Clinical trials: Pulmonary Disease (COPD), Chronic Obstructive
HIV, Cardiovascular Disease
Ugandan Non-Communicable Diseases and Aging Cohort
Longitudinal cohort study of older-aged people living with HIV infection in southwestern Uganda and age and gender-matched HIV uninfected controls with the primary aim of measuring the epidemiology of cardiovascular and pulmonary…
- Conditions
- HIV, Cardiovascular Disease, Chronic Obstructive Pulmonary Disease, Atherosclerosis
- Trial name
- UGANDAC (NCT02445079)
- Testing
- This is an observational study only
- Where
- Uganda
- Volunteers
- 309 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Chronic Obstructive Pulmonary Disease
Roflumilast on Markers of Bone Metabolism and Endothelial Function in COPD
Our primary hypothesis is that Roflumilast (500 μcg, once daily) will significantly decrease surrogate markers of bone metabolism and early cardiovascular disease in individuals with moderate to severe airflow obstruction and a…
- Trial name
- NCT01745848
- Testing
- Roflumilast
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Pittsburgh
Chronic Obstructive Pulmonary Disease
Efficacy of Morphine in Reducing the Rate of Early Non-Invasive Ventilation Failure in Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Phase I/IIa
Acute exacerbations of Chronic Obstructive Pulmonary Disease (COPD) are a major source of morbidity and mortality for patients and cost to the society.
- Trial name
- MORPHEUS I/IIa (NCT04427826)
- Testing
- Morphine hydrochloride
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Grenoble
Chronic Obstructive Pulmonary Disease
High Flow Nasal Cannula During Pulmonary Rehabilitation
The primary purpose of this study is to compare and assess the immediate and long-term effects on pulmonary rehabilitation training with the usage of HFNC or conventional oxygen therapy device.
- Trial name
- NCT03237962
- Testing
- High Flow Nasal Cannula, Nasal Cannula
- Where
- 2 sites in Taiwan
- Volunteers
- 32 people
- Sponsor
- Chang Gung University
Lung Diseases, Obstructive
Cigarette Smoke Nasal and Whole Blood Challenge in Patients With Chronic Obstructive Pulmonary Disease (COPD)
This is a clinical research study to assess whether after exhaling a single cigarette smoke through the nose there are changes in the inflammatory cells and proteins of nasal secretions.
- Trial name
- NCT00159341
- Testing
- Nasal lavage, Nasal filter paper, Blood sampling
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Chronic Obstructive Pulmonary Disease
Walking Speeds in Patients With Chronic Obstructive Pulmonary Disease
A growing body of evidence suggests that in individuals with chronic lung disease their walk speed is related to their daily function and quality of life.
- Trial name
- NCT01768754
- Testing
- Usual and Fast Walking Speeds
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- West Park Healthcare Centre
Chronic Obstructive Pulmonary Disease
Coping Skills for Patients With Chronic Obstructive Pulmonary Disease (COPD) and Their Caregivers
This study is an NIH-funded clinical trial conducted at Duke University Medical Center and Ohio State University. The purpose of this study is to examine the effects of a telephone-based, care-giver assisted, coping skills…
- Trial name
- NCT00736268
- Testing
- Telephone-based Enhanced Coping Skills Training (CST), Usual Medical Care and COPD education and symptom monitoring (UMC)
- Where
- 2 sites in United States
- Volunteers
- 746 people
- Sponsor
- Duke University
Pulmonary Disease, Chronic Obstructive
Internet-based Rehabilitation Aftercare Focusing on Physical Activity Promotion in Persons With COPD
The aim of the study is to evaluate a 12-week internet-based rehabilitation aftercare program with an emphasis on physical activity promotion for persons with COPD.
- Trial name
- COPD-AReNa (NCT05006560)
- Testing
- Pulmonary Rehabilitation (usual care), Pulmonary Rehabilitation (usual care) + familiarization with components of the aftercare program, After care: Exercise and physical activity promotion
- Where
- Germany
- Volunteers
- 48 people
- Sponsor
- University of Erlangen-Nürnberg
COPD
Objective Assessment of Adherence to Inhalers by COPD Patients
Rationale: Objective adherence to inhaled therapy by patients with chronic obstructive pulmonary disease (COPD) has not been reported.
- Trial name
- NCT04025242
- Volunteers
- 244 people
- Sponsor
- Beaumont Hospital
Chronic Obstructive Pulmonary Disease
Pain in Individuals With COPD During Pulmonary Rehabilitation
This study is aimed at determining the role of pain in individuals with chronic obstructive pulmonary disease (COPD) who are enrolled in a pulmonary rehabilitation (PR) program.
- Trial name
- NCT02979379
- Testing
- Pain
- Where
- Canada
- Volunteers
- 68 people
- Sponsor
- West Park Healthcare Centre
Pulmonary Disease, Chronic Obstructive
Legend: TRELEGY Real World Chronic Obstructive Pulmonary Disease (COPD) Effectiveness Study
The primary purpose of this study is to assess the effectiveness of TRELEGY ELLIPTA single inhaler triple therapy (SITT) (fluticasone furoate/umeclidinium bromide/vilanterol [FF/UMEC/VI]) relative to non-ELLIPTA multiple inhaler…
- Trial name
- LEGEND (NCT03949842)
- Testing
- Inhaled corticosteroids/long-acting beta2-adrenergic/long-acting muscarinic receptor antagonists, Fluticasone furoate/umeclidinium/vilanterol
- Where
- 3 sites in United States
- Sponsor
- GlaxoSmithKline
Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Comparison of Aerosol Inhalation and Intravenous Glucocorticoid in the Treatment of Severe AECOPD
Comparison of aerosol inhalation and intravenous glucocorticoid in the treatment of severe AECOPD-------Multicenter, prospective, randomized, controlled clinical study
- Trial name
- NCT06189586
- Testing
- aerosol inhalation of glucocorticoids, intravenous injection of glucocorticoids
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Dong Yang
Stable COPD Patients
Study on the Mechanism of Yifei Moxibustion Improving Immune Function in COPD Based on Plasma Exosome miRNAs
This study adopted a randomized controlled design, enrolling 90 patients and 30 healthy volunteers. The patients were randomly divided into the Yifei Moxibustion group, the conventional Western medicine treatment group, and the…
- Trial name
- NCT07131020
- Testing
- Yifei moxibustion, Conventional Western medicine treatment, TCM syndrome differentiation treatment
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Henan University of Traditional Chinese Medicine
COPD
Exercise Training in Chronic Obstructive Pulmonary Disease (COPD)
Exercise training is the key component of respiratory rehabilitation.The success of long-term program resides in the integration between exercise prescription and patients'compliance with home training.
- Trial name
- NCT01218282
- Testing
- Home exercise training, NO Exercise Training
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Università degli Studi di Ferrara
Tuberculosis, Pulmonary
Atorvastatin to Reduce Inflammation After Tuberculosis Treatment Completion
This is a proof-of-concept phase IIB, double-blind, randomized, placebo-controlled trial to evaluate the safety and efficacy of 40 mg atorvastatin to reduce persistent lung inflammation after successful TB treatment completion in…
- Trial name
- StatinTB (NCT04147286)
- Testing
- Atorvastatin 40mg
- Where
- South Africa
- Volunteers
- 220 people
- Sponsor
- University of Cape Town
Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Patients With Acute Respiratory Distress Syndrome
Registry on the EXperience of Extracorporeal CO2 Removal in Intensive Care Units
Investigators will aim to conduct an observational study in order to assess very thoroughly all patients implanted by Extracorporeal carbon dioxide removal (ECCO2R) in 10 critical care units of Paris and its surburb (APHP…
- Trial name
- REXECOR (NCT02965079)
- Testing
- ECCO2R
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Rexecor
COPD
This is a Multicenter, Prospective and Retrospective and Descriptive Epidemiology Study in Patients With Chronic Obstructive Pulmonary Disease (COPD) in Korea
This study is designed as a multicenter, prospective and retrospective and descriptive epidemiology study. This study is planned to evaluate 2 years of exacerbation in COPD patients and to investigate correlation of COPD disease…
- Trial name
- EPOCH (NCT01419379)
- Where
- 14 sites in South Korea
- Volunteers
- 1,118 people
- Sponsor
- Takeda
COPD Postural Control IMT
The Effect of Inspiratory Muscle Training on Postural Control in Chronic Obstructive Pulmonary Disease
Deficits in postural control are increasingly recognized among the important secondary impairments in patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT03790410
- Testing
- Complex pulmonary rehabilitation, Inspiratory muscle training
- Where
- Hungary
- Volunteers
- 40 people
- Sponsor
- Szeged University
Chronic Obstructive Pulmonary Disease
A Study to Investigate the Differential Effects of Inhaled Symbicort and Advair on Lung Microbiota
This study will evaluate the effects of budesonide (using Symbicort which is budesonide and formoterol) and fluticasone (using Advair which is fluticasone and salmeterol) on the airway microorganisms of patients with…
- Trial name
- DISARM (NCT02833480)
- Testing
- Fluticasone group, Budesonide group, Formoterol group
- Where
- 2 sites in Canada
- Volunteers
- 69 people
- Sponsor
- University of British Columbia
Pulmonary Disease, Chronic Obstructive
Changes in Blood Gases, Disturbance of Breath During Sleep and Cardiovascular Co-morbidity in COPD Patients
Respiration failure type 2 is loss of the lungs ability to take up oxygen (O2) and get rid of carbon dioxide (CO2). The diagnosis is based on blood gas measurement of pressures of O2 and CO2.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Hypercapnia, Hypoxemia
- Trial name
- NCT00888342
- Testing
- supplementary oxygen, zopiclone, alcohol
- Where
- 2 sites in Norway
- Volunteers
- 150 people
- Sponsor
- LHL Helse
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