Clinical trials: Pulmonary Gas Exchange
One-lung Ventilation (OLV), Thoracic Surgery
Comparison of FCV and VCV in One-Lung Ventilation
One-lung ventilation (OLV) is commonly used during thoracic surgery but may negatively affect lung mechanics and gas exchange. Different ventilation strategies are used during OLV, and their effects on respiratory parameters…
- Conditions
- One-lung Ventilation (OLV), Thoracic Surgery, Respiratory Mechanics
- Trial name
- FCVOLVent (NCT07392086)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Obesity
Impact of Increased Tidal Volumes on Oxygenation and Cardiac Output
General anaesthesia impairs respiratory function in overweight patients. The investigators wanted to compare arterial concentration of sevoflurane and oxygen in overweight patients ventilated with increased tidal volume, or…
- Trial name
- NCT01343017
- Testing
- Ventilatory pattern
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Region Skane
Lung Diffusion, Acute Respiratory Failure
Evaluation of Gas Exchange by the Measurement of Lung Diffusion for Carbon Monoxide During General Anaesthesia
Mechanical ventilation is a therapeutic method used in order to keep gas exchange adequate to cell metabolism in patients with acute respiratory failure.
- Trial name
- NCT01503879
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- San Gerardo Hospital
Chronic Respiratory Disease, Hypoxia, Altitude
Validation of a Predictive Score for HAST
Patients with chronic lung diseases travelling by plane often suffer with symptoms related to lower oxygen levels they are exposed to while flying.
- Conditions
- Chronic Respiratory Disease, Hypoxia, Altitude, COPD, ILD
- Trial name
- NCT03728595
- Testing
- Venepuncture, Spirometry, Hypoxic altitude simulation test (HAST)
- Where
- United Kingdom
- Volunteers
- 96 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
HSCT, Respiratory
Assessing Pulmonary Changes in HSCT
This will be an un-blinded, open-label study of children and adults, including those who are being evaluated for or who have undergone HSCT, those with existing respiratory conditions and/or diagnosed gas-exchange impairment, and…
- Conditions
- HSCT, Respiratory, Gas Exchange Impairment
- Trial name
- NCT07823036
- Testing
- Hyperpolarized 129 Xenon
- Where
- United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Acute Lung Injury, Acute Respiratory Distress Syndrome
Strategies to Optimize Positive End-expiratory Pressure (PEEP) in Patients With Acute Lung Injury
The purpose of this study in patients suffering from acute lung injury is to determine whether positive end-expiratory pressure (PEEP) setting guided by electrical impedance tomography (EIT) influences pulmonary gas exchange…
- Conditions
- Acute Lung Injury, Acute Respiratory Distress Syndrome, Respiratory Failure
- Trial name
- EIT-PEEP (NCT01326208)
- Testing
- PEEP titration
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University Hospital, Bonn
Artificial Respiration, Surgery
Effects of Mechanical Ventilation Guided by Transpulmonary Pressure on Gas Exchange During Robotic Surgery: a Pilot Study
Laparoscopy and robotic techniques are widespread procedures for pelvic gynecologic, urologic and abdominal surgery often performed in Trendelenburg position, with the application of pneumoperitoneum by inflating carbon dioxide.
- Conditions
- Artificial Respiration, Surgery, Atelectasis
- Trial name
- Vetrapo (NCT03153592)
- Testing
- Transpulmonary pressure driven ventilation strategy, Conventional ventilation strategy
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Chronic Obstructive Pulmonary Disease
The Effect of Cycling Off Criteria During Pressure Support Ventilation in Chronic Obstructive Pulmonary Disease (COPD) Patients
The investigators' aim is to study the effect of cycling off criteria during pressure support ventilation in COPD patients at two levels of PEEP and PSV.
- Trial name
- NCT00141440
- Testing
- mechanical ventilation
- Where
- Italy
- Volunteers
- 13 people
- Sponsor
- Policlinico Hospital
Pulmonary Atelectasis, Patient Comfort
HFNC During Awake Craniotomy - Impact on Patient Comfort
Background: Patients undergoing awake brain surgery are exposed to non-humidified, non-warmed oxygen/air mix flow through a face mask for a prolonged duration.
- Trial name
- NCT03763461
- Testing
- HFNC, Oxygen Mask
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Western University, Canada
COPD (Chronic Obstructive Pulmonary Disease)
HFNC Versus NIV in Hypercapneic COPD Patients
Aim: To compare gas exchange trends, clinical outcomes, and tolerability between HFNC and NIV in COPD patients with mild-to-moderate hypercapnic respiratory failure.
- Trial name
- NCT07854210
- Testing
- high flow nasal cannula, non invasive ventilation
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Mohammed Shehta
Acute Respiratory Distress Syndrome, Ventilation Therapy; Complications
Phrenic Nerve Stimulation-Induced Lung ReAeration Trial
The Lungpacer PROTECT Diaphragm Pacing Therapy System (DPTS) is a temporary, percutaneously-placed, transvenous, phrenic nerve-stimulating device intended to stimulate the diaphragm to preserve and improve inspiratory muscle…
- Trial name
- PIRAT (NCT04844892)
- Testing
- Lungpacer PROTECT Diaphragm Pacing Therapy
- Where
- France
- Volunteers
- 13 people
- Sponsor
- Lungpacer Medical Inc.
Idiopathic Pulmonary Fibrosis
Inhaled Nitric Oxide (iNO) in Idiopathic Pulmonary Fibrosis (IPF).
Idiopathic Pulmonary Fibrosis (IPF) is a progressive lung disease marked by reduced exercise capacity and activity-related breathlessness (commonly termed dyspnea).
- Trial name
- NCT05052229
- Testing
- Nitric Oxide, Medical air
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Dr. Denis O'Donnell
Asthma
Zileuton and Exhaled Nitric Oxide in Asthmatics
Evaluate the additive role of zileuton 600mg qid to clinically stable asthmatics on Advair 250/50 bid. Since asthma is an endogenous inflammatory disease there usually is increased total exhaled, bronchial and alveolar nitric…
- Trial name
- NCT00575861
- Testing
- zileuton
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Gelb, Arthur F., M.D.
Chronic Obstructive Pulmonary Disease, Pulmonary Hypertension
Iloprost in Gas Exchange/Pulm Mechanics in Chronic Obstructive Pulmonary Disease (COPD)
The investigators believe that iloprost will improve gas exchange in COPD patients with pulmonary hypertension.
- Trial name
- Iloprost (NCT00561223)
- Testing
- iloprost Inhalation, iloprost
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Oklahoma
Positive Pressure Ventilation
Flow- Versus Volume-controlled Ventilation During Robot-assisted Laparoscopic Radical Prostatectomy
During robot-assisted laparoscopic radical prostatectomy (RALRP), patients are placed under general anesthesia and supported with mechanical ventilation.
- Trial name
- NCT07453810
- Testing
- Flow-Controlled Ventilation, Volume-Controlled Ventilation
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ankara Etlik City Hospital
Ventilator Lung, Gas Exchange
A Pilot Validation Study of Continuous CO2-based End-expiratory Lung Volume Measurements in Humans.
The capnodynamic method non-invasively calculates effective lung volume (ELV) continuously during surgery. In this study ELV is compared to functionalresidual capacity (FRC) measured with Nitrogen Multiple Breath Wash out (NMBW)…
- Conditions
- Ventilator Lung, Gas Exchange, Pulmonary Function
- Trial name
- ELVIS (NCT03501446)
- Where
- Sweden
- Volunteers
- 23 people
- Sponsor
- Karolinska Institutet
Idiopathic Pulmonary Fibrosis, Hypersensitivity Pneumonitis
129Xe Gas Exchange Imaging in IPF and cHP: A Reliability Study
This research is a study to test the reliability of Hyperpolarized Xenon MRI (HXe MRI) as a biomarker in interstitial lung disease.
- Trial name
- NCT04677426
- Testing
- Hyperpolarized Xe129
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
SARS Pneumonia
Respiratory Mechanics and Gas Exchange in Patients With COVID-19 and Hypoxemic Acute Respiratory Failure
Data on respiratory mechanics and gas exchange in acute respiratory failure in COVID-19 patients is limited. Knowledge of respiratory mechanics and gas exchange in COVID-19 can lead to different selection of mechanical…
- Trial name
- COVID-VENT (NCT04445961)
- Testing
- Respiratory mechanics measurement, Gas exchange measurement
- Where
- 3 sites in Russia
- Volunteers
- 117 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Hypertension, Pulmonary, Pulmonary Disease, Chronic Obstructive
Single Dose Study in Patients With Chronic Obstructive Pulmonary Disease (COPD) Associated Pulmonary Hypertension.
This study is to demonstrate the safety, tolerability, pharmakokinetic and pharmacodynamic effect of a single oral dose of BAY63-2521 in patients with pulmonary hypertension due to chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT00640315
- Testing
- Riociguat (Adempas, BAY63-2521) 1.0 mg, Riociguat (Adempas, BAY63-2521) 2.5 mg
- Where
- 7 sites in Germany
- Volunteers
- 23 people
- Sponsor
- Bayer
Chronic Obstructive Pulmonary Disease
Effect of Pressure Support Ventilation and Neurally Adjusted Ventilatory Assist (NAVA) in Chronic Obstructive Pulmonary Disease (COPD) Patients
The investigators' aim is to study the effect of pressure support ventilation at two levels of PEEP and Pressure Support versus neurally adjusted ventilatory assist (NAVA) in COPD patients.
- Trial name
- NCT00568100
- Testing
- PSV and NAVA
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Policlinico Hospital