Clinical trials: Pulmonary Hypertension (PH)
Pulmonary Hypertension, Interstitial Lung Disease
Safety and Efficacy of Inhaled Treprostinil in Adult PH With ILD Including CPFE
This was a multicenter, randomized (1:1 inhaled treprostinil: placebo), double-blinded, placebo-controlled trial to evaluate the safety and efficacy of inhaled treprostinil in subjects with pre-capillary pulmonary hypertension…
- Conditions
- Pulmonary Hypertension, Interstitial Lung Disease, Combined Pulmonary Fibrosis and Emphysema
- Trial name
- NCT02630316
- Testing
- Inhaled Treprostinil
- Where
- 97 sites in United States, Puerto Rico
- Volunteers
- 326 people
- Sponsor
- United Therapeutics
Myeloproliferative Disorders, Pulmonary Hypertension
Pulmonary Hypertension in Patients With Myeloproliferative Neoplasms
This is an observational prospective study aiming to clarify the prevalence of pulmonary hypertension in patients with Myeloproliferative Neoplasms and their prognosis.
- Trial name
- MPNPH (NCT02580903)
- Testing
- Radiology
- Where
- Denmark
- Volunteers
- 180 people
- Sponsor
- Odense University Hospital
Pulmonary Hypertension
Insights Into Pediatric Pulmonary Hypertension: A Real-World Registry of Epidemiology and Outcomes
Pediatric pulmonary hypertension (PH) shares similarities with PH in adulthood, but specific differences still require unique approaches.
- Trial name
- INSPIRE-PPH (NCT07495774)
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Guangdong Provincial People's Hospital
Pulmonary Hypertension
Extended Access Program to Assess Long-term Safety of Bardoxolone Methyl in Patients With Pulmonary Hypertension RANGER
This extended access study will assess the long-term safety and tolerability of bardoxolone methyl in qualified patients with pulmonary hypertension (PH) who previously participated in controlled clinical studies with bardoxolone…
- Trial name
- RANGER (NCT03068130)
- Testing
- Bardoxolone methyl
- Where
- 96 sites in United States, Argentina and 13 more
- Volunteers
- 261 people
- Sponsor
- Biogen
Heart Failure, Pulmonary Hypertension
Rivet PVS Therapy in Group 2 PH-HFpEF
This clinical investigation is a prospective, multicenter, non-randomized, open-label, Early Feasibility Study to evaluate the safety, performance, and initial clinical efficacy of the Rivet PVS therapy in patients with…
- Trial name
- NCT05205265
- Testing
- Rivet Shunt
- Where
- 3 sites in United States
- Sponsor
- NXT Biomedical
Pulmonary Hypertension
Evaluation of Novel Lung Function Parameters in Patients With Pulmonary Hypertension (PH)
Little is known about affection of small airways in patients with pulmonary hypertension as well as the ideal diagnostic approach.
- Trial name
- NCT03667794
- Testing
- body plethysmography, impulse oscillometry, multiple breath washout
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Universitätsmedizin Mannheim
Pulmonary Hypertension Associated With Interstitial Lung Disease
Efficacy and Safety of Seralutinib in Adult Subjects With Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
This Phase 3 study is designed as a 24-week randomized, double-blind, placebo-controlled period (PCP) followed by a 144-week long-term extension (LTE) period.
- Trial name
- SERANATA (NCT07181382)
- Testing
- Seralutinib, Generic Dry Powder Inhaler
- Where
- 4 sites in United States, Israel
- Volunteers
- 480 people
- Sponsor
- GB002, Inc.
Pulmonary Hypertension
RUS-registry of PH
Russian National Registry of Patients With Pulmonary Arterial Hypertension (PAH) and Chronic Thromboembolic Pulmonary Hypertension (CTEPH) is a multicenter, observational study of the clinical course and disease management of PAH…
- Trial name
- NCT03707561
- Testing
- Right Heart Catheterization (RHC)
- Volunteers
- 200 people
- Sponsor
- Russian Cardiology Research and Production Center
Pulmonary Hypertension
Noninvasive Cardiac Output Measurements in Patients With Pulmonary Hypertension Undergoing Right Heart Catheterization With Acute Vasodilator Testing
Subjects in this study have been diagnosed with pulmonary hypertension (PH) and their doctors have referred them for a right heart catheterization (RHC).
- Trial name
- NCT01275690
- Sponsor
- University of Chicago
Pulmonary Hypertension (PH) Due to Left Heart Disease
TReatment of Pulmonary Hypertension Group II Study
The objective of this study is to assess the safety and initial effectiveness of the TIVUS™ System when used for pulmonary artery denervation in group II PH patients through change in clinical parameters including hemodynamics…
- Trial name
- TROPHY-II (NCT03611270)
- Testing
- Pulmonary Denervation
- Where
- 3 sites in United States
- Volunteers
- 15 people
- Sponsor
- SoniVie Inc.
Pulmonary Arterial Hypertension
Mobile Health Intervention to Improve Exercise in Pediatric PH
Children and adults with pulmonary arterial hypertension (PAH) have severely reduced daily activity compared to healthy populations.
- Trial name
- MhOVE-PPH (NCT06549452)
- Testing
- mHealth Intervention, Usual Care
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Vanderbilt University Medical Center
Pulmonary; Hypertension, Heart Failure
A Study of Oral Nitrate in Adults With Pulmonary Hypertension With Heart Failure and Preserved Ejection Fraction
This is an open-label, single-center study to examine distinguishing features of the structure and function of the oral and gut microbiome in healthy adult normal volunteers compared to volunteers with PH-HFpEF in the breakdown…
- Conditions
- Pulmonary; Hypertension, Heart Failure, Preserved Ejection Fraction
- Trial name
- PMED (NCT02980068)
- Testing
- 15N Nitrate, 14N Nitrate
- Where
- 2 sites in United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Gladwin, Mark, MD
Hypertension, Pulmonary
Impact of Multiple Doses of BAY63-2521 on Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Patients With Interstitial Lung Disease (ILD) Associated Pulmonary Hypertension (PH)
The purpose of this study is to assess multiple ascending doses of a new drug (BAY63-2521) given orally, to evaluate if it is safe and can help to improve the well-being, symptoms (e.g.
- Trial name
- NCT00694850
- Testing
- Riociguat (Adempas, BAY63-2521).
- Where
- 5 sites in Germany
- Volunteers
- 22 people
- Sponsor
- Bayer
Pulmonary Hypertension, Chronic Obstructive Pulmonary Disease
A Phase 3 Adaptive Study to Evaluate the Safety and Efficacy of Inhaled Treprostinil in Participants With Pulmonary Hypertension (PH) Due to Chronic Obstructive Pulmonary Disease (COPD)
The primary objective of this study is to demonstrate the efficacy of inhaled treprostinil compared to placebo in improving exercise ability as measured by change from baseline in 6-Minute Walk Distance (6MWD) following 12 weeks…
- Trial name
- PERFECT (NCT03496623)
- Testing
- Inhaled treprostinil solution
- Where
- 76 sites in United States, Argentina and 2 more
- Volunteers
- 188 people
- Sponsor
- United Therapeutics
Pulmonary Hypertension Due to Lung Diseases
Collagen Fingerprinting for Stratification of Pulmonary Hypertension (PH) Patients
Chronic lung diseases such as pulmonary fibrosis and chronic obstructive pulmonary disease (COPD) can lead to pulmonary hypertension.
- Trial name
- NCT07498244
- Where
- Austria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Pulmonary Hypertension
Side Effects of Pulmonary Hypertension Medications
The study seeks to analyze the patient reported effects of pulmonary hypertension medications and compare these with the side effects described on the package inserts.
- Trial name
- NCT01571713
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Stanford University
Hypertension, Pulmonary
The Exercise Capacity and Quality of Life in the Patients With IPAH and Secondary PH
Pulmonary hypertension (PH) is a progressive disease with high mortality rate, but due to the development of drugs, the prognosis of the disease has improved.
- Trial name
- NCT02647060
- Where
- Taiwan
- Volunteers
- 26 people
- Sponsor
- National Taiwan University Hospital
Pulmonary Hypertension, Interstitial Lung Disease
A Study of Mosliciguat in PH-ILD
This is a Phase 2, randomized, double-blind, placebo-controlled, multi-center clinical study to evaluate the safety and efficacy of inhaled mosliciguat in participants with pulmonary hypertension associated with interstitial lung…
- Conditions
- Pulmonary Hypertension, Interstitial Lung Disease, Lung Diseases, Vascular Diseases
- Trial name
- PHocus (NCT06635850)
- Testing
- Mosliciguat, Dry Powder Inhaler
- Where
- 85 sites in United States, Argentina and 18 more
- Volunteers
- 135 people
- Sponsor
- Pulmovant, Inc.
Chronic Thromboembolic Pulmonary Hypertension
Exercise Therapy After Pulmonary Thromboendarterectomy or Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension
This study is being completed to determine the feasibility and acceptability of completing a home-based, structured, low-to-moderate intensity exercise training program in chronic thromboembolic pulmonary hypertension (CTEPH)…
- Trial name
- EXPECT-PH (NCT05693779)
- Testing
- Home exercise training
- Sponsor
- University of Michigan
1- Haemodynamic Phenotyping of the Out - of - Proportion PH to Guide Different Therapeutic Lines
Phenotyping of the Out-of-proportion Pulmonary Hypertension
Pulmonary hypertension (PH) is a pathophysiological disorder that may involve multiple clinical conditions and may be associated with a variety of cardiovascular and respiratory diseases.
- Trial name
- NCT06051396
- Testing
- Right sided heart catheterization
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University