Clinical trials: Pulmonary Nodules, Multiple
Pulmonary Nodules
New Method to Differentiate Benign and Malignant Pulmonary Nodules.
The goal of this observational clinical trial is to establish a new method for differentiating benign and malignant pulmonary nodules by peripheral blood detection in patients with pulmonary nodules (<3cm).
- Trial name
- NCT06056999
- Where
- China
- Volunteers
- 150 people
- Sponsor
- China-Japan Friendship Hospital
Pulmonary Nodule, Solitary
Circulating Tumor DNA Methylation Test to Differentiate Benign and Malignant Pulmonary Nodules
Current state-of-the-art lung cancer early screening utilizes low-dose CT scan to identify lung nodules smaller than 3 cm in diameter.
- Trial name
- NCT03181490
- Testing
- Circulating Tumor DNA Methylation Test
- Where
- 14 sites in China
- Volunteers
- 1,490 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Cigarette Smoker, Current Smoker
18F-FSPG PET/CT in Diagnosing Early Lung Cancer in Patients With Lung Nodules
This phase II trial studies how well 18F-FSPG positron emission tomography (PET)/computed tomography (CT) work in diagnosing early lung cancer in patients with indeterminate lung nodules.
- Conditions
- Cigarette Smoker, Current Smoker, Former Smoker, Multiple Pulmonary Nodules
- Trial name
- NCT03824535
- Testing
- Computed Tomography, Fludeoxyglucose F-18, Fluorine F 18 L-glutamate Derivative BAY94-9392
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Andrei Iagaru
Solitary Pulmonary Nodule, Multiple Pulmonary Nodules
Evaluation of Lung Nodule Detection With Artificial Intelligence Assisted Computed Tomography in North China
Lung cancer is one of the leading cause of cancer related death in China. Lung cancer screening with low-dose computed tomography was considered as a better approach than radiography.
- Trial name
- NCT03487952
- Testing
- Questionnaire Administration
- Volunteers
- 5,000 people
- Sponsor
- Peking University People's Hospital
Pulmonary Nodules
Multicenter Prospective Validation of AI Models for Malignancy Risk Prediction in Pulmonary Nodules
This multicenter prospective diagnostic accuracy study will compare the performance of three artificial intelligence (AI) models (MVCS, LungDoc, and a United Imaging AI model) for predicting the malignancy risk of pulmonary…
- Trial name
- NCT07727122
- Where
- 5 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Guangdong Provincial People's Hospital
Pulmonary Neoplasms, Solitary Pulmonary Nodules
Diagnosis of Lung Lesions by Endobronchial Ultrasound With an Alternative Guide Sheath
The purpose of this study is to examine the usefulness of a balloon covered sheath as a guide sheath in endobronchial ultrasound guided transbronchial biopsy and bronchial brushing cytology for diagnosis of peripheral lung lesions
- Trial name
- NCT00922155
- Testing
- guide sheath
- Where
- Taiwan
- Volunteers
- 180 people
- Sponsor
- Chang Gung Memorial Hospital
Pulmonary Nodule
Augmented Reality Navigation Versus Traditional CT Guidance for Preoperative Localization of Pulmonary Nodules
This study aims to conduct a large-sample randomized controlled clinical trial, using traditional CT-guided thoracic puncture localization as a comparison, to explore the accuracy, safety and clinical advantages of Intelligent AR…
- Trial name
- NCT06335563
- Testing
- AR glasses-assisted pulmonary nodule puncture localization, CT-guided pulmonary nodule puncture localization
- Where
- China
- Volunteers
- 166 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Multiple Primary Lung Cancers
The Efficacy of PD-1 Antibody Sintilimab on Early-stage Multiple Primary Lung Cancer With Ground Glass Density.
A single-center,prospective interventional study to explore the efficacy of PD-1 antibody Sintilimab on early-stage multiple primary lung cancer patients with ground-glass nodules in CT scan.
- Trial name
- NCT04026841
- Testing
- PD-1 antibody Sintilimab
- Where
- China
- Volunteers
- 36 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Lung Non-Small Cell Carcinoma, Stage I Lung Cancer AJCC v8
Pembrolizumab in Preventing Lung Cancer in Patients With Stage I-II Non-Small Cell Lung Cancer or High-Risk Pulmonary Nodules, the IMPRINT-Lung Study
This phase II trial studies how well pembrolizumab works in preventing lung cancer patients with stage I-II non-small cell lung cancer or high-risk pulmonary nodules.
- Conditions
- Lung Non-Small Cell Carcinoma, Stage I Lung Cancer AJCC v8, Stage IA1 Lung Cancer AJCC v8, Stage IA2 Lung Cancer AJCC v8
- Trial name
- NCT03634241
- Testing
- Pembrolizumab, Quality-of-Life Assessment, Computed Tomography
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Lung Cancer, Pulmonary Nodule
Exhaled Breath Electronic Nose for Multi-Disease Risk Prescreening
This prospective multicenter observational study will evaluate whether an electronic nose that analyzes patterns in exhaled breath can be developed as a noninvasive tool for early risk prescreening across several disease areas.
- Conditions
- Lung Cancer, Pulmonary Nodule, Chronic Respiratory Disease, Metabolic Disease
- Trial name
- BREATH-PAN (NCT07804017)
- Testing
- Electronic-Nose Breath Assessment
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Lung Nodule
Epigenetic Nucleosomes in Plasma for Pulmonary Nodule Differentiation
Investigators aim to evaluate the diagnostic accuracy of the Nu.Q blood test for lung cancer in the Taiwanese population and compare its diagnostic performance with low-dose computed tomography (LDCT) or computed tomography (CT).
- Trial name
- NCT06838806
- Testing
- blood draw
- Where
- Taiwan
- Volunteers
- 500 people
- Sponsor
- National Taiwan University Hospital
Pulmonary Nodule, Suspected Lung Cancer
Preoperative Decision-Making in Patients With Pulmonary Nodules Suspected of Lung Cancer
Patients with pulmonary nodules that are highly suspected to be lung cancer often need to make important treatment decisions before a definite pathological diagnosis is available.
- Conditions
- Pulmonary Nodule, Suspected Lung Cancer, Preoperative Decision-Making
- Trial name
- NCT07590596
- Testing
- Questionnaire-Based Decision-Making Assessment
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Peripheral Pulmonary Nodules, Lung; Node
CBCT-Guided Navigational Bronchoscopy For Lung Nodules
The purpose of this study is to determine if the cone beam computed tomography (CBCT)-guided navigation bronchoscopy is better in diagnosing lung nodules compared to navigation bronchoscopy alone.
- Conditions
- Peripheral Pulmonary Nodules, Lung; Node, Cone Beam Computed Tomography, Guided Navigation Bronchoscopy
- Trial name
- NCT04758403
- Testing
- Navigation Bronchoscopy, Cone beam computed tomography (CBCT)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Solitary Pulmonary Nodule, Multiple Pulmonary Nodules
Multiparametric Lung MRI With Diffusion-Weighted Imaging in Lung-RADS 4 Lesion Characterization
This study evaluates whether multiparametric chest magnetic resonance imaging (MRI) with diffusion-weighted imaging (DWI), performed without any contrast material, can distinguish malignant from benign lung lesions that were…
- Conditions
- Solitary Pulmonary Nodule, Multiple Pulmonary Nodules, Lung Neoplasms, Lung Cancer Screening
- Trial name
- NCT07768046
- Testing
- Multiparametric chest MRI with diffusion-weighted imaging
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Florida