Clinical trials: Pulmonary Disease (COPD), Chronic Obstructive
COPD
TELE-monitoring in Chronic Obstructive Pulmonary Disease
COPD is the fourth cause of death worldwide and it is expected to be the third in 2020. Non-invasive ventilation (NIV) has a positive impact in reducing mortality related to chronic respiratory failure in stable patients with…
- Trial name
- TELECOPD (NCT03129477)
- Testing
- Telemonitoring in noninvasive ventilation
- Where
- Portugal
- Volunteers
- 50 people
- Sponsor
- Conde, Bebiana, M.D.
Obstructive Lung Disease, Chronic Obstructive Pulmonary Disease
Treatment With AKL1 in Obstructive Airways Disease (The TAKL Study)
Obstructive airways disease is a very common condition. This condition includes patients with asthma, chronic obstructive pulmonary disease (COPD), emphysema or chronic bronchitis.
- Conditions
- Obstructive Lung Disease, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- TAKL (NCT00920127)
- Testing
- AKL1
- Where
- United Kingdom
- Volunteers
- 164 people
- Sponsor
- University of East Anglia
Chronic Obstructive Pulmonary Disease
Comparison of Bronchodilator Response From Three Different Aerosol Delivery Methods in Patients With COPD Using Hyperpolarized Xe 129 MRI Ventilation Imaging
The goal of this clinical trial is to compare responses to bronchodilator treatment delivered by three different aerosol delivery methods in patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT06271408
- Testing
- Albuterol Sulfate, 2.5 Mg/3 mL (0.083%) Inhalation Solution, Vibrating Mesh Nebulizer, Metered Dose Inhaler
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Polarean, Inc.
COPD
Enhancement of Corticosteroid Efficacy in COPD
This is a pilot study designed to evaluate the effects of theophylline and roflumilast on circulating Histone deacetylase (HDAC) levels in subjects with COPD, and the bronchodilator effects of corticosteroids.
- Trial name
- NCT02340520
- Testing
- Theophylline, Roflumilast
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- UConn Health
Chronic Obstructive Pulmonary Disease (COPD), Asthma
A Study to Evaluate the Disposition of Drug in Body and Safety After Administration of Single Inhaled Doses of Drugs Abediterol and AZD7594 Administered Alone, in Fixed Dose Combination and in Free Combination Using the Dry Powder Inhaler in Healthy Male Participants
AZD7594 is a non steroidal, potent and selective modulator of the glucocorticoid receptor (GR) under development for once daily inhaled treatment of chronic obstructive pulmonary disease (COPD) and asthma.
- Trial name
- NCT02967159
- Testing
- Abediterol, AZD7594, AZD7594/abediterol
- Where
- Germany
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Lung Diseases, Obstructive, Blood Eosinophil Count
Corticosteroid Reduction in COPD
This study explores whether patients hospitalized with chronic obstructive pulmonary disease (COPD) exacerbation may have fewer days with prednisolone and with the same treatment effect by controlling the treatment by daily…
- Conditions
- Lung Diseases, Obstructive, Blood Eosinophil Count, Glucocorticoids, COPD
- Trial name
- Cortico-cop (NCT02857842)
- Testing
- Prednisolone
- Where
- 4 sites in Denmark
- Volunteers
- 318 people
- Sponsor
- Chronic Obstructive Pulmonary Disease Trial Network, Denmark
Chronic Obstructive Pulmonary Disease
Long-term Effect of an Health Education Program on Daily Physical Activity in Patients With Moderate to Very Severe Chronic Obstructive Pulmonary Disease
Main objective: To compare the level of physical activity (PAL) at 12 months in patients with moderate to very severe chronic obstructive pulmonary disease (COPD) between those who completed a health education program and those…
- Trial name
- EA-EPOC (NCT02924870)
- Testing
- Health education program, Conventional management
- Where
- Spain
- Volunteers
- 128 people
- Sponsor
- Hospital Universitario La Paz
Low Back Pain, Chronic Obstructive Pulmonary Disease
Nonspecific Low Back Pain in Association With Chronic Obstructive Pulmonary Disease
Introduction. Nonspecific low back pain (NSLBP) is a very prevalent medical condition, especially in subjects with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT03227523
- Where
- Spain
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- University of Alcala
Pulmonary Disease, Chronic Obstructive
Negative Pressure Ventilator in Long-term Pulmonary Rehabilitation for Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow obstruction with chronic airway inflammation and emphysematous changes in the lung parenchyma, thus leading to air-trapping, as well as…
- Trial name
- NCT03540862
- Testing
- maintenance negative pressure ventilation (Philips Respironics Lifecare NEV-100)
- Where
- Taiwan
- Volunteers
- 500 people
- Sponsor
- Chang Gung Memorial Hospital
Chronic Obstructive Pulmonary Disease, Depression
The Effect on Depressive Symptoms in ECF Residents With COPD
The purpose of this study is to assess the effect of treatment with Advair Diskus on depression using the Cornell depression scale in COPD patients in the nursing home.
- Trial name
- DISK-02 (NCT00974246)
- Testing
- Advair diskus
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Valley Medical Research
Chronic Obstructive Pulmonary Disease
Steroid Withdrawal Intervention in Fife and Tayside
The SWIFT trial is a cluster randomised trial to determine if a patient identification, feedback and inhaled corticosteroid (ICS) withdrawal intervention in primary care can result in more appropriate inhaled corticosteroid use…
- Trial name
- SWIFT (NCT03489746)
- Testing
- ICS withdrawal protocol, Standard care
- Where
- 2 sites in United Kingdom
- Sponsor
- NHS Tayside
Chronic Obstructive Pulmonary Disease (COPD)
Effects of a 4-week Acu-Transcutaneous Electrical Nerve Stimulation (Acu-TENS) Program on Subjects With Stable Chronic Obstructive Pulmonary Disease (COPD)
The objectives of this study are to investigate the effectiveness of Acu-TENS (transcutaneous electrical nerve stimulation applied on acupoints) on lung functions and quality of life and to explore the associated underlying…
- Trial name
- NCT00971490
- Testing
- Acu-TENS (Transcutaneous electrical nerve stimulation)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The Hong Kong Polytechnic University
COPD, Emphysema or COPD
Utilising Hull Lung Health Study Data to Investigate the Performance of TidalSense Diagnostic Algorithms to Identify COPD and Pre-COPD Among Participants in the FRONTIER Programme.
Aim: To investigate the potential for N-Tidal to improve COPD diagnosis and enable detection of pre-COPD*. Objectives: 1. To assess the performance of TidalSense COPD Diagnostic Algorithms for COPD diagnosis in a real-world…
- Conditions
- COPD, Emphysema or COPD, Emphysema
- Trial name
- NCT06788613
- Volunteers
- 1,200 people
- Sponsor
- Chiesi UK
Pulmonary Disease, Chronic Obstructive
Usage of Spacers and the Relationship With Symptoms Severity in COPD Elderly Patients
The goal of this observational study is to investigate the usage of spacers and their relationship with symptom severity in chronic obstructive pulmonary disease elderly patients.
- Trial name
- NCT06467162
- Where
- Taiwan
- Volunteers
- 164 people
- Sponsor
- Ai-Ling Chang
COPD
Nasal High Flow (NHF) in COPD - Effects on Ventilation in Wakefulness
Controlled randomized crossover trial in patients with chronic obstructive respiratory disease (COPD), who are treated with Nasal High Flow (NHF) therapy during wakefulness with a small amount of CO2 added to the inhaled air to…
- Trial name
- NCT05053074
- Testing
- Nasal High Flow (NHF)
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Institut für Pneumologie Hagen Ambrock eV
COPD Exacerbation (AECOPD), Pulmonary Hypertension
Dynamic Changes in Right Ventricle and Pulmonary Artery Coupling Among COPD Patients With Acute Exacerbation
Chronic obstructive pulmonary disease (COPD) is a common, preventable, and manageable disease characterized by persistent respiratory symptoms and airflow limitation.
- Trial name
- NCT07694713
- Testing
- Echocardiography assessment
- Where
- Egypt
- Volunteers
- 115 people
- Sponsor
- Assiut University
Chronic Obstructive Pulmonary Disease
Discharge Coordinator Intervention in Patients With Chronic Obstructive Pulmonary Disease (COPD)
This is a single-centre randomized controlled clinical trial which will enroll COPD patients in Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage II-IV, hospitalized due to acute exacerbation.
- Trial name
- NCT01225627
- Testing
- Coordinated discharge, Control
- Where
- Slovenia
- Volunteers
- 253 people
- Sponsor
- The University Clinic of Pulmonary and Allergic Diseases Golnik
Chronic Obstructive Pulmonary Disease
Effects of Supplemental Oxygen Delivery Via Demand Versus Continuous Flow in Hypoxemic COPD Patients
Oxygen supplementation has been proven to be effective in hypoxemic COPD patients by increasing oxygenation and reducing dyspnea.
- Trial name
- NCT02744170
- Testing
- 1 continuous flow oxygen supplementation, 2 demand delivery liquid oxygen supplementation, 3 demand delivery oxygen supplementation via concentrator
- Where
- Germany
- Volunteers
- 70 people
- Sponsor
- Schön Klinik Berchtesgadener Land
Delirium, Copd
ABCDEF Bundle to Prevent Delirium for COPD Patients
Abstract Chronic Obstructive Pulmonary Disease (COPD) is a progressive respiratory disorder characterized by persistent airflow limitation and chronic respiratory symptoms, resulting from abnormalities in the bronchi…
- Conditions
- Delirium, Copd, Nurse's Role
- Trial name
- COPD (NCT06974318)
- Testing
- ABCDEF Bundle to Prevent Delirium, Standard Care to Prevent Delirium
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Istanbul Saglik Bilimleri University
Pulmonary Disease, Chronic Obstructive
The Use of Wearable Technology to Acquire Signals for COPD Research
Chronic Obstructive Pulmonary Disease (COPD) is a respiratory condition which affects approximately 3 million people in the UK and 210 million worldwide.
- Trial name
- NCT04495062
- Where
- United Kingdom
- Volunteers
- 63 people
- Sponsor
- Royal Free Hospital NHS Foundation Trust
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