Clinical trials: Pulmonary Nodule, Solitary, open to volunteers
Lung Nodules
Bronchoscopic Navigation Robot-guided Dye Marking-assisted Thoracoscopic Pulmonary Nodule Resection
With the widespread use of low-dose spiral CT screening for the lungs, an increasing number of small nodules are being detected, and surgical resection is the preferred method for clinical intervention of pulmonary nodules.
- Trial name
- NCT06821451
- Testing
- Bronchoscopic navigation robot, Conventional electromagnetic navigation bronchoscope
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Ruijin Hospital
Progression
A Prospective, Two-center, Single Arm Phase II Clinical Study to Evaluate Safety and Effectiveness of Ablation Therapy in the Treatment of Lung Cancer Presenting as Ground-glass Nodules
A prospective, two-center, single arm phase II clinical study to evaluate safety and effectiveness of ablation therapy in the treatment of lung cancer presenting as ground-glass nodules
- Trial name
- NCT04905056
- Testing
- Ablation therapy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai Zhongshan Hospital
Pulmonary Nodule, Solitary, Peripheral Pulmonary Nodules
Intraoperative Longitude-Latitude-Depth Localization Versus Preoperative CT-Guided Percutaneous Lung Puncture Localization for 0.8-2 cm Peripheral Pulmonary Nodules
The goal of this clinical trial is to learn whether intraoperative longitude-latitude-depth three-dimensional localization (LLD localization) is non-inferior to preoperative CT-guided percutaneous lung puncture localization for…
- Conditions
- Pulmonary Nodule, Solitary, Peripheral Pulmonary Nodules, Pulmonary Nodules
- Trial name
- NCT07675889
- Testing
- Longitude-Latitude-Depth Localization, CT-Guided Percutaneous Lung Puncture Localization
- Where
- 4 sites in China
- Volunteers
- 274 people
- Sponsor
- Qilu Hospital of Shandong University
Solitary Pulmonary Nodules, Lung Cancer
Plasma Metabolomics as a Tool to Distinguish PET-positive Malignant From PET-positive Benign Nodules
Positron emission tomography-computed tomography (PET-CT) is an important technique in lung cancer staging, where almost no lung lesion goes undetected.
- Trial name
- NCT07087080
- Testing
- Blood sampling
- Where
- Belgium
- Volunteers
- 350 people
- Sponsor
- Hasselt University
Solitary Pulmonary Nodule, Oncology
18F-2-fluoro-2-deoxy-D-glucose in Positron Emission Tomography Computed Tomography
The study objectives are as follows: To determine the safety of trial 18F-2-fluoro-2-deoxy-D-glucose, produced by a new manufacturer, by surveillance for adverse events in patients having Positron Emission Tomography Computed…
- Conditions
- Solitary Pulmonary Nodule, Oncology, 18F-2-fluoro-2-deoxy-D-glucose, Adverse Event
- Trial name
- NCT04615156
- Testing
- 18F-2-fluoro-2-deoxy-D-glucose
- Volunteers
- 10,000 people
- Sponsor
- Eastern Health, Canada
Pulmonary Nodule, Solitary
ICG Fluorescence Versus CO₂ Inflation-Deflation for Intersegmental Plane Identification During Thoracoscopic Segmentectomy
Intersegmental plane identification is a critical step in thoracoscopic anatomical segmentectomy because it helps ensure adequate surgical margins while preserving healthy lung tissue.
- Trial name
- NCT07745738
- Testing
- Indocyanine Green Fluorescence Imaging, Carbon Dioxide Inflation-Deflation
- Volunteers
- 50 people
- Sponsor
- Tongji Hospital
Pulmonary Nodule, Lung Cancer
European Real-World Registry for Use of the Ion Endoluminal System
The objective of this study is to collect collect real-world data for the Ion endoluminal system.
- Trial name
- NCT06923774
- Testing
- Ion endoluminal system
- Where
- 9 sites in France, Germany and 2 more
- Volunteers
- 1,200 people
- Sponsor
- Intuitive Surgical
Nodule Solitary Pulmonary, Non-small Cell Lung Cancer
Biomarkers for Risk Stratification in Lung Cancer
This is a prospective observational study that will follow patients who undergo lung cancer screening at the San Francisco VA Medical Center, University of California, San Francisco (UCSF) Medical Center, and the San Francisco…
- Trial name
- NCT03774758
- Testing
- Guardant Health ct-DNA LUNAR assay
- Where
- 3 sites in United States
- Volunteers
- 1,440 people
- Sponsor
- University of California, San Francisco
AI (Artificial Intelligence), Pulmonary Nodule, Solitary
DOLCE: Determining the Impact of Optellum's Lung Cancer Prediction Solution
This study is a multi-centre prospective observational cohort study recruiting patients with 5-30mm solid and part-solid pulmonary nodules that have been detected on CT chest scans performed as part of routine practice.
- Conditions
- AI (Artificial Intelligence), Pulmonary Nodule, Solitary, Pulmonary Nodule, Multiple, Lung Cancer
- Trial name
- DOLCE (NCT05389774)
- Where
- 10 sites in United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Pulmonary Nodule, Solitary, Lung Cancer
Pulmonary Nodule Cohort
The aim of this study is to identify the clinical features of pulmonary nodules and establish a cohort to identify biomarkers for lung cancer.
- Trial name
- liquidNodule (NCT04049422)
- Volunteers
- 1,000 people
- Sponsor
- Seoul National University Hospital
Solitary Lung Nodule, Multiple Pulmonary Nodules
A Prospective, Non-interventional Cohort Study of Subsolid Pulmonary Nodules
Some studies have shown that the model for judging and predicting the growth of sub-solid pulmonary nodules through big data and deep learning can detect nodule growth earlier.
- Trial name
- NCT06458673
- Where
- China
- Volunteers
- 1,184 people
- Sponsor
- Guangdong Provincial People's Hospital
Solitary Pulmonary Nodule, Multiple Pulmonary Nodules
Multiparametric Lung MRI With Diffusion-Weighted Imaging in Lung-RADS 4 Lesion Characterization
This study evaluates whether multiparametric chest magnetic resonance imaging (MRI) with diffusion-weighted imaging (DWI), performed without any contrast material, can distinguish malignant from benign lung lesions that were…
- Conditions
- Solitary Pulmonary Nodule, Multiple Pulmonary Nodules, Lung Neoplasms, Lung Cancer Screening
- Trial name
- NCT07768046
- Testing
- Multiparametric chest MRI with diffusion-weighted imaging
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Florida
Multiple Pulmonary Ground-Glass Nodules, Lung Neoplasms
Nebulized Inhalation of Recombinant Human p53 Adenovirus Injection for Treatment of Multiple Ground-Glass Lung Nodules: A Single-Arm Clinical Study
This study aims to evaluate the safety and efficacy of nebulized inhalation of Recombinant Human Ad-p53 Injection (Gendicine®) for the treatment of multiple ground-glass lung nodules.
- Conditions
- Multiple Pulmonary Ground-Glass Nodules, Lung Neoplasms, Precancerous Conditions
- Trial name
- NCT07150416
- Testing
- Recombinant Human Ad-p53 Injection
- Where
- China
- Volunteers
- 38 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Lung Ground-glass Opacities, Active Surveillance
Surveillance for Multifocal GGNs
This study is a single-arm, multi-center, phase III trial conducted under the Eastern Cooperative Thoracic Oncoloy Project (ECTOP) with the identification number ECTOP-1021.
- Trial name
- NCT06097910
- Testing
- Watchful waiting
- Where
- China
- Volunteers
- 370 people
- Sponsor
- Fudan University
Lung Nodule, Solitary, Lung Nodule
Iriscope for the Diagnosis of Peripheral Pulmonary Lesions: a Multicentre Randomised Controlled Trial
A pulmonary nodule is a small mass detected in your lungs during a scan. When a nodule is suspicious, we need to determine its nature (benign or malignant). To do this, a bronchoscopy is performed.
- Conditions
- Lung Nodule, Solitary, Lung Nodule, Lung Cancer (Diagnosis)
- Trial name
- NCT07798362
- Testing
- Use of Iriscope via guide sheath to guide biopsies, Bronchoscopy
- Volunteers
- 140 people
- Sponsor
- Erasme University Hospital
Pulmonary Nodule Cm
Sedation of Remazolam Combined With Afentanil in Non-intubated Thoracoscopic Pulmonary Surgery
Non-intubated Thoracoscopic surgery (NITS) is a newly emerging minimally invasive surgical technique in recent years . Compared with traditional intubation general anesthesia, it has the advantages of less trauma, faster recovery…
- Trial name
- R-A NITS (NCT06810843)
- Testing
- Remazolam combined with afentanil for non-intubated thoracoscopic surgery, Propofol combined with afentanil in non-intubated thoracoscopic surgery
- Where
- China
- Volunteers
- 390 people
- Sponsor
- Qianfoshan Hospital
Non-Small Cell Lung Cancer, Malignant Neoplasm
Cadherin 3(CDH3)-Targeted PET in Lung Malignant Tumors
Lung malignant tumors are a significant health threat with high incidence and mortality rates, and molecular imaging is crucial for early diagnosis, staging, prognosis evaluation, and therapeutic efficacy assessment.
- Conditions
- Non-Small Cell Lung Cancer, Malignant Neoplasm, Pulmonary Nodules, PET/CT
- Trial name
- NCT07487883
- Testing
- PET/CT scans
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking University People's Hospital
Pulmonary Nodules, Multiple, Pulmonary Nodules, Solitary
Differentiation of Benign and Malignant Pulmonary Nodules by Volatile Organic Compounds in Human Exhaled Breath
The goal of this observational study is to develop an advanced expiratory algorithm model utilizing exhaled breath volatile organic compound (VOC) markers.
- Conditions
- Pulmonary Nodules, Multiple, Pulmonary Nodules, Solitary, Lung Cancer
- Trial name
- NCT06518655
- Testing
- Gas chromatography-mass spectrometry(GC-MS) and micro Gas Chromatography-photoionisation detector (μGC-PID) system
- Where
- 15 sites in China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- ChromX Health
Solitary Pulmonary Nodule, Lung Neoplasms
Radiomics for Distinguishing Benign and Malignant Lung Nodules
Differentiating between benign (non-cancerous) and malignant (cancerous) pulmonary nodules is a critical step in determining appropriate patient management and cancer treatment planning.
- Conditions
- Solitary Pulmonary Nodule, Lung Neoplasms, Multiple Pulmonary Nodules
- Trial name
- NCT07852000
- Volunteers
- 255 people
- Sponsor
- Assiut University
Pulmonary Nodules, Lung Cancer (Diagnosis)
The Percutaneous Interventional Surgery Control System for Pulmonary Nodule Biopsy
This prospective, single-center, non-inferiority, randomized controlled clinical trial aims to evaluate the efficacy and safety of a percutaneous interventional surgical control system in performing percutaneous needle biopsy of…
- Conditions
- Pulmonary Nodules, Lung Cancer (Diagnosis), Percutaneous Needle Biopsy, Transthoracic Needle Biopsy
- Trial name
- NCT07277088
- Testing
- Percutaneous Needle Biopsy with Interventional Surgical Control System, Conventional Manual Percutaneous Needle Biopsy
- Where
- China
- Volunteers
- 158 people
- Sponsor
- Jiayuan Sun