Clinical trials: Pulmonary Failure
Acute Heart Failure
Preemptive Lung Impedance-guided Therapy of Evolving Acute Heart Failure in Acute Myocardial Infarction Patients
It is well known that 20-25% of patients hospitalized for acute myocardial infarction will develop acute heart failure during their hospitalization.
- Trial name
- NCT01264159
- Testing
- Lung impedence-guided therapy, Usual treatment of patients with developing acute heart failure
- Where
- Israel
- Volunteers
- 70 people
- Sponsor
- Hillel Yaffe Medical Center
Heart Failure
Mechanisms of Altered Ventilatory Control in Heart Failure
This study is being done because the investigators are trying to understand how feedback from the muscles can influence your blood pressure and breathing during exercise, and if the investigators can reduce this response in heart…
- Trial name
- NCT02421341
- Testing
- Fentanyl, Catheters, Exercise
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Pulmonary Hypertension, Heart Failure, Diastolic
Inhaled Nitrite in Subjects With Pulmonary Hypertension
This is a single-center, open label phase II study to evaluate the effect of inhaled nitrite delivered in a dose escalation manner on the change in pulmonary vascular resistance (PVR) in subjects with pulmonary hypertension…
- Trial name
- NCT01431313
- Testing
- Inhaled Nitrite
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Schmidhofer, Mark, MD
Lung Transplant Failure and Rejection
Clinical Trials in Organ Transplantation Extension Study
The purpose of the study is to continue to follow subjects who were enrolled in the CTOT-20 CLAD Phenotypes study. Subjects will provide clinical data and complete quality of life questionnaires that will be used to determine the…
- Trial name
- CTOT-ES (NCT04126746)
- Where
- 5 sites in United States, Canada
- Volunteers
- 501 people
- Sponsor
- Duke University
ARDS (Acute Respiratory Distress Syndrome), Respiratory Failure
Prone Position Assessed by 3D EIT
To investigate global and regional changes in lung ventilation and perfusion induced by prone position in ARDS patients assessed by 3D-EIT. And to investigate the difference between 2D-EIT and 3D-EIT in prone position monitoring.
- Trial name
- NCT07083973
- Testing
- Prone position
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking Union Medical College Hospital
Heart Failure
Voice Analysis to Detect Pulmonary Arterial Pressure Changes in Heart Failure
VAPP-HF is a prospective, multi-center, observational study assessing whether daily voice recordings analyzed by a machine learning algorithm can detect changes in pulmonary arterial (PA) pressure in heart failure patients with…
- Trial name
- VAPP-HF (NCT07443670)
- Testing
- Daily Voice Recording
- Where
- 3 sites in United States, Germany
- Volunteers
- 60 people
- Sponsor
- Noah Labs
COVID-19, Sleep Disorder
Investigation of Respiratory Muscle Strength, Exercise Capacity, Physical Activity and Sleep Quality Level in Individuals With Covid-19 Infection
COVID-19 infection was identified in Wuhan, China at the end of 2019 and turned into a pandemic in a short time. In our country, the pandemic continues at full speed and patients are being treated in various clinical pictures.
- Conditions
- COVID-19, Sleep Disorder, Respiratory Failure
- Trial name
- NCT06008470
- Testing
- observational tests
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Chronic Kidney Diseases, Chronic Renal Disease
Evaluation of Respiratory Function and Functional Capacity in Pediatric Patients With Chronic Kidney Disease (CKD)
Chronic kidney disease (CKD) is defined as a permanent abnormality in kidney structure or function that persists for more than 3 months (for example, glomerular filtration rate [GFR] <60 mL/min/1.73 m2 or albuminuria ≥30 mg/24…
- Conditions
- Chronic Kidney Diseases, Chronic Renal Disease, Chronic Renal Failure
- Trial name
- NCT05339997
- Testing
- 6 minute walk test,
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Acibadem University
Respiratory Failure
Transpulmonary Assessment for Individualized Lung Optimization in Obese Patients
This protocol describes a randomized controlled feasibility vanguard study designed to investigate the implementation and effects of esophageal pressure-guided positive end-expiratory pressure (PEEP) titration in patients with…
- Trial name
- TAILOR-PEEP (NCT07359261)
- Testing
- Esophageal pressure-guided PEEP titration, Standard care PEEP management
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- University of Alberta
Lung Cancer
Concomitant Tracheostomy and Lung Resection
This protocol has been designed to determine if tracheostomy performed immediately after lung operation (i.e. concomitant tracheotomy) could improve the postoperative outcome of high risk patients.
- Trial name
- NCT01053624
- Testing
- Tracheostomy
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Clermont-Ferrand
Acute Respiratory Failure, Pneumonia
Physiological Effects of Nebulized Salbutamol in Acute Respiratory Failure Patients on HFNC
This is a prospective physiological interventional study that assess the feasibility and safety of administering salbutamol using a vibrating mesh nebulizer during HFNC in patients with acute hypoxemic respiratory failure (AHRF).
- Trial name
- PENSAFE-HFNC (NCT06815679)
- Testing
- salbutamol 2.5 mg via vibrating mesh nebulizer (VMN)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Università degli Studi di Ferrara
Respiratory Insufficiency
Bedside Spirometry for Acute Lung Injury
The diagnosis of Acute Respiratory Distress Syndrome (ARDS) is a syndromic diagnosis that groups together patients who may have very different prognoses and respond differently to the same therapies.
- Trial name
- SPIRALI (NCT07750717)
- Testing
- Hand-held spirometer, NIV
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Non Squamous Non Small Cell Lung
SHR1020 Plus Docetaxel as Compared to Placebo Plus Docetaxel in 2nd Line Non Squamous Non Small Cell Lung Cancer
The present trial will be performed to evaluate whether SHR1020 in combination with docetaxel in patients with Local Advanced or Metastatic or recurrent Non Squamous NSCLC is more effective as compared to placebo in combination…
- Trial name
- NCT02766140
- Testing
- SHR1020 plus Docetaxel
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Acute Respiratory Failure, Delirium in Old Age
Exploring the Correlations of Lung Ultrasound with Delirium and Outcomes in Acute GEriatrics World: a Multicenter, Prospective, Observational Study from the GRETA Group of the Italian Society of Gerontology and Geriatrics
The purpose of this observational study is to investigate the prognostic relevance of lung ultrasound (LUS) performed on older patients (aged 65 and above) admitted to the hospital with acute respiratory symptoms.
- Conditions
- Acute Respiratory Failure, Delirium in Old Age, Pneumonia, Acute Heart Failure (AHF)
- Trial name
- ECO-AGE (NCT06670118)
- Where
- Italy
- Volunteers
- 480 people
- Sponsor
- University of Milano Bicocca
Melanoma, Li-Fraumeni Syndrome
Clinical Genetics Branch Eligibility Screening Survey
Background: Clinical Genetics Branch (CGB) researchers study individuals and populations at high genetic risk of cancer in order to improve our understanding of cancer and to improve cancer care.
- Conditions
- Melanoma, Li-Fraumeni Syndrome, Pulmonary Blastoma, Chordoma
- Trial name
- NCT07005297
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- National Cancer Institute (NCI)
Cancer, Congestive Heart Failure (CHF)
Outlook Quality of Life Intervention Study
The purpose of this study is to determine whether discussions of life story, forgiveness, and future goals improve quality of life for patients with serious illness.
- Conditions
- Cancer, Congestive Heart Failure (CHF), Chronic Obstructive Pulmonary Disease (COPD), End Stage Renal Disease (ESRD)
- Trial name
- NCT01044290
- Testing
- Life Completion, Attention Control
- Where
- United States
- Volunteers
- 221 people
- Sponsor
- VA Office of Research and Development
Respiratory Disease, Respiratory Failure
Clinical Evaluation of FreeO2 (Version 4) in All Patients Receiving Oxygen
Evaluation of automatic titration of oxygen with a new version of FreeO2 (V4)
- Conditions
- Respiratory Disease, Respiratory Failure, COPD Exacerbation, Asthma
- Trial name
- FreeO24G (NCT03119727)
- Testing
- FreeO2
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Laval University
Non-Small Cell Lung Cancer
A Retrospective Study About Treatment Strategy After First/Second Line EGFR-TKI Failure
This is a multi-center retrospective study, designing to access the best treatment strategy in non-small cell lung cancer (NSCLC) patients harboring EGFR mutant type after first/second line EGFR-TKI failure.
- Trial name
- NCT02618590
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Sun Yat-sen University
Esophageal Cancer, Radiation Pneumonitis
Neoadjuvant Therapy for Esophageal Cancer and Cardiopulmonary Physiology
Although recent global trends indicate reduced postoperative mortality after esophagectomy, major morbidity, in particular pulmonary, remains high, with considerable health and economic costs.
- Conditions
- Esophageal Cancer, Radiation Pneumonitis, Pulmonary Fibrosis, Respiratory Failure
- Trial name
- NCT03462524
- Testing
- Esophagectomy
- Where
- 2 sites in Ireland
- Volunteers
- 384 people
- Sponsor
- St. James's Hospital, Ireland
Respiratory Distress Syndrome
Non-Invasive High-Frequency Oscillatory Ventilation vs Conventional Ventilation for Preterm Neonates.
Given the high burden of respiratory distress syndrome (RDS) and its complications in resource-constrained settings, identifying effective, low-risk interventions is imperative.
- Trial name
- NCT07307079
- Testing
- Non-Invasive High-Frequency Oscillatory Ventilation, Conventional Mechanical Ventilation
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Muhammad Aamir Latif