Clinical trials: Pulmonary Procedures
Parapneumonic Effusion, Empyema, Pleural
Treatment of Complicated Parapneumonic Effusion With Fibrinolytic Therapy Versus VATs Decortication
This study aims to standardize the treatment of pleural space (parapneumonic) infections by comparing the difference in outcomes between 2 methods of treatment: early VATS (Video Assisted Thorascopic Surgery) decortication versus…
- Conditions
- Parapneumonic Effusion, Empyema, Pleural, Coagulopathy
- Trial name
- NCT03583931
- Testing
- VATS Decortication, Fibrinolytic Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Denver Health and Hospital Authority
Peripheral Pulmonary Nodules, Ablation Techniques
Diagnosis and Treatment of Lung Lesions
To evaluate the safety and feasibility of a single-session "diagnose and treat" (one-stop) paradigm utilizing robotic-assisted bronchoscopy (RAB).
- Trial name
- NCT07642986
- Testing
- A single-session "diagnose and treat" (one-stop) paradigm utilizing robotic-assisted bronchoscopy (RAB)
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Jisong Zhang
Chronic Obstructive Pulmonary Disease
REported Outcomes in COPD With Trixeo in Real worlD
Chronic obstructive pulmonary disease (COPD) is characterized by persistent respiratory symptoms (including breathlessness, cough, and sputum production), which has a substantial impact on health-related quality of life (HRQoL).
- Trial name
- RECORD (NCT05213611)
- Where
- 31 sites in United Kingdom
- Volunteers
- 150 people
- Sponsor
- AstraZeneca
Osteosarcoma Metastatic
A Look Back at How Well Interventional Treatments Work for Bronchopleural Fistulas in Patients With Lung Metastases From Osteosarcoma
Patients with pulmonary metastasis of osteosarcoma complicated with BPF often suffer from massive hemoptysis, refractory pneumothorax and difficult fistula healing due to tumor erosion of bronchial arteries.
- Trial name
- NCT06927596
- Testing
- Interventional therapy
- Volunteers
- 28 people
- Sponsor
- Ruijin Hospital
Non Small Cell Lung Cancer
A Prospective ,Multicenter ,Non-interventional ,Real-world Study Observing Changes in Molecular Markers Osimertinib Targeted Therapy in EGFRm NSCLC
A prospective ,multicenter ,non-interventional ,real-world study observing changes in molecular markers after three weeks of osimertinib targeted therapy in EGFRm NSCLC
- Trial name
- pre-FLAME (NCT06422546)
- Where
- China
- Volunteers
- 950 people
- Sponsor
- Beijing Cancer Prevention & Treatment Society
Lung Cancer
Respiratory Distress Symptom Intervention (RDSI) Trial
This study aims to determine the effects of adding the Respiratory Distress Symptom Intervention (RDSI) to usual care for the self management of the Respiratory Distress Symptom Cluster (breathlessness-cough-fatigue) for patients…
- Trial name
- RDSI-LC (NCT03223805)
- Testing
- Respiratory Distress Symptom Intervention
- Where
- 7 sites in United Kingdom
- Volunteers
- 263 people
- Sponsor
- The Christie NHS Foundation Trust
Long COVID
Developing an Integrative, Recovery-Based, Post-Acute COVID-19 Syndrome (PACS) Psychotherapeutic Intervention
Post-Acute COVID-19 Syndrome (PACS), colloquially known as Long COVID, is a prevalent phenomenon that affects thousands of Veterans in VA care.
- Trial name
- NCT05453201
- Testing
- Long COVID Coping and Recovery (LCCR) Intervention
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- VA Office of Research and Development
Smoking Cessation, Smoking Cessation Counseling Ability and Practice
Evaluating the Impact of CONNECT in a Multilingual Population
This study aims to broaden the reach of the lung cancer screening (LCS) CONNECT program (NCT04149249, NCT06213532), by developing a version of the program to be available to multilingual communities.
- Conditions
- Smoking Cessation, Smoking Cessation Counseling Ability and Practice, Smoking Cessation Counselling, Lung Cancer Screening
- Trial name
- CONNECT-ML (NCT07111936)
- Testing
- CONNECT Intervention for multilingual populations, Saliva Sample, Interview
- Where
- United States
- Volunteers
- 439 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Rehabilitation After Lung Cancer Surgery
Exercise Intervention After Lung Cancer Surgery
A combination of supervised and un-supervised exercise in patients after lung cancer surgery is evaluated with regards to aerobic capacity, strength, physical activity and health-related quality of life.
- Trial name
- NCT06150131
- Testing
- Exercise
- Where
- Sweden
- Volunteers
- 90 people
- Sponsor
- Region Örebro County
Long COVID-19 Syndrome
Long COVID-19 Syndrome Lifestyle Intervention Study
Rationale: Hyper-inflammatory responses seen in acute COVID-19 are also a feature of long covid, a condition of long-term consequences that are persisting or appearing after initial infection and recovery from acute COVID-19.
- Trial name
- NCT05836402
- Testing
- Low carbohydrate diet intervention
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Southern California
Pulmonary Tuberculosis
A Phase II Clinical Study of LCB01-0371 to Evaluate the EBA, Safety and PK
A Prospective, Randomized, Open, Active-controlled, Interventional, Exploratory, Phase II Trial of LCB01-0371.
- Trial name
- NCT02836483
- Testing
- LCB01-0371 800mg, QD, LCB01-0371 400mg, BID, LCB01-0371 800mg, BID
- Where
- South Korea
- Volunteers
- 79 people
- Sponsor
- LigaChem Biosciences, Inc.
Lung Cancer (Non-Small Cell), Self-management Behavior
Evaluating the Feasibility and Preliminary Effects of BE+
This non-randomized, single group study will test a 12-week, behavioral intervention for physical activity and stress management for survivors of non-small cell lung cancer (NSCLC) and a partner (family member or friend).
- Conditions
- Lung Cancer (Non-Small Cell), Self-management Behavior, Physical Activity, Stress
- Trial name
- NCT07214441
- Testing
- Breathe Easier+
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of South Carolina
Transplant;Failure,Kidney, Transplant; Failure, Heart
EASE-SOT Pilot Study
Many transplant recipients may experience physical and emotional symptoms, such as anxiety, fatigue, sleep problems, pain, etc. Often, these symptoms are not reported or managed well, and can affect a patient's quality-of-life.
- Conditions
- Transplant;Failure,Kidney, Transplant; Failure, Heart, Transplant; Failure, Liver, Transplant; Failure, Pancreas
- Trial name
- NCT06396702
- Testing
- EASE-SOT
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University Health Network, Toronto
Pneumonia, Acute Pyelonephritis
NGS-Based Assay of Blood Samples of Sepsis Patients for Rapid Bacterial Identification
Rapid detection of microorganisms is a promising approach towards early administration of appropriate antibiotics for sepsis. This study aims to investigate the potential of a new NGS platform for the rapid diagnosis of…
- Conditions
- Pneumonia, Acute Pyelonephritis, Bacteremia, Biliary Tract Infection
- Trial name
- BIOARTE (NCT06141395)
- Testing
- NGS-based assay for bacterial identification
- Where
- 4 sites in Greece
- Volunteers
- 100 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
COVID-19 Infection
Integrated Mindfulness-based Health Qigong Intervention for COVID-19 Survivors and Caregivers
This study examines the effectiveness of a 16-week Integrated Mindfulness-based Health Qigong (iMBHQ) program, delivered via a mobile application, in improving the mental and physical well-being of COVID-19 survivors, their…
- Trial name
- NCT06194357
- Testing
- Mindfulness-based Health Qigong Intervention
- Where
- 2 sites in Hong Kong
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- TSANG Hector Wing-Hong
Local Advanced Non-small Cell Lung Cancer
Study of Early Nutritional Intervention During Concurrent Chemoradiotherapy for Local Advanced Non-small Cell Lung Cancer
This single-arm phase II prospective study is to determine the efficacy of early nutritional intervention during concurrent chemoradiotherapy for local advanced non-small cell lung cancer.
- Trial name
- NCT03673657
- Testing
- Early Nutrition Intervention from the start of CCRT, Thoracic radiotherapy, Weekly DP chemotherapy concurrent with thoracic radiotherapy
- Where
- China
- Volunteers
- 67 people
- Sponsor
- Sun Yat-sen University
Non-small Cell Lung Cancer(NSCLC)
Bronchial Artery Chemoembolization (BACE) Combination Therapy for Advanced NSCLC
Patients with advanced non-small cell lung cancer (NSCLC) who experience disease progression after standard systemic therapies or are unable to tolerate such therapies have limited subsequent treatment options.
- Trial name
- NCT07738367
- Testing
- Bronchial Arterial Chemoembolization (BACE), Systemic anti-tumor combination medications
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Fujian Cancer Hospital
Non-small Cell Lung Cancer
Non-interventional, Prospective Study to Determine Prevalence of EGFR Mutations in Non-small Cell Lung Cancer
This prospective, multicountry, multicentre, non-interventional study plans to include patients who have undergone surgery for early-stage (IA to IIIB on the basis of pathologic criteria) non-squamous NSCLC up to 6 weeks prior to…
- Trial name
- EARLY-EGFR (NCT04742192)
- Where
- 33 sites in Argentina, Chile and 13 more
- Volunteers
- 601 people
- Sponsor
- AstraZeneca
Type-2 Diabetes, Cardiovascular Diseases
Feasibility of a Preventive Program Against Lifestyle Related Diseases
The continuously increasing prevalence of cardiovascular diseases, type-2 diabetes, and COPD is a major health problem in developed countries and is mainly caused by an unhealthy lifestyle.
- Conditions
- Type-2 Diabetes, Cardiovascular Diseases, Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- NCT02797392
- Testing
- Lifestyle intervention
- Where
- 6 sites in Denmark, Norway and 1 more
- Volunteers
- 9,400 people
- Sponsor
- University of Southern Denmark
Breast Cancer, ALL
Collaborative Network to Take Responsibility for Oral Anticancer Therapy
This study aims to develop, implement and evaluate a care pathway for patients with cancer who are treated with oral anticancer drugs (OACD).
- Conditions
- Breast Cancer, ALL, Lung Cancer, Melanoma
- Trial name
- CONTACT (NCT02861209)
- Testing
- Implementation of a care pathway
- Where
- 4 sites in Belgium
- Volunteers
- 228 people
- Sponsor
- KU Leuven
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