Clinical trials: Pulmonary Failure
Respiratory Diseases, Chronic and Acute Respiratory Failure
Validation of a Simulated Clinical Evaluation of Ventilators
The purpose of this study is to evaluate the ability of a device reproducing patients' respiratory characteristics to select in-VITRO the most appropriate ventilator for a given pathology.
- Trial name
- SIMULVENTI (NCT01113255)
- Testing
- bench-evaluation, of three ventilators
- Where
- France
- Volunteers
- 54 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Noninvavie Ventilation to Patients With COVID-19
The Noninvasive Ventilation to COVID-19 Patients
Noninvasive ventilation(NIV) is an important treatment to the respiratory failure patients.The severe Corona Virus Disease-19(COVID-19) patients are incline to respiratory failure.The NIV may reduce the intubtion rate.This…
- Trial name
- NCT04568655
- Testing
- noninvasive ventilation
- Where
- China
- Volunteers
- 23 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Small Cell Lung Cancer
Anlotinib Plus Penpulimab as Second-line Treatment for Patients With Small Cell Lung Cancer After Failure of Platinum-based Chemotherapy
Anlotinib is a multi-target receptor tyrosine kinase inhibitor in domestic research and development. It can inhibit the angiogenesis related kinase, such as VEGFR, FGFR, PDGFR, and tumor cell proliferation related kinase -c-Kit…
- Trial name
- NCT05001971
- Testing
- Anlotinib Plus Penpulimab
- Where
- China
- Volunteers
- 65 people
- Sponsor
- Hunan Cancer Hospital
Heart Failure, Acute Decompensated Heart Failure
Use of POC Pocket Ultrasound in the Estimation of Left and Right Atrial Pressures
This study will assess the reliability of POC ultrasound in estimating right and left atrium pressures in patients with acute decompensated heart failure.
- Trial name
- POCUSP (NCT03897647)
- Testing
- General Electric (GE) VScan
- Sponsor
- Montefiore Medical Center
Nonsquamous Non-Small Cell Lung Cancer
A Study of Sintilimab Compared With Docetaxel or Pemetrexed as Second-line Treatment for Patients With Stage IV Nonsquamous Non-small Cell Lung Cancer After Failure With Platinum-Containing Chemotherapy
This prospective, single-center, randomized, controlled study will evaluate the efficacy and safety of sintilimab compared with docetaxel or pemetrexed as second-line treatment for patients with stage IV nonsquamous non-small…
- Trial name
- NCT03830411
- Testing
- Sintilimab, Docetaxel, Pemetrexed
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Xin-Hua Xu
Transplant Failure
T-lymphocytes CD8+/HLA-DR+ and Acute Rejection After Lung Transplantation
The objectives of the study is to identify associations between acute rejection and the increase of T (CD4/CD8) and B circulating lymphocytes expressing specific markers of activation and differentiation (HLA-DR, CD25, CD38…
- Trial name
- NCT03587493
- Testing
- BLOOD SAMPLE ANALYSIS
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Sepsis, Pneumonia
Benefit of Clarithromycin in Patients With Severe Infections Through Modulation of the Immune System
High mortality associated with sepsis and Multiple Organ Dysfunction Syndrome (MODS) calls for alternative, individualized therapies in selected patients that might benefit form specific interventions.
- Conditions
- Sepsis, Pneumonia, Gram-Negative Bacteria Infection, Multiple Organ Failure
- Trial name
- INCLASS (NCT03345992)
- Testing
- Clarithromycin, Water for injection
- Where
- 12 sites in Belgium, Greece
- Volunteers
- 110 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Cancer, Heart Failure
Improving Pharmacological Transition of Palliative Care Patients From Inpatient to Outpatient Care
The transition of palliative care patients from inpatient to outpatient care is aimed to be improved through structured pharmaceutical discharge management by a trained pharmacist.
- Conditions
- Cancer, Heart Failure, COPD
- Trial name
- EntMedPall (NCT06648733)
- Testing
- Structured pharmaceutical discharge management
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University Hospital Muenster
Comorbid Chronic Lung Disease on Heart Failure
Comorbid Chronic Lung Disease on Heart Failure
Comorbid chronic lung disease (CLD) increases mortality in heart failure (HF) patients. Understanding the predictors and pathophysiology of HF can improve the efficacy of HF treatment.
- Trial name
- NCT04141345
- Testing
- cardiopulmonary exercise test
- Volunteers
- 169 people
- Sponsor
- Chang Gung Memorial Hospital
Pneumonia, Bacterial, Respiratory Failure
CPAP Therapy Through a Helmet or a Full Face Mask in Patients With Acute Hypoxemic Respiratory Failure: Cross-over Study
Observational and randomized trials have demonstrated the high effectiveness of non-invasive helmet ventilatory support, demonstrating a reduction in intubation rate mortality compared with high-flow and standard oxygen therapy.
- Conditions
- Pneumonia, Bacterial, Respiratory Failure, COVID-19 Pneumonia
- Trial name
- NCT06113432
- Testing
- Arterial blood gases, Respiratory rate (RR), Pulseoximeter
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Pulmonary Disease, Chronic Obstructive (COPD), Chronic Respiratory Failure With Hypercapnia
RESET-COPD Cohort: Real-Time Monitoring and Early Warning in COPD Patients Receiving Home NPPV
This is a multicenter prospective cohort study designed to develop and validate a multisensor-based real-time monitoring and intelligent early warning model for acute exacerbations in patients with chronic obstructive pulmonary…
- Conditions
- Pulmonary Disease, Chronic Obstructive (COPD), Chronic Respiratory Failure With Hypercapnia, Noninvasive Ventilation
- Trial name
- RESET-COPD (NCT07701096)
- Testing
- Not applicable- observational study
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Beijing Chao Yang Hospital
Sepsis, Acute Lung Injury(ALI)
Recovery of Physical Function After Critical Illness In Older Adults
The proposed study is a prospective, observational study assessing the recovery of muscle and physical function in patients surviving critical illness (n =150) at hospital discharge (baseline) and repeated serially.
- Trial name
- RETURN (NCT07225257)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
COPD, Heart Failure
Implementation of Telemonitoring in Chronic Heart or Lung Failure
The aims of the study are to: 1. Implement a telemonitoring programme in heart failure and obstructive pulmonary disease (COPD) /chronic respiratory patients by assessing the real world impact of on readmissions, consults, home…
- Conditions
- COPD, Heart Failure, Respiratory Failure
- Trial name
- TELECRAFT (NCT02180919)
- Testing
- CE marked Philips Motiva system
- Where
- 2 sites in United Kingdom
- Volunteers
- 85 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Weaning Invasive Mechanical Ventilation, Weaning-induced Pulmonary Edema
Ultrasound Evaluation of Cardiac Function During Spontaneous Breathing Trials
The goal of this clinical trial is to evaluate the evolution of a cardiac ultrasound index (E/E') during 3 spontaneous breathing trials in Intensive Care Unit (ICU) adults (over 18 years) patients at risk for weaning failure.
- Conditions
- Weaning Invasive Mechanical Ventilation, Weaning-induced Pulmonary Edema, Weaning Failure of Mechanical Ventilation, Spontaneous Breathing Test
- Trial name
- ATARI (NCT06923267)
- Testing
- No Pressure Support No Positive End Expiratory Pressure Spontaneous Breathing Trial, Pressure Support Spontaneous Breathing trial, Humidified High Flow Spontaneous Breathing Trial
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Pneumonia, Viral, Corona Virus Infection
Enhanced Platelet Inhibition in Critically Ill Patients With COVID-19
This is a compassionate use, proof of concept, phase IIb, prospective, interventional, pilot study in which the investigators will evaluate the effects of compassionate-use treatment with IV tirofiban 25 mcg/kg, associated with…
- Conditions
- Pneumonia, Viral, Corona Virus Infection, Respiratory Failure, Embolism and Thrombosis
- Trial name
- PIC-19 (NCT04368377)
- Testing
- Tirofiban Injection, Clopidogrel, Acetylsalicylic acid
- Where
- Italy
- Volunteers
- 5 people
- Sponsor
- University of Milan
Acute Coronary Syndrome, Heart Failure
Impact of COVID19 Outbreak in Cardiac Acute Care
This registry will evaluate the impact of the COVID19 outbreak on Cardiac patients admitted in the Intensive Care Unit of the Pitie-Salpetriere Hospital in Paris, France
- Conditions
- Acute Coronary Syndrome, Heart Failure, COVID
- Trial name
- CCU-COVID19 (NCT04344912)
- Testing
- Data collection
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetes Mellitus, Congestive Heart Failure
Homing in on Health: Study of a Home Delivered Chronic Disease Self Management Program
The purpose of the study is to determine the effectiveness of a home-delivered variant of the chronic disease self management program in improving health outcomes in patients with chronic conditions.
- Conditions
- Diabetes Mellitus, Congestive Heart Failure, Arthritis, COPD
- Trial name
- NCT00263939
- Testing
- Homing in on Health
- Where
- United States
- Volunteers
- 415 people
- Sponsor
- Agency for Healthcare Research and Quality (AHRQ)
Weaning Failure
Evaluation of a Combined Model in Predicting Weaning Outcome in Critically Ill Patients.
The purpose of our study is to assess lung aeration and diaphragmatic indices by transthoracic ultrasonography in patients ready to be weaned from mechanical ventilation as predictors of weaning success
- Trial name
- NCT05431036
- Testing
- transthoracic ultrasonography
- Volunteers
- 100 people
- Sponsor
- Assiut University
Acute Respiratory Distress Syndrome
This Study Collects Information on the Safety of Inhaled Pegylated Adrenomedullin (PEG-ADM), How the Drug is Tolerated and How it Affects Patients Suffering From a Type of Lung Failure That Cause Fluid to Build up in the Lungs Making Breathing Difficult (ARDS)
The study is composed of two parts. In part A of the study two active doses of inhaled pegylated adrenomedullin (PEG-ADM) will be compared regarding safety and efficacy to a substance that has no therapeutic effect (placebo) in…
- Trial name
- SEAL (NCT04417036)
- Testing
- BAY1097761 Active Dose 1, BAY1097761 Active Dose 2
- Where
- 22 sites in Austria, Czechia and 5 more
- Volunteers
- 90 people
- Sponsor
- Bayer
Heart Failure With Preserved Ejection Fraction
Exercise Lower-body Negative Pressure in Heart Failure With Preserved Ejection Fraction
The heart is a pump that must both fill and empty effectively to move blood; if it cannot move enough, heart failure may ensue. Approximately half of all adults living with heart failure have a form where the heart stiffens…
- Trial name
- NCT05582044
- Testing
- Lower-body Negative Pressure (-25 mmHg), Lower-body Negative Pressure (-15 mmHg), Lower-body Neutral Pressure (0 mmHg)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
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