Clinical trials: Pulmonary Resistance
Complicated Intra-abdominal Infection, Hosptial Acquired Pneumonia
A Study to Determine the Efficacy, Safety and Tolerability of Aztreonam-Avibactam (ATM-AVI) ± Metronidazole (MTZ) Versus Meropenem (MER) ± Colistin (COL) for the Treatment of Serious Infections Due to Gram Negative Bacteria.
A Phase 3 comparative study to determine the efficacy, safety and tolerability of Aztreonam-Avibactam (ATM-AVI) ± Metronidazole (MTZ) versus Meropenem (MER) ± Colistin (COL) for the treatment of serious infections due to Gram…
- Conditions
- Complicated Intra-abdominal Infection, Hosptial Acquired Pneumonia, Ventilator Associated Pneumonia
- Trial name
- REVISIT (NCT03329092)
- Testing
- ATM-AVI, MTZ, MER
- Where
- 157 sites in United States, Argentina and 19 more
- Volunteers
- 422 people
- Sponsor
- Pfizer
Carcinoma, Non-Small-Cell Lung
T-DM1 and Osimertinib Combination Treatment to Target HER2 Bypass Track Resistance in EGFR Mutation Positive NSCLC
This is a single arm open-label multi-center phase II study, investigating disease control rate after 3 months of treatment with trastuzumab-emtansine/osimertinib combination therapy in patients with advanced EGFR mutation…
- Trial name
- TRAEMOS (NCT03784599)
- Testing
- Trastuzumab emtansine, Osimertinib
- Where
- 5 sites in Netherlands
- Volunteers
- 28 people
- Sponsor
- The Netherlands Cancer Institute
Advanced Non Small Cell Lung Cancer, Advanced (Inoperable) Non Small Cell Lung Cancer
AZD9291 First Time In Patients Ascending Dose Study
This study will treat patients with advanced NSCLC who have already received at least one course of specific anti-cancer treatment but the tumour has started to re-grow following that treatment.
- Trial name
- AURA (NCT01802632)
- Testing
- AZD9291
- Where
- 45 sites in United States, Australia and 8 more
- Volunteers
- 603 people
- Sponsor
- AstraZeneca
Cystic Fibrosis, Methicillin-resistant Staphylococcus Aureus
Pharmacokinetics of Vancomycin for Inhalation in Cystic Fibrosis
The purpose of this study is to determine the pharmacokinetics and safety of inhaled vancomycin in patients with cystic fibrosis.
- Trial name
- NCT01509339
- Testing
- Vancomycin
- Where
- United States
- Sponsor
- Case Western Reserve University
Small Cell Lung Cancer Extensive Stage, Resistance to Immunotherapy
Sintilimab Plus Anlotinib as Second or Further-line Therapy for ES-SCLC Who Have Progressed After Anti-PD-1/L1 Therapy
The phase II study enrolled ES-SCLC patients who had disease progression after anti-PD-1/L1 therapy. Participants received intravenous sintilimab 200 mg on day one and oral daily anlotinib 8-12 mg on days 1-14 once every three…
- Trial name
- NCT07022301
- Testing
- sintilimab combined with anlotinib
- Volunteers
- 25 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Melanoma, Non Small Cell Lung Cancer
Identification of Marker of Primary or Acquired Resistance to Anti Tumorous Treatment
Lung Cancer and melanoma relapsed frequently whereas its very sensitive to treatment such as chemotherapy or radiotherapy. The purpose of this study is to have a better understanding of why those patients are relapsing using next…
- Conditions
- Melanoma, Non Small Cell Lung Cancer, Small Cell Lung Cancer
- Trial name
- MSN (NCT02105168)
- Testing
- Blood sample, Tumorous biopsy, Healthy material sample
- Where
- France
- Volunteers
- 2,200 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Chronic Obstructive Pulmonary Disease
The Role of Resistance Exercise in Chronic Obstructive Pulmonary Disease Exacerbation
The purpose of this study is to determine whether resistance exercise are effective in combating the decline in muscle strength during an exacerbation of Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- RECOPD (NCT01786928)
- Testing
- Resistance training
- Where
- Brazil
- Volunteers
- 34 people
- Sponsor
- University of Sao Paulo
Small Cell Lung Cancer ( SCLC )
Phase 1/2 Multicenter, Open-label, Dose-escalation Study of IDP- 121 in Patients With Platinum-resistant Small Cell Lung Cancer (MYCrocytic)
Phase 1/2 clinical trial is to evaluate the safety, pharmacokinetics and pharmacodynamics of escalating doses of IDP-121 combined with chemotherapy in patients with advanced unresectable/metastatic SCLC that have progressed after…
- Trial name
- MYCrocytic (NCT07864207)
- Testing
- IDP-121
- Where
- 10 sites in Spain
- Volunteers
- 60 people
- Sponsor
- IDP Discovery Pharma S.L.
Non-Small Cell Lung Cancer
DREAM Study: DNA/RNA-NGS Co-Testing in Driver-Negative, Treatment-Resistant NSCLC
The study is divided into two parts, Part A and Part B. The purpose of Part A is to reveal the proportion of NSCLC patients who are primarily resistant to first-line non-targeted therapy due to the omission of driver genes…
- Trial name
- NCT06846762
- Testing
- This study did not include intervention between the two cohorts
- Where
- China
- Volunteers
- 508 people
- Sponsor
- Baohui Han
Advanced Non-Small Cell Lung Cancer
Nimotuzumab Plus Docetaxel in Chemotherapy-Refractory/Resistant Patients With Advanced Non-Small-Cell Lung Cancer
Nimotuzumab is a humanized monoclonal anti-body targeting the epidermal growth factor receptor (EGFR). Clinical trials are ongoing globally to evaluate nimotuzumab in different indications.
- Trial name
- NCT00983047
- Testing
- Nimotuzumab and Docetaxel
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Biotech Pharmaceutical Co., Ltd.
Ventilator Associated Pneumonia, Respiratory Infection
Aerosolized Antibiotics and Respiratory Tract Infection in Patients on Mechanical Ventilation
The purpose of this study was to determine the effect of aerosolized antibiotics on respiratory infection in mechanically ventilated patients.We hypothesize that aerosolized antibiotics , which achieve high drug concentrations in…
- Conditions
- Ventilator Associated Pneumonia, Respiratory Infection, Tracheobronchitis
- Trial name
- NCT00396578
- Testing
- aerosolized vancomycin or gentamicin
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Stony Brook University
Exercise
An Investigation of Different Type Single Limb Exercise Training Effects in Copd
COPD presents not only respiratory symtoms but also vascular or muscle dysfunction. Exercise limitation is observed in COPD. Especially, decreased exercise performance related to vascular and fatique in quadriceps muscle.
- Trial name
- COPD (NCT06471439)
- Testing
- single leg exercise intervantion in COPD
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Hacettepe University
Chronic Obstructive Pulmonary Disease, Metabolic Syndrome
Impact of Roflumilast on Visceral Adiposity and Metabolic Profile in Chronic Obstructive Pulmonary Disease
The purpose of this study is to determine whether roflumilast can improve metabolic profile and reduce visceral adiposity in patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- RAMBO (NCT01701934)
- Testing
- Roflumilast
- Where
- 5 sites in Canada
- Volunteers
- 14 people
- Sponsor
- Laval University
Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease
Assessment of Total Pulmonary Resistance sPAP/CO Between High Altitude HA vs. Sea Level LA in Patients With Pulmonary Arterial Hypertension PAH
To study the effect of relocation from high altitude (Quito Ecuador: 2850m) to sea level on pulmonary resistance (sPAP/CO) and other hemodynamic outcomes in patients with pulmonary arterial hypertension PAH, who live permanently…
- Conditions
- Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease, High Altitude, Echocardiography
- Trial name
- NCT07804524
- Testing
- Descent from 2850m to sea level
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Silvia Ulrich Somaini
Pulmonary Tuberculoses, Aspergillosis
Pulmonary Aspergillosis in Tuberculosis Patients
Pulmonary tuberculosis (PTB) is the most common cause of lung destruction, contributing to coinfections development, and Aspergillosis spp. is one of the most important.
- Conditions
- Pulmonary Tuberculoses, Aspergillosis, Old Tuberculosis, Active Tuberculosis
- Trial name
- NCT05045391
- Testing
- Aspergillus IgG detection
- Where
- Uzbekistan
- Volunteers
- 200 people
- Sponsor
- Research Institute of Epidemiology, Microbiology and Infectious Diseases, Uzbekistan
PAH
PRIMEx - A Study of 2 Doses of Oral CXA-10 in Pulmonary Arterial Hypertension (PAH)
This is a multicenter double-blind, placebo-controlled study to evaluate the safety, efficacy and pharmacokinetics of 2 doses of CXA-10 on stable background therapy in 96 subjects 18 to 80 years of age with PAH.
- Trial name
- PAH (NCT03449524)
- Testing
- 75mg CXA-10, 150mg CXA-10
- Where
- 46 sites in United States, United Kingdom
- Volunteers
- 69 people
- Sponsor
- Complexa, Inc.
Carbapenem Resistant Bacteria Infection
European Prospective Cohort Study on Enterobacteriaceae Showing Resistance to Carbapenems
Among antibiotic-resistant organisms, the Gram-negative bacteria are now the most important challenge because of the rapid worldwide spread of mechanisms conferring resistance to multiple drugs.
- Trial name
- EURECA (NCT02709408)
- Where
- 50 sites in Albania, Bulgaria and 9 more
- Volunteers
- 2,515 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Pseudomonas Aeruginosa, COVID-19
Pseudomonas Aeruginosa Infections Among COVID-19 Patients in Intensive Care Units at CHRU of Nancy (Pyo-COVID-3)
P. aeruginosa is an opportunistic bacterium known to be responsible for numerous healthcare-associated infections, particularly in intensive care units (ICU).
- Trial name
- Pyo-COVID-3 (NCT06141837)
- Testing
- Observation
- Volunteers
- 51 people
- Sponsor
- Central Hospital, Nancy, France
Pulmonary Vascular Resistance Abnormality
PV Loop and Pulmonary Hypertension
The right ventricular (RV) systolic function is a key determinant of outcome in patients with pulmonary hypertension and elevated pulmonary vascular resistance.
- Trial name
- NCT05484596
- Testing
- Measuring VA Coupling
- Where
- 2 sites in United States
- Volunteers
- 65 people
- Sponsor
- Hythem Nawaytou
Non-Small Cell Lung Cancer, ROS1 Gene Rearrangement
Real-world Observational Study of Targeted Therapy in Patients With Advanced ROS1-positive NSCLC
The purpose of this project is to conduct an observational study on the efficacy and safety of entrectinib in real-world patients with ROS1-positive NSCLC who have received entrectinib treatment, while exploring the mechanism of…
- Conditions
- Non-Small Cell Lung Cancer, ROS1 Gene Rearrangement, Resistance, Targeted Therapy
- Trial name
- NCT06694129
- Testing
- Entrectinib
- Volunteers
- 40 people
- Sponsor
- National Cancer Center, China