Clinical trials: Pulmonary Thromboembolisms
Small Cell Lung Cancer
A Randomized Study to Evaluate the Effect of Two Different Doses of Enoxaparin Sodium in Combination With Standard Chemotherapy in Patients With Stage Small Cell Lung Cancer (SCLC)
The purpose of this research study is to see if adding enoxaparin sodium to standard treatment with the chemotherapy drugs cisplatin and etoposide will help treat extensive stage SCLC.
- Trial name
- NCT00916669
- Testing
- Etoposide, Cisplatin, enoxaparin sodium
- Where
- 4 sites in United States
- Sponsor
- Massachusetts General Hospital
Recurrent Venous Thrombosis
Risk of Recurrent Venous Thromboembolism After Provoked Venous Thromboembolism
Venous thromboembolism (VTE) is a common disease with an incidence of 1-2/1000 persons per year. VTE is a chronic disease with a considerable risk of recurrence. Patients with unprovoked VTE, i.e.
- Trial name
- AURECpro (NCT04124159)
- Where
- Austria
- Volunteers
- 200 people
- Sponsor
- Medical University of Vienna
Pulmonary Embolism
Crux Biomedical Evaluation of the Crux Inferior Vena Cava Filter System 3 ("RETRIEVE 3")
The purpose of this study is to determine if the Crux Vena Cava Filter System is safe and effective in preventing pulmonary embolism.
- Trial name
- RETRIEVE 3 (NCT01120522)
- Testing
- Inferior Vena Cava Filter
- Where
- 2 sites in Belgium
- Volunteers
- 17 people
- Sponsor
- Crux Biomedical
Venous Thromboembolism, Active Cancer
Edoxaban Versus Apixaban in Cancer-Associated Venous Thromboembolism
This prospective, multicenter, randomized, open-label, blinded-endpoint trial aims to compare the clinical efficacy and safety of edoxaban-based treatment versus apixaban-based treatment in patients with cancer-associated venous…
- Trial name
- NEXT-CAT (NCT07852637)
- Testing
- edoxaban, Apixaban
- Where
- 12 sites in South Korea
- Volunteers
- 2,300 people
- Sponsor
- Samsung Medical Center
Venous Thrombosis
Evaluation of PD 0348292 for Preventing Blood Clots in the Lungs or Deep Leg Veins of Patients After Knee Surgery
To study the safety and effectiveness of several doses of PD 0348292 compared to enoxaparin in preventing blood clots in the lungs or deep leg veins of patients after knee surgery
- Trial name
- NCT00306254
- Testing
- PD 0348292, Enoxaparin
- Where
- 134 sites in United States, Australia and 14 more
- Volunteers
- 1,225 people
- Sponsor
- Pfizer
Venous Thromboembolism, Deep Vein Thrombosis
Weight-Based Enoxaparin Dosing and Real-Time Dose Adjustment in Orthopaedic Trauma
The rates of Venous thromboembolism (VTE) after orthopedic surgery are as high as 40-60% without prophylactic measures. Enoxaparin, a low-molecular-weight heparin, produces an anticoagulant effect by binding antithrombin, thereby…
- Conditions
- Venous Thromboembolism, Deep Vein Thrombosis, Pulmonary Embolus
- Trial name
- NCT03339349
- Testing
- Enoxaparin
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Utah
Coronavirus Disease 2019
Covid-19 Associated Coagulopathy Predicted by Thrombodynamic Markers (CoViTro-I)
The aim of the study is estimating the predictive and preventative capability of thrombodynamics for severe pneumonia coagulopathy complications in patients with COVID-19 infection.
- Trial name
- NCT05330832
- Testing
- Thrombodynamics test
- Where
- Russia
- Volunteers
- 2,200 people
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Deep Vein Thrombosis, Superficial Thrombophlebitis
DOACT Algorithm Versus AI-Based Decision Models in Oral Anticoagulant Therapy for Vascular Patients
Study using a decision algorithm for the application of an oral anticoagulant calculator in vascular diseases, aimed at validating a clinical decision-support tool for conditions such as deep vein thrombosis, superficial…
- Conditions
- Deep Vein Thrombosis, Superficial Thrombophlebitis, Pulmonary Thromboembolisms, Clinical Decision Support Systems
- Trial name
- DOACT (NCT07290608)
- Testing
- DOACT algorithm, No algorithm, LLM-based tools
- Where
- Brazil
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- ITALO EUGENIO SOUZA GADELHA DE ABREU
Venous Thromboembolism, Postpartum Period
The PARTUM Trial: Postpartum Aspirin to Reduce Thromboembolism Undue Morbidity
The goal of the PARTUM trial is to determine if taking low-dose aspirin daily for 6 weeks after delivery is similar (non-inferior) to usual care low-molecular-weight heparin injections to prevent venous thromboembolism (VTE…
- Conditions
- Venous Thromboembolism, Postpartum Period, Aspirin, Low Molecular Weight Heparin
- Trial name
- NCT06494878
- Testing
- Aspirin, Low-molecular-weight heparin
- Where
- 12 sites in Belgium, Canada and 5 more
- Volunteers
- 8,805 people
- Sponsor
- University of Calgary
Venous Thromboembolism
Follow-up in Rivaroxaban Patients in Setting of Thromboembolism
In patients with acute clots (deep vein thrombosis or pulmonary embolism) the investigators will collect real world data on their short and long term outcomes.
- Trial name
- FIRST (NCT02248610)
- Testing
- Non-interventional study
- Where
- 4 sites in United Kingdom
- Volunteers
- 1,343 people
- Sponsor
- King's College Hospital NHS Trust
Pulmonary Embolism, Deep Vein Thrombosis
PET Fibrin Imaging of DVT and PE
This study aims to investigate a novel positron emission tomography(PET)-probe for imaging of fresh intravascular blood clots in pulmonary embolism (PE) and deep venous thrombosis (DVT).
- Conditions
- Pulmonary Embolism, Deep Vein Thrombosis, Venous Thromboembolism
- Trial name
- NCT04022915
- Testing
- 64Cu-FBP8, PET-CT imaging
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Peter Caravan
Thrombosis, Pulmonary Embolism
Association of Anti-factor Xa Activity With Venous Thromboembolism in Critically Ill Patients
The goal of this observational study is to analyse the association between anti-factor Xa activity (antiXa) and the occurence of venous thromboembolism (VTE; either deep vein thrombosis and/or pulmonary embolism) in critically…
- Conditions
- Thrombosis, Pulmonary Embolism, Enoxaparin
- Trial name
- AntiXa-ICU (NCT06357403)
- Testing
- Anti-factor Xa activity calibrated for enoxaparin
- Where
- 3 sites in Austria
- Volunteers
- 1,300 people
- Sponsor
- Medical University of Vienna
Venous Thromboembolism, Postpartum Period
Pilot PARTUM Trial: Postpartum Aspirin to Reduce Thromboembolism Undue Morbidity
The pilot PARTUM trial is a randomized, multicenter, placebo-controlled trial. Women who are at modest risk of VTE (as defined by the inclusion criteria) will be identified during pregnancy, labor and delivery and up to 48 hours…
- Conditions
- Venous Thromboembolism, Postpartum Period, Aspirin
- Trial name
- PARTUM (NCT04153760)
- Testing
- Aspirin 81 mg
- Where
- 7 sites in Canada, France and 2 more
- Volunteers
- 257 people
- Sponsor
- University of Calgary
Pulmonary Thromboembolism, Obstructive Sleep Apnea
Obstructive Sleep Apnea in Pulmonary Embolism
Obstructive sleep apnea (OSA) is a clinical syndrome characterized by repetitive closure of the airway and frequent awakenings during sleep.
- Trial name
- NCT01580085
- Testing
- polysomnography
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- University of Gaziantep
Recent Stroke, Pulmonary Embolism
Pulmonary Embolism and Stroke in Patient With Patent Foramen Ovale
The cause of ischemic stroke remains frequently unknown. In patients with patent foramen ovale (PFO), the link between PFO and Stroke is unclear.
- Conditions
- Recent Stroke, Pulmonary Embolism, Patent Foramen Ovale
- Trial name
- EPIC-FOP (NCT01216423)
- Where
- 4 sites in France
- Volunteers
- 374 people
- Sponsor
- University Hospital, Brest
COVID, Acute Coronary Syndrome
Cardiovascular Complications and COVID-19 (CovCardioVasc-Study)
Patients with COVID-19 in the Intensive Care Unit (ICU) or hospitalized with severe form have a poor prognosis (almost 30% rate of death).
- Conditions
- COVID, Acute Coronary Syndrome, Myocardial Infarction, Myocarditis
- Trial name
- CovCardioVasc (NCT04335162)
- Where
- 8 sites in France
- Volunteers
- 198 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Venous Thromboembolism, Deep Vein Thrombosis (DVT)
Comparative Investigation of Low Molecular Weight (LMW) Heparin/Edoxaban Tosylate (DU176b) Versus (LMW) Heparin/Warfarin in the Treatment of Symptomatic Deep-Vein Blood Clots and/or Lung Blood Clots. (The Edoxaban Hokusai-VTE Study).
Evaluation of heparin/edoxaban tosylate (DU176b) versus heparin/warfarin in preventing recurrence of blood clots in patients with acute symptomatic deep-vein blood clots in the legs and/or blood clots in the lungs.
- Conditions
- Venous Thromboembolism, Deep Vein Thrombosis (DVT), Pulmonary Embolism (PE), Thromboembolism
- Trial name
- NCT00986154
- Testing
- edoxaban tosylate(DU-176b), low molecular weight heparin/unfractionated heparin, warfarin
- Where
- 454 sites in United States, Argentina and 36 more
- Volunteers
- 8,292 people
- Sponsor
- Daiichi Sankyo
Acute Coronary Syndrome, Venous Thrombosis
Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Practice (Sweden)
This prospective cohort study will provide information about: Characteristics of Rivaroxaban use in patients who are prescribed Rivaroxaban for the first time compared to patients who are prescribed standard of care for the first…
- Conditions
- Acute Coronary Syndrome, Venous Thrombosis, Pulmonary Embolism, Atrial Fibrillation
- Trial name
- NCT02468102
- Testing
- Rivaroxaban (Xarelto, BAY59-7939), Standard of care drugs
- Where
- Sweden
- Volunteers
- 99,999 people
- Sponsor
- Bayer
Pulmonary Embolism
Crux Biomedical Vena Cava Filter Study - United States
The purpose of this study is to determine if the Crux Vena Cava Filter System is safe and effective in preventing pulmonary embolism.
- Trial name
- RETRIEVE 2 (NCT01120509)
- Testing
- Inferior Vena Cava Filter
- Where
- 17 sites in United States
- Volunteers
- 88 people
- Sponsor
- Crux Biomedical
Deep Vein Thrombosis, Venous Thromboembolism
Post-Market Celect Platinum Vena Cava Filter and Gunther Tulip Retrieval Set Study
This prospective, observational, post-market study will be performed to collect patient-level data on the Celect Platinum Vena Cava Filter Sets and the Günther Tulip Vena Cava Filter Retrieval Set to confirm continued safety and…
- Conditions
- Deep Vein Thrombosis, Venous Thromboembolism, Pulmonary Embolism
- Trial name
- NCT05881798
- Testing
- Celect Platinum Vena Cava Filter
- Where
- 7 sites in United States, Spain and 1 more
- Volunteers
- 82 people
- Sponsor
- Cook Research Incorporated