Clinical trials: Pulmonary Vein Isolation
Atrial Fibrillation
PeAF-BOX: Feasibility, Safety and Efficacy of PVI + Box Ablation in Persistent Atrial Fibrillation
Title: PeAF-Box. Feasibility, Safety and Efficacy of Isolating the Left Atrial Posterior Wall (PWI) added to Pulmonary Vein Isolation (PVI) as First-Line Strategy in Treatment of Persistent Atrial Fibrillation (PeAF) Design: A…
- Trial name
- PeAF-BOX (NCT05045131)
- Testing
- Left atrial combined pulmonary vein isolation and posterior wall isolation
- Volunteers
- 24 people
- Sponsor
- René Husted Worck
Atrial Fibrillation, Atrial Fibrillation Paroxysmal
Intensive Molecular and Electropathological Characterization of Patients Undergoing Atrial Fibrillation Ablation
Rationale: Although there are several individual factors which are known to influence the chances of successful atrial fibrillation (AF) ablation, it remains a challenge to identify patients at risk for ablation failure with…
- Conditions
- Atrial Fibrillation, Atrial Fibrillation Paroxysmal, Atrial Fibrillation, Persistent
- Trial name
- ISOLATION (NCT04342312)
- Testing
- Pulmonary vein isolation
- Where
- 2 sites in Netherlands
- Volunteers
- 500 people
- Sponsor
- Maastricht University
Atrial Fibrillation
Safety and Effectiveness of Pulmonary Vein isOLation And posterioR Wall Ablation wIth pulSed Field Energy in Patients With Paroxysmal and Persistent AF
The primary objective of this clinical investigation is to demonstrate the safety and 12-month effectiveness of pulmonary vein isolation (PVI) and posterior LA wall isolation in the treatment of subjects with symptomatic…
- Trial name
- POLARIS (NCT06099730)
- Testing
- Pulsed Field Ablation (PFA)
- Where
- 6 sites in United States
- Volunteers
- 442 people
- Sponsor
- Massachusetts General Hospital
Atrial Fibrillation (AF), Pulsed-field Ablation
Durability of Pulmonary Vein Isolation With Farapulse System Using Minimal Fluoroscopy
Objective: To evaluate the feasibility, acute, and three-month efficacy and safety of near-zero fluoroscopy PVI performed with the Farapulse system (Faravawe catheter, Faradrive sheath, Faraview module).
- Trial name
- Faraview Remap (NCT07752771)
- Testing
- catheter ablation
- Where
- Hungary
- Volunteers
- 20 people
- Sponsor
- Semmelweis University
Atrial Fibrillation (AF)
Finerenone After Catheter Ablation to Reduce Atrial Fibrillation Recurrence
Atrial fibrillation (AF) is a common heart rhythm disorder associated with stroke, heart failure, and increased mortality. Catheter ablation with pulmonary vein isolation (PVI) is an effective rhythm-control strategy, but 20-30%…
- Trial name
- FINE-CA (NCT07799519)
- Testing
- Finerenone
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Cheng-Kung University Hospital
Atrial Fibrillation
Trigger- vs. Substrate-Ablation for Paroxysmal Atrial Fibrillation
The purpose of this study is to compare two strategies of catheter-based treatment of paroxysmal atrial fibrillation: Pulmonary vein isolation either alone or combined with electrogram-guided substrate-ablation.
- Trial name
- NCT00196183
- Testing
- trigger-guided catheter-ablation, trigger+substrate-guided catheter ablation
- Where
- Germany
- Volunteers
- 98 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Atrial Fibrillation
A Study of the Effectiveness of Anti-Arrhythmic Medications After Atrial Fibrillation Ablation
The purpose of this study is to examine the overall effectiveness of anti-arrhythmic medicines (to control heart rhythm) prescribed after an ablation procedure for atrial fibrillation.
- Trial name
- NCT00408200
- Testing
- propafenone; flecainide; sotalol; dofetilide, Radiofrequency catheter ablation
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- University of Pennsylvania
Paroxysmal Atrial Fibrillation
Adenosine vs AF Termination for Paroxysmal AF Ablation
This study investigates impact of adenosine versus AF inducibility and subsequent termination on the acute and long-term outcome of paroxysmal AF ablation.
- Trial name
- NCT02238392
- Testing
- Adenosine test, Termination of AF
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Johannes Gutenberg University Mainz
Atrial Fibrillation
The Ablate-by-LAW Study
Of all the determinants of lesion creation during atrial fibrillation (AF) ablation, left atrial wall thickness (LAWT), as measured with multi-detector cardiac tomography (MDCT) is one key element that has been evaluated in some…
- Trial name
- NCT04218604
- Testing
- Personalized atrial fibrillation ablation
- Where
- 5 sites in Germany, Italy and 1 more
- Volunteers
- 106 people
- Sponsor
- Centro Medico Teknon
Atrial Fibrillation
Cryoballoon vs. Rhythmia Guided Ablation for Recurrent AFib
The purpose of this research is to evaluate whether cryoballoon ablation vs. radiofrequency ablation guided by high-fidelity mapping (Rhythmia) is the best treatment strategy to perform repeat ablation for recurrent atrial…
- Trial name
- NCT03811795
- Testing
- ECG monitoring with a Kardia Mobile monitor
- Where
- 3 sites in United States
- Volunteers
- 9 people
- Sponsor
- Valley Health System
Atrial Fibrillation
Comparison of Operator-guided and Automatic Algorithm-guided Atrial Fibrillation Ablation
Catheter ablation in the treatment of atrial fibrillation (i.e. pulmonary vein isolation) is now the most effective method of prevention of arrhythmia recurrence. Use of 3D electroanatomical system is now a golden standard.
- Trial name
- NCT02476227
- Testing
- Ablation using CARTO system
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Military Institute od Medicine National Research Institute
Esophagus Injury, Atrial Fibrillation
Prevalence and Predictors of Esophageal Thermal Lesions in High-power-Short-duration Ablation of Atrial Fibrillation
Patients with documented atrial fibrillation who were referred to our clinic for catheter ablation will undergo standard HPSD ablation and subsequent esophagoscopy.
- Trial name
- VISUAL-AF (NCT05709756)
- Where
- 2 sites in Germany
- Volunteers
- 263 people
- Sponsor
- Helios Health Institute GmbH
Atrial Fibrillation, Atrial Flutter
Feasibility Study for Optically Guided Radiofrequency Ablation Catheter
Clinical study intended to evaluate the feasibility of a new irrigated RF ablation catheter that allows the physiologist to perform a regular RF ablation procedure while it is being monitored through an imaging technique known as…
- Trial name
- NEOVIEW (NCT03589742)
- Testing
- AblaView® Ablation Catheter
- Where
- Czechia
- Volunteers
- 4 people
- Sponsor
- Medlumics
Atrial Fibrillation (AF)
Extended Ablation Versus Pulmonary Vein Isolation to Treat Persistent Atrial Fibrillation
The aim is to determine the effect of extended ablation (pre-specified linear PF/RF lesion set) in addition to PVI in symptomatic persistent AF patients on AF/AT/AFL recurrence.
- Trial name
- EXTEND-PVI (NCT07424326)
- Testing
- PVI-plus, PVI-only
- Where
- 4 sites in Czechia
- Volunteers
- 450 people
- Sponsor
- Charles University, Czech Republic
Recurred Atrial Fibrillation
Comparison of Circumferential Pulmonary Vein Isolation and Complex Pulmonary Vein Isolation Additional Linear Ablation for Recurred Atrial Fibrillation After Previous Catheter Ablation: Prospective Randomized Trial (RILI Trial)
The purpose of this study is to compare the clinical outcomes depending on catheter ablation strategy for repeat ablation procedure among the patients with recurred atrial fibrillation after de novo catheter ablation.
- Trial name
- NCT02747498
- Testing
- Procedure with circumferential pulmonary vein isolation, Procedure with linear ablation in addiction to pulmonary vein isolation
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Yonsei University
Atrial Fibrillation Recurrent, Pulmonary Venous Isolation
Dapagliflozin to Prevent Atrial Fibrillation Recurrence After Transcatheter Pulmonary Venous Isolation.
Transcatheter left atrial antral ablation, aiming at complete electrical isolation of the pulmonary veins (PVI), has become mainstay in atrial fibrillation (AF) treatment.
- Conditions
- Atrial Fibrillation Recurrent, Pulmonary Venous Isolation, Catheter Ablation, Sodium-glucose Co-transporter 2 Inhibitors
- Trial name
- NCT04780438
- Testing
- Dapagliflozin
- Where
- 2 sites in Greece
- Volunteers
- 350 people
- Sponsor
- G.Gennimatas General Hospital
Ventricular Arrhythmias, Atrial Fibrillation
Ventricular Arrhythmias After Pulmonary Vein Isolation
The investigators study aimed to observe the occurrence of new premature ventricular complexes and other ventricular arrhythmias after pulmonary vein isolation.
- Trial name
- NCT02699255
- Where
- Germany
- Volunteers
- 111 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Atrial Fibrillation
Prospective Study on the Effectiveness and Safety of Bi-polar Pulse-field Tip-catheter Ablation for Atrial Fibrillation in China（POTENTIAL-AF）
POTENTIAL-AF is a prospective, multicentre, observational registry study evaluating the real-world effectiveness and safety of bi-polar pulse-field tip-catheter ablation (PFA) for atrial fibrillation (AF) in China.
- Trial name
- POTENTIAL-AF (NCT07627685)
- Testing
- Bi-polar Pulse-field Ablation (PFA) - LEAD-PFA System with PulsedFA catheter
- Where
- China
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Beijing Anzhen Hospital
Atrial Fibrillation, Atrial Fibrillation (Paroxysmal)
Wide-Antral Pulmonary Vein Isolation in Atrial Fibrillation Ablation with a Single-shot Technique (WIDER-PVI)
The WIDER PVI study is a multicentre randomized clinical trial to compare the efficacy of antral versus extended antral PVI in patients with paroxysmal or persistent AF undergoing this procedure using a cryoablation balloon…
- Trial name
- WIDER-PVI (NCT06698159)
- Testing
- Cryoablation with cryoballoon 28 mm, Cryoablation with cryoballoon 31 mm
- Where
- 17 sites in Italy, Spain
- Volunteers
- 440 people
- Sponsor
- Hospital Universitario 12 de Octubre
Atrial Fibrillation, Persistent
Noninvasive 3D Mapping in Persistent Atrial Fibrillation, to Describe Modifications of the Arrhythmogenic Substrate After Pulmonary Vein Isolation and Identify Potential Predicting Factors of Ablation Success
Atrial fibrillation (AF) is the most common cardiac arrhythmia in adults. It is a major cause of ischemic stroke and heart failure.
- Trial name
- CRYOVEST (NCT04229160)
- Testing
- Noninvasive mapping (Cardioinsight® system), long-term cardiac monitoring (LINQ system), Atrial Fibrillation ablation procedure
- Where
- 4 sites in France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Rouen