Clinical trials: Pulmonary Hypertension (Diagnosis)
Pulmonary Hypertension (PH), End Stage Kidney Disease (ESRD)
Euvolemia-Based Assessment of Pulmonary Hypertension in Stable Hemodialysis Patients
Pulmonary hypertension (PH) is a frequent and clinically significant complication in patients with end-stage kidney disease (ESKD) undergoing maintenance hemodialysis (HD).
- Conditions
- Pulmonary Hypertension (PH), End Stage Kidney Disease (ESRD), Hemodialysis Patients, Volume Overload
- Trial name
- EU-PHASE-HD (NCT07676786)
- Testing
- Observational Assessment
- Where
- 2 sites in Romania
- Volunteers
- 30 people
- Sponsor
- Stefan Lujinschi
Pulmonary Arterial Hypertension
A Pharmacokinetics Study for Pediatric Participants With Pulmonary Arterial Hypertension
The purpose of this study is to see how much study drug is in the blood of children with pulmonary arterial hypertension (PAH) after dosing to establish the correct dose for further clinical research.
- Trial name
- NCT01484431
- Testing
- Tadalafil- Tablet or Oral suspension
- Where
- 16 sites in United States, Canada and 4 more
- Volunteers
- 20 people
- Sponsor
- Eli Lilly and Company
High Altitude Polycythemia
Treatment of High Altitude Polycythemia by Acetazolamide
The prevalence of High Altitude Polycythemia (or Chronic Mountain Sickness) is between 8 and 15% in the high altitude regions of South America. There is no pharmacological treatment available.
- Trial name
- NCT00424970
- Testing
- acetazolamide
- Where
- Peru
- Volunteers
- 55 people
- Sponsor
- Association pour la Recherche en Physiologie de l'Environnement
Chronic Thromboembolic Pulmonary Hypertension, Sleep Disordered Breathing
Sleep-Disordered Breathing in Chronic Thromboembolic Pulmonary Hypertension
There is evidence for a high prevalence of Sleep Disorder Breathing (SDB) in patients with Chronic Thromboembolic Pulmonary Hypertension (CTEPH).
- Trial name
- NCT03074539
- Testing
- Riociguat, Pulmonary Endarteriectomy, Ballon Pulmonary Angioplasty
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Medical University of Vienna
Pulmonary Embolism, Pulmonary Hypertension
Peripheral Systemic Thrombolysis Versus Catheter Directed Thrombolysis for Submassive PE
To determine whether peripheral low dose systemic thrombolysis (PLST) is non-inferior to catheter directed acoustic pulse thrombolysis (ACDT) in improving RV function and reducing pulmonary artery pressures in submassive…
- Conditions
- Pulmonary Embolism, Pulmonary Hypertension, Thromboembolism, Right Ventricular Dysfunction
- Trial name
- NCT03581877
- Testing
- Alteplase, EKOS
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- Northwell Health
Pulmonary Arterial Hypertension
Long-term Safety and Efficacy of Ralinepag in Pulmonary Arterial Hypertension
This study was an open-label extension study to determine the long-term safety and tolerability of ralinepag in subjects with World Health Organization (WHO) Group 1 pulmonary arterial hypertension (PAH) who have completed Study…
- Trial name
- NCT02279745
- Testing
- Ralinepag
- Where
- 46 sites in United States, Australia and 8 more
- Volunteers
- 45 people
- Sponsor
- United Therapeutics
Pulmonary Artery Hypertension
Impact of Aerobic Training on Sleep Quality and Aerobic Fitness in Male Patients With Pulmonary Artery Hypertension
This study investigated the effect of 12 weeks of aerobic training on sleep quality and aerobic fitness in patients with Pulmonary arterial hypertension(PAH).
- Trial name
- NCT04337671
- Testing
- Moderate intensity aerobic training
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Hypertension, Diabetes Mellitus, Type 2
ENCOMPASS: Expansion Study A, RCT
Some patients living with multiple long-term health conditions have difficulty accessing the services they need, despite available primary care and community resources.
- Conditions
- Hypertension, Diabetes Mellitus, Type 2, Chronic Kidney Diseases, Ischemic Heart Disease
- Trial name
- ENCOMPASS (NCT04790604)
- Testing
- Community Health Navigator Program
- Where
- Canada
- Volunteers
- 96 people
- Sponsor
- University of Calgary
Pulmonary Hypertension, Pulmonary Arterial Hypertension
The Effects of Commercial Air Travel on Patients Suffering From Pulmonary Hypertension
The aim of this study is to 1) descriptively report possible in flight events and 2) to provide regression analysis if the number of events are statistically significant in their prevalence and thus are useful in finding possible…
- Trial name
- PEGASUS (NCT03051763)
- Where
- 5 sites in Germany, Switzerland
- Volunteers
- 1,000 people
- Sponsor
- University of Giessen
Pulmonary Hypertension, Interstitial Lung Disease
The Benefits of Home Exercise in Pulmonary Hypertension Interstitial Lung Disease
This study evaluates the effects of a structured home exercise program in participants with pulmonary hypertension associated with interstitial lung disease.
- Trial name
- NCT07561034
- Testing
- Home Exercise Program, Aerobic Plus Strength Training, Home Exercise Program, Aerobic Only
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Rochester
Pulmonary Arterial Hypertension (PAH)
Patient-Reported Outcomes and Adherence After Transition From Inhaled Iloprost to Oral Selexipag in Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a rare and serious condition that affects the blood vessels of the lungs and can significantly limit daily activities and quality of life.
- Trial name
- PROMISE (NCT07356375)
- Testing
- Selexipag
- Volunteers
- 32 people
- Sponsor
- University of Sao Paulo General Hospital
Pulmonary Arterial Hypertension
Effect of Pharmacologic Interaction Between ERAs and PDE-5 Inhibitors on Medication Serum Levels and Clinical Disease Status in Patients With PAH
The development of disease-targeted medication for the treatment of pulmonary arterial hypertension (PAH) has significantly improved within the last years, leading to the development of 10 approved agents.
- Trial name
- EPIC (NCT02484807)
- Testing
- no intervention, only observation of different groups
- Where
- Germany
- Volunteers
- 125 people
- Sponsor
- Heidelberg University
Pulmonary Hypertension
Investigation of H01 in Adults With Pulmonary Hypertension Including Interstitial Lung Disease (The SATURN Study).
This study is a prospective, randomized, double-blind, study of H01 (Hymecromone) in adults with pulmonary hypertension (PH). The primary objective of this study is to evaluate the safety and tolerability of oral H01 and the…
- Trial name
- SATURN (NCT05128929)
- Testing
- Hymecromone (H01)
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Stanford University
Congenital Heart Disease, Pulmonary Hypertension
A Comparative Study of Three Modes of Ventilation During CPB in Pediatrics With Pulmonary Hypertension Undergoing Congenital Heart Surgeries
Aim of Work: The aim of this randomized, double-blinded, study is to compare between three modes of ventilation during cardiopulmonary bypass in pediatric patients with pulmonary hypertension undergoing corrective cardiac…
- Trial name
- NCT04262037
- Testing
- lung ultrasound
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Cairo University
Hypertension, Pulmonary
Measuring Outcomes In Patients With Pulmonary Arterial Hypertension Not on Active Treatment (MOTION)
The MOTION study was a prospective, Phase IV study for patients with Pulmonary Arterial Hypertension (PAH). The study was designed to further explore patient-reported outcomes in PAH subjects who were not on active treatment and…
- Trial name
- NCT02191137
- Testing
- Riociguat (Adempas, BAY63-2521)
- Where
- 59 sites in United States, Puerto Rico
- Volunteers
- 75 people
- Sponsor
- Bayer
Oesophageal Cancer, Non Small Cell Lung Cancer
Cardiopulmonary Toxicity of Thoracic Radiotherapy
Radiotherapy improves locoregional control and survival of thoracic tumour patients. However, the associated exposure of normal tissues, often leads to side effects and possibly even reduces survival.
- Trial name
- CLARIFY (NCT03978377)
- Where
- 3 sites in Belgium, Netherlands and 1 more
- Volunteers
- 320 people
- Sponsor
- University Medical Center Groningen
Hypertension, Pulmonary, Pulmonary Disease, Chronic Obstructive
Single Dose Study in Patients With Chronic Obstructive Pulmonary Disease (COPD) Associated Pulmonary Hypertension.
This study is to demonstrate the safety, tolerability, pharmakokinetic and pharmacodynamic effect of a single oral dose of BAY63-2521 in patients with pulmonary hypertension due to chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT00640315
- Testing
- Riociguat (Adempas, BAY63-2521) 1.0 mg, Riociguat (Adempas, BAY63-2521) 2.5 mg
- Where
- 7 sites in Germany
- Volunteers
- 23 people
- Sponsor
- Bayer
Pulmonary Artery Hypertension
Evaluation of Respiratory Muscle in Patient With Pulmonary Arterial Hypertension
The aim of the study is that evaluation of basic and accessory respiratory muscles and their relationship of six minute walk test in patient with pulmonary arterial hypertension (PAH)
- Trial name
- NCT05056532
- Testing
- patient assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Giresun University
Pulmonary Hypertension, Pulmonary Hypertension Due to Lung Diseases
Bioenergetic Effect of Pioglitazone in CLD-PH
The goal of this clinical trial is to learn about the safety and efficacy of Pioglitazone in people with Pulmonary Hypertension (PH) due to Chronic Lung Disease (CLD).
- Trial name
- NCT06336798
- Testing
- Pioglitazone 30mg, Labs
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Emory University
Pulmonary Hypertension
Pulmonary Hypertension and Arrhythmia
Patients with pulmonary hypertension underwent (routine) Holter ECG and were screened for (malignant) arrhyhtmias. Results of Holter ECGs were correlated with clinicial and technical data (echocardiography and right heart…
- Trial name
- NCT05496504
- Testing
- Holter ECG
- Volunteers
- 222 people
- Sponsor
- Asklepios Neurological Clinic Bad Salzhausen
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