Clinical trials: Pulmonary Resistance
Non-Small-Cell Lung
Anlotinib Hydrochloride Combined With EGFR TKIs in Advanced Non-small Cell Lung Cancer
After the second-line treatment of patients with non-T790M mutations, chemotherapy with platinum-containing drugs was used, and chemotherapy-related toxicity was high.
- Trial name
- NCT03766490
- Testing
- Anlotinib Hydrochloride, Gefitinib, Icotinib
- Where
- China
- Volunteers
- 66 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Tuberculosis
Effect of Xpert MTB/RIF on Patient Outcomes
A parallel-group prospective cohort study among adult persons living with HIV/AIDS to study the effect of a new TB diagnostic test, Xpert MTB/RIF on: 1) TB case detection; 2) time to TB diagnosis and TB treatment; 3) presumptive…
- Trial name
- NCT02729532
- Testing
- Xpert
- Where
- Zambia
- Volunteers
- 776 people
- Sponsor
- University of North Carolina, Chapel Hill
Control Condition, Pulmonary Disease (COPD), Chronic Obstructive
Acute Muscular and Vascular Responses to a Single Session of Exercise With BFR in COPD
Exercise training is a cornerstone of pulmonary rehabilitation (PR) in patients with chronic obstructive pulmonary disease (COPD). However, some patients derive limited benefits from conventional exercise programs.
- Conditions
- Control Condition, Pulmonary Disease (COPD), Chronic Obstructive, Blood Flow Restriction Training (BFRT)
- Trial name
- 2BFREE_aigu (NCT07668921)
- Testing
- Blood Flow Restriction, Standard exercise session
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Grenoble
Tuberculosis, Multidrug-Resistant, Tuberculosis
Linezolid Dosing Strategies in Drug-Resistant TB
The purpose of the study was to evaluate the efficacy (how well the medicines work) and tolerability (whether participants stop treatment because of side effects from a drug) of an anti-TB treatment regimen that compared two…
- Conditions
- Tuberculosis, Multidrug-Resistant, Tuberculosis, Tuberculosis, Pulmonary
- Trial name
- NCT05007821
- Testing
- Linezolid 600 mg, Linezolid 1200 mg (QD), Linezolid 1200 mg (TIW)
- Where
- 13 sites in Botswana, Brazil and 5 more
- Volunteers
- 138 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pancreatic Adenocarcinoma, Cholangiocarcinoma
Clinical Efficacy and Safety of Paclitaxel Polymeric Micelles for Injection in the Treatment of Patients With Taxans-resistant Pancreatic Adenocarcinoma, Cholangiocarcinoma, Lung Cancer, Gastric Cancer, Esophageal Carcinoma, or Breast Cancer
This study is a single-center, single-arm, open-label, phase II clinical trial designed to evaluate the efficacy and safety of Paclitaxel Polymeric Micelles for Injection for the treatment of patients with advanced pancreatic…
- Conditions
- Pancreatic Adenocarcinoma, Cholangiocarcinoma, Lung Cancer, Stomach Cancer
- Trial name
- NCT06199895
- Testing
- Paclitaxel Polymeric Micelles for Injection
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Liu Huang
Metastatic Castration Resistant Prostate Cancer (mCRPC), Small Cell Lung Cancer (SCLC)
A Study of Mevrometostat for Treatment of Relapsed/Refractory SCLC, Castration Resistant Prostate Cancer, and Follicular Lymphoma
The purpose of this study is to learn about the safety and effects of the study medicine (called Mevrometostat) for the possible treatment of Relapsed/ Refractory Small Cell Lung Cancer (SCLC), Castration Resistant Prostate…
- Conditions
- Metastatic Castration Resistant Prostate Cancer (mCRPC), Small Cell Lung Cancer (SCLC), Follicular Lymphoma (FL)
- Trial name
- NCT03460977
- Testing
- Mevrometostat (PF-06821497), Enzalutamide, Itraconazole
- Where
- 85 sites in United States, Bulgaria and 6 more
- Volunteers
- 453 people
- Sponsor
- Pfizer
Tuberculosis
Multi-Drug Resistant Tuberculosis in Korea
This study, conducted in Korea, will examine why some people are more susceptible to tuberculosis (TB) than others and why some strains of M tuberculosis (the bacteria that causes TB) are more difficult to treat or become…
- Trial name
- NCT00341601
- Where
- 2 sites in South Korea
- Volunteers
- 777 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Non-small Cell Lung Cancer, EGFR Mutations
Understanding Mechanisms of Acquired Resistance to BIBW2992
In this research study we are looking to see how effective BIBW 2992 is at suppressing the development of the T790M mutation in non-small cell lung cancer (NSCLC) patients.
- Trial name
- NCT01074177
- Testing
- BIBW 2992
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Massachusetts General Hospital
Solid Tumor, Small Cell and Non-small Cell Lung Cancer
RAPA-201 Therapy of Solid Tumors
The therapy of solid tumors has been revolutionized by immune therapy, in particular, approaches that activate immune T cells in a polyclonal manner through blockade of checkpoint pathways such as PD-1 by administration of…
- Conditions
- Solid Tumor, Small Cell and Non-small Cell Lung Cancer, Head and Neck Cancer, Squamous Cell Carcinoma of Oral Cavity
- Trial name
- NCT05144698
- Testing
- RAPA-201 Rapamycin Resistant T Cells, Chemotherapy Prior to RAPA-201 Therapy, Pembrolizumab (PD-1 Blocking Antibody)
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Rapa Therapeutics LLC
Non Small Cell Lung Cancer
β-elemene Combine With EGFR-TKI for Advanced EGFR-TKI-resistant NSCLC
Epidermal Growth Factor Receptor tyrosine-kinase inhibitors （EGFR-TKIs）, including gefitinib，erlotinib and icotinib demonstrate excellent effect on the treatment of non small cell lung cancer (NSCLC) patients with EGFR mutations.
- Trial name
- NCT03123484
- Testing
- β-elemene, EGFR-TKIs(Erlotinib, Gefitinib and Icotinib)
- Volunteers
- 80 people
- Sponsor
- China Medical University, China
COPD Exacerbation, Invasive Mechanical Ventilation
Sevoflurane in Chronic Obstructive Pulmonary Disease Exacerbation
Prospective, open-label, single-center, study to investigate the effect of sevoflurane sedation compared to a propofol-controlled arm during COPD exacerbation requiring invasive mechanical ventilation in ICU.
- Trial name
- SEVOCOPD (NCT03460015)
- Testing
- Sevoflurane, Propofol
- Where
- France
- Volunteers
- 16 people
- Sponsor
- University Hospital, Montpellier
Pulmonary Arterial Hypertension
Estimation of Pulmonary Vascular Resistance by Contrast Echocardiography
An echocardiogram using Definity contrast can provide the same information as the standard right heart catheterization.
- Trial name
- NCT02028299
- Testing
- 2D doppler echo with Definity solution
- Volunteers
- 38 people
- Sponsor
- George Washington University
Lower Respiratory Tract Infection (LRTI), Pneumonia
Optimising Antibiotic Use for Paediatric Lower Respiratory Tract Infections in Africa
Lower respiratory tract infections (LRTIs) remain a leading cause of hospitalisation and death among young children in Africa. Although viral infections account for a substantial proportion of LRTIs, antibiotics are frequently…
- Conditions
- Lower Respiratory Tract Infection (LRTI), Pneumonia, Bronchopneumonia, Bronchiolitis
- Trial name
- BEACON (NCT07841691)
- Testing
- CRP- and PREPARE-guided Antibiotic Prescription
- Where
- South Africa
- Volunteers
- 400 people
- Sponsor
- University of Witwatersrand, South Africa
Asthma, Obesity
Examining the Link Between Obesity, Inflammation, and Response to Asthma Medications
Asthma is a common, long-term disease that is caused by inflammation of the airways. Inflammation also plays a role in obesity and may affect the way a person responds to asthma medication.
- Trial name
- NCT00557180
- Testing
- Beclomethasone dipropionate HFA, Tiotropium bromide, Salmeterol xinafoate
- Where
- 10 sites in United States
- Volunteers
- 33 people
- Sponsor
- National Jewish Health
Resistance Training
Chronic Effects Using Light-Emitting Diode Therapy (LEDT) During a Resistance Exercise Protocol for Asthmatic Patients
The objective of this study is to evaluate the effects of LED phototherapy associated with a resistance training protocol on the peripheral muscle function of moderate to severe asthmatic patients ..
- Trial name
- NCT03112239
- Testing
- Light-Emitting Diode Therapy (LEDT)
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Nove de Julho
Acute Myeloid Leukemia, Brain Glioblastoma
Health Care Coach Support in Reducing Acute Care Use and Cost in Patients With Cancer
This randomized pilot clinical trial studies health care coach support in reducing acute care use and cost in patients with cancer.
- Conditions
- Acute Myeloid Leukemia, Brain Glioblastoma, Estrogen Receptor Negative, Extensive Stage Small Cell Lung Carcinoma
- Trial name
- NCT03154190
- Testing
- Best Practice, Laboratory Biomarker Analysis, Supportive Care
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Stanford University
Covid19
CISCO-21 Prevent and Treat Long COVID-19.
Many people have long-lasting symptoms after COVID-19, such as breathlessness, fatigue and chest pain. So far, research studies of treatments for COVID-19 have focused on the life-threatening acute illness; few studies look at…
- Trial name
- CISCO-21 (NCT04900961)
- Testing
- Resistance Exercise
- Where
- 2 sites in United Kingdom
- Volunteers
- 233 people
- Sponsor
- NHS Greater Glasgow and Clyde
Lung Neoplasms, Lung Cancer, Nonsmall Cell
Therapeutic ResistAnce and Clonal Evolution Assessed With Liquid Biopsy of NSCLC Patients in China
To evaluate the concordance of sensitizing mutations detected between paired plasma and tissue samples; the correlation between the clonal status of sensitizing mutations and targeted therapy response; and the prognostic impact…
- Conditions
- Lung Neoplasms, Lung Cancer, Nonsmall Cell, Adenocarcinoma of Lung, Squamous Cell Lung Cancer
- Trial name
- NCT03059641
- Where
- 14 sites in China
- Volunteers
- 300 people
- Sponsor
- Geneplus-Beijing Co. Ltd.
NSCLC Patients With EGFR Activating Mutation
A Multicenter Randomized Phase III Study Comparing Second-line Treatment With Chemotherapy Associated or Not to Erlotinib in NSCLC Patients With Secondary Resistance to TKI-EGFR
The current first line treatment of patients with EGFR activating mutation lung cancer is EGFR TKI. Compared to platinum-based chemotherapy, EGFR-TKIs are superior in terms of response rate and progression-free survival.
- Trial name
- FLARE (NCT02178397)
- Testing
- ERLOTINIB WITH CHEMOTHERAPY, CHEMOTHERAPY ONLY
- Where
- 35 sites in France
- Volunteers
- 6 people
- Sponsor
- Centre Francois Baclesse
Non-small Cell Lung Cancer
Efficacy of Cadonilimab in Non-squamous Non-small Cell Lung Cancer Patients Resistant to EGFR-TKI
This study was designed to evaluate the efficacy and safety of cadonilimab (anti PD-1 and CTLA-4 bispecific antibody) in combination with pemetrexed and anlotinib for treatment of elderly patients with T790M-negative advanced…
- Trial name
- NCT06277674
- Testing
- Cadonilimab plus Pemetrexed and Anlotinib
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Guangzhou University of Traditional Chinese Medicine