Clinical trials: Pulmonary Resection Surgery, open to volunteers
NSCLC (Advanced Non-small Cell Lung Cancer), Post Surgical
Radiotherapy Plus Anti-PD-1 Versus Anti-PD-1 Alone in ypTanyN⁺M0 NSCLC
Patients with stage III non-small-cell lung cancer (NSCLC) who receive neoadjuvant chemoimmunotherapy may achieve good response in the primary tumor but still have residual nodal disease after surgery (ypTanyN⁺M0), which is…
- Trial name
- NCT07353476
- Testing
- radiotherapy, PD -1/PD-L1 monoclonal antibody
- Volunteers
- 38 people
- Sponsor
- Shanghai Zhongshan Hospital
Lung Diseases
Comparison of Two Strategies of One-lung Ventilation in Patients Undergoing Carcinological Lung Resection Surgery.
During thoracic surgery, one-lung ventilation (OLV) is associated with hypoxemia, lung injury, and perioperative respiratory complications.
- Trial name
- I-PEEP-THO (NCT05525312)
- Testing
- "Open-lung" protective ventilation strategy, "Standard" protective ventilation strategy
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Montpellier
Lung, Lung Adenocarcinoma
Reinforced and Non-Reinforced Staple Lines in Fissureless Lobectomy
Prolonged Air Leak (PAL) is a common and serious problem after lung surgery. It can lead to worse patient outcomes, longer hospital stays, and higher costs.
- Conditions
- Lung, Lung Adenocarcinoma, Lung Adenosquamous Carcinoma, Lung Cancer, Non-Small Cell
- Trial name
- NCT06602661
- Testing
- Fissureless Lobectomy with Reinforced Staple Lines, Fissureless Lobectomy with Non-Reinforced Staple Lines
- Where
- Canada
- Volunteers
- 65 people
- Sponsor
- Surrey Thoracic Surgery Group
Lung Cancer (Non-Small Cell)
Short- and Mid-term Therapeutic, Prognostic, and Societal Impact of Implementing Intraoperative Assessment of Pulmonary Resection Quality for Lung Cancer
QUALITYSURG is a multicenter interventional study evaluating whether a collaborative intraoperative quality checklist (QualitySurg List) can improve the oncological quality of lung cancer resections.
- Trial name
- QualitySurg (NCT07828938)
- Testing
- QualitySurg List
- Where
- 20 sites in France
- Volunteers
- 2,400 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Stage II-III Non-small Cell Lung Cancer
Real World Stage II-III NSCLC Patients Receiving Neoadjuvant Chemo-immunotherapy and no Surgical Resection
Neoadjuvant chemo-immunotherapy, with or without adjuvant immunotherapy, is currently the standard of care for resectable stage II-III NSCLC.
- Trial name
- NoSurgery (NCT07131163)
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Sheba Medical Center
Carcinoma, Non-Small-Cell Lung
A Study of QL1706 Combined With Platinum-containing Chemotherapy in Adjuvant Treatment of Stage II-IIIB Non-small Cell Lung Cancer After Complete Surgical Resection.
The purpose of this study is to evaluate the efficacy and safety of QL1706 combined with platinum-based chemotherapy versus placebo combined with platinum-based chemotherapy in adjuvant treatment of stage II-IIIB NSCLC without…
- Trial name
- NCT05487391
- Testing
- QL1706 injection, Vinorelbine Tartrate, Paclitaxel
- Where
- China
- Volunteers
- 632 people
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Lung Cancer
Lung Cancer Detection in Never Smokers Using Urine Volatile Organic Compound (VOCs)
The goal of this observational study is to learn whether a urine-based test that measures volatile organic compounds (VOCs) can help detect lung cancer in people who have never smoked.
- Trial name
- NCT07871656
- Testing
- Biosensor Platform
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Thomas Jefferson University
Electrical Impedance Tomography (EIT), Postoperative Pulmonary Complications (PPCs)
EIT-guided PEEP Titration Versus Standard Ventilation in Bariatric Surgery
This study is a prospective, single-center, single-blind, randomized controlled clinical trial. Patients scheduled for laparoscopic bariatric surgery will be selected and randomly assigned to either the EIT-guided individualized…
- Conditions
- Electrical Impedance Tomography (EIT), Postoperative Pulmonary Complications (PPCs), Recruitment, Mechanical Ventilation Complication
- Trial name
- EIT (NCT07207772)
- Testing
- Group P-eit, Group P-8
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Jianbo Wu
Non-Small Cell Lung Cancer (NSCLC), Rehabilitation
Digital Rehabilitation With Wearable Monitors for Sequential Lung Cancer Resection
This is a prospective, open-label, parallel-group, 1:1 randomized controlled trial designed to evaluate whether a digital rehabilitation program integrated with wireless wearable continuous monitoring devices can shorten the time…
- Conditions
- Non-Small Cell Lung Cancer (NSCLC), Rehabilitation, Thoracic Surgery
- Trial name
- WEAR-MPLC (NCT07797075)
- Testing
- Wireless Wearable Vital Sign and Activity Monitor, Digital Pulmonary Rehabilitation Program, Standard ERAS Perioperative and Rehabilitation Care
- Where
- China
- Volunteers
- 222 people
- Sponsor
- West China Hospital
Nerve Block, Thoracoscopic Radical Resection of Lung Cancer
Analgesic Effects of Retro-superior Costotransverse Ligament Space Block for Video-assisted Thoracoscopic Surgery
The aim of this clinical trial is to investigate the effects of postoperative analgesia during retro-SCTLB(retro superior costotransverse ligament space block) and TPVB(thoracic paravertebral block) in patients undergoing…
- Trial name
- NCT07745881
- Testing
- Ultrasound-guided retro-SCTLB, Ultrasound-guided TPVB
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Lung Cancer
Robotic Assisted Major Lung Resection in Elderly Patients
The study is a retrospective observational study. The study is designed to be multicentric and it will analyze medical records from selected patients that underwent major lung resection using DaVinci surgical platform performed…
- Trial name
- ELDERLY (NCT06496386)
- Where
- 2 sites in Italy
- Volunteers
- 386 people
- Sponsor
- Scientific Institute San Raffaele
Surgical Procedures, Operative
A Study Comparing ETHICON™ 4000 Stapler System With Standard of Care Stapling Devices in Adults Undergoing Gastric and Thoracic Procedures
The purpose of this study is to compare how well the ETHICON™ 4000 Stapler works as compared to the standard stapling devices by assessing how often air leaks and bleeding along the staple line occur during lung and stomach…
- Trial name
- NCT07744568
- Testing
- ETHICON™ 4000 Stapler System, Standard of Care Stapler and Reloads
- Volunteers
- 300 people
- Sponsor
- Ethicon Endo-Surgery
Lung Cancer Metastatic, Surgical Resection
Primary Tumor Resection for M1a Stage Lung Cancer
This is a clinical trial from Eastern Cooperative Thoracic Oncology Project (ECTOP), numbered as ECTOP-1023. This study aims to explore the safety and efficacy of primary lesion resection in the treatment of M1a stage lung cancer…
- Trial name
- ECTOP-1023 (NCT06547710)
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Fudan University
Liver Cancer, Esophageal Cancer
Pre- and Post-operative TEG Indices in Patients With or Without Adenocarcinoma Undergoing Surgical Resection
The investigators hypothesize that abnormalities in thromboelastography (TEG) parameters in patients with liver, pancreas, biliary, esophageal, colorectal, and lung adenocarcinoma can serve as biomarkers for oncologic disease…
- Conditions
- Liver Cancer, Esophageal Cancer, Colorectal Cancer, Lung Adenocarcinoma
- Trial name
- TEG (NCT05517811)
- Testing
- TEG indices
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Lung Cancer
Application of SERS Technology Based Intraoperative Navigation System in Lung Cancer
This study aims to explore the application of Surface-enhanced Raman Scatting (SERS) technology in lung cancer surgery and clarify its mechanism through multi-omics mass spectrometry platform, and then further prove the clinical…
- Trial name
- NCT05881057
- Volunteers
- 200 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Lung Surgery, Chest Tube Removal
Patient Reported Outcomes Targeting Early Chest Tube Removal (PROTECTR) Study
This study is a single centre, prospective clinical trial evaluating the safety and feasibility of implementing a same day chest tube removal protocol in patients undergoing Video Assisted Thoracic Surgery (VATS) anatomical…
- Conditions
- Lung Surgery, Chest Tube Removal, Enhanced Recovery After Surgery (ERAS)
- Trial name
- PROTECTR (NCT06444854)
- Testing
- early chest tube removal
- Where
- Canada
- Volunteers
- 130 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
NSCLC, Non Small Cell Lung Cancer
Radical Resection With Contralateral Lymph Node Dissection for Clinical N3 NSCLC
*Study Overview This study is investigating a surgical approach for patients with a serious type of lung cancer known as non-small cell lung cancer (NSCLC), particularly those in an advanced stage where cancer has spread to both…
- Trial name
- NCT07003490
- Testing
- Radical Resection with Bilateral Lymph Node Dissection
- Where
- 2 sites in China
- Volunteers
- 30 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Lung Cancer, Surgery
Nutritional Therapy Enriched With Omega-3 in Patients With Lung Resection
The aim of this study is to analyze the effect of enriched formula with omega-3 in the 30-day incidence infection and inflammatory response following lung resection surgery in lung cancer patients.
- Trial name
- NCT06531460
- Testing
- Fish oil enteral supplementation, Fish oil oral supplementation, Enteral nutrition without fish oil
- Where
- Mexico
- Volunteers
- 310 people
- Sponsor
- National Institute of Respiratory Diseases, Mexico
Cancer, Lung Resection
The PRIMROSE Trial
Smoking is a major cause for developing lung cancer. People diagnosed with lung cancer, may be offered surgery which offers a complete cure.
- Conditions
- Cancer, Lung Resection, Inspiratory Muscle Training, Prehabilitation
- Trial name
- PRIMROSE (NCT07365072)
- Testing
- Inspiratory muscle training (POWERBreathe), Standard Prehab
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Swansea Bay University Health Board
Non-Small Cell Lung Cancer
SDTM001 Injection as Adjuvant Therapy for NSCLC Patients After Radical Surgical Resection
The goal of this clinical trial is to evaluate the safety profile and tolerability of SDT-M001 injection in NSCLC patients with driver-gene-negative and negative PD-L1 expression after radical surgical resection; to determine the…
- Trial name
- NCT07096882
- Testing
- SDT-M001 injection
- Where
- China
- Volunteers
- 22 people
- Sponsor
- Cytocraft Biopharmaceutical Co., Ltd.