Clinical trials: Pulmonary Sepsis
Pneumonia, Acute Pyelonephritis
NGS-Based Assay of Blood Samples of Sepsis Patients for Rapid Bacterial Identification
Rapid detection of microorganisms is a promising approach towards early administration of appropriate antibiotics for sepsis. This study aims to investigate the potential of a new NGS platform for the rapid diagnosis of…
- Conditions
- Pneumonia, Acute Pyelonephritis, Bacteremia, Biliary Tract Infection
- Trial name
- BIOARTE (NCT06141395)
- Testing
- NGS-based assay for bacterial identification
- Where
- 4 sites in Greece
- Volunteers
- 100 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Sepsis, ARDS
The Effect of Positive End Expiratory Pressure on Central Venous Pressure Among Patients With Different Lung Compliance
To observe the effect of PEEP on CVP among patients with different respiratory compliance
- Conditions
- Sepsis, ARDS, Traumatic Brain Injury
- Trial name
- NCT03341572
- Testing
- 5,10 and 15cmH2O positive end expiratory pressure
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Jingyuan,Xu
Gastroenteritis, Bronchiolitis
Isotonic Versus Hypotonic Fluid for Maintenance IV Therapy
Hyponatremia associated with administration of hypotonic intravenous (IV) fluids may have serious complications. It has recently been suggested that isotonic saline may be a more appropriate choice of maintenance IV fluid.
- Conditions
- Gastroenteritis, Bronchiolitis, Sepsis, Urinary Tract Infection
- Trial name
- NCT00457873
- Testing
- 0.9% saline in 5% dextrose (intravenous), 0.45% saline in 5% dextrose (intravenous)
- Where
- Canada
- Volunteers
- 38 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Sepsis, Lung Injury
Inhalational Versus Intravenous Anesthesia on Postoperative Lung Injury in Septic Patients Undergoing Surgery
This randomized controlled trial will compare the effects of intraoperative inhalational anesthesia versus intravenous anesthesia on postoperative lung injury in septic patients undergoing surgery.
- Trial name
- NCT07601256
- Testing
- Inhalation Anesthesia, intravenous anesthesia
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Critically Ill
Coated Devices to Decrease Infection in the Intensive Care Unit
Pilot explanatory, randomized, open label, controlled trial. Critically ill patients which will demand placement of invasive devices for organ support (endotracheal tube, central venous catheter and urinary Foley catheter) will…
- Trial name
- CRITIC (NCT03868241)
- Testing
- Coated devices, Control
- Where
- 6 sites in Brazil
- Volunteers
- 103 people
- Sponsor
- Hospital do Coracao
Blood Stream Infections, Ventilator Associated Pneumonia
EaRly impAct theraPy With Ceftazidime-avibactam Via rapID Diagnostics
RAPID is an investigator initiated Phase 4, multinational, multicentre, open-label, randomised controlled superiority trial evaluating the clinical impact of rapid microbiological diagnostics combined with antimicrobial…
- Conditions
- Blood Stream Infections, Ventilator Associated Pneumonia, Healthcare Associated Infection, Carbapenem-Resistant Enterobacteriaceae Infection
- Trial name
- RAPID (NCT05979545)
- Testing
- Rapid Diagnostics
- Where
- 21 sites in India, Malaysia and 5 more
- Volunteers
- 1,526 people
- Sponsor
- National University of Singapore
Covid19
Convalescent Plasma for Treatment of COVID-19
Convalescent plasma has been shown to be safe and effective for treatment of several diseases. Preliminary data indicate that it is safe for treatment of COVID-19.
- Trial name
- NCT04649879
- Testing
- SARS-CoV-2 convalescent plasma, Standard of care
- Where
- 3 sites in Sweden
- Volunteers
- 59 people
- Sponsor
- Joakim Dillner
Hypoxemia, Pulmonary Sepsis
Lung Protective One-lung Ventilation With Fix and Variable Tidal Volume
During One-lung ventilation, the use of lower tidal volumes (VT) is helpful to avoid over-distension, provide sufficient oxygenation, but can result in increased atelectasis.
- Conditions
- Hypoxemia, Pulmonary Sepsis, ARDS, Human, Pneumonia
- Trial name
- NCT03364465
- Testing
- change of ventilatory settings
- Where
- Hungary
- Volunteers
- 140 people
- Sponsor
- University of Debrecen
Malnutrition, Pneumonia
Childhood Acute Illness and Nutrition Network
The CHAIN Network aims to identify modifiable biomedical and social factors driving the greatly increased risk of mortality among young undernourished children admitted to hospital with acute illness, as inpatients and after…
- Conditions
- Malnutrition, Pneumonia, Diarrhea, Sepsis
- Trial name
- CHAIN (NCT03208725)
- Where
- 8 sites in Bangladesh, Kenya and 3 more
- Volunteers
- 4,335 people
- Sponsor
- University of Oxford
Acute Respiratory Distress Syndrome
Mesenchymal Stem Cells (MSCs) and Conditioned Medium Mesenchymal Stem Cells as Adjuvant Therapy for Sepsis
This study was conducted to determine the effect of Umbilical Cord Mesenchymal Stem Cell (UC-MSC) and Secretome in severe ARDS patients.
- Trial name
- NCT07439848
- Testing
- Control (NaCl 0.9%), UC-MSC, UC-MSC and Secretome
- Where
- Indonesia
- Volunteers
- 15 people
- Sponsor
- PT. Prodia Stem Cell Indonesia