Clinical trials: Pulmonary Infection
Pneumonia, Idiopathic Pneumonia Syndrome
Effectiveness of Etanercept for Idiopathic Pneumonia Syndrome Following Stem Cell Transplantation (BMT CTN 0403)
The study is designed as a Phase III, multi-center randomized, double-blind, placebo-controlled trial investigating the use of etanercept for the treatment of acute, non-infectious pulmonary dysfunction (IPS) occurring after…
- Trial name
- NCT00421174
- Testing
- Etanercept
- Where
- 12 sites in United States
- Volunteers
- 37 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Lung Transplant Infection, Lower Respiratory Tract Infection
Preliminary Study of Dornase Alfa to Treat Chest Infections Post Lung Transplant.
Patients who have undergone lung transplantation are at an increased risk of developing chest infections due to long-term medication suppressing the immune response.
- Trial name
- NCT01952470
- Testing
- Dornase Alfa, Isotonic Saline.
- Where
- Australia
- Volunteers
- 32 people
- Sponsor
- The Alfred
Ventilator-associated Pneumonia
Study of Biotene OralBalance Gel for Oral Care in Critically-Ill Mechanically Ventilated Neonates
The goal of this pilot study is to test the hypothesis that mechanically ventilated infants receiving Biotene OralBalance® gel for oral care would have a reduced intubation time compared to infants receiving oral care placebo.
- Trial name
- NCT01314742
- Testing
- Biotene OralBalance® gel, Sterile Water moisten cotton tipped applicator
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Wake Forest University Health Sciences
COVID-19, Bariatric Surgery Candidate
Bariatric Surgery and COVID-19
The National Bariatric Surgical Registry (NBSR) is a prospectively collected database for all patients undergoing elective bariatric surgery in the UK.
- Trial name
- NCT05532891
- Testing
- COVID-19 pandemic
- Where
- United Kingdom
- Volunteers
- 11,545 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Covid19
A Study of Inhaled Ampion in Adults With Respiratory Distress Due to COVID-19
This is phase II study to evaluate the safety and efficacy of inhaled Ampion in adults with respiratory distress due to COVID-19
- Trial name
- NCT04868890
- Testing
- Ampion
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Ampio Pharmaceuticals. Inc.
Streptococcus Pneumonia, Controlled Human Infection
Experimental Human Pneumococcal Challenge With SPN3
The 'Experimental Human Pneumococcal challenge' (EHPC) model is a way of putting drops of bacteria into the nose. Investigators have studied this model of putting bacteria in the nose safely in over 1500 volunteers over the past…
- Trial name
- Challenge3 (NCT05535868)
- Testing
- Serotype 3 Experimental Human Pneumococcal Challenge - Liverpool Isolate (LIV014-S3), Serotype 3 Experimental Human Pneumococcal Challenge - Malawi Isolate (MLW-10V)
- Where
- United Kingdom
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
Coronavirus Disease 2019, Disease Caused by Severe Acute Respiratory Syndrome Coronavirus 2
Study of Varespladib in Patients Hospitalized With Severe COVID-19
This is a 2-part, multi-center, randomized, double-blind, placebo-controlled, phase 2 study designed to evaluate the safety, tolerability, and efficacy of oral varespladib, in addition to standard of care, in patients…
- Trial name
- STAIRS (NCT04969991)
- Testing
- Varespladib
- Where
- 7 sites in United States
- Volunteers
- 18 people
- Sponsor
- Ophirex, Inc.
Covid19
Assessing Testing Strategies for Safe Return to K-12 Schools in an Underserved Population
The primary goal of this study is to determine the most effective SARS-CoV-2 testing strategy for successful return of in-person school in the under-served communities of St. Louis.
- Trial name
- NCT04875520
- Testing
- Screening testing strategy, No screening testing strategy
- Where
- 5 sites in United States
- Volunteers
- 1,390 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Pulmonary Tuberculosis
Controlled Comparison of Two Moxifloxacin Containing Treatment Shortening Regimens in Pulmonary Tuberculosis
REMoxTB is a study for the "Rapid Evaluation of Moxifloxacin in the treatment of sputum smear positive tuberculosis". REMoxTB aims to find and evaluate new drugs and regimens that shorten the duration of tuberculosis therapy.
- Trial name
- REMoxTB (NCT00864383)
- Testing
- Moxifloxacin, Ethambutol, Isoniazid, Pyrazinamide & Rifampicin
- Where
- 47 sites in China, India and 7 more
- Volunteers
- 1,931 people
- Sponsor
- Global Alliance for TB Drug Development
COVID-19, SARS-CoV-2
Treatment for COVID-19 in High-Risk Adult Outpatients
This is a randomized trial for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in high-risk adults not requiring hospital admission.The overarching goal of this study is to assess the…
- Trial name
- NCT04354428
- Testing
- Ascorbic Acid, Hydroxychloroquine Sulfate, Azithromycin
- Where
- 6 sites in United States
- Volunteers
- 289 people, healthy volunteers welcome
- Sponsor
- University of Washington
Pulmonary Tuberculosis
A Phase 3 Trial Assessing Safety and Efficacy of B-Pa-L in Participants With DR-TB
The purpose of this study is to evaluate the efficacy, safety, tolerability and pharmacokinetics of bedaquiline plus PA-824 plus linezolid after 6 months of treatment (option for 9 months for participants who remain culture…
- Trial name
- NCT02333799
- Testing
- Bedaquiline, PA-824, Linezolid
- Where
- 3 sites in South Africa
- Volunteers
- 109 people
- Sponsor
- Global Alliance for TB Drug Development
COVID-19
INB03 for the Treatment of Pulmonary Complications From COVID-19
The purpose of this study is to determine whether XPro1595 can prevent the progression of respiratory complications in COVID19 patients.
- Trial name
- NCT04370236
- Testing
- INB03
- Where
- 9 sites in United States
- Volunteers
- 79 people
- Sponsor
- Inmune Bio, Inc.
COVID19
Phase I/II Safety, Dose Finding & Antiviral Activity of RD-X19 in Mild/Moderate Outpatient COVID-19
This randomized, Phase I/II feasibility study will evaluate the safety and efficacy of the RD-X19 device in SARS-CoV-2 infected individuals with uncomplicated COVID-19.
- Trial name
- NCT04662671
- Testing
- RD-X19
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- EmitBio Inc.
Coronavirus Infection, Coronavirus
Convalescent Plasma for Patients With COVID-19
Pilot study of tolerability and efficacy of transfusion of 200mL of convalescent plasma in patients with COVID-19 respiratory disease.
- Conditions
- Coronavirus Infection, Coronavirus, COVID
- Trial name
- NCT04385199
- Testing
- Convalescent plasma
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Henry Ford Health System
COVID-19
Povidone-Iodine Oral Rinse Study
This study is a two-arm, randomized, 2-phase study. Phase I will be double blinded clinical trial of the safety and efficacy of an antiseptic mouthwash solution on reducing SARS-CoV-2 load in COVID 19+ adult individuals.
- Trial name
- NCT05239598
- Testing
- Mouth rinse
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pennsylvania
Pneumonia, Bacterial
PROcalcitonin Impact on Antibiotic Reduction, adverSe Events and AVoidable healthcarE Costs (ProSAVE): A RCT
Trials comparing PCT-guided antibiotic algorithms to standard management show a significant reduction in antibiotic exposure without an increase in mortality or treatment failure.
- Trial name
- ProSAVE (NCT04158804)
- Testing
- procalcitonin
- Where
- 6 sites in United States
- Volunteers
- 700 people
- Sponsor
- Massachusetts General Hospital
Mycobacterium Infections, Nontuberculous, Mycobacterium Abscessus Infection
Oral Omadacycline vs. Placebo in Adults With NTM Pulmonary Disease Caused by Mycobacterium Abscessus Complex (MABc)
The purpose of this study is to evaluate the efficacy, safety and tolerability of oral omadacycline as compared to placebo in the treatment of adults with Nontuberculous Mycobacterial (NTM) pulmonary disease caused by…
- Conditions
- Mycobacterium Infections, Nontuberculous, Mycobacterium Abscessus Infection, Nontuberculous Mycobacterial Lung Disease, Nontuberculous Mycobacterial Pulmonary Infection
- Trial name
- NCT04922554
- Testing
- Omadacycline Oral Tablet
- Where
- 17 sites in United States
- Volunteers
- 66 people
- Sponsor
- Paratek Pharmaceuticals Inc
Covid19, SARS-CoV Infection
COVID-OUT: Early Outpatient Treatment for SARS-CoV-2 Infection (COVID-19)
1. The purpose of this trial is to conduct a 2x3 factorial randomized trials, which efficiently allows the parallel conduct of three randomized trials to understand whether metformin, ivermectin, or fluvoxamine, is superior to…
- Trial name
- NCT04510194
- Testing
- Metformin, Fluvoxamine, Ivermectin
- Where
- 7 sites in United States
- Volunteers
- 1,323 people
- Sponsor
- University of Minnesota
COVID-19 Severe Pneumonia, Acute Lung Injury
Efficacy and Safety Study of IV Ravulizumab in Patients With COVID-19 Severe Pneumonia
This study evaluated the efficacy, safety, pharmacokinetics, and pharmacodynamics of ravulizumab administered in adult participants with coronavirus disease 2019 (COVID-19) severe pneumonia, acute lung injury, or acute…
- Conditions
- COVID-19 Severe Pneumonia, Acute Lung Injury, Acute Respiratory Distress Syndrome, Pneumonia, Viral
- Trial name
- NCT04369469
- Testing
- Ravulizumab, BSC
- Where
- 39 sites in United States, France and 3 more
- Volunteers
- 202 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Sickle Cell Disease, Anemia, Sickle Cell
Daily Vitamin D for Sickle-cell Respiratory Complications
This study aims to answer the question whether daily oral vitamin D supplementation can reduce the risk of respiratory or lung complications in children and adolescents with sickle cell disease.
- Conditions
- Sickle Cell Disease, Anemia, Sickle Cell, Anemia, Hemolytic, Congenital, Respiratory Tract Diseases
- Trial name
- ViDAS-2 (NCT04170348)
- Testing
- Daily oral vitamin D3, 3,333 IU, Monthly oral vitamin D3, 100,000 IU
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Columbia University
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