Clinical trials: Pulmonary Edema
Acute Respiratory Distress Syndrome, Shock
Non-Invasive Ventilation Via a Helmet Device for Patients Respiratory Failure
The objective of our study is to evaluate the efficacy of helmet ventilation as compared with Face mask in patients with respiratory failure.
- Conditions
- Acute Respiratory Distress Syndrome, Shock, Ventilatory Failure, Cardiogenic Pulmonary Edema
- Trial name
- NCT01680783
- Testing
- Non invasive ventilation using a helmet hyperbaric device, Noninvasive ventilation via facemask
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- University of Chicago
Respiratory Infection, Fluid Overload
Fluid Restriction Keeps Children Dry
Rationale: Fluid overload is a common complication in children who are admitted to the pediatric intensive care for mechanical ventilation.
- Conditions
- Respiratory Infection, Fluid Overload, Critical Illness, Respiratory Insufficiency
- Trial name
- LESSER (NCT02989051)
- Testing
- Restrictive fluid regimen, Liberal fluid regimen
- Where
- Netherlands
- Volunteers
- 34 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Contrast Induced Nephropathy
Preventing Contrast Nephropathy With Sodium Bicarbonate in Patients With Pulmonary Edema,Heart Failure,Uncontrolled HTN
Radio Contrast Induced Nephropathy (RCIN) remains a well recognized complication in patients undergoing diagnostic or interventional procedures requiring radiographic contrast agents.
- Trial name
- NCT00513825
- Testing
- Sodium Bicarbonate
- Where
- Iran
- Volunteers
- 72 people
- Sponsor
- Tehran University of Medical Sciences
Burns
Cardiovascular Biomarkers and Lung Edema in Severe Burns Patients
Burn injury leads to hypovolemic then distributive shock. Fluid resuscitation remains the cornerstone of initial treatment of burn shock.
- Trial name
- CAROLE (NCT03271268)
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Saint-Louis Hospital, Paris, France
Edema, Heart Failure
Effect of Normatec Pump for Relief of Leg Edema
The investigators hypothesize that leg edema will decrease rapidly when using the NormaTec pump, patients will lose weight, will feel better, will be less prone to infections in their legs and to congestion of the liver.
- Conditions
- Edema, Heart Failure, Pulmonary Hypertension
- Trial name
- NCT01112150
- Testing
- NormaTec Pump
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Hillel Yaffe Medical Center
Acute Cardiac Event, Acute Cardiac Failure
Monitoring Patients With Acute Cardiac Disease Using a Wireless, Wearable, Non-invasive Monitor
A prospective observational study in patients admitted with an acute cardiac disease, in which the PPG-based device will be attached to them on admission, for frequent monitoring of their vitals during hospitalization and…
- Conditions
- Acute Cardiac Event, Acute Cardiac Failure, Acute Cardiac Pulmonary Edema
- Trial name
- NCT04635371
- Testing
- Non-invasive Monitoring
- Where
- Israel
- Volunteers
- 70 people
- Sponsor
- Biobeat Technologies Ltd.
Immersion Pulmonary Edema (IPE), Swimming Induced Pulmonary Edema (SIPE)
Prevention and Treatment of Immersion Pulmonary Edema
Immersion pulmonary edema (IPE) is a condition in which fluid fills the lungs during diving or swimming, particularly in cold water. Some individuals appear to be predisposed to developing IPE.
- Trial name
- NCT00815646
- Testing
- Sildenafil
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Duke University
Weaning-induced Pulmonary Edema
Hemodynamic Impact of the Spontaneous Ventilation Test in Patients at Risk of Weaning Pulmonary Oedema
Weaning-induced pulmonary edema (WIPE) from the ventilator is a frequent cause of extubation failure or delay, which prolongs the duration of invasive mechanical ventilation and the associated morbidity and mortality.
- Trial name
- WAPITI 2 (NCT07666880)
- Testing
- T-piece SBT, PS-ZEEP SBT
- Where
- 4 sites in France
- Volunteers
- 88 people
- Sponsor
- University Hospital, Limoges
Contusions Pulmonary, Lung Injury
Efficacy of Lung Ultrasound in Monitoring Fluid Resuscitation in Chest Trauma Patients
Efficacy of Lung ultrasound in monitoring fluid resuscitation in chest trauma patients with lung contusions
- Conditions
- Contusions Pulmonary, Lung Injury, Chest Trauma, Fluid Overload Pulmonary Edema
- Trial name
- NCT05054270
- Testing
- Chest examination with Ultrasound device
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Fluid Overload, Kidney Injury
Association Between Venous Excess Ultrasound Grading System and Acute Kidney Injury in the ICU Population
Fluid resuscitation is one of the cornerstones of treatment in ICU patients. Nonetheless, excessive fluid administration can lead to fluid overload which has been associated with worse outcomes in the ICU.
- Conditions
- Fluid Overload, Kidney Injury, Make-30
- Trial name
- VExUS ICU (NCT06585722)
- Where
- Netherlands
- Volunteers
- 136 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Acute Mountain Sickness, Subclinical High Altitude Pulmonary Edema
The Incidence of Subclinical High-altitude Pulmonary Oedema at High Altitude
The aim of this investigation is to determine the incidence of silent interstitial pulmonary edema by chest ultrasound at moderate altitude (3905m).
- Trial name
- NCT01794130
- Where
- Italy
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Institute of Mountain Emergency Medicine
Cardiogenic Pulmonary Oedema
Non-invasive Ventilation Versus Continuous Positive Airway Pressure in Cardiogenic Pulmonary Edema
The aim of the present study was to demonstrate that an Non-Invasive Ventilation (NIV) performs better than a Continuous Positive Airway Pressure (CPAP) in the management of Cardiogenic Pulmonary Edema (CPE) within an Intensive…
- Trial name
- NCT02977572
- Testing
- Non-Invasive Ventilation, Continuous Positive AirwayPressure CPAP
- Volunteers
- 114 people
- Sponsor
- Hospital General Universitario de Castellón
Pulmonary Edema
High Versus Low Dose Nitroglycerin in Acute Pulmonary Edema
The goal of this randomized controlled trial is evaluate the out come of: Low dose (< 100 mic/min )versus High dose (> 100 mic/min) of nitroglycerin in management of patients with acute pulmonary edema presented to Emergency…
- Trial name
- NCT06107465
- Testing
- Nitroglycerin
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Alexandria University
ARDS
Safety and Preliminary Efficacy of Sequential Multiple Ascending Doses of Solnatide to Treat Pulmonary Permeability Oedema in Patients With Moderate-to-severe ARDS
This phase IIb, randomized, placebo-controlled, double-blind, dose escalation study will assess the local and systemic safety of 7 days orally inhaled sequential multiple ascending doses of solnatide in patients with pulmonary…
- Trial name
- NCT03567577
- Testing
- Solnatide 25 mg powder for reconstitution for solution for inhalation, 0.9% Saline Solution
- Where
- 15 sites in Austria, Germany
- Volunteers
- 92 people
- Sponsor
- Apeptico Forschung und Entwicklung GmbH
Pulmonary Edema - Acute, Extravascular Lung Water
Increased Extravascular Lung Water in Asymptomatic Open-water Swimmers
Previous studies suggest that increased extravascular lung water might be found in open water swimmers without respiratory symptoms.
- Trial name
- NCT06984120
- Testing
- Lung ultrasound, Peripheral oxygen saturation, Lung auscultation
- Where
- 2 sites in Sweden
- Volunteers
- 609 people, healthy volunteers welcome
- Sponsor
- Dalarna County Council, Sweden
COPD, ILD
Validation and Clinical Utility of the Lung Sliding Index (LSI) for Differentiating Pulmonary Diseases
This upcoming case-control study aims to confirm the Lung Sliding Index (LSI), a new ultrasound score that measures how well the pleura moves, in various lung diseases.
- Conditions
- COPD, ILD, Bronchiectasis, Pneumothorax
- Trial name
- NCT06983366
- Testing
- Lung Ultrasound
- Where
- Egypt
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Assiut University
Heart Failure, Congestive
Influence of Angiotensin Converting Enzyme (ACE) Genotype on Lung Diffusion in Heart Failure
In patients with chronic heart failure ACE-inhibitor treatment improves lung diffusion and prevents pulmonary edema after fluid overload. In the western country, 3 population types of ACE genotypes exist (DD, ID, II).
- Trial name
- NCT00361127
- Testing
- isotonic saline infusion
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Piergiuseppe Agostoni
Congenital Cystic Adenomatoid Malformation
Prenatal Steroids for Treatment of Congenital Cystic Adenomatoid Malformations (CCAM)
Congenital cystic adenomatoid malformations (CCAMs) are theorized to be growing immature lung tissue. Administration of maternal steroids in the mid-trimester may stop the growth or decrease the size of the CCAM, thus increasing…
- Trial name
- CCAM Steroids (NCT00670956)
- Testing
- Betamethasone
- Where
- 3 sites in United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Acute Heart Failure
Early and Comprehensive Care Bundle in Elderly for Acute Heart Failure: a Stepped Wedge Cluster Randomized Trial
This is a prospective multicentre (N=15), stepped-wedge randomized trial that aims to evaluate the benefit of a protocolised comprehensive care bundle for early management of acute heart failure in the ED.
- Trial name
- ELISABETH (NCT03683212)
- Testing
- Early intensive care bundle
- Where
- France
- Volunteers
- 503 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pulmonary Disease, Postoperative Respiratory Complications
Screening of Postoperative Pulmonary Complications by Electrical Impedance Tomography
The purpose of this study is to determine whether Electrical Impedance Tomography can be used as sensitive and specific predictor in the detection of postoperative pulmonary complications (e.g.
- Conditions
- Pulmonary Disease, Postoperative Respiratory Complications, Malignant Neoplasm of Stomach, Liver Diseases
- Trial name
- NCT02337673
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- Johannes Gutenberg University Mainz