Clinical trials: Pulmonary Failure
COVID-19 Severe Respiratory Failure
Combination of Inhaled DNase, Baricitinib and Tocilizumab in Severe COVID-19
In patients with COVID-19, severe hypoxemic respiratory failure (SRF) leading to invasive mechanical ventilation (IMV), raises the mortality rate substantially.
- Trial name
- NCT05279391
- Testing
- Dexamethasone, Low molecular weight heparin, Anakinra 100Mg/0.67Ml Inj Syringe
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- Democritus University of Thrace
Hypertension, Diabetes Mellitus
Clinical Decision Support for Medication Management and Adherence
This three-year, grant funded project will be conducted by the Division of Clinical Informatics in the Department of Community and Family Medicine at Duke University Medical Center.
- Conditions
- Hypertension, Diabetes Mellitus, Stroke, Myocardial Ischemia
- Trial name
- NCT00979225
- Testing
- Medication Management report, Care manager email notices
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Duke University
COVID-19, Respiratory Failure With Hypoxia
Elmo Respiratory Support Project - COVID-19
The number of COVID-19 cases has been growing exponentially, so that the industrialized economies are facing a significant shortage in the number of ventilators available to meet the demands imposed by the disease.
- Trial name
- NCT04470258
- Testing
- ELMO PROJECT AT COVID-19: STUDY IN HUMANS, ELMO PROJECT AT COVID-19: PROOF OF CONCEPT AND USABILITY
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Escola de Saúde Pública do Ceará
Healthy Volunteers
A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Efficacy of BC 007 in Healthy Subjects
Berlin Cures develops BC 007 to treat patients suffering from diseases (chronic heart failure, pulmonary hypertension, chronic fatigue syndrome etc.) which are associated with functional autoantibodies (AAB) directed against…
- Trial name
- NCT02955420
- Testing
- BC 007, NaCl 0.9 %
- Where
- Germany
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Berlin Cures GmbH
COPD (Chronic Obstructive Pulmonary Disease)
HFNC Versus NIV in Hypercapneic COPD Patients
Aim: To compare gas exchange trends, clinical outcomes, and tolerability between HFNC and NIV in COPD patients with mild-to-moderate hypercapnic respiratory failure.
- Trial name
- NCT07854210
- Testing
- high flow nasal cannula, non invasive ventilation
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Mohammed Shehta
Kidney Failure, Chronic, Covid19
Assessment of Immune Response After Vaccination Against COVID-19 in Patients Treated With Renal Replacement Therapy
Chronically dialyzed patients and kidney transplant recipients have been identified as particularly vulnerable to SARS-CoV-2 infection due to unavoidable exposure.
- Conditions
- Kidney Failure, Chronic, Covid19, Vaccine Reaction, Vaccine Adverse Reaction
- Trial name
- COViNEPH-1 (NCT04905862)
- Testing
- Immune response, Solicited common and expected adverse reactions shortly following vaccination (reactogenicity), use of antipyretic or pain medications and unsolicited adverse events and serious adverse events
- Where
- 4 sites in Poland
- Volunteers
- 180 people
- Sponsor
- Medical University of Gdansk
Heart Failure，Congestive, Mental Health (Depression)
Evaluation of Nurse-led Integrated Care of Complex Patients Facilitated By Telemonitoring: The SMaRT Study
In Canada, 3 out of 4 Canadians aged 65 and older have at least one chronic condition, while 1 in 4 seniors reported having three or more.
- Conditions
- Heart Failure，Congestive, Mental Health (Depression), Diabetes Mellitus, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT05543720
- Testing
- Medly
- Where
- 4 sites in Canada
- Volunteers
- 350 people
- Sponsor
- University Health Network, Toronto
Hypertension, Pulmonary, Cardiac Failure
Treatment of Pulmonary Hypertension in High-risk Cardiac Surgery Patients Using Inhalational and Intravenous Agents
The aim of this study is to examine and compare the effect of Levosimendan and Milrinone administered intravenously and via inhalation respectively in cardiac surgery patients with pulmonary hypertension and right ventricular…
- Conditions
- Hypertension, Pulmonary, Cardiac Failure, Pulmonary Vascular Resistance Abnormality
- Trial name
- levos-milr (NCT04718350)
- Testing
- levosimendan at a dose of 6 mcg/kg, milrinone at a dose of 50 mcg/kg
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- Aretaieion University Hospital
Bronchoalveolar Lavage Fluid, Sensitivity and Specificity
Aspergillosis Detection Via EBC-GM in Ventilated Patients
Brief Research Proposal: Non-Invasive Detection of Invasive Pulmonary Aspergillosis in ICU Patients Background: Invasive Pulmonary Aspergillosis (IPA) is a critical threat to patients in ICUs, especially those undergoing…
- Conditions
- Bronchoalveolar Lavage Fluid, Sensitivity and Specificity, Critical Illness, Respiration Failure
- Trial name
- NCT06333379
- Testing
- Compare the levels of Galactomannan (GM) levels in exhaled breath condensate (EBC) and BALF
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Lin Chen
Cardiogenic Shock, Cardiac Arrest
Outcome of Patients Treated With ECLS
Extracorporeal life support (ECLS), also called extracorporeal membrane oxygenation (ECMO), is an extracorporeal technique of providing effective circulatory and (or) respiratory failure, with a growing number of critically ill…
- Conditions
- Cardiogenic Shock, Cardiac Arrest, Heart Failure, Acute Respiratory Failure
- Trial name
- NCT04405817
- Testing
- ECMO
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Nanjing Medical University
Heart Failure
Mechanically Optimizing Cardiac Preload in Heart Failure Patients
The purpose of the current study is to determine if partial balloon occlusion of the inferior vena cava can optimize cardiac pre-load and subsequently pulmonary pressures and cardiac output as a novel method to unload pulmonary…
- Trial name
- NCT04338503
- Testing
- Partial IVC occlusion
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Cardioflow Technologies, LLC
Neonatal Respiratory Failure
Flow and Grow - The Ideal Time to Wean CPAP Off In Extremely Low Birth Weight Infants
Preterm neonates born at less than 30 weeks' gestation are commonly maintained on invasive or non-invasive respiratory support to facilitate gas exchange.
- Trial name
- Flow&Grow (NCT06123143)
- Testing
- Standardized/structured CPAP weaning protocol
- Where
- 5 sites in United States
- Volunteers
- 130 people
- Sponsor
- University of California, San Diego
Respiratory Failure, Hepatitis C
Pan-genotypic Direct Acting Antiviral Therapy in Donor HCV-positive to Recipient HCV-negative Lung Transplant
This is a proof of concept, single center study for the donation of HCV-positive lungs to HCV negative recipient patients, with preemptive, interventional treatment with 8 weeks of commercially available DAA therapy to prevent…
- Trial name
- NCT03625687
- Testing
- Clinically prescribed direct acting antiviral (Mavyret or Epclusa) HCV treatment for 8 weeks
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Massachusetts General Hospital
Exercise Tolerance, Dyspnea
Study of Exercise and Heart Function in Patients With Heart Failure and Pulmonary Vascular Disease
Heart Failure with Preserved Ejection Fraction (HFpEF) and Pulmonary Hypertension (PH) can be diagnosed noninvasively by Exercise Echocardiography (ExE) and Cardiopulmonary Exercise Testing (CPX) as compared with gold standard…
- Conditions
- Exercise Tolerance, Dyspnea, Heart Failure, Pulmonary Hypertension
- Trial name
- EXEC (NCT01418248)
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Mayo Clinic
Covid19, Thrombosis
Enoxaparin at Prophylactic or Therapeutic Doses in COVID-19
SINGLE CENTER PHASE III INTERVENTIONAL RANDOMIZED CONTROLLED TRIAL comparing efficacy and safety of enoxaparin at prophylactic dose (standard treatment) and enoxaparin at therapeutic dose (OFF-LABEL treatment) in 300 COVID-19…
- Trial name
- EMOS-COVID (NCT04646655)
- Testing
- Enoxaparin
- Where
- Italy
- Volunteers
- 142 people
- Sponsor
- ASST Fatebenefratelli Sacco
Respiratory Failure
Nebulized Hypertonic Saline for Mechanically Ventilated Children
Children who need to be on a ventilator often have thick secretions/mucus in their lungs. These secretions can obstruct the breathing tube and their windpipe, which can worsen lung function and prolong the need for the…
- Trial name
- NCT01945944
- Testing
- Hypertonic saline (3%)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University Hospitals Cleveland Medical Center
Acute Respiratory Failure, Ventilator-Induced Lung Injury
New Automated System for Continuous Real-time Monitoring of Transpulmonary Pressure
Patients admitted to Intensive Care Unit often are affected by acute respiratory failure at admission or during hospital stay, with a mortality of 30%.
- Trial name
- NCT03945409
- Testing
- OPTIVENT
- Where
- 2 sites in Italy
- Volunteers
- 40 people
- Sponsor
- University of Milan
Respiratory Failure
Integrated Pulmonary Index as a Predictor of Respiratory Compromise in Critically Ill Patients
The integrated pulmonary index (IPI) is a newly developed index for respiratory monitoring. However, there is limited evidence on its effectiveness and usefulness in critically ill patients.
- Trial name
- NCT06395532
- Testing
- Observetional
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Dyspnea, Respiratory Insufficiency
Cognitive and Behavioral Intervention for the Management of Episodic Breathlessness in Patients With Advanced Disease
Episodic breathlessness is a common and distressing symptom in patients with advanced disease such as cancer, chronic obstructive pulmonary disease (COPD) and chronic heart failure.
- Conditions
- Dyspnea, Respiratory Insufficiency, Neoplasms, Pulmonary Disease, Chronic Obstructive
- Trial name
- CoBeMEB (NCT04630743)
- Testing
- Cognitive and Behavioral intervention for the Management of Episodic Breathlessness
- Where
- Germany
- Volunteers
- 49 people
- Sponsor
- University of Cologne
Mechanical Ventilation Complication, Respiratory Failure
Effect of PEEP on Lung Regional Ventilation and Perfusion
Investigate effects of PEEP on pulmonary regional ventilation and perfusion assessed by EIT
- Conditions
- Mechanical Ventilation Complication, Respiratory Failure, Hypoxia
- Trial name
- PEEP (NCT04081155)
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Yun Long
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