Clinical trials: Pulmonary Nodules, open to volunteers
Lung Cancer, Pulmonary Nodule
Improving Detection of Early Lung Cancer in a Diverse Population (IDEAL) Study
The goal of this trial is to (a) identify people at high risk of lung cancer who would benefit from LDCT screening but are currently ineligible based on current lung cancer screening criteria (b) provide the framework to manage…
- Trial name
- IDEAL (NCT06628102)
- Testing
- Chest CT Scan
- Where
- Canada
- Volunteers
- 3,600 people, healthy volunteers welcome
- Sponsor
- British Columbia Cancer Agency
Lung Cancer Screening
Lung Cancer Screening for Early Detection of Suspicious Lung Nodules in Latin America(LUCAS-LATAM)
Prospective study to assess lung cancer screening with low dose CT scan (LDCT) in Latin America (LATAM) and prospectively evaluate chest-XRay analyzed with artificial intelligence (AI) using qXRin (QURE ai) at the initial visit…
- Trial name
- LUCAS-LATAM (NCT07524803)
- Testing
- Chest X-Ray, Low Dose CT scan
- Where
- 2 sites in Colombia, Costa Rica
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Latin American Consortium for the Lung Cancer Research
Pulmonary Nodules
The SEQUENCE Trial
This study will randomize participants undergoing a bronchoscopic biopsy of a peripheral pulmonary nodule for their standard of care to receive robotic-assisted bronchoscopy (RaB) and then staging linear endobronchial ultrasounnd…
- Trial name
- SEQUENCE (NCT06676956)
- Testing
- Linear EBUS first, Robotic-assisted bronchoscopy first
- Where
- 5 sites in United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Pancreatic Cancer, Thyroid Cancer
Integrated Cancer Repository for Cancer Research
The iCaRe2 is a multi-institutional resource created and maintained by the Fred \& Pamela Buffett Cancer Center to collect and manage standardized, multi-dimensional, longitudinal data and biospecimens on consented adult cancer…
- Conditions
- Pancreatic Cancer, Thyroid Cancer, Lung Cancer, Esophageal Cancer
- Trial name
- iCaRe2 (NCT02012699)
- Where
- 42 sites in United States
- Volunteers
- 999,999 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Lung Cancer
Research on Early Screening and Diagnosis of Pulmonary Nodules Based on Novel Non-invasive Technologies.
This is a prospective observational study designed to address the clinical challenge posed by the high false-positive rate associated with CT imaging in early lung cancer screening.
- Trial name
- NCT07370077
- Testing
- Employing multi-omics diagnostic approaches to enhance diagnostic efficacy
- Where
- China
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Chen KeZhong
Lung Cancer, Lung Nodule
SPARC - Screening for Lung Cancer With Platelets Via an AI-enabled RNA-based Classifier
The purpose of this study is to test whether combining a unique analytical approach with changes in platelet RNA expression accurately diagnoses lung cancer.
- Trial name
- SPARC (NCT07460440)
- Testing
- Platelet RNA-based assay
- Where
- 2 sites in United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Utah
Lung Cancer, Pulmonary Nodule
Exhaled Breath Electronic Nose for Multi-Disease Risk Prescreening
This prospective multicenter observational study will evaluate whether an electronic nose that analyzes patterns in exhaled breath can be developed as a noninvasive tool for early risk prescreening across several disease areas.
- Conditions
- Lung Cancer, Pulmonary Nodule, Chronic Respiratory Disease, Metabolic Disease
- Trial name
- BREATH-PAN (NCT07804017)
- Testing
- Electronic-Nose Breath Assessment
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Lung Adenocarcinoma
Osimertinib to Suppress the Progression of Remaining GGN for EGFR Mutation-positive Stage IB-IIIA Lung Adenocarcinoma
This is an open label, phase II study to assess the efficacy of osimertinib (80 mg, orally, once daily) to suppress the progression of remaining GGN(s) in other lobes following surgical resection for actionable EGFR…
- Trial name
- NCT05528458
- Testing
- Osimertinib 80Mg Tab
- Where
- South Korea
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Pneumococcal Polysaccharide Vaccine, Influenza Vaccines
Preoperative Pneumococcal and Influenza Vaccination to Prevent Postoperative Pulmonary Infection in Patients Undergoing Lung Resection for Pulmonary Nodules or Lung Cancer
Postoperative pneumonia (POP) affects 4%-24% of lung cancer surgery patients, increasing mortality, stay, costs and worsening prognosis, especially in older patients.
- Conditions
- Pneumococcal Polysaccharide Vaccine, Influenza Vaccines, Preoperative, Lung Resection Surgery
- Trial name
- NCT07885540
- Testing
- 23-valent pneumococcal polysaccharide vaccine, Quadrivalent split-virion influenza vaccine
- Volunteers
- 1,278 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Lung Cancer (Diagnosis), Pulmonary Nodule Persistent
Multi-omics Detection Techniques for Differentiating Benign and Malignant Pulmonary Nodules
Research objective: To explore the clinical application effect of multi-omics detection based on flow cytometry analysis, single-cell data and images combined with clinical features in differentiating the benign and malignant…
- Trial name
- NCT07047573
- Testing
- PBMCS were isolated from the peripheral blood of hospitalized patients with pulmonary nodules and incubated with nanoparticles loaded with tumor antigens for a specific period of time to detect cancer
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Zhao Jun
Pulmonary Nodules, Multiple, Pulmonary Nodules, Solitary
Differentiation of Benign and Malignant Pulmonary Nodules by Volatile Organic Compounds in Human Exhaled Breath
The goal of this observational study is to develop an advanced expiratory algorithm model utilizing exhaled breath volatile organic compound (VOC) markers.
- Conditions
- Pulmonary Nodules, Multiple, Pulmonary Nodules, Solitary, Lung Cancer
- Trial name
- NCT06518655
- Testing
- Gas chromatography-mass spectrometry(GC-MS) and micro Gas Chromatography-photoionisation detector (μGC-PID) system
- Where
- 15 sites in China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- ChromX Health
Lung Nodules
Specimens for Lung Cancer Panel Design
This is an observational study designed to determine the optimal combination of biomarkers and clinical data for the early detection, confirmation, and better treatment of lung cancer including minimizing recurrence.
- Trial name
- NCT07401797
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Maverix Medical
Lung Cancer (Diagnosis)
Prospective Multicenter Cohort Study for the Development and Evaluation of Risk Stratification Tools for Lung Cancers and Their Postoperative Recurrences Using Multimodal Clinical, Radiological, Tissue and Longitudinal Biological Phenotyping Among People at Risk of Lung Cancer
Interventional study with minimal risks and constraints, involving annual assessment of the prevalence and incidence of lung cancer using low-dose contrast-free thoracic CT scans, immunological, inflammatory, metabolic, blood…
- Trial name
- LUCA-pi COHORT (NCT07042867)
- Testing
- biobanking, low dose scan
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Lung Cancer (Diagnosis), Nodule, Solitary Pulmonary
Non-Invasive Malignancy Classifiers Using Blood-Biomarkers for Lung Nodule Evaluation
The goal of the NIMBLE study is to evaluate blood-based biomarkers for lung cancer risk prediction in patients referred with a lung nodule.
- Trial name
- NIMBLE (NCT07623473)
- Testing
- Blood tests
- Where
- Denmark
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Herlev and Gentofte Hospital