Clinical trials: Pulmonary Failure
Chronic Heart Failure
Snapshot Evaluation of Acute and Chronic Heart Failure in Real Life in Turkey
This study, which will be conducted at 23 sites representing the determined NUTS-1 regions in Turkey, in which all patients who were admitted to clinic or were hospitalized with Heart Failure (Acute or Chronic) diagnosis will be…
- Trial name
- SELFIE-TR (NCT02578225)
- Testing
- Non interventional study
- Where
- 23 sites in Turkey (Türkiye)
- Volunteers
- 1,054 people
- Sponsor
- Prof. Dr. Mehmet Birhan Yılmaz
Covid19
suPAR-Guided Anakinra Treatment for Management of Severe Respiratory Failure by COVID-19
The SAVE-MORE is a pivotal, confirmatory, phase III randomized clinical trial (RCT) aiming to evaluate the efficacy and safety of early start of anakinra guided by suPAR in patients with LRTI by SARS-CoV-2 in improving the…
- Trial name
- SAVE-MORE (NCT04680949)
- Testing
- Anakinra
- Where
- 40 sites in Greece, Italy
- Volunteers
- 606 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Mechanical Ventilation, Pulmonary Rehabilitation
Rehabilitation Practices in Critically Ill Patients Receiving Invasive Mechanical Ventilation in the Intensive Care Unit.
This international, multicenter, observational study aims to describe rehabilitation practices in Intensive Care Units (ICUs) worldwide.
- Conditions
- Mechanical Ventilation, Pulmonary Rehabilitation, Intensive Care Units (ICUs), Quality of Life (QOL)
- Trial name
- REPOrt (NCT07093125)
- Where
- Italy
- Volunteers
- 2,400 people
- Sponsor
- Universita degli Studi di Genova
Contrast Induced Nephropathy
Preventing Contrast Nephropathy With Sodium Bicarbonate in Patients With Pulmonary Edema,Heart Failure,Uncontrolled HTN
Radio Contrast Induced Nephropathy (RCIN) remains a well recognized complication in patients undergoing diagnostic or interventional procedures requiring radiographic contrast agents.
- Trial name
- NCT00513825
- Testing
- Sodium Bicarbonate
- Where
- Iran
- Volunteers
- 72 people
- Sponsor
- Tehran University of Medical Sciences
ARDS, Human
EIT in Patient Ventilator Asynchrony
Patient-ventilator asynchrony is an important clinical issue in mechanically ventilated patients. For patients with moderate to severe acute respiratory distress syndrome (ARDS), various types of patient ventilator asynchrony may…
- Trial name
- NCT04442815
- Where
- Taiwan
- Volunteers
- 32 people
- Sponsor
- National Cheng-Kung University Hospital
Heart Failure
Inspiratory Muscular Training
Objectives: To evaluate regional lung ventilation distribution in patients suffering from chronic heart failure (CHF) after completing inspiratory muscle training (IMT) and correlate it with functional capacity and quality of…
- Trial name
- NCT01593007
- Testing
- Inspiratory muscle training, Control group
- Where
- Brazil
- Volunteers
- 19 people
- Sponsor
- Universidade Federal de Pernambuco
End Stage Cardiac Failure, Pulmonary Failure
Human Tissue Distribution of Orally Supplemented Natural Vitamin E Tocotrienol
Levels of tocotrienol in human tissues following supplementation is not currently known. The objective of this present study is to determine the levels of this form of vitamin E in the human tissues such as skin, heart, lung…
- Conditions
- End Stage Cardiac Failure, Pulmonary Failure, End Stage Liver Disease, Morbid Obesity
- Trial name
- NCT00678834
- Testing
- To surgery patients, Tocopherol capsules., Tocotrienol to healthy subjects., To surgery patients, Tocotrienol capsules.
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chandan K Sen
Advanced Lung Cancer
CAR-T Cell Immunotherapy for Advanced Lung Cancer
The NSCLC patients who failed the standard treatments, with positive Programmed Death-Ligand 1 (PD-L1) expression, were enrolled into this trial. About 22 advanced NSCLC patients will be screened according to the criteria.
- Trial name
- NCT03330834
- Testing
- CAR-T cells to treat advanced lung cancer
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Sun Yat-sen University
Non-Small-Cell Lung Cancer
A Trial of SHR1701 Combined With Radiotherapy for Metastatic Non-small Cell Lung Cancer Failure After First-line Treatment
This study is a single center, single arm, open study design. The main purpose of this study is to evaluate the tolerance and efficacy of SHR1701 with synchronous radiotherapy in patients with metastatic non-small cell lung…
- Trial name
- NCT04560244
- Testing
- SHR1701
- Volunteers
- 15 people
- Sponsor
- Shandong Cancer Hospital and Institute
Pneumonia, Respiratory Failure
CPAP Versus HFNO for the Treatment of Acute Hypoxemic Respiratory Failure Due to Community Acquired Pneumonia
the study compares two non-invasive respiratory support modalities ie CPAP and High Flow nasal cannula oxygen for the treatment of severe hypoxemic respiratory failure attributed to Community acquired Pneumonia.
- Trial name
- NCT05755425
- Testing
- CPAP, HFNO
- Where
- 2 sites in Greece
- Volunteers
- 100 people
- Sponsor
- Evangelismos Hospital
Diabetic Retinopathy, Macular Degeneration
Advancing Understanding of Transportation Options
This Stage II randomized, controlled, longitudinal trial seeks to assess the acceptability, feasibility, and effects of a driving decision aid use among geriatric patients and providers.
- Conditions
- Diabetic Retinopathy, Macular Degeneration, Glaucoma, Retinitis Pigmentosa
- Trial name
- AUTO (NCT04141891)
- Testing
- Driving Decision Aid, Older Drivers Website
- Where
- 3 sites in United States
- Volunteers
- 529 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Pulmonary Arterial Hypertension, Right Heart Failure
Repurposing a Histamine Antagonist to Benefit Patients With Pulmonary Hypertension
This is a Phase 2, single-center, randomized placebo controlled trial of famotidine (an H2 receptor antagonist) in adults with pulmonary arterial hypertension.
- Trial name
- REHAB-PH (NCT03554291)
- Testing
- Famotidine 20 MG
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Washington
Pulmonary Hypertension Due to Left Heart Disease, Pulmonary Hypertension (PH)
Evaluation of the BMPR2-Activin Signaling Pathway in Group II Pulmonary Hypertension.
Previous data from our group showed reduced BMPR2 isoform A in pulmonary hypertension associated with left heart disease (PH-LHD) of valvular origin.
- Conditions
- Pulmonary Hypertension Due to Left Heart Disease, Pulmonary Hypertension (PH), Heart Failure
- Trial name
- BREATHE-PH (NCT07537517)
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
SCLC, Recurrent
Paclitaxel Polymeric Micelles Plus Ivonescimab in Recurrent or Refractory SCLC
This is a multicenter, open-label, single-arm phase 2 study evaluating the efficacy and safety of ivonescimab combined with paclitaxel polymeric micelles in adults with recurrent or refractory small cell lung cancer after failure…
- Trial name
- NCT07819591
- Testing
- Paclitaxel Polymeric Micelles, Ivonescimab
- Where
- China
- Volunteers
- 47 people
- Sponsor
- Shaodong Hong
Interstitial Lung Disease (ILD)
Non-Invasive Hemodynamic Monitoring of MV ILD Patients With ARF
Non-invasive hemodynamic monitoring of interstitial lung disease (ILD) patients admitted to respiratory ICU with acute respiratory failure and differentiate according to different modes of mechanical ventilation.
- Trial name
- NCT06927089
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
COPD, Hypercapnic Respiratory Failure
Efficacy of High-intensity NPPV and Low-intensity NPPV in Patients With Chronic Hypercapnic COPD
High-intensity noninvasive positive pressure ventilation (NPPV), which can well improve the gas exchange and reduce the work of breathing of patients, is a new strategy targeted at maximally reducing arterial carbon dioxide.
- Trial name
- NPPV;COPD (NCT03238014)
- Testing
- Noninvasive positive pressure ventilation
- Where
- China
- Volunteers
- 14 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Cancer, Chronic Heart Failure
Open Video System in Medicine (oVID)
Currently, there are no telemedical visits between patients and/or their relatives and a palliative physician for the evaluation of symptom and progress monitoring.
- Conditions
- Cancer, Chronic Heart Failure, Chronic Obstructive Pulmonary Disease, Palliative Care
- Trial name
- oVID (NCT06054048)
- Testing
- Telemedicine
- Where
- Germany
- Volunteers
- 34 people
- Sponsor
- University Hospital Muenster
Pulmonary Hypertension, Heart Failure With Normal Ejection Fraction
Chlorhexidine Mouthwash and Oral Nitrate in Adults With Pulmonary Hypertension
This is an open-label, single-center study to examine distinguishing features of the structure and function of the oral and gut microbiome in volunteers with PH in the breakdown of oral nitrate and effect on hemodynamics.
- Conditions
- Pulmonary Hypertension, Heart Failure With Normal Ejection Fraction, Pulmonary Heart Disease and Diseases of Pulmonary Circulation
- Trial name
- NCT03787082
- Testing
- Nitrates, Chlorhexidine Gluconate Mouthwash
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Gladwin, Mark, MD
Pulmonary Arterial Hypertension, Chronic Thromboembolic Pulmonary Hypertension
Prognostic Value of Estimated Plasma Volume in Pulmonary Hypertension
Assessment of the prognostic value of the estimation of plasma volume or its variation in patients with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH) after acute right heart…
- Conditions
- Pulmonary Arterial Hypertension, Chronic Thromboembolic Pulmonary Hypertension, Acute Right Heart Failure
- Trial name
- NCT05861479
- Volunteers
- 100 people
- Sponsor
- Central Hospital, Nancy, France
Acute Hypoxemic Respiratory Failure, COVID 19
Predictive Model for High-Flow Nasal Cannula Failure in COVID-19-related Acute Hypoxemic Respiratory Failure Based on Metabolomics and Clinical Data
The aim of this prospective observational cohort study is to develop a predictive model for high-flow nasal cannula (HFNC) failure in patients with acute hypoxemic respiratory failure (AHRF) caused by SARS-CoV-2.
- Trial name
- COVIDOMICS (NCT06695442)
- Where
- Spain
- Volunteers
- 111 people
- Sponsor
- Hospital del Mar Research Institute (IMIM)