Clinical trials: Pulmonary Vein Ablation
Atrial Fibrillation (AF)
Extended Ablation Versus Pulmonary Vein Isolation to Treat Persistent Atrial Fibrillation
The aim is to determine the effect of extended ablation (pre-specified linear PF/RF lesion set) in addition to PVI in symptomatic persistent AF patients on AF/AT/AFL recurrence.
- Trial name
- EXTEND-PVI (NCT07424326)
- Testing
- PVI-plus, PVI-only
- Where
- 4 sites in Czechia
- Volunteers
- 450 people
- Sponsor
- Charles University, Czech Republic
Persistent Atrial Fibrillation
PVI Alone Versus PVI Plus PWI and SVCI With PFA
Catheter based ablation of atrial fibrillation (AF) is an established treatment modality for rhythm control of AF, with pulmonary vein isolation (PVI) being the cornerstone of this technique.
- Trial name
- PVI-PLUS (NCT07405359)
- Testing
- AF Ablation: PVI + PWI + SVCI, PFA, Implantable loop recorder
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Edward Gerstenfeld, MD
Atrial Fibrillation
Treatment of Atrial Fibrillation by Minimal Invasive Surgery
The purpose of this study is to determine the feasability of a new epicardial and minimal invasive ablation technique of the left atrium isolating the pulmonary veins for prevention of atrial fibrillation recurrences in patients…
- Trial name
- ABOLISH-AF (NCT00448656)
- Testing
- ablation of pulmonary veins by video assisted thoracic surgery
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- University Medical Center Groningen
Atrial Fibrillation, Persistent Common Pulmonary Vein
Adenosine Effect on Persistent Pulmonary Vein Isolation Line Evaluation (APPLE Trial)
The investigators studied the effects of adenosine on the reconnection rate after successful pulmonary veins isolation by radiofrequency catheter ablation in patients with drug-resistant atrial fibrillation
- Trial name
- APPLE (NCT01932112)
- Testing
- Adenosine arm
- Where
- South Korea
- Volunteers
- 378 people
- Sponsor
- Yong Seog Oh
Atrial Fibrillation
Efficacy of Different Ablation Strategies for Controlling Atrial Fibrillation
This study involves treatment for atrial fibrillation (AF)-the most common heart condition in the US-where the upper chambers of the heart beat very fast and in a disorganized manner.
- Trial name
- RASTA (NCT00379301)
- Testing
- Radiofrequency ablation
- Where
- United States
- Volunteers
- 166 people
- Sponsor
- University of Pennsylvania
Atrial Fibrillation
A Study of the Effectiveness of Anti-Arrhythmic Medications After Atrial Fibrillation Ablation
The purpose of this study is to examine the overall effectiveness of anti-arrhythmic medicines (to control heart rhythm) prescribed after an ablation procedure for atrial fibrillation.
- Trial name
- NCT00408200
- Testing
- propafenone; flecainide; sotalol; dofetilide, Radiofrequency catheter ablation
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- University of Pennsylvania
Atrial Fibrillation, Arrhythmia
The Use of Statins Following a Left Atrial Catheter Ablation Procedure to Prevent Atrial Fibrillation
To investigate whether statin therapy utilizing the drug Lipitor (atorvastatin) might be effective in preventing short-and long-term atrial fibrillation (AF) following a left atrial ablation procedure.
- Conditions
- Atrial Fibrillation, Arrhythmia, Inflammation, Endothelial Dysfunction
- Trial name
- ATTAC (NCT00579098)
- Testing
- Atorvastatin
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Mayo Clinic
Atrial Fibrillation
Effect of Amiodarone on the Procedure Outcome in Long-standing Persistent Atrial Fibrillation Undergoing Pulmonary Vein Antral Isolation
This prospective randomized study aims to investigate the effect of continuous versus interrupted use of Amiodarone on the procedure outcome in long-standing persistent (LSP) atrial fibrillation patients undergoing pulmonary vein…
- Trial name
- SPECULATE (NCT01173809)
- Testing
- Amiodarone
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- Texas Cardiac Arrhythmia Research Foundation
Atrial Fibrillation, Arrhythmia
Comparison of Rotational Angiography/Electroanatomical Mapping Fusion Versus CT/Electroanatomical Mapping Fusion to Guide AF Ablation
The purpose of this study is to compare rotational angiography (3DATG technology)intra-procedure (during the ablation procedure) with CT (x-ray) pre-procedure (before the ablation procedure) fusion to create an anatomical picture…
- Trial name
- 3DATGvsCT (NCT01537237)
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- Steward St. Elizabeth's Medical Center of Boston, Inc.
Cardiac Arrhythmia, Atrial Fibrillation
Spanish Registry of Redo Procedures Following Pulmonary Vein Ablation by Pulsed Field Ablation Technology: RESET-PFA
RESET-PFA is a prospective, multicenter, non-randomized post-market study. All patients will be treated according to the standard care followed by each center.
- Conditions
- Cardiac Arrhythmia, Atrial Fibrillation, Pulsed Field Ablation
- Trial name
- RESET-PFA (NCT07185412)
- Testing
- Pulsed Field ablation: Ablation to treat atrial fibrillation
- Where
- Spain
- Volunteers
- 1,100 people
- Sponsor
- Instituto de Investigación Sanitaria Aragón
Atrial Fibrillation
ABLATE Versus PACE: PVI or AV Node Ablation and PM Implantation for Elderly Patients With Persistent AF
As patients age, symptom control and treatment of atrial fibrillation become equally difficult, often leading to increased hospitalization.
- Trial name
- NCT04906668
- Testing
- Cryoballoon pulmonary-vein isolation, Pacemaker implantation and ablation of atrioventricular-node
- Where
- 12 sites in Austria, Germany
- Volunteers
- 196 people
- Sponsor
- St. Josefs-Hospital Wiesbaden GmbH
Atrial Fibrillation
Ten-year Outcomes After AF Ablation
Ablation of atrial fibrillation (AF) using pulmonary vein isolation is employed when patients do not respond favorably to medical therapy.
- Trial name
- NCT01867099
- Where
- United States
- Volunteers
- 445 people
- Sponsor
- Valley Health System
Atrial Fibrillation
Feasibility of Ethanolization of Vein of Marshall With Specific Catheter in Atrial Fibrillation Ablation
In patients with persistent AF (PsAF), ablation limited to pulmonary vein (PV) isolation is the most straightforward approach, but results only in 50% of arrhythmia freedom at 1 year follow-up.
- Trial name
- Innov Marshall (NCT05427435)
- Testing
- Marshall ethanolisation
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Bordeaux
Atrial Fibrillation Paroxysmal
Posterior Wall Substrate Modification Using Irreversible Electroporation for Paroxysmal Atrial Fibrillation
The purpose of this study is to compare the efficacy and safety between pulmonary vein isolation (PVI) alone versus PVI with left atrial (LA) posterior wall isolation (PWI) using pulsed-field ablation (PFA) in the treatment of…
- Trial name
- (SMILE-AF) (NCT06364215)
- Testing
- Farapulse PFA, Pulmonary Vein Isolation alone, Farapulse PFA, Pulmonary Vein Isolation and Left atrial Posterior Wall Isolation
- Where
- 18 sites in United States
- Volunteers
- 198 people
- Sponsor
- Jorge Romero
Ablation of Arrhythmia's
Cerebral Microembolization During Pulmonary Vein Isolation: Comparison of Different Pulsed Field Ablation Systems
This prospective, randomized, parallel-group interventional study will compare cerebral microembolization during pulmonary vein isolation between different pulsed field ablation systems in patients with paroxysmal or persistent…
- Trial name
- MICROPFA (NCT07610018)
- Testing
- Pulsed field ablation using PulseSelect system, Pulsed field ablation using Varipulse system, Pulsed field ablation using Farapulse system
- Where
- 2 sites in Croatia
- Volunteers
- 100 people
- Sponsor
- Ivan Zeljkovic
Atrial Fibrillation
CLOSE to CURE Study
Title: CLOSE-guided pulmonary vein isolation (PVI) as Cure for Paroxysmal Atrial Fibrillation ('CLOSE to CURE' study) Design: This is a prospective, observational, single-center, unblinded, clinical 3-year study.
- Trial name
- NCT02925624
- Testing
- Pulmonary vein isolation
- Where
- Belgium
- Volunteers
- 105 people
- Sponsor
- AZ Sint-Jan AV
Atrial Fibrillation and Flutter, Atrial Fibrillation
HIgh Power Short Duration Radiofrequency Ablation or Cryoballoon Ablation for Paroxysmal Atrial Fibrillation
Pulmonary vein isolation (PVI) using the cryoballoon has been proven equal to RF-PVI and is widely used. High Power Short Duration Ablation in RF-PVI has been successfully tested in several trials.
- Conditions
- Atrial Fibrillation and Flutter, Atrial Fibrillation, Paroxysmal Atrial Fibrillation
- Trial name
- HIPAF (NCT04855890)
- Testing
- Ablation
- Where
- Germany
- Volunteers
- 170 people
- Sponsor
- Universitätsklinikum Köln
Persistent Atrial Fibrillation
Optimized Posterior Left Atrial Wall Ablation Strategy for PeAF
This is an open-label, multicenter, randomized parallel-controlled clinical trial. The study aims to investigate the optimal ablation method for the posterior left atrial wall in patients with persistent atrial fibrillation…
- Trial name
- NCT06633523
- Testing
- PVI + Posterior Wall Isolation (PWI) + Electrogram Ablation (EGM), PVI + Posterior Wall Isolation (PWI), Pulmonary Vein Isolation (PVI) alone
- Volunteers
- 384 people
- Sponsor
- Shanghai Chest Hospital
Atrial Fibrillation (AF), Atrial Fibrillation Ablation
Comparative Intra-procedural Evaluation of Farapulse and FARAWAVE Nav Catheters
The FARAPULSE PFA catheter (Boston Scientific), a first-generation Pulsed Field Ablation (PFA) tool, has demonstrated good performance in isolating pulmonary veins (PV).
- Conditions
- Atrial Fibrillation (AF), Atrial Fibrillation Ablation, Pulsed Field Ablation
- Trial name
- NCT07130773
- Testing
- Second-generation FARAWAVE Nav catheter without the use of pre-ablation CT, FARAPULSE with pre-ablation CT
- Where
- Switzerland
- Volunteers
- 58 people
- Sponsor
- Cardiocentro Ticino
Atrial Fibrillation, Pulmonary Vein Isolation
Lesion Characteristics After Pulsed-Field Ablation in Patients With Atrial Fibrillation and a Left Common Ostium
This study aims to investigate the lesion characteristics after pulmonary vein isolation using pulsed-field ablation in patients with atrial fibrillation and a common of the left pulmonary veins.
- Conditions
- Atrial Fibrillation, Pulmonary Vein Isolation, Ablation Therapy
- Trial name
- PFALCO Remap (NCT05812261)
- Testing
- Creating an electro-anatomical map
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- Onze Lieve Vrouwe Gasthuis