Clinical trials: Pulmonary Ventilation
Lung Collapse
Spontaneous Ventilation Versus Controlled Ventilation on Lung Atelectasis in Children.
This is an observational study to compare the effect of spontaneous ventilation versus controlled ventilation on lung atelectasis using lung score measured by lung ultrasound.
- Trial name
- NCT03142997
- Testing
- Lung ultrasound
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
COPD, Cancer
SELF - BREATHE for Chronic Breathlessness
Semi-structured qualitative interviews will be conducted to understand key factors that would enable / facilitate patients with chronic breathlessness to potentially use an online breathlessness intervention (SELF-BREATHE).
- Conditions
- COPD, Cancer, Heart Failure, Interstitial Disease
- Trial name
- NCT04466020
- Testing
- Qualitative research interviews to be conducted
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- King's College Hospital NHS Trust
Intensive Care, Ventilator Lung
Respiratory Mechanics in Intensive Care Patients
This study aims at assessing the respiratory mechanics of intubated patients in intensive care unit.
- Trial name
- PREMIER (NCT03420417)
- Testing
- Esophageal pressure measurement
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Angers
Neoplasms
Chest Imaging of Lung Nodule(s) Under High-frequency Non-invasive Ventilation (HF-NIV)
Imaging of chest disorders is mainly achieved by using computed tomography. This is especially the case for detection, morphologic assessment and followup of pulmonary nodules.
- Trial name
- NCT03553368
- Testing
- HF-NIV-MR, HF-NIV-PET, MR
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Complication of Ventilation Therapy, Intubation Complication
Bronchial Blocker for One-lung Ventilation in Cardiac Surgery
To investigate if bronchial blocker is more suitable for one-lung ventilation during thoracoscope assisted mitral valve replacement surgery with Cardiopulmonary Bypass than the double-lumen endobronchial tube.
- Conditions
- Complication of Ventilation Therapy, Intubation Complication, Postoperative; Dysfunction Following Cardiac Surgery
- Trial name
- NCT02729610
- Testing
- double-lumen endotracheal tube (DLT group), endobronchial blocker (BB group)
- Volunteers
- 58 people
- Sponsor
- Xijing Hospital
Acute Respiratory Distress Syndrome
Comparison of the PaO2/FiO2 Ratio to Other Oxygenation Indexes for the Classification of Severity of Acute Respiratory Distress Syndrome
In mechanically ventilated patients the PaO2/FiO2 ratio might not be the best reflection of the severity of ARDS. It does not incorporate variables and settings used during mechanical ventilatory support such as the positive end…
- Trial name
- NCT03946189
- Testing
- Obtaining arterial blood gases
- Where
- Lebanon
- Volunteers
- 150 people
- Sponsor
- American University of Beirut Medical Center
COPD
Comparative Effects of Wim Hoff Method and Box Breathing Method in Mild COPD
The goal of this clinical trial is to support the role of effective, non-pharmacological interventions in the management of the symptoms of mild Chronic Obstructive Pulmonary Disease (COPD) or the anxiety, dyspnea, and peak…
- Trial name
- NCT07506317
- Testing
- Box Breathing, Wim Hoff Breathing Technique
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Riphah International University
Pulmonary Regurgitation, Pulmonary Insufficiency
Pulmonic Valve REplacement Multi-discIpline EMEA Registry
The purpose of this registry is to retrospectively and prospectively obtain clinical data in consecutively treated patients, in order to demonstrate that the commercially available Edwards SAPIEN Valve with the RF3 delivery…
- Conditions
- Pulmonary Regurgitation, Pulmonary Insufficiency, Pulmonary Stenosis
- Trial name
- PREMIER (NCT01356108)
- Testing
- Transcatheter Pulmonic Valve Replacement (TPVR) (Edwards SAPIEN™ THV)
- Where
- 16 sites in Belgium, Germany and 7 more
- Volunteers
- 127 people
- Sponsor
- Edwards Lifesciences
Respiratory Disease
Results of Manual Therapy on Pulmonary Parameters
The main objective of this study is to evaluate the effectiveness of different manual techniques included traditionally on respiratory physical therapy
- Trial name
- NCT01735474
- Testing
- Manual technique
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Lung Collapse
The Effect of Lateral Tilt on Ventilation Distribution in Lungs Assessed by Electrical Impedance Tomography
Prevention of lung inhomogeneity is an essential part of preventive strategy in neurocritical care, reducing the risks of secondary brain damage from hypoxemia, hypo/hypercapnia or pneumonia.
- Trial name
- N-LAT-EIT (NCT04235231)
- Testing
- Bed tilting, Body positioning
- Where
- Czechia
- Volunteers
- 250 people
- Sponsor
- Regional Hospital Liberec
Chronic Obstructive Lung Disease (COLD)
ANTEAB: a Study of Early Antibiotherapy in the ICU Management of Acute Exacerbations of COPD
Intensive Care Unit (ICU) admission for acute exacerbation of chronic obstructive lung disease (COLD) is a major cause of morbidity and mortality in such patients. Although bacterial of mortality in such patients.
- Trial name
- NCT00190437
- Testing
- Amoxicillin-clavulanic
- Where
- 2 sites in France
- Volunteers
- 520 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COPD, Chronic Obstructive Pulmonary Disease
Study of Ambulatory Respiratory Assist Device in Chronic Obstructive Pulmonary Disease Patients
The study is a two-part small scale, open-label, pilot study to evaluate feasibility and proof-of-concept for a respiratory assist medical device.
- Trial name
- NCT03531489
- Testing
- AIR-AD
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Right-Air
Chronic Obstructive Pulmonary Disease
Oral Sildenafil for Exercise Capacity, Dyspnea and Cardiopulmonary Function in COPD
Chronic obstructive pulmonary disease (COPD) is a condition characterized by airway obstruction. Patients with COPD experience significant shortness of breath on exertion.
- Trial name
- NCT05061368
- Testing
- Sildenafil Citrate
- Where
- Canada
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Alberta
COPD, Cough
A Clinical Validation Study to Evaluate the Diagnostic Accuracy of a Cough-based Auxiliary Diagnosis Algorithm for COPD
Cough is one of the most common symptoms in COPD patients, and its different characteristics in amplitude, frequency and waveform can be analyzed by intelligent algorithms for the auxiliary diagnosis of COPD.
- Conditions
- COPD, Cough, Algorithm
- Trial name
- NCT06082791
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Chronic Obstructive Pulmonary Disease, Exercise
Mind-Body Walking Exercise for Chronic Obstructive Pulmonary Disease
Mind-body exercise improves symptom of negative moods, dyspnea and quality of life in chronic diseases, but these improvements for chronic obstructive pulmonary disease (COPD) are unproven.
- Conditions
- Chronic Obstructive Pulmonary Disease, Exercise, Anxiety, Depression
- Trial name
- NCT03388489
- Testing
- Mind-Body Walking
- Volunteers
- 84 people
- Sponsor
- National Taiwan University Hospital
Pulmonary Edema, Respiratory Distress Syndrome
Performance Evaluation of Clinical Ultrasound in Management of Acute Pulmonary Edema in Elderly Patient
The main objective is to assess the validation of the diagnosis early acute pulmonary edema in elderly patients with acute respiratory distress, admitted in a host of vital emergency services by lung ultrasound associated with…
- Trial name
- ECHOP (NCT02638350)
- Testing
- Strategy with lung ultrasound
- Where
- France
- Volunteers
- 123 people
- Sponsor
- University Hospital, Toulouse
ICU Patients, Healthy Lung
Effects of End-expiratory Positive Pressure Optimization in Intubated Patients With Healthy Lung or Acute Respiratory Distress Syndrome
PEEP titration is a recommended during invasive mechanical ventilation of ICU patients. However, little is known about the right way to conduct this titration.
- Conditions
- ICU Patients, Healthy Lung, Positive End-Expiratory Pressure, ARDS
- Trial name
- PEEP-Réa (NCT04503876)
- Testing
- Increasing PEEP setting, Decreasing PEEP setting
- Where
- France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Clermont-Ferrand
COVID-19, COVID
Early CPAP in COVID-19 Confirmed or Suspected Patients
There is surge in COVID infected patients in New York City with a shortage of hospital beds, ICU beds and ventilators. Strategies to reduce the need for all of the above are immediately needed.
- Conditions
- COVID-19, COVID, Coronavirus
- Trial name
- PAP-COVID (NCT04390191)
- Testing
- Continuous Positive Airway Pressure
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
COPD, Respiratory Acidosis
Evaluation of the Effects on Carbon Dioxide (paCO2) of a New Oronasal Mask in Patients With Severe COPD Exacerbation Requiring Non-Invasive Mechanical Ventilation
This single-center, crossover study aims to investigate the effects of the new OptiNIV oronasal mask used during NIV in COPD patients with respiratory acidosis following an exacerbation.
- Trial name
- OPTIMUS-MASK (NCT07081776)
- Testing
- OptiNIV, Visairo
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Sickle Cell Disease (SCD)
Early Diagnosis of Sickle Acute Chest Syndrome Using a Combination of Plasma Bimarkers and Chest Imaging
Background: Painful vasoocclusive crisis (VOC) occurs in people with sickle cell disease (SCD). People with VOC have many visits to the hospital.
- Trial name
- NCT03478917
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)