diseases
Evaluation and Reconditioning of Marginal Lung Donors to Transplantation by ex Vivo Lung Perfusion
Only about 15% of the potential candidates for lung donation are considered suitable for transplantation. A new method for ex vivo lung perfusion (EVLP) has been developed and can be used for evaluation and reconditioning of…
- Trial name
- NCT01353105
- Testing
- Ex vivo lung transplantation
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- InCor Heart Institute
Chronic Obstructive Pulmonary Disease, Emphysema
Macrophages in Smokers' Lung
Cigarette smoking causes an increase in inflammation in the lungs. In about 20% of smokers this inflammation leads to damage in lungs including making holes in the lung tissue.
- Conditions
- Chronic Obstructive Pulmonary Disease, Emphysema, Chronic Bronchitis
- Trial name
- NCT00298402
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Imperial College London
COPD
A 28-Day Parallel Group Study of TD-4208 in Chronic Obstructive Pulmonary Disease (COPD)
This study evaluated the safety and efficacy of four doses of TD-4208 and a placebo product when administered once daily for 28 days using a jet nebulizer to patients with moderate to severe chronic obstructive pulmonary disease.
- Trial name
- NCT02040792
- Testing
- TD-4208
- Where
- United States
- Volunteers
- 355 people
- Sponsor
- Mylan Inc.
Chronic Obstructive Pulmonary Disease (COPD)
Magnesium Loading in Chronic Obstructive Pulmonary Disease
Dietary magnesium (Mg) intake has been shown to be independently related to lung function, airway reactivity, and respiratory symptoms in the general population.
- Trial name
- NCT00500864
- Testing
- Magnesium Sulfate 2 grams
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- University of Sao Paulo
Chronic Obstructive Pulmonary Disease
GIRH Chronic Obstructive Pulmonary Disease Observational Study
The purpose of this study is to establish the large COPD cohort and biological database in China, aiming for precision medicine to optimize diagnosis and treatment choices.
- Trial name
- NCT03893409
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- zili zhang
Loneliness
Impact of Pulmonary Rehabilitation on Loneliness in COPD
Loneliness is the feeling of sadness because one wants friends or company. This feeling is common in patients with chronic lung disease, who suffer from breathing difficulty, chronic cough, and reduced physical and mental health.
- Trial name
- NCT05435963
- Testing
- Pulmonary rehabilitation (PR)
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- McMaster University
Interstitial Lung Disease, Chronic Obstructive Pulmonary Disease
Titrated Ambulatory Oxygen in Fibrotic ILD and COPD With Isolated Exertional Hypoxemia
Fibrotic forms of interstitial lung disease (ILD) and chronic obstructive pulmonary disease (COPD) are chronic lung disease which often affect how well oxygen can get from the lungs into the blood.
- Conditions
- Interstitial Lung Disease, Chronic Obstructive Pulmonary Disease, Hypoxemia
- Trial name
- NCT07512687
- Testing
- Portable Oxygen Concentrator, Portable compressed oxygen D-tanks, No ambulatory oxygen therapy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- State University of New York at Buffalo
Chronic Obstructive Pulmonary Disease
Low-dose Theophylline as Anti-inflammatory Enhancer in Severe Chronic Obstructive Pulmonary Disease
The main objective of the study is to determine the effects of low-dose oral theophylline added to combination treatment with long-acting β-agonist (LABA) and inhaled corticosteroid (ICS) in patients with severe Chronic…
- Trial name
- ASSET (NCT01599871)
- Testing
- theophylline
- Where
- 10 sites in Spain
- Volunteers
- 70 people
- Sponsor
- Hospital Son Espases
Pulmonary Disease, Chronic Obstructive
Fluticasone Propionate-salmeterol Combination Adherence in Patients With Chronic Obstructive Pulmonary Disease (COPD)
The specific aim of this study is to describe 1 year Advair dispensing rates for patients with COPD, and to measure the association between Advair adherence and healthcare utilization (e.g.
- Trial name
- NCT01381471
- Testing
- fluticasone propionate/salmeterol xinafoate combination
- Volunteers
- 11,060 people
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease, Pulmonary Emphysema
Volumetric HRCT in Stable COPD Patients.
This study evaluates the role of volumetric high-resolution computed tomography (HRCT) of the chest in assessing patients with stable chronic obstructive pulmonary disease (COPD).
- Conditions
- Chronic Obstructive Pulmonary Disease, Pulmonary Emphysema, Airway Obstruction
- Trial name
- NCT07809399
- Testing
- Volumetric HRCT chest, Spirometry and Body Plethysmography
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Mansoura University
COPD
The Effect of Volitional Pursed-lips Breathing
Simulation of pursed-lips breathing by defined stenoses in pulmonary function diagnostics to quantify the effect of the pursed-lips breathing
- Trial name
- PLB (NCT04663698)
- Testing
- Baseline, MESH-Resistor 5, MESH-Resistor 10
- Where
- Germany
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Karl Josef Franke, PD DR med
COPD
Evaluation by Electrical Impedancemetry of the Variation in Lung Volumes Under Non-invasive Ventilation (NIV) in Patients With Chronic Obstructive Pulmonary Disease (COPD)
The aim of this physiologic research is to assess lung volumes variations under NIV in stable COPD patients to understand the impact of "high-intensity" ventilation following the current recommendations.
- Trial name
- Eval 3V-BPCO (NCT05953298)
- Testing
- Electrical impedance tomography (EIT)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Bordeaux
Hypertension, Diabetes Mellitus, Type 2
ENCOMPASS: Expansion Study A, RCT
Some patients living with multiple long-term health conditions have difficulty accessing the services they need, despite available primary care and community resources.
- Conditions
- Hypertension, Diabetes Mellitus, Type 2, Chronic Kidney Diseases, Ischemic Heart Disease
- Trial name
- ENCOMPASS (NCT04790604)
- Testing
- Community Health Navigator Program
- Where
- Canada
- Volunteers
- 96 people
- Sponsor
- University of Calgary
Chronic Obstructive Pulmonary Disease, COPD
Sustained Effects of Hypertonic Saline on Mucociliary Clearance in Subjects With Chronic Bronchitis
The purpose of this research study is to examine the effects of two weeks of daily dosing of inhaled salt water mist (hypertonic saline - HS) on actual measurements of mucociliary and cough clearance in patients with the chronic…
- Conditions
- Chronic Obstructive Pulmonary Disease, COPD, Chronic Bronchitis
- Trial name
- NCT01792271
- Testing
- Inhaled 7% HS (NaCl) home treatment
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of North Carolina, Chapel Hill
Extracorporeal CO2 Removal, Acute Respiratory Distress Syndrome
Effects of Blood Pulsatility on Von Willebrand Factor During ECCO2R
The primary objective of the study is to demonstrate that the ECCO2R pulsatile configuration prevents the Willebrand factor high molecular weight multimers decrease observed under continuous blood flow configurations.
- Conditions
- Extracorporeal CO2 Removal, Acute Respiratory Distress Syndrome, Chronic Obstructive Pulmonary Disease Exacerbation, Pulmonary Disease
- Trial name
- FLOW-ECCO2R (NCT05079009)
- Testing
- ECCO2R pulsatile configuration
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Non-Small Cell Lung Cancer, Chronic Obstructive Lung Disease
Singing Training vs Usual Care 6-18 Months After Surgical Resection for Non-small Cell Lung Cancer (NSCLC)
People who have undergone curative surgery for non-small cell lung cancer (NSCLC) often experience reduced quality of life (QoL), a high burden of symptoms, and physical deconditioning.
- Trial name
- Sing-a-Lung 2 (NCT07460999)
- Testing
- Singing training (Singing for Lung Health (SLH)), Control group: Usual care
- Where
- 5 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Zealand University Hospital
Inspiratory Muscle Training
Inspiratory Muscle Training in Lung Transplant Candidates
Recovery after lung transplantation (LTx) may be complicated by prolonged mechanical ventilation (MV) and protracted intensive care unit (ICU) stay leading to immobilization and impaired health-related quality of life (HRQoL).
- Trial name
- NCT06370832
- Testing
- IMT and exercise training group
- Where
- 4 sites in Canada
- Volunteers
- 90 people
- Sponsor
- University Health Network, Toronto
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