Clinical trials: Pulmonary Disease (COPD), Chronic Obstructive
Chronic Obstructive Pulmonary Disease
Role of A Disintegrin and Metalloproteinase (ADAM) in Epithelial Dysfunction
Despite emerging implications for ADAMs (and matrix metalloproteinases (MMPs)) in disease progression, the mechanisms that lead to activation of specific ADAMs (and MMPs) and their actions in chronic obstructive pulmonary disease…
- Trial name
- NCT00898859
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Chronic Obstructive Pulmonary Disease
Advanced eHealth for Chronic Obstructive Pulmonary Disease (COPD) in Colorado
Chronic obstructive pulmonary disease (COPD) is the 4th leading cause of death in the United States, affects 24 million people and is responsible for up to $32 billion annually in direct and indirect health care costs.
- Trial name
- NCT01044927
- Testing
- Integrated Care, Standard Therapy
- Where
- 2 sites in United States
- Volunteers
- 511 people
- Sponsor
- University of Colorado, Denver
COPD, Asthma
Perception of the Benefits and Effectiveness of Inhalation Therapy in Patients With Obstructive Dyspnea
Obstructive ventilatory disorders, including chronic obstructive pulmonary disease (COPD), asthma, and pulmonary emphysema, are chronic conditions characterized by progressive airflow limitation and worsening dyspnea, leading to…
- Trial name
- NCT07903597
- Testing
- Survey
- Where
- Italy
- Volunteers
- 101 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Pulmonary Disease, Chronic Obstructive
Pharmacokinetics and Safety Comparison of Tiotropium Inhalation Powder Administered as the Bromide Salt From Hard Polyethylene Capsule Via the HandiHaler® 2 and Spiriva® HandiHaler® in Patients With Chronic Obstructive Pulmonary Disease (COPD)
The primary objective of this trial was to establish non-inferiority of lung function response to tiotropium 10 μg, formulated as inhalation powder in the polyethylene hard capsule and delivered via the HandiHaler® 2, compared to…
- Trial name
- NCT02242266
- Testing
- Tiotropium low dose, Tiotropium medium dose, Spiriva® HandiHaler® high dose
- Volunteers
- 121 people
- Sponsor
- Boehringer Ingelheim
Chronic Obstructive Pulmonary Disease
Post Marketing Surveillance of Roflumilast in Korea
The purpose of this study is to evaluate the safety and efficacy of roflumilast in the real-use conditions with its registered indications.
- Trial name
- NCT02068456
- Testing
- Roflumilast
- Where
- South Korea
- Volunteers
- 1,837 people
- Sponsor
- AstraZeneca
Chronic Obstructive Lung Disease (COLD)
Evaluation of the Safety and Efficacy of HSK39004 Dry Powder Inhaler and HSK39004 Inhalation Suspension in Chinese Patients With Chronic Obstructive Pulmonary Disease (COPD)
To evaluate the safety and efficacy of the HSK39004 Dry Powder Inhaler and HSK39004 Inhalation Suspension compared with the placebo in the treatment of Chinese patients with COPD.
- Trial name
- NCT07140328
- Testing
- HSK39004 Dry Powder Inhaler -0.75mg BID, HSK39004 Dry Powder Inhaler -1.5mg BID, HSK39004 Inhalation Suspension -3mg BID
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
Study to Evaluate the Pharmacokinetic Characteristics, Safety, Tolerability, and Preliminary Efficacy of 9MW1911 in Patients With Chronic Obstructive Pulmonary Disease (COPD).
The study will evaluate the pharmacokinetic characteristics, safety, tolerability, and preliminary efficacy of 9MW1911 in combination with standard of care COPD maintenance therapy in patients with moderate to severe COPD.
- Trial name
- NCT06175351
- Testing
- 9MW1911
- Where
- 22 sites in China
- Volunteers
- 80 people
- Sponsor
- Mabwell (Shanghai) Bioscience Co., Ltd.
COPD, Hyperglycemia
Phase II Study of Safety and Feasibility of Intensive Blood Glucose Control With Insulin on Acute Medical Wards
Patients with chronic obstructive pulmonary disease (COPD) are commonly admitted to hospital with exacerbations of their lung disease.
- Trial name
- IPS2008 (NCT00764556)
- Testing
- Insulin
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- St George's, University of London
COPD
Zofin to Treat Chronic Obstructive Pulmonary Disease (COPD)
A Phase I/II Randomized, Double Blinded, Placebo Trial to Evaluate the Safety and Potential Efficacy of Intravenous Infusion (IV) of Zofin for the Treatment of Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- NCT05643729
- Testing
- Zofin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- ZEO ScientifiX, Inc.
Chronic Obstructive Pulmonary Disease
A Study to Evaluate the Efficacy and Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease
This study will evaluate the efficacy, safety, and pharmacokinetics of astegolimab in combination with standard of care chronic obstructive pulmonary disease (COPD) maintenance therapy in patients with COPD who are former or…
- Trial name
- NCT05037929
- Testing
- Astegolimab
- Where
- 193 sites in United States, Argentina and 22 more
- Volunteers
- 1,334 people
- Sponsor
- Genentech, Inc.
Chronic Obstructive Pulmonary Disease
Efficacy and Safety of Glycopyrrolate Bromide of COPD Patients
The purpose of this study is to evaluate the efficacy and safety of CHF 5259 (glycopyrrolate bromide) for the treatment of COPD patients.
- Trial name
- Trigon (NCT02189577)
- Testing
- CHF 5259
- Where
- 29 sites in Bulgaria, Germany and 2 more
- Volunteers
- 100 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Healthy Non-smokers, Current Smokers
Markers for Chronic Obstructive Pulmonary Disease (COPD)
The primary aim of this study is to exploit a difference between COPD patients, chronic smokers without COPD and healthy non-smoking subjects.
- Conditions
- Healthy Non-smokers, Current Smokers, COPD Patients
- Trial name
- NCT00180622
- Testing
- Spirometry, Exhaled Nitric Oxide and Carbon Monoxide, Exhaled Breath Condensate
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Imperial College London
Chronic Obstructive Pulmonary Disease
Clinical Presentation and Outcome of COPD Patients With Acute Exacerbation Attending Sohag University Hospital
Chronic obstructive pulmonary disease (COPD) is a worldwide public health challenge because of high prevalence and related disability and mortality (1).
- Trial name
- NCT06684353
- Volunteers
- 200 people
- Sponsor
- Sohag University
HIV Infections, Emphysema
Prevalence and Pathogenesis of Lung Disease in a Large HIV Cohort-coordinating Center
Despite the availability of highly active antiretroviral therapy (HAART), lung diseases remain a leading cause of morbidity and mortality in those with HIV infection.
- Conditions
- HIV Infections, Emphysema, Chronic Obstructive Pulmonary Disease, Pneumocystis
- Trial name
- MACS (NCT00870857)
- Where
- 2 sites in United States
- Volunteers
- 407 people
- Sponsor
- University of Pittsburgh
Chronic Obstructive Pulmonary Disease
Effect of Remote Physiologic Monitoring (RPM) on Outcomes in COPD Patients
This pre/post study was a retrospective analysis of unplanned hospitalization rates in a cohort of COPD subjects started on remote physiologic monitoring (RPM) at a large, outpatient pulmonary practice.
- Trial name
- NCT05518981
- Testing
- Respiratory Remote Patient Monitor (Spire Health Tag)
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Spire, Inc.
Chronic Obstructive Pulmonary Disease
Molecular, Cytological Features and Genetic Susceptibility of COPD Attributable to Different Environmental Exposures 2
The objective of this study is to investigate molecular, cytological and genetic features of occupational chronic obstructive pulmonary disease (COPD) in conditions of different occupational exposures.
- Trial name
- NCT02284295
- Testing
- exposure to respirable silica dust, exposure to aromatic hydrocarbons
- Where
- Russia
- Volunteers
- 352 people
- Sponsor
- Novosibirsk City Hospital #2
COPD, Education
Efficacy of an Education Protocol in the Correction of Inhalation Techniques in COPD
This study evaluates the implementation of an education protocol and its impact on the correct inhalation technique in COPD patients presenting errors or mistakes.
- Trial name
- NCT03144557
- Testing
- Education
- Where
- Argentina
- Volunteers
- 61 people
- Sponsor
- Hospital Italiano de Buenos Aires
Chronic Obstructive Pulmonary Disease
Long Term Effect of an Education and Training Program for Patients With Chronic Obstructive Pulmonary Disease
A parallell group study comparing the effect of an education program with an education and training program for patients with COPD. 30 participants in each group. Participants self-select which group they wanted to be in.
- Trial name
- NCT00159549
- Testing
- education and training program
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Norwegian University of Science and Technology
Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease (COPD) and Advance Directives
The aim of this study is to evaluate if the participation of COPD patients to a workshop on advance directives increases the number of patients who write them.
- Trial name
- DIABPCO (NCT04459143)
- Testing
- Advance directives
- Where
- France
- Volunteers
- 525 people
- Sponsor
- Hôpital NOVO
Diabetes Type 2, COPD
Effectiveness of a Team-based Follow-up Program in General Practice Among People With Chronic Conditions
The study will develop and evaluate the effectiveness of a team-based follow-up program in general practice (GP) among people with chronic conditions.
- Trial name
- NCT04076384
- Testing
- Guided Self-Determination, Standard care
- Where
- Norway
- Volunteers
- 228 people
- Sponsor
- Bergen University College
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