Clinical trials: Pulmonary Tuberculosis (TB)
Recurrent Tuberculosis
Vitamin D to Resolve Inflammation After Tuberculosis (ResolveD-TB)
This Strategic Research Project is a translational proof-of-concept study that will determine whether vitamin D3 has potential to prevent recurrent tuberculosis (TB), as indicated by enhanced resolution of pulmonary inflammation…
- Trial name
- ResolveD-TB (NCT03011580)
- Testing
- Fultium-D3
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Queen Mary University of London
Pulmonary Tuberculosis
The Safety and Efficacy of BDL(Bedaquiline Plus Delamanid Plus Linezolid) Regimen in Subjects With Pulmonary Infection of Multi-drug Resistant Tuberculosis (MDR-TB) or Rifampicin-Resistant Tuberculosis (RR-TB)
The goal of this investigator initiated trial (IIT) is to learn if a 6-9months BDL regimen (bedaquiline plus delamanid plus linezolid）works to treat adults with multi-drug resistant tuberculosis or rifampicin-resistant pulmonary…
- Trial name
- NCT06476210
- Testing
- BDL regimen
- Where
- 7 sites in China
- Volunteers
- 45 people
- Sponsor
- Beijing Chest Hospital
Tuberculosis, Pulmonary
Early Bactericidal Activity (EBA) of SQ109 in Adult Subjects With Pulmonary TB
SQ109 was developed with the aim of shortening TB treatment and providing new drugs for resistant TB. The drug has demonstrated efficacy in toxicology studies and an acceptable safety profile in first-in-man studies.
- Trial name
- SQ109EBA (NCT01218217)
- Testing
- SQ109, Rifampicin
- Where
- 2 sites in South Africa
- Volunteers
- 90 people
- Sponsor
- Michael Hoelscher
Tuberculosis
A Trial of Stratified Patient-Centered Treatment Regimens for Active TB (SPECTRA-TB)
The A5414 study will evaluate whether treatment for drug-susceptible pulmonary tuberculosis (TB) can be tailored according to a participant's risk of an unfavorable outcome.
- Trial name
- NCT07595042
- Testing
- Isoniazid, Rifampin, Pyrazinamide
- Where
- 29 sites in Argentina, Australia and 14 more
- Volunteers
- 900 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tuberculosis
Reactogenicity, Safety and Immunogenicity of a TB/FLU-01L Tuberculosis Vaccine
The study is a single centre, phase I, open, randomized, by intranasal and sublingual application trial that explored the safety and immunogenicity of 2 doses (Day 1 and Day 21) TB/FLU-01L tuberculosis vaccine in BCG-vaccinated…
- Trial name
- NCT03017378
- Testing
- TB/FLU-01L
- Where
- Kazakhstan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Research Institute for Biological Safety Problems
Smear Positive Pulmonary Tuberculosis
L-arginine and Vitamin D Adjunctive Therapy in Pulmonary Tuberculosis (TB)
The purpose of this study is to determine whether adjunctive L-arginine and vitamin D can improve response to standard short course TB therapy in people with newly diagnosed pulmonary TB.
- Trial name
- AVDAPT (NCT00677339)
- Testing
- L-arginine, Vitamin D
- Where
- Indonesia
- Volunteers
- 200 people
- Sponsor
- Menzies School of Health Research
Tuberculosis, Pulmonary, Households
Acceptability and Feasibility of Home-based TB Testing
This study aims to evaluate the utility of home-based point-of-care TB testing for early diagnosis and linkage to care of household contacts of TB patients, addressing the need for active case finding and early detection of…
- Trial name
- NCT04973371
- Testing
- Home-based point-of-care (POC) TB testing using GeneXpert device + MTB/RIF test
- Where
- South Africa
- Volunteers
- 98 people
- Sponsor
- Foundation for Professional Development (Pty) Ltd
Tuberculosis, Pulmonary
Evaluation of the Efficacy and Safety of a 4-month Daily Regimen (2HZPM/2HPM) for Treatment of Pulmonary TB
The development of efficacious, safe, and shorter treatment regimens could significantly improve TB management and treatment success rates.
- Trial name
- ESCAPE-TB (NCT04856644)
- Testing
- 4-month rifapentine-based regimen
- Where
- 4 sites in Taiwan
- Volunteers
- 333 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Tuberculosis, Pulmonary
Co-Infection of NTM in Patients With Smear Positive Pulmonary TB
The aim of this study is to elucidate the prevalence of nontuberculous mycobacterial (NTM) co-infection in patients with smear positive pulmonary TB.
- Trial name
- NCT00567151
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Seoul National University Hospital
Tuberculosis, Pulmonary, Tuberculosis, Extrapulmonary
Clinical Evaluation of the NanoDetect-TB Mycobacterium Tuberculosis Detection Kit for the Diagnosis of Tuberculosis Disease
The goal of this observational study is investigate the accuracy of the NanoDetect-TB kit in diagnosing tuberculosis (TB) using frozen serum and plasma samples collected from individuals suspected to have TB disease.
- Conditions
- Tuberculosis, Pulmonary, Tuberculosis, Extrapulmonary, Tuberculosis Active
- Trial name
- NCT05981495
- Testing
- NanoDetect-TB
- Volunteers
- 460 people
- Sponsor
- NanoPin Technologies, Inc.
Tuberculosis, Pulmonary
Evaluation of PET/MRI Using a Somatostatin Analog Tracer as a Novel Approach to Detecting Pathology in High Risk TB-exposed Contacts
PET/MRI (positron emission tomography/magnetic resonance imaging) with somatostatin analog tracers has the potential to provide an imaging technique targeting subclinical granulomatous disease in those with latent tuberculosis…
- Trial name
- NCT02967666
- Testing
- FDG ligand, DOTANOC ligand
- Where
- 2 sites in Singapore
- Volunteers
- 30 people
- Sponsor
- National University Hospital, Singapore
Tuberculosis, Tuberculosis, Pulmonary
A Systemic Screening for TB Disease in High-risk Groups in Barcelona
The purpose of this screening study is to identify and screen vulnerable population in Barcelona for active pulmonary tuberculosis
- Trial name
- SYS-TB-S (NCT06706596)
- Testing
- Screening for TB symptoms, Chest X-ray
- Where
- Spain
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Fundació Institut Germans Trias i Pujol
TB - Tuberculosis HIV
Lipoarabinomannan (LAM) in Urine for Diagnosis of Pulmonary Tuberculosis in HIV Patients
A diagnostic validity study in which urinary LAM was done in seropositive HIV patients with symptoms suggestive of TB who were included and investigated with battery of tests to reach the final diagnosis.
- Trial name
- NCT04813666
- Testing
- Urinary LAM ELISA:
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Lung Diseases, Tuberculosis
Promoting Adherence to TB Regimens in Latino Adolescents
To test a public health model of screening, preventive isoniazid treatment, and adherence counseling plus medical education of primary care clinicians to enhance their skills and attention to TB control.
- Trial name
- NCT00005738
- Sponsor
- San Diego State University
Tuberculosis, Multidrug-Resistant, Tuberculosis
Evaluating Newly Approved Drugs in Combination Regimens for Multidrug-Resistant TB With Fluoroquinolone Resistance (endTB-Q)
endTB-Q Clinical Trial is a Phase III, randomized, controlled, open-label, non-inferiority, multi-country trial evaluating the efficacy and safety of two new, all-oral, shortened regimens for multidrug-resistant tuberculosis…
- Conditions
- Tuberculosis, Multidrug-Resistant, Tuberculosis, Pulmonary Tuberculoses, Mycobacterial Infections
- Trial name
- endTB-Q (NCT03896685)
- Testing
- Bedaquiline 100 MG, Delamanid 50 MG Oral Tablet, Clofazimine 100 MG Oral Capsule
- Where
- 10 sites in India, Kazakhstan and 4 more
- Volunteers
- 323 people
- Sponsor
- Médecins Sans Frontières, France
Lung Tuberculosis, MDR TB
Tuberculosis Research of INA-RESPOND On Drug Resistance
This study is a prospective observational cohort study of TB patients who are treated or evaluated at 10 study sites. Patients presenting with cough for 2 weeks or longer with at least one additional TB symptom and a chest X-ray…
- Trial name
- TRIPOD (NCT02758236)
- Testing
- No Intervention
- Where
- 7 sites in Indonesia
- Volunteers
- 490 people
- Sponsor
- Ina-Respond
Multi-drug Resistant Tuberculosis
Single-dose Study in Two Panels of Healthy Adult Participants to Assess Immediate-Release and Dispersible Formulations of Pretomanid
This is a single-dose, open-label, randomized, four-period, four-treatment, crossover study in healthy adult subjects.
- Trial name
- NCT04309656
- Testing
- Pretomanid
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Global Alliance for TB Drug Development
Endobronchial Mass, Tuberculosis, Pulmonary
Bronchoscopic Role in Early Detection of Endobronchial Tuberculosis in Suspected Pulmonary Tuberculosis Patients.
The aim of the present study is to evaluate the role of bronchoscopy in diagnosis of endobronchial tuberculosis in suspected pulmonary tuberculosis patients whose sputum samples are negative for Ziehl Neelsen stain.
- Trial name
- NCT07350356
- Testing
- fiberoptic bronchoscopy evaluation of endobronchial features of TB
- Where
- Egypt
- Volunteers
- 63 people
- Sponsor
- Ain Shams University
Lung Disease, Obstructive, Tuberculosis
Tiotropium in Patients With Tuberculosis (TB) Destroyed Lung
The aim of this study to evaluate clinical efficacy of tiotropium in patients with airflow obstruction due to Tuberculosis (TB) destroyed lung.
- Trial name
- NCT01365702
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Seoul National University Bundang Hospital
Rifampicin-resistant/Multidrug-resistant Pulmonary Tuberculosis, Type 2 Diabetes Mellitus (T2DM)
A Study on the Short - Course Treatment Regimen Containing Pretomanid for Diabetes Mellitus Complicated With Rifampicin - Resistant/Multidrug - Resistant Pulmonary Tuberculosis
The treatment of rifampicin-resistant/multidrug-resistant pulmonary tuberculosis (RR-TB) is characterized by a long treatment course, a high incidence of adverse reactions, a low cure rate, and a high recurrence rate.
- Conditions
- Rifampicin-resistant/Multidrug-resistant Pulmonary Tuberculosis, Type 2 Diabetes Mellitus (T2DM), Pretomanid
- Trial name
- NCT07191834
- Volunteers
- 60 people
- Sponsor
- Wuhan Pulmonary Hospital