Clinical trials: Pulmonary Disease (COPD), Chronic Obstructive
Chronic Obstructive Pulmonary Disease
The China National COPD Screening Program
The national COPD screening program is in a cross-sectional manner at the baseline, planning to recruit a total of 800,000 participants from 160 districts or counties (5,000 for each site on average) from 31 provinces, autonomous…
- Trial name
- NCT05480176
- Testing
- Comprehensive intervention and management Ⅰ, Comprehensive intervention and management Ⅱ, Comprehensive intervention and management Ⅲ
- Where
- China
- Volunteers
- 800,000 people
- Sponsor
- China-Japan Friendship Hospital
Pulmonary Disease, Chronic Obstructive, Lung Transplantation
Evaluating Quality of Life for Patients With Chronic Obstructive Pulmonary Disease Who Are Undergoing Lung Transplantation
Most people undergoing lung transplantation have chronic obstructive pulmonary disease (COPD), a disease in which the lung airways are partly damaged and obstructed, making it difficult to breathe.
- Trial name
- NCT00675376
- Where
- United States
- Volunteers
- 419 people
- Sponsor
- Washington University School of Medicine
Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Decision-making and Optimization of Ventilatory Support for AECOPD Patients
The goal of this retrospective observational study is to learn about how respiratory support is selected and adjusted in hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).
- Trial name
- OPTIVENT-COPD (NCT07508943)
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Sir Run Run Shaw Hospital
Copd, COPD Exacerbation
Clinical Study for the Effectiveness of Roflumilast Treatment in COPD Greek Patients Based on Standard Clinical Practice.
Preferred pharmacological management for COPD according to the GOLD guidelines are the long-acting anticholinergic LAMAs (Long-Acting / Short-Acting Muscarinic Antagonists), and long-acting β 2-Agonists LABA (Long-acting LABA) /…
- Trial name
- ARGO (NCT05426915)
- Where
- Greece
- Volunteers
- 750 people
- Sponsor
- Elpen Pharmaceutical Co. Inc.
Tuberculosis, Pulmonary, Undernutrition
The INSTITUT Study Tuberculosis Nutritional Support
Undernutrition is a leading global risk factor of tuberculosis (TB) and a prevalent comorbidity associated with TB. In Benin, the National TB Program systematically provides nutritional support to all persons with TB (PWTB)…
- Trial name
- INSTITUT (NCT06084715)
- Testing
- Nutritional support
- Where
- 2 sites in Benin, Togo
- Volunteers
- 769 people
- Sponsor
- Boston Medical Center
Healthy Volunteers, Chronic Obstructive Pulmonary Disease
Cardiac Safety of Indacaterol
This study compares the cardiac safety of inhaled indacaterol with that of placebo and oral moxifloxacin.
- Trial name
- NCT01263808
- Testing
- Indacaterol 150 µg, Indacaterol 300 µg, Indacaterol 600 µg
- Where
- United States
- Volunteers
- 404 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
COPD
A Safety, Tolerability and Efficacy Study in Chronic Obstructive Pulmonary Disease (COPD) Patients With QBM076.
This was a 2 Part study. Part 1 was a safety and tolerability study in GOLD I-III COPD patients. Part 2 was an efficacy study in GOLD I-III COPD patients.
- Trial name
- NCT01972776
- Testing
- QBM076
- Where
- 7 sites in United States, Germany and 2 more
- Volunteers
- 48 people
- Sponsor
- Novartis Pharmaceuticals
Chronic Obstructive Pulmonary Disease (COPD)
PBMT Associated With a Pulmonary Rehabilitation Program on the Functional Capacity of Patients With COPD
This study aims to evaluate the effectiveness of photobiomodulation therapy (PBMT) as an adjunct to the pulmonary rehabilitation program on the functional capacity of patients with COPD.
- Trial name
- NCT07878884
- Testing
- Intervention Group, control group
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Federal University of Health Science of Porto Alegre
Pulmonary Disease, Chronic Obstructive (MeSH)
Efficacy of Corticosteroids to Treat Outpatients With Acute Exacerbations of COPD
Primary objective: The aim of this study is to determine the efficacy and safety of five days of oral corticosteroids (40 mg / day) for the treatment of acute exacerbations of COPD (AECOPD) in outpatients.
- Trial name
- BECOMEG (NCT02330952)
- Testing
- Prednisone
- Where
- France
- Volunteers
- 189 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pulmonary Disease, Chronic Obstructive
Tiotropium Respimat Pharmacokinetic Study in COPD
The purpose of this study is compare the effect of different doses of tiotropium delivered by the HandiHaler and Respimat device on lung function.
- Trial name
- NCT01222533
- Testing
- Tiotropium medium, Tiotropium low, Tiotropium high
- Where
- 11 sites in Belgium, Denmark and 3 more
- Volunteers
- 154 people
- Sponsor
- Boehringer Ingelheim
Pulmonary Disease, Chronic Obstructive, Pulmonary Fibrosis
Interferon-alpha Treatment of Chronic Cough in Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis
The purpose of this study is to determine whether lozenges containing interferon-alpha can reduce the frequency and severity of coughing in patients with chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Pulmonary Fibrosis, Cough
- Trial name
- NCT00690885
- Testing
- interferon-alpha lozenges
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Ainos, Inc. (f/k/a Amarillo Biosciences Inc.
Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease (COPD) Activity: Serotonin Transporter (SERT), Cytokines and Depression (CASCADE Study)
The goal of the study is to look at how genes and certain chemicals in the body are related to depression and chronic obstructive pulmonary disease.
- Trial name
- CASCADE (NCT01074515)
- Where
- 4 sites in United States
- Volunteers
- 350 people
- Sponsor
- University of Washington
Pulmonary Disease, Chronic Obstructive
Randomized Study Evaluating the Effect of Danirixin on Neutrophil Extracellular Traps (NETs) in Chronic Obstructive Pulmonary Disease (COPD)
The inflammation associated with COPD is characterized by a prominent infiltration of neutrophils in lung tissue and airways. The CXC chemokine receptor type 2 (CXCR2) plays a pivotal role in neutrophil recruitment to the lungs…
- Trial name
- NCT03250689
- Testing
- Danirixin, Rescue medication, Inhaled COPD maintenance medication
- Where
- United Kingdom
- Volunteers
- 19 people
- Sponsor
- GlaxoSmithKline
Pulmonary Disease, Chronic Obstructive
Pilot Study Comparing Tiotropium (Spiriva) to Salmeterol (Serevent) Plus Fluticasone (Flixotide) in Chronic Obstructive Pulmonary Disease (COPD)
The primary objective of this study is to estimate the comparative bronchodilator effect size and variability for tiotropium (Spiriva, 18 µg q.d.) with the free combination of salmeterol (Serevent, 50 µg b.i.d.) and fluticasone…
- Trial name
- NCT00239499
- Testing
- Tiotropium, Salmeterol plus Fluticasone
- Where
- 12 sites in South Africa
- Volunteers
- 107 people
- Sponsor
- Boehringer Ingelheim
Copd, Adherence, Medication
Triple Therapy Convenience by the Use of One or Multiple Inhalers and Digital Support in Chronic Obstructive Pulmonary Disease
TRICOLON is an investigator initiated, prospective, interventional, open-label, randomized, real-world, multi-centre, 3-arms study in the Netherlands.
- Trial name
- TRICOLON (NCT05495698)
- Testing
- single-inhaler triple therapy (Trimbow), E-health application: Curavista app & FindAir e-device, multi-inhaler triple therapy (Qvar + Bevespi)
- Where
- Netherlands
- Volunteers
- 300 people
- Sponsor
- Franciscus Gasthuis
COPD (Chronic Obstructive Pulmonary Disease)
Changing Outcomes Through Achievement Emails in COPD Using Routine Healthcare Audits
This study is exploring how to improve prescribing for people with chronic obstructive pulmonary disease (COPD) in primary care. COPD is a long-term lung condition.
- Trial name
- COACH (NCT07181915)
- Testing
- Generic email - control, Personalised email - Intervention
- Where
- United Kingdom
- Volunteers
- 265 people
- Sponsor
- University of Leeds
Pulmonary Disease, Chronic Obstructive
Mepolizumab as Add-on Treatment IN Participants With COPD Characterized by Frequent Exacerbations and Eosinophil Level
This is a multi-center, randomized, placebo-controlled, double-blind, parallel group study designed to confirm the benefits of mepolizumab treatment on moderate or severe exacerbations in chronic obstructive pulmonary disease…
- Trial name
- MATINEE (NCT04133909)
- Testing
- Mepolizumab
- Where
- 339 sites in United States, Argentina and 24 more
- Volunteers
- 806 people
- Sponsor
- GlaxoSmithKline
Thoracic Diseases, Respiratory Tract Diseases
A Phase I Study of iPS Cell Generation From Patients With COPD
As part of the long-term goal of successfully implementing tissue regeneration strategies in an individualized manner for patients with thoracic diseases including, but not limited to: cystic fibrosis, pulmonary fibrosis and…
- Conditions
- Thoracic Diseases, Respiratory Tract Diseases, Cancer of Lung, Cancer of the Lung
- Trial name
- NCT01860898
- Testing
- Skin Biopsy
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Mayo Clinic
Smoke Induced Lung Disease
Ancillary T Cell Based Studies in SPIROMICS
The long-term objectives of this ancillary application are to characterize a subpopulation of smokers with auto-reactive T cell response, to validate immunodiagnostic assays that could detect emphysema, and to find molecular…
- Trial name
- NCT02036190
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- University of California, San Francisco
Chronic Obstructive Pulmonary Disease
Understanding the Importance of Plasticity in the Brain Mechanisms of Dyspnoea Perception
Dyspnoea is the uncomfortable shortness of breath that debilitates millions of patients with lung disease, heart failure and cancer. It is often very difficult to treat.
- Trial name
- NCT01985750
- Testing
- d-cycloserine
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Oxford
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