Clinical trials: Pulmonary Emphysema
Chronic Obstructive Pulmonary Disease
Long-term Safety, Tolerability and Efficacy of Aclidinium Bromide in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) (LAS-MD-35)
The purpose of this study is to evaluate the safety, tolerability and efficacy of inhaled aclidinium bromide at two dose levels in patients with moderate to severe, stable chronic obstructive pulmonary disease.
- Trial name
- LAS-MD-35 (NCT01044459)
- Testing
- Aclidinium Bromide 200 µg, Aclidinium Bromide 400 µg
- Where
- 113 sites in United States, Canada
- Volunteers
- 605 people
- Sponsor
- AstraZeneca
Pulmonary Emphysema, COPD
AeriSeal System in Patients With Advanced Upper Lobe Predominant Emphysema and Collateral Ventilation
The purpose of this study is to characterize the safety and efficacy of the AeriSeal System in patients with advanced upper lobe predominant emphysema and significant collateral ventilation as determined by the Chartis System.
- Conditions
- Pulmonary Emphysema, COPD, Lung Diseases
- Trial name
- CV+ (NCT01460108)
- Testing
- AeriSeal System
- Where
- Austria
- Volunteers
- 10 people
- Sponsor
- LudwLudwig Boltzmann Institute for COPD and Respiratory Epidemiology
Alpha 1-Antitrypsin Deficiency
A Study of KB408 for the Treatment of Alpha-1 Antitrypsin Deficiency
The Sponsor is developing KB408, a replication-defective, non-integrating herpes simplex virus type 1 (HSV-1)-derived vector engineered to deliver functional full-length human SERPINA1 to the airways of people with alpha-1…
- Trial name
- Serpentine-1 (NCT06049082)
- Testing
- KB408 (Nebulization)
- Where
- 3 sites in United States
- Volunteers
- 15 people
- Sponsor
- Krystal Biotech, Inc.
Smoke Induced Lung Disease
Ancillary T Cell Based Studies in SPIROMICS
The long-term objectives of this ancillary application are to characterize a subpopulation of smokers with auto-reactive T cell response, to validate immunodiagnostic assays that could detect emphysema, and to find molecular…
- Trial name
- NCT02036190
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- University of California, San Francisco
Pulmonary Disease, COPD
Improving the Quality of End-of-Life Communication for Patients With Chronic Obstructive Pulmonary Disease (COPD)
The purpose of this study is to evaluate a multifaceted intervention to improve the quality of end-of-life communication between patients with COPD and their primary care providers using information about patients preferences for…
- Conditions
- Pulmonary Disease, COPD, Chronic Bronchitis, Emphysema
- Trial name
- NCT00106080
- Testing
- Audit and Feedback
- Where
- United States
- Volunteers
- 376 people
- Sponsor
- VA Office of Research and Development
Alpha 1-Antitrypsin Deficiency, Emphysema or COPD
PiMZ Longitudinal Cohort (PiMZ Logic)
Alpha-1 Anti-trypsin Deficiency (AATD) is a genetic disease with lung and liver disease presentations. Presentations are variable in the heterozygous population, the most predominant genotype being PiMZ.
- Trial name
- NCT06505603
- Where
- 5 sites in United States
- Volunteers
- 80 people
- Sponsor
- Columbia University
Asthma, Bronchitis
Tucson Epidemiology Study of Chronic Obstructive Lung Diseases
To determine the natural history, etiology, and interrelationships of emphysema, chronic bronchitis, asthma, and related airways obstructive diseases.
- Conditions
- Asthma, Bronchitis, Emphysema, Lung Diseases, Obstructive
- Trial name
- NCT00005279
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Chronic Pancreatitis
Alpha-1 Antitrypsin (AAT) Enhances Islet Autograft Survival in Patients With Chronic Pancreatitis
Primary objective: To describe and compare the safety and efficacy of treatment with AAT in chronic pancreatitis patients who undergo total pancreatectomy and islet autotransplantation (TP-IAT).
- Trial name
- NCT02947087
- Testing
- Prolastin-C
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Medical University of South Carolina
Emphysema
Assessing the DIAphragM Before ANd After Endobronchial Valve Treatment
Rationale: The diaphragm is the principal respiratory muscle, which separates the thorax from the abdomen. Hyperinflation of the lung places the diaphragm at a mechanical disadvantage, shortens its operating length and changes…
- Trial name
- DIAMANT (NCT04735731)
- Testing
- Echography
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- University Medical Center Groningen
Emphysema or COPD, Aneurysm
The Effects of Discontinuation of Vitamin K Antagonists on the Rate of Elastin Degradation
Background: Elastin is a unique protein providing elasticity, resilience and deformability to dynamic tissues, such as lungs and vasculature. Elastin fibers are characterized by their high affinity for calcium.
- Conditions
- Emphysema or COPD, Aneurysm, Cystic Fibrosis, Alpha 1-Antitrypsin Deficiency
- Trial name
- NCT03285100
- Testing
- Venipuncture
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Canisius-Wilhelmina Hospital
Chronic Obstructive Pulmonary Disease (COPD)
Efficacy and Safety of Levalbuterol in Chronic Obstructive Pulmonary Disease (COPD)
To investigate the efficacy and safety of repeated dosing of Levalbuterol over 6 weeks of treatment in COPD.
- Trial name
- NCT00665600
- Testing
- Levalbuterol HCl, Albuterol Sulfate
- Where
- 24 sites in United States, Canada
- Volunteers
- 257 people
- Sponsor
- Sumitomo Pharma America, Inc.
Alpha1-antitrypsin Deficiency
Preparation of IPSC for Cell Gene Editing for the Treatment of AATD
Alpha 1-antitrypsin (AAT) deficiency is a genetic condition that leads to lung and/or liver diseases; current treatment of weekly augmentation of AAT addresses only lung diseases with moderate efficacy.
- Trial name
- NCT06892236
- Testing
- iPSC generation
- Where
- Italy
- Volunteers
- 3 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Emphysema
Lung Volume Reduction Coil Treatment in Emphysema.
BACKGROUND: Medical therapeutic options for the treatment of emphysema remain limited. Lung volume reduction surgery is infrequently used because of its high morbi-mortality.
- Trial name
- STICREVOLENS (NCT01822795)
- Testing
- Lung volume reduction coïl treatment, Regular medical treatment
- Where
- 9 sites in France
- Volunteers
- 100 people
- Sponsor
- CHU de Reims
Emphysema or COPD
Airway Bypass - Safety and Feasibility Study
The objective of this study is to evaluate its safety and feasibility of the Airway Bypass Stent System in patients with severe emphysema.
- Trial name
- AIRWAY (NCT06249529)
- Testing
- Airway Bypass
- Where
- Georgia
- Volunteers
- 10 people
- Sponsor
- Zoar Engelman
COPD, CT
Effects of Bronchodilation on Computed Tomography (CT) Parameters Reflecting Airways Remodelling, and Pulmonary Emphysema Extent.
CT studies considering bronchial dimensions in chronic obstructive pulmonary disease (COPD) were conducted without control of bronchodilation.
- Conditions
- COPD, CT, Bronchodilation
- Trial name
- NCT01142531
- Testing
- Chest CT scan
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Erasme University Hospital
Lung Cancer, Chronic Obstructive Pulmonary Disease
Blood, Hair and Lung Concentrations of Metals and Metalloids in Patients With Lung Cancer or Chronic Obstructive Pulmonary Disease
Prospective research to study the relationship between concentrations of metals/metalloids in blood, hair and lung tissue with the occurence of lung cancer or chronic obstructive pulmonary disease.
- Conditions
- Lung Cancer, Chronic Obstructive Pulmonary Disease, Emphysema, Lung Surgery
- Trial name
- Métaux/Poumons (NCT01949181)
- Testing
- Lung surgery
- Where
- 2 sites in France
- Volunteers
- 251 people
- Sponsor
- Hopital Foch
Severe Emphysema
A Multi-center RCT to Evaluate Subsegmental BTVA Treatment for Severe Emphysema
To compare the efficacy and safety of subsegmental treatment and segmental treatment with InterVapor in patients with severe emphysema
- Trial name
- BTVA (NCT06152107)
- Testing
- BTVA treatment plus optimal medical therapy (GOLD guidelines)
- Where
- 9 sites in China
- Volunteers
- 100 people
- Sponsor
- Shanghai Chest Hospital
Emphysema
A Trial on the Effects of Bronchoscopic Lung Volume Reduction in Severe Emphysema.
Rationale: The published clinical trials investigating the bronchoscopic lung volume reduction, showing important patient-related improvements in efficacy, led to the acknowledgement of the treatment in the GOLD-COPD2017…
- Trial name
- SOLVE (NCT03474471)
- Testing
- Pulmonary rehabilitation, EBV treatment
- Where
- 2 sites in Netherlands
- Volunteers
- 96 people
- Sponsor
- University Medical Center Groningen
Chronic Obstructive Pulmonary Disease
Effects of Pulmonary Rehabilitation on Skeletal Muscle in COPD Patients
In a former study, the investigator observed significant differences in the response to pulmonary rehabilitation between COPD patients with the "normal" genetic variant of alpha-1 antitrypsin (PiMM) and those with a homozygous…
- Trial name
- NCT02915614
- Testing
- Pulmonary rehabilitation
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Schön Klinik Berchtesgadener Land
Chronic Obstructive Pulmonary Disease, Emphysema
LVR in Severe Emphysema Using Bronchoscopic Autologous Blood Instillation in Combination With Intra-bronchial Valves
A single arm pilot study of lung volume reduction in severe emphysema using bronchoscopic autologous blood instillation in combination with intra-bronchial valves.
- Trial name
- BLOOD-VALVES (NCT03010449)
- Testing
- Intra-bronchial valve and blood
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust