Clinical trials: Pulmonary Resection, open to volunteers
NSCLC, Stage I
Osimertinib Therapy After Resection in High-risk Stage I EGFRm NSCLC (OSTAR)
This is a prospective, open, single-center, single-arm phase II clinical study with common EGFR-sensitive mutations (Ex19del and L858R) identified in the central laboratory.To evaluate the efficacy and safety of adjuvant…
- Trial name
- NCT05686434
- Testing
- Osimertinib
- Where
- China
- Volunteers
- 65 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Non Small Cell Lung Cancer
3-Dimensional Virtual Reality Modelling With Intravascular Indocyanine Green Fluorescence Mapping for Targeted Pulmonary Segmental Resection Trial
With the advent of CT screening for lung cancer, an increasing number of NSCLCs are being detected at very early stages, and the demand for pulmonary segmentectomy is rising rapidly.
- Trial name
- NCT06638125
- Testing
- 3-Dimensional VR Modelling (Elucis) with Intravascular Indocyanine Green Fluorescence Mapping, 3-Dimensional Modelling (Synapse 3D) with Intravascular Indocyanine Green Fluorescence Mapping
- Where
- Canada
- Volunteers
- 89 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Lung Cancer
Totally Robotic Versus Surgeon-Assisted Robotic Lung Resection For Early-Stage NSCLC
Robotic-assisted thoracoscopic surgery (RTS) is safe and effective for patients with early-stage non-small cell lung cancer (NSCLC).
- Trial name
- NCT06348030
- Testing
- Medtronic Signia Stapler, Vessel Sealer Extend Energy Device and SureForm Stapler
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Lung Cancer, Lung Cancer Stage I
Feasibility Study to Treat Lung Cancer With the Permanently Implantable LDR CivaSheet®
This is a feasibility study to determine the usefulness of a brachytherapy device that utilizes active components (palladium-103) of standard devices in a novel configuration, which may benefit lung cancer patients by reducing…
- Conditions
- Lung Cancer, Lung Cancer Stage I, Lung Cancer Stage II
- Trial name
- NCT03290534
- Testing
- CivaSheet
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- CivaTech Oncology
Lung Cancer, Surgery
Intraoperative Blood Pressure Management and Dexamethasone in Lung Cancer Surgery
Surgery is the front-line therapy for non-small cell lung cancer (NSCLC) but postoperative complications remains high and patients' long-term outcome is still challenging.
- Conditions
- Lung Cancer, Surgery, Blood Pressure Management, Dexamethasone
- Trial name
- NCT04209218
- Testing
- Dexamethasone, Targeted blood pressure management, Routine blood presure management
- Where
- China
- Volunteers
- 1,988 people
- Sponsor
- Peking University First Hospital
Prolonged Air Leak, Persistent Air Leak
Comparison of 40% Glucose Solution and Autologous Blood Patch Pleurodesis for Postoperative Air Leak After Lung Resections
Prolonged or persistent air leak (PAL) is one of the most common complications in patients after surgery on the lung parenchyma.
- Trial name
- GLUC-PAL (NCT06936969)
- Testing
- Autologous blood patch pleurodesis, 40% glucose solution pleurodesis
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Wielkopolskie Centrum Pulmonologii i Torakochirurgii
Non-small Cell Lung Cancer (NSCLC)
Phase 3 Study of Taletrectinib vs Placebo as an Adjuvant Therapy in ROS1 Positive NSCLC (TRUST-IV)
The purpose of this phase 3 multicenter double-blind randomized study is to assess the use of taletrectinib in the early-stage non-small cell lung cancer (NSCLC).
- Trial name
- NCT07154706
- Testing
- Taletrectinib
- Where
- 33 sites in United States, Canada and 1 more
- Volunteers
- 180 people
- Sponsor
- Nuvation Bio Inc.
Lung Cancer (Suspected or Confirmed), Thoracoscopic Lobectomy
Right Ventricular Afterload Indices in Lung Surgery
Lung cancer is a leading cause of cancer death in Scotland and the UK. Surgery, typically using a keyhole approach, provides the best chance of cure.
- Conditions
- Lung Cancer (Suspected or Confirmed), Thoracoscopic Lobectomy, One Lung Ventillation (OLV)
- Trial name
- RAILS (NCT07812207)
- Testing
- Contrast cardiac magnetic resonance imaging, Right heart catheterisation, Perioperative plasma sampling
- Volunteers
- 15 people
- Sponsor
- University of Glasgow
Non-Small Cell Lung Cancer, Chronic Obstructive Lung Disease
Singing Training vs Usual Care 6-18 Months After Surgical Resection for Non-small Cell Lung Cancer (NSCLC)
People who have undergone curative surgery for non-small cell lung cancer (NSCLC) often experience reduced quality of life (QoL), a high burden of symptoms, and physical deconditioning.
- Trial name
- Sing-a-Lung 2 (NCT07460999)
- Testing
- Singing training (Singing for Lung Health (SLH)), Control group: Usual care
- Where
- 5 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Zealand University Hospital
Non-Small Cell Lung Cancer
Umbrella Trial of Adjuvant Therapy in Completely Resected High-risk Stage IA-IB NSCLC: Focus on Driver Mutations
This study explores how adjuvant therapy affects survival in completely resected high-risk stage IA-IB NSCLC patients with different driver gene mutations.
- Trial name
- UPLIFT (NCT06955325)
- Testing
- Icotinib, Rezivertinib, Ensartinib
- Volunteers
- 270 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Stage I Lung Cancer AJCC v8, Stage IA1 Lung Cancer AJCC v8
Respiratory Muscle Training Before Surgery in Preventing Lung Complications in Patients With Stage I-IIIB Lung Cancer
This phase II trial studies how well respiratory muscle training before surgery works in preventing lung complications after surgery in patients with stage I-IIIB lung cancer.
- Conditions
- Stage I Lung Cancer AJCC v8, Stage IA1 Lung Cancer AJCC v8, Stage IA2 Lung Cancer AJCC v8, Stage IA3 Lung Cancer AJCC v8
- Trial name
- NCT04067830
- Testing
- Best Practice, Laparoscopic Surgery, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Roswell Park Cancer Institute
Non Small Cell Lung Cancer
Primary Tumor Resection With Sintilimab and Chemotherapy in Advanced NSCLC
This study aims to evaluate whether resecting the primary tumor can improve the outcomes of treatment with sintilimab and chemotherapy in advanced EGFR/ALK-negative non-small cell lung cancer (NSCLC).
- Trial name
- SURGAN-ICI (NCT07177105)
- Testing
- Cytoreductive surgery, Immunochemotherapy
- Volunteers
- 118 people
- Sponsor
- Jianxing He
Non-small Cell Lung Cancer
A Clinical Trial of Adjuvant Intismeran (V940) With or Without Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) in High-Risk Stage I Non-Small Cell Lung Cancer (V940-014)
Researchers are looking for new ways to treat high-risk, localized non-small cell lung cancer (NSCLC) that has been removed with surgery. People with high-risk, localized NSCLC are often treated with surgery.
- Trial name
- INTerpath-014 (NCT07513376)
- Testing
- Intismeran, Pembrolizumab coformulated with berahyaluronidase alfa
- Where
- 124 sites in United States, Australia and 18 more
- Volunteers
- 876 people
- Sponsor
- Merck Sharp & Dohme LLC
Surgical Procedures, Operative
A Study Comparing ETHICON™ 4000 Stapler System With Standard of Care Stapling Devices in Adults Undergoing Gastric and Thoracic Procedures
The purpose of this study is to compare how well the ETHICON™ 4000 Stapler works as compared to the standard stapling devices by assessing how often air leaks and bleeding along the staple line occur during lung and stomach…
- Trial name
- NCT07744568
- Testing
- ETHICON™ 4000 Stapler System, Standard of Care Stapler and Reloads
- Volunteers
- 300 people
- Sponsor
- Ethicon Endo-Surgery
Non-Small Cell Lung Cancer
JoLT-Ca Sublobar Resection (SR) Versus Stereotactic Ablative Radiotherapy (SAbR) for Lung Cancer
To Determine if SAbR improves survival over SR in High Risk Operable Stage I NSCLC
- Trial name
- STABLE-MATES (NCT02468024)
- Testing
- Lung Surgery, Radiation therapy
- Where
- 50 sites in United States, Australia and 2 more
- Volunteers
- 272 people
- Sponsor
- University of Texas Southwestern Medical Center
ARDS (Acute Respiratory Distress Syndrome)
The Effect of Catheter Size on the Efficacy of Ultralow-flow Extracorporeal Carbon Dioxide Removal System in Acute Respiratory Distress Syndrome
This pilot randomized controlled trial will evaluate whether catheter size affects the efficacy and performance of ultra-low-flow extracorporeal carbon dioxide removal (ECCO₂R) in mechanically ventilated adults with acute…
- Trial name
- Cath-COR (NCT07858136)
- Testing
- 12F Catheter, 13F Catheter, 15F Catheter
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Chulalongkorn University
VATS, Lung Hernia
The Application Value of Intercostal Suturing in Preventing Postoperative Thoracoscopic Lung Resection Chest Wall Pulmonary Hernia
The purpose of this trial is to understand whether intercostal suture can effectively prevent postoperative chest wall lung herniation, mainly to verify the following questions Can intercostal suture reduce postoperative chest…
- Trial name
- NCT06924515
- Testing
- Intercostal suture
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Mingjian Ge
Non-Small Cell Lung Cancer
Comparison of Biportal Versus Multiportal Robotic Approaches for Pulmonary Resection in NSCLC
This study compares two established robotic surgical approaches for removing lung tumors in adults with non-small cell lung cancer: biportal robotic-assisted thoracic surgery (biRATS) and multiportal robotic-assisted thoracic…
- Trial name
- EC-UMUR (NCT07818135)
- Testing
- Biportal Robotic-Assisted Thoracic Surgery, Multiportal Robotic-Assisted Thoracic Surgery
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Carlos Déniz
Lung Cancer (Non-Small Cell)
Short- and Mid-term Therapeutic, Prognostic, and Societal Impact of Implementing Intraoperative Assessment of Pulmonary Resection Quality for Lung Cancer
QUALITYSURG is a multicenter interventional study evaluating whether a collaborative intraoperative quality checklist (QualitySurg List) can improve the oncological quality of lung cancer resections.
- Trial name
- QualitySurg (NCT07828938)
- Testing
- QualitySurg List
- Where
- 20 sites in France
- Volunteers
- 2,400 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Brain Metastases, Adult, Brain Tumor - Metastatic
Stereotactic Radiation for Growing/Changing Brain Metastases With Same-Day Radiation Planning and Treatment With Margin Reduction
The goal of this study is to evaluate the feasibility and effectiveness of same-day radiation planning and treatment. The study will shorten the time interval between radiation planning (radiation mapping) and radiation…
- Conditions
- Brain Metastases, Adult, Brain Tumor - Metastatic, Brain Metastases From Non-small Cell Lung Cancer (NSCLC), Brain Metastases From Extra-cranial Solid Tumors
- Trial name
- NCT07132190
- Testing
- Linear accelerator-based stereotactic radiation for brain metastases using 0mm or 1mm PTV
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Ayal A. Aizer, MD