Clinical trials: Pulmonary Procedures
Covid19, Lung Inflammation
P-Co-Li (Pulmonary Covid-19 Study)
The aim of this study is to determine whether the use of steroids versus watchful waiting improves pulmonary function tests in patients with history of COVID 19 infection who have residual hypoxemia and lung infiltrates.
- Conditions
- Covid19, Lung Inflammation, Hypoxemic Respiratory Failure
- Trial name
- NCT04782700
- Testing
- Steroid Taper (Prednisone)
- Where
- United States
- Sponsor
- Northwell Health
Chronic Obstructive Pulmonary Disease
Tissue Regeneration in Patients With Chronic Obstructive Pulmonary Disease After an Exercise Intervention.
The main objective of this project is to identify mechanisms for lung regeneration in patients with COPD induced by exercise training.
- Trial name
- T-Rex (NCT06335992)
- Testing
- Exercise regime
- Where
- 2 sites in Sweden
- Volunteers
- 80 people
- Sponsor
- Uppsala University
Cerebrovascular Accident, Cancer
Multidisciplinary Inpatient Palliative Care Intervention
Palliative care is believed to improve care of patients with life-limiting illnesses. This study evaluated the impact of a multi-center randomized trial of a palliative care team intervention on the quality and cost of care of…
- Conditions
- Cerebrovascular Accident, Cancer, Coronary Arteriosclerosis, Heart Failure, Congestive
- Trial name
- NCT00325611
- Testing
- Multidisciplinary palliative care team met with patient
- Where
- United States
- Volunteers
- 550 people
- Sponsor
- Kaiser Permanente
Cystic Fibrosis
Comparison of Non-invasive Measurement Methods of Hepatic Fibrosis in Cystic Fibrosis
Non-invasive methods of the quantification of fibrosis may help to assess the development of fibrosis at a specific moment of the evolution of the disease, in the order to decide the initiation of treatment with ursodeoxycholic…
- Trial name
- MUCO-FIBRO (NCT02342964)
- Testing
- Measure of hepatic elasticity
- Where
- France
- Volunteers
- 56 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Alpha 1-Antitrypsin Deficiency
Experimental Gene Transfer Procedure to Treat Alpha 1-Antitrypsin Deficiency
Individuals with a deficiency of the Alpha 1-antitrypsin (AAT) protein are at risk for developing emphysema and liver damage. Researchers have developed a way to introduce normal AAT genes into muscle cells so that the AAT…
- Trial name
- NCT00377416
- Testing
- rAAV2-CB-hAAT Gene Vector
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Massachusetts, Worcester
Cystic Fibrosis
Effectiveness of Respiratory Physiotherapy on Frequency of Exacerbations, Lung Function and Quality of Life After 6 Months in Children With Cystic Fibrosis
Daily respiratory physiotherapy is a fundamental part of cystic fibrosis treatment, however, patients adherence is low. Thus, there is a need for studies that evaluate the impact of physiotherapy supervision in patients with…
- Trial name
- NCT07088614
- Testing
- Remote respiratory physiotherapy
- Where
- Chile
- Volunteers
- 9 people
- Sponsor
- University of Americas - Chili
Breast Cancer, Lung Cancer
Using an End-of-life Conversation Game to Engage Patients With Cancer in Advance Care Planning
The goal of this clinical trial is to explore feasibility, acceptability, and effectiveness of end-of-life conversation game "Hello" as a tool to help individuals with breast, lung, and/or genito-urinary cancers treated at Penn…
- Conditions
- Breast Cancer, Lung Cancer, Genito Urinary Cancer
- Trial name
- NCT06028152
- Testing
- End-of-life conversation game called "Hello"
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Milton S. Hershey Medical Center
Air Pollution, mHealth Intervention
1/2- Bangladesh Center for Global Environmental and Occupational Health- Bangladesh
Almost 3 billion people worldwide, including 89% people in Bangladesh, are exposed to harmful household air pollutants (HAP) emitted from combustion of biomass (wood, agricultural residue, cow dung, etc.) fuel use for cooking.
- Conditions
- Air Pollution, mHealth Intervention, Cardiopulmonary Function, Immune Function
- Trial name
- GEOHealth-II (NCT05570552)
- Testing
- mHealth based behavioral change communication intervention
- Where
- Bangladesh
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Lung Cancer, Esophageal Cancer
Pilot Study of Allogeneic Tumor Cell Vaccine With Metronomic Oral Cyclophosphamide and Celecoxib in Patients Undergoing Resection of Lung and Esophageal Cancers, Thymic Neoplasms, and Malignant Pleural Mesotheliomas
Background: Certain types of lung, esophageal, or thymic cancers and mesotheliomas have specific antigens (protein molecules) on their surfaces.
- Conditions
- Lung Cancer, Esophageal Cancer, Malignant Pleural Mesothelioma, Sarcoma
- Trial name
- NCT01143545
- Testing
- Allogeneic Tumor Cell Vaccine (K562), Celecoxib, cyclophosphamide
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Cancer Institute (NCI)
Non-Tuberculous Mycobacteria Pulmonary Disease, Bronchiectasis
Health Impact of Non-Tuberculous Mycobacteria Pulmonary Disease (NTM-PD)
Nontuberculous mycobacteria (NTM) are environmental organisms found in soil and water. The majority do not cause human disease. When they do, this is mostly as a chronic lung infection in people with long-term lung problems such…
- Trial name
- NCT07192705
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University College, London
Non Small Cell Lung Cancer
Evaluation of Lymph Node Analysis Using One Step Nucleic Acid Amplification (OSNA) in Patients With Lung Cancer Who Underwent Robotic Lung Resection, Comparison With Traditional Methods
This prospective study aims to evaluate the effectiveness of the One-Step Nucleic Acid Amplification (OSNA) technique for detecting micrometastases in lymph nodes of patients with clinical stage I-II non-small cell lung cancer…
- Trial name
- LALC (NCT07301983)
- Testing
- lymph node analysis using the OSNA assay
- Where
- Italy
- Volunteers
- 130 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Idiopathic Pulmonary Fibrosis
NICEFIT-ON: A Study Under Routine Clinical Practice in Taiwan to Observe the Long-term Outcome of People With Certain Types of Lung Disease (PF-ILD, SSc-ILD, IPF) Who Start Treatment With Nintedanib
To better understand the clinical characteristics of Idiopathic Pulmonary Fibrosis (IPF) / Systemic Sclerosis-associated-Interstitial Lung Disease (SSc-ILD)/ Progressive Fibrosing Interstitial Lung Disease (PF-ILD) patients…
- Trial name
- NCT04614441
- Testing
- OFEV®
- Where
- 26 sites in Taiwan
- Volunteers
- 214 people
- Sponsor
- Boehringer Ingelheim
Lung Cancer
Radiograph Accelerated Detection and Identification of Cancer in the Lung
Lung cancer is the most common cause of cancer death in the UK yet compared to Europe it has low survival rates.The NHS aims to find 75% of cancers at an early stage as this can improve the chances of survival.
- Trial name
- RADICAL (NCT06044454)
- Testing
- qXR
- Where
- 4 sites in United Kingdom
- Volunteers
- 60,000 people
- Sponsor
- NHS Greater Glasgow and Clyde
Population at Risk
Educating QUitline Callers About Lung Cancer Screening
The specific aims are: 1. To evaluate the potential barriers of providing educational lung screening interventions to quitline users, the investigators will seek input from 10-20 stakeholders on the newly adapted print version of…
- Trial name
- EQUAL (NCT05046951)
- Testing
- Should I Screen website, Should I Screen print booklet
- Where
- United States
- Volunteers
- 298 people
- Sponsor
- Georgetown University
Non-Small Cell Lung Cancer
MRD-Guided Aumolertinib-Based Adjuvant Therapy for Resected EGFR-Mutant NSCLC
Despite complete (R0) resection, patients with EGFR-mutant stage IIA-IIIB non-small cell lung cancer (NSCLC) still face a substantial risk of postoperative recurrence.
- Trial name
- NCT07873086
- Testing
- Aumolertinib, Pemetrexed, Carboplatin
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking University People's Hospital
Lung Neoplasms, Liver Neoplasms
A Comparison of Methods for Assisting Needle Angle Selection During Image-guided Tissue Biopsy
Background: Currently, standard procedures for biopsies that are guided by computed tomography (CT) imaging involve CT scans and a computer program to plan and illustrate where the physician will place the needle to obtain the…
- Conditions
- Lung Neoplasms, Liver Neoplasms, Kidney Neoplasms, Cancer
- Trial name
- NCT01218854
- Testing
- Needle angle measurement
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
COPD, Asthma
A Pharmacist-Led Intervention to Increase Inhaler Access and Reduce Hospital Readmissions (PILLAR)
The goal of this study is to assess the impact of pharmacist-led benefits investigations and application of clinical practice guidelines on patient access to inhalers and time to hospital readmission or Emergency Department (ED)…
- Trial name
- PILLAR (NCT03927820)
- Testing
- Benefits investigation
- Where
- United States
- Volunteers
- 914 people
- Sponsor
- Vanderbilt University Medical Center
Hepatocellular Carcinoma, Immunotherapy
GPC3-CAR-T Cells for Immunotherapy of Cancer With GPC3 Expression
The third/fourth generation of CAR-T cells that target GPC3 (GPC3-CART cell) and/or soluble TGFβ (GPC3/TGFβ-CART )have been constructed and their anti-HCC function has been verified by multiple in vitro and in vivo studies.
- Conditions
- Hepatocellular Carcinoma, Immunotherapy, CAR, GPC3 Gene Inactivation
- Trial name
- NCT03198546
- Testing
- GPC3 and/or TGFβ targeting CAR-T cells
- Where
- 2 sites in China
- Volunteers
- 30 people
- Sponsor
- Second Affiliated Hospital of Guangzhou Medical University
Non Small Cell Lung Cancer, Chronic Obstructive Pulmonary Disease
Study of Use of CTC in NSCLC
The purpose of this study is to assess whether the detection of circulating tumor cells (CTC) could be used as a tool to earlier diagnose, more accurately predict treatment response / failure and predict overall survival in…
- Trial name
- NCT01990651
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Infectious Disease, Pneumonia, Bacterial
Vaccination Education Through Pharmacists and Senior Centers (VEPSC)
The study consists of two arms (PHARM and PEER) designed to educate participants about three vaccine-preventable diseases (zoster, pneumonia, and influenza) and vaccination.
- Conditions
- Infectious Disease, Pneumonia, Bacterial, Influenza, Zoster; Herpes
- Trial name
- VEPSC (NCT03239665)
- Testing
- Pharmacist-led Intervention (PHARM), Peer-led Intervention (PEER)
- Where
- United States
- Volunteers
- 335 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
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