Clinical trials: Pulmonary Emphysema
Alpha-1 Antitrypsin Deficiency
The Alpha-1 Foundation's and University of Florida's Alpha-1 Coded Testing (ACT) Study
The Alpha-1 Coded Testing (ACT) Study was established to study genetic testing and outcomes of individuals at risk for alpha-1 antitrypsin deficiency.
- Trial name
- ACT (NCT00500123)
- Testing
- Alpha-1 Antitrypsin Genotype
- Where
- United States
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- University of Florida
Chronic Obstructive Pulmonary Disease (COPD), Alpha1-Antitrypsin Deficiency
A Study of RYMPHYSIA for Alpha1-Proteinase Inhibitor (A1PI) Therapy in Adults With A1PI Deficiency and Chronic Obstructive Pulmonary Disease (COPD)-Emphysema
The main purpose of this study is to evaluate the efficacy of RYMPHYSIA [Alpha1-Proteinase Inhibitor (Human)] compared to another available alpha-1 proteinase Inhibitor (A1PI) in adults with A1PI deficiency and COPD-emphysema.
- Trial name
- NCT05466747
- Testing
- RYMPHYSIA, Another Available A1PI
- Sponsor
- Takeda
Chronic Obstructive Pulmonary Disease
Identifying Inflammatory Biomarkers of Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a condition that is characterized by airway obstruction due to inflammation. Levels of inflammatory proteins may be linked to when and to what extent COPD develops.
- Trial name
- NCT00394940
- Where
- United States
- Volunteers
- 2,085 people
- Sponsor
- University of Arizona
Emphysema, Chronic Obstructive Pulmonary Disease
Safety and Efficacy of Endobronchial Valve for Bronchoscopic Lung Volume Reduction Surgery: a Prospective Pilot Study
The goal of this pliot study al is to preliminarily evaluate the effectiveness and safety of transbronchial lung volume reduction surgery using the self-devloped endobronchial valves for chronic obstructive pulmonary disease…
- Trial name
- NCT06349174
- Testing
- bronchoscopic lung volume reduction surgery using endobronchial valve
- Where
- China
- Volunteers
- 10 people
- Sponsor
- China-Japan Friendship Hospital
Emphysema
Spiration Valve System 9 mm European Post Market Evaluation Study
The purpose of this observational study is to investigate the efficacy of 9 mm intrabronchial valve treatment in patients with heterogeneous emphysema and to gain further insights and experience on the treatment with this valve…
- Trial name
- NCT03008226
- Testing
- Implementation of 9 mm intrabronchial valves
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Irritable Bowel Syndrome (IBS)
IBS-Oriented CDED Versus Low FODMAP Diet for Irritable Bowel Syndrome
Background: Irritable Bowel Syndrome (IBS) affects approximately 4.1% of the global population and imposes a significant personal and healthcare burden.
- Trial name
- IBS-CDED (NCT07707635)
- Testing
- Modified Crohn's Disease Exclusion Diet (CDED), Low FODMAP Diet
- Volunteers
- 150 people
- Sponsor
- Ariel University
Alpha-1 Antitrypsin Deficiency (AATD)
Study of YOLT-202 in the Treatment of Alpha-1 Antitrypsin Deficiency (AATD)
This is a single-arm, open-label, single-dose, dose-escalation exploratory study to evaluate the safety and tolerability of a single dose of YOLT-202 in patients with AATD and determine the optimal biologically active dose (OBD)…
- Trial name
- AATD (NCT07193615)
- Testing
- YOLT-202
- Where
- China
- Volunteers
- 18 people
- Sponsor
- RenJi Hospital
Chronic Obstructive Pulmonary Disease
Efficacy and Safety Study of Two Fixed-dose Combinations of Aclidinium Bromide With Formoterol Fumarate Compared With Aclidinium Bromide, Formoterol Fumarate and Placebo
The purpose of this study is to evaluate the efficacy of this multicenter, randomized, double-blind, placebo-controlled, 4-period, incomplete-block crossover, dose-ranging study comparing 2 fixed dose combinations (FDCs) of…
- Trial name
- LAC-MD-27 (NCT01049360)
- Testing
- Aclidinium 400 μg / Formoterol 12 μg, Aclidinium 400 μg / Formoterol 6 μg, Aclidinium 400 μg
- Where
- 20 sites in United States
- Volunteers
- 128 people
- Sponsor
- AstraZeneca
Alpha 1-Antitrypsin Deficiency
Safety Study of Alfalastin (Human Alpha-1 Antitrypsin) Administered at Home
The purpose of this study is to collect safety data on ALFALASTIN® infusions performed at home or in out-of hospital locations.
- Trial name
- NCT01676688
- Volunteers
- 17 people
- Sponsor
- Laboratoire français de Fractionnement et de Biotechnologies
Patients With Advanced Homogeneous Emphysema
Emphysematous Lung Sealant Therapy in Homogeneous Emphysema
This study will test that hypothesis that endoscopic lung volume reduction therapy performed using emphysematous lung sealant treatment can be improved using smaller doses delivered to more a larger number of treatment sites.
- Trial name
- NCT01728662
- Testing
- ELVR Procedure
- Where
- Israel
- Volunteers
- 8 people
- Sponsor
- Rabin Medical Center
Smoking, HIV Infections
Smoking Cessation Using Motivational Therapy and Varenicline
People that are infected with HIV appear to be especially susceptible to the adverse effects of cigarette smoking. The purpose of this study is to determine if quitting smoking by using a specialized smoking cessation treatment…
- Trial name
- NCT00701896
- Testing
- Varenicline tartrate, Nicotine Replacement Therapy, Biological Control
- Where
- United States
- Volunteers
- 294 people
- Sponsor
- Philip Diaz
Advanced Emphysema
A Dose Ranging Study of the Aeris Polymeric Lung Volume Reduction (PLVR) System in Patients With Advanced Upper Lobe Predominant Emphysema
This is a multi-center, open-label, non-controlled Pilot Study. Approximately 24 patients will be assigned to one of 3 treatment groups (8 patients each group).
- Trial name
- NCT00884962
- Testing
- Polymeric Lung Volume Reduction System (PLVR)
- Where
- 6 sites in Germany
- Volunteers
- 25 people
- Sponsor
- Aeris Therapeutics
Emphysema, Lung Diseases
Emphysema: Physiologic Effects of Nutritional Support
To determine if enteral nutrition support (ENS) restores normal body weight and improves muscle strength, exercise performance, sensation of dyspnea, and quality of life in malnourished patients with chronic obstructive pulmonary…
- Conditions
- Emphysema, Lung Diseases, Lung Diseases, Obstructive, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT00000573
- Testing
- enteral nutrition
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Chronic Obstructive Pulmonary Disease, Emphysema
Macrophage Phagocytosis in COPD
Patients with chronic obstructive pulmonary disease (COPD) that have frequent chest infections are the patients most likely to become worse over time. Why these people are more susceptible to chest infections is not known.
- Conditions
- Chronic Obstructive Pulmonary Disease, Emphysema, Chronic Bronchitis
- Trial name
- NCT00298389
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Imperial College London
COPD
7 Days of TD-4208 in Subjects With Chronic Obstructive Pulmonary Disease
This study will characterize the dose response of TD-4208 after 7 days of dosing in subjects with Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- NCT01704404
- Testing
- TD-4208
- Where
- New Zealand
- Volunteers
- 62 people
- Sponsor
- Mylan Inc.
HIV Infections, COPD
Prevalence and Determinants of Chronic Obstructive Pulmonary Disease (COPD) in HIV+ Patients
The prevalence of COPD in HIV+ and AIDS patients is unknown. The pathophysiology of HIV infection and COPD might be of interest to both conditions.
- Trial name
- HIV&COPD (NCT00904384)
- Where
- Spain
- Volunteers
- 350 people
- Sponsor
- Cimera
Chronic Obstructive Pulmonary Disease
Efficacy and Safety of Two Fixed Dose Combinations of Aclidinium Bromide With Formoterol Fumarate
The purpose of this multicenter, dose-ranging study is to compare two Fixed-Dose Combinations of aclidinium bromide and formoterol fumarate with placebo, aclidinium bromide and formoterol fumarate, all administered BID in…
- Trial name
- ALIGHT-COPD (NCT01078623)
- Testing
- Aclidinium 200 μg / formoterol 12 μg, Formoterol 12 μg, Aclidinium 200 μg
- Where
- 10 sites in Czechia, Romania
- Volunteers
- 176 people
- Sponsor
- AstraZeneca
Emphysema
Safety and Feasibility Study of Administration of Mesenchymal Stemcells for Treatment of Emphysema
The purpose of this study is to show safety and feasibility to administer patients own mesenchymal stem cells to show signs of repair of emphysematous lung tissue
- Trial name
- NCT01306513
- Testing
- autologous bone marrow derived mesenchymal stromal cells
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Leiden University Medical Center
HIV Infections, Pulmonary Disease
Systems Biology of Diffusion Impairment in Human Immunodeficiency Virus (HIV)
Diffusing capacity for carbon monoxide (DLco) abnormalities are common in HIV+ individuals and associated with significant morbidity and mortality.
- Trial name
- BoDI (NCT03572335)
- Testing
- PFT's (pulmonary function testing)
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- University of Pittsburgh
Emphysema or COPD
A Pilot Study to Assess Treatment of Patients With Homogeneous Emphysema Using Sequential Segmental Bronchoscopic Thermal Vapor Ablation (NEXT STEP)
This study is a Prospective, single arm, single center pilot study following outcomes for 12 months after initial BTVA treatment.
- Trial name
- NEXT STEP (NCT03670121)
- Testing
- Bronchoscopic Thermal Vapor Ablation (BTVA)
- Where
- Germany
- Volunteers
- 11 people
- Sponsor
- Uptake Medical Technology, Inc.