Clinical trials: Pulmonary Failure
Non Small Cell Lung Cancer
OSE2101 Versus Chemotherapy in HLA-A2 Positive Patients With Advanced NSCLC After Immune Checkpoint Inhibitor Failure
The aim of this clinical trial was to determine if the therapeutic cancer vaccine OSE2101 (TEDOPI) was more effective than standard chemotherapy (docetaxel or pemetrexed) in treating HLA-A2 positive patients with metastatic NSCLC…
- Trial name
- ATALANTE-1 (NCT02654587)
- Testing
- OSE2101, Docetaxel, Pemetrexed
- Where
- 78 sites in United States, Czechia and 8 more
- Volunteers
- 219 people
- Sponsor
- OSE Immunotherapeutics
COVID-19, Acute Respiratory Failure
High Flow Nasal Cannula Versus High Velocity Nasal Insufflation in Covid-19
To compare the outcomes of HFNC and HVNI in COVID-19 patients with acute respiratory failure as regard need for mechanical ventilation, changes of arterial blood gases (ABG) parameters, duration of ventilatory support and delay…
- Trial name
- NCT05216640
- Testing
- High Flow Oxygen Therapy
- Volunteers
- 50 people
- Sponsor
- Assiut University
SARS CoV 2 Infection, Hypoxemic Respiratory Failure
Prone Position During ECMO in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Hypoxaemic Patient
Introduction: The main manifestation of COVID-19 pneumonia is acute respiratory distress syndrome (ARDS), which in some cases can be more severe than intubation, extracorporeal membrane venous oxygenation (VV-ECMO) to ensure…
- Trial name
- NCT04995289
- Testing
- Prone position on ECMO patient
- Where
- Morocco
- Volunteers
- 23 people
- Sponsor
- Mohammed VI University Hospital
Non-Small Cell Lung Cancer
Erlotinib and Docetaxel in Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) After Failure of One Chemotherapy Regimen
Erlotinib has demonstrated efficacy as a single agent in patients with NSCLC and the addition of erlotinib to chemotherapy has not achieved better results in the general population.
- Trial name
- NCT00908336
- Testing
- Docetaxel and Erlotinib, Erlotinib
- Where
- 8 sites in Spain
- Volunteers
- 70 people
- Sponsor
- Hospital Arnau de Vilanova
Cardiovascular Disease, Asthma
Effectiveness of Pollution Monitoring in Clinical Exercise Rehabilitation
The primary objective of EPIC-AIR is to evaluate the feasibility and potential effectiveness of integrating real-time air pollution monitoring into cardiac rehabilitation (CR) and pulmonary rehabilitation (PR) programmes via an…
- Conditions
- Cardiovascular Disease, Asthma, COPD, Interstitial Lung Disease Due to Systemic Disease
- Trial name
- EPIC-AIR (NCT07500948)
- Testing
- Progressive Walking Exercise Programme, Real-time air quality information and guidance
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Leicester
COVID-19, Acute Respiratory Distress Syndrome
Study of Decidual Stromal Cells to Treat COVID-19 Respiratory Failure
This is a research study to see how safe and effective decidual stromal cells are in treating patients with respiratory failure (breathing problem where not enough oxygen is passed from the lungs into the blood) caused by…
- Trial name
- NCT04451291
- Testing
- Decidual Stromal Cells (DSC)
- Where
- 3 sites in Canada
- Volunteers
- 19 people
- Sponsor
- University Health Network, Toronto
Lymphoma
Revlimid® Capsules Drug Use-results Surveillance (Relapsed or Refractory ATLL)
To understand the safety and efficacy of Revlimid® Capsules 2.5 mg and 5 mg (hereinafter referred to as Revlimid) under actual conditions of use in patients with relapsed or refractory adult T-cell leukemia lymphoma (hereinafter…
- Trial name
- NCT03098589
- Testing
- Revlimid
- Where
- Japan
- Volunteers
- 1,149 people
- Sponsor
- Celgene
COPD, COPD Exacerbation Acute
The Italian Registry of Patients With Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a treatable but debilitating medical condition associated with persistent symptoms and chronic airflow obstruction.
- Conditions
- COPD, COPD Exacerbation Acute, Comorbid Chronic Lung Disease on Heart Failure, Mortality
- Trial name
- ICoRe (NCT06652776)
- Testing
- Pharmacological treatment
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- University of Milan
Bronchiolitis
The Genetics of Respiratory Failure in Bronchiolitis
Bronchiolitis is a potentially severe infection of the airway in infants and children, and among the most frequent diagnoses leading to pediatric intensive care unit admission in infants.
- Trial name
- NCT01271491
- Where
- United States
- Volunteers
- 174 people
- Sponsor
- Connecticut Children's Medical Center
Cardiogenic Shock, Heart Failure
NIVIA-Hemodynamics
This is an investigator-initiated, single-center, single-arm prospective study to compare non-invasive hemodynamic assessment using transthoracic echocardiography (TTE) and lung ultrasound (LUS) and hemodynamic assessment using…
- Conditions
- Cardiogenic Shock, Heart Failure, Shock, Hemodynamic Instability
- Trial name
- NCT06330597
- Testing
- Echocardiography and lung ultrasound
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Non-Small Cell Lung Cancer
A Study of Tarceva (Erlotinib) to Compare Two Different Doses in in Currently Smoking Patients With Advanced or Metastatic Non-Small Cell Lung Cancer (CURRENTS)
This prospective, double-blind, randomized study will evaluate the safety and efficacy of two dose levels of erlotinib [Tarceva] on progression-free survival, response and disease control rates and overall survival in patients…
- Trial name
- NCT01183858
- Testing
- Erlotinib [Tarceva]
- Where
- 63 sites in China, Denmark and 7 more
- Volunteers
- 315 people
- Sponsor
- Hoffmann-La Roche
ARDS (Acute Respiratory Distress Syndrome)
Continuous vs Bolus Neuromuscular Blockade Regimens in Moderate to Severe Hypoxemic Respiratory Failure and ARDS (COBRA)
Current clinical guidelines, such as those from the Surviving Sepsis Campaign and ARDSNet, recommend short-term NMBA use for patients with moderate to severe ARDS who exhibit persistent ventilator dyssynchrony or high plateau…
- Trial name
- COBRA (NCT07567768)
- Testing
- Neuromuscular Blocking Agent - Bolus Dosing, Neuromuscular Blocking Agent - Continuous Infusion
- Volunteers
- 100 people
- Sponsor
- University of Calgary
Respiratory Distress Syndrome, Adult
High Flow Nasal Oxygen for Acute Hypoxemic Respiratory Failure in the Emergency Room
The aim of this multicenter, randomized, controlled, open-label trial is to investigate the efficacy of early treatment with HFNO compared with SOT in preventing early deterioration of patients admitted to the ER because of acute…
- Trial name
- GLAMOUR (NCT06489379)
- Testing
- high flow nasal cannula, standard oxygen
- Volunteers
- 234 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Chronic Obstructive Pulmonary Disease, Respiratory Failure
Effects of L-arginine and Liposomial Vitamin C on Severe Copd Patients Undergoing Pulmonary Rehabilitation.
The hypothesis that is being tested is that the supplementation of L-arginine plus Vitamin C to multidisciplinary pulmonary rehabilitation (PR) in patients with a previous diagnosis of chronic obstructive pulmonary disease (COPD)…
- Trial name
- NCT06439875
- Testing
- effect of L-arginine and liposomial vitamin C on pulmonary rehabilitation
- Where
- 3 sites in Italy
- Volunteers
- 101 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Heart Failure With Reduced Ejection Fraction, Mitral Regurgitation
The CardioClip Study
The CardioClip study is exploring the use of a wireless sensor to monitor pressure in the pulmonary artery. This sensor is inserted much like the mTEER procedure, a non-surgical method through a vein in the groin.
- Trial name
- CardioClip (NCT06241430)
- Testing
- CardioMEMS
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Columbia University
Heart Failure
Monitoring Pulmonary Artery Pressure by Implantable Device Responding to Ultrasonic Signal (PAPIRUS III)
The PAPIRUS III study will continue to follow patients initially enrolled in PAPIRUS II. Pressure readings from the investigational device will continue to be collected and will be correlated to physiological changes during…
- Trial name
- PAPIRUSIII (NCT00893828)
- Where
- Germany
- Volunteers
- 18 people
- Sponsor
- Boston Scientific Corporation
Lung Cancer
Amrubicin (AMR) Trial in Patients With Non-small Cell Lung Cancer
The study is to evaluate the effect of amrubicin (AMR) compared to docetaxel (DOC) in the treatment of non-small cell lung cancer (NSCLC).
- Trial name
- NCT01207011
- Testing
- Amrubicin hydrocloride, Docetaxel
- Where
- Japan
- Volunteers
- 202 people
- Sponsor
- Sumitomo Pharma Co., Ltd.
Pulmonary Disease, Chronic Obstructive, Congestive Heart Failure
CHF COPD Sip Feed Anabolic Response
Weight loss commonly occurs in patients with chronic heart failure (CHF) and chronic obstructive pulmonary disorder (COPD), negatively influencing their quality of life, treatment response and survival.
- Trial name
- NCT02770092
- Testing
- sip feeding with stable isotope infusion
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
COVID19, Ophthalmopathy
Ocular Sequelae of Patients Hospitalized for Respiratory Failure During the COVID-19 Epidemic
Ophthalmologic damages secondary to COVID-19 coronavirus infection are little described. The ocular involvement is probably multiple, ranging from pathologies of the anterior segment such as conjunctivitis and anterior uveitis to…
- Trial name
- SOCOVID (NCT04387292)
- Testing
- Ophthalmologic exam
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Atrial Fibrillation, Heart Failure
Cryoballoon Ablation Versus Medical Therapy in Patients With Heart Failure and Atrial Fibrillation
Rationale: Atrial fibrillation (AF) and heart failure (HF) can cause each other and sustain each other. Combined, the two diseases negatively influence each other's prognosis and lead to higher mortality.
- Conditions
- Atrial Fibrillation, Heart Failure, Heart Failure With Reduced Ejection Fraction, Heart Failure, Systolic
- Trial name
- RACE-8-HF (NCT04342832)
- Testing
- Cryoballoon ablation
- Where
- 2 sites in Netherlands
- Volunteers
- 64 people
- Sponsor
- Maastricht University
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