Clinical trials: Pulmonary Ventilation
Surgery, One-lung Ventilation
Esophageal Pressure Measurements During One-lung Ventilation
The investigators will assess the feasibility and validity of esophageal pressure measurements during one-lung ventilation in the lateral position for surgery by comparing to lung collapse estimated from electrical impedance…
- Trial name
- NCT04725318
- Testing
- One-lung ventilation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Beth Israel Deaconess Medical Center
Acute Respiratory Failure, Mechanical Ventilation Complication
Assessing Ventilator Safety in Patients on Pressure-Support Ventilation
ASOP is a prospective cohort study comparing three methods for assessing risk of self-induced lung injury in patients with acute respiratory failure being managed with pressure-support ventilation.
- Conditions
- Acute Respiratory Failure, Mechanical Ventilation Complication, Ventilator-Induced Lung Injury
- Trial name
- ASOP (NCT05125952)
- Testing
- Viasys Avea Ventilator, Philips Respironics NM3 device, Servo U ventilator
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Duke University
Chronic Obstructive Pulmonary Disease, Noninvasive Ventilation
Determination of the Prevalence and Severity of Expiratory Flow Limitation in Chronic Obstructive Pulmonary Disease Patients
Expiratory Flow Limitation (EFL) occurs when the airways become compressed, which usually results when the pressure outside the airway exceeds the pressure inside the airway.
- Trial name
- NCT03851510
- Testing
- Vector ventilator, Resmon Pro
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Philips Respironics
Pulmonary Ventilation
Tegarderm® Placement for Bag Mask Ventilation in the Bearded Patient
Difficult Bag Mask Ventilation is well described in the anesthesiology literature, and bearded patients are likely to experience this phenomenon.
- Trial name
- NCT04274686
- Testing
- Tegaderm placement, No Tegaderm
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of New Mexico
Inadequate; Pulmonary Ventilation, Newborn, Infant, Very Low Birth Weight
Nasal Noninvasive NAVA in the Very Low Birth Weight Infant
The purpose of this study is to determine if a new type of mechanical ventilation, or breathing machine (called neurally adjusted ventilatory assist or NAVA), will provide additional support to infants who were born prematurely.
- Trial name
- NCT01785563
- Testing
- Nasal NIV-NAVA
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Tarah T Colaizy
Double Lumen Endotracheal Tube, Single Lung Ventilation
VivaSight Double Lumen Tube for Single Lung Ventilation
This prospective, randomized, comparative study is intended to enroll a total of 50 patients undergoing thoracic surgery that necessitates single lung ventilation.
- Trial name
- NCT03690284
- Testing
- Conventional Double Lumen Tube, VivaSight Double Lumen Tube
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
ARDS, Mechanical Ventilation Complication
Ventilator-induced Lung Injury Vortex in Patients With SARS-CoV-2
The concept of Ventilator-induced Lung Injury Vortex (VILI vortex) has recently been proposed as a progressive lung injury mechanism in which the alveolar stress/strain increases as the ventilable lung "shrinks" (1).
- Conditions
- ARDS, Mechanical Ventilation Complication, Ventilator-Induced Lung Injury
- Trial name
- VILIVORTEX (NCT04174313)
- Testing
- CT scan
- Where
- Argentina
- Volunteers
- 65 people
- Sponsor
- Hospital El Cruce
Thoracic Surgery, One-lung Ventilation
Intraoperative Neuromuscular Blockade and Postoperative Atelectasis
During one-lung ventilation in thoracic surgery, the intensity of neuromuscular blockade may change the compliance and resistance of ventilated lung, thereby affecting postoperative atelectasis.
- Trial name
- NCT03503565
- Testing
- intraoperative neuromuscular blockade
- Where
- South Korea
- Volunteers
- 118 people
- Sponsor
- Kyung Hee University Hospital at Gangdong
Lung Collapse, One-Lung Ventilation
Physiology of Lung Collapse Under One-Lung Ventilation: Underlying Mechanisms
Lung isolation technique and one-lung ventilation (OLV) are the mainstays of thoracic anesthesia. Two principal lung isolation techniques are mainly use by clinicians, the double lumen tubes (DLT) and the bronchial blockers (BB).
- Conditions
- Lung Collapse, One-Lung Ventilation, Thoracic Surgery, Video-Assisted
- Trial name
- PLC-OLV (NCT02919267)
- Testing
- Double lumen tube, Bronchial blocker
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Laval University
One-lung Ventilation
Clamping the Double Lumen Tube
Nowadays, lung isolation techniques are an essential part of thoracic anesthesia. The two principal devices used in order to achieve one-lung ventilation (OLV) are the double lumen tube (DLT) and the bronchial blocker (BB).
- Trial name
- C-TDL (NCT03508050)
- Testing
- Clamping the Double Lumen Tube
- Where
- Canada
- Volunteers
- 37 people
- Sponsor
- Jean Bussières
Respiratory Failure, Mechanical Ventilation
Mechanical Ventilation in the Emergency Department: A Prospective Cross-Sectional Study
Despite its life-saving potential, the mechanical ventilator has great potential to do harm. Despite years of research, the mortality in acute lung injury (ALI) remains very high.
- Conditions
- Respiratory Failure, Mechanical Ventilation, Acute Lung Injury
- Trial name
- NCT01628523
- Testing
- For inclusion in the study, patients will have to require mechanical ventilation either via an endotracheal tube or tracheostomy tube.
- Where
- 4 sites in United States
- Volunteers
- 219 people
- Sponsor
- Washington University School of Medicine
Lung Diseases, Ultrasonography
Lung Ultrasonography vs Fiberoptic Bronchoscopy for Aiding Lung Collapse in Patient Using Double Lumen Tube
The study contains the result from a comparison of diagnostic outcomes about lung collapse by using lung ultrasonography as a new diagnostic test compares to fiberoptic bronchoscopy as the standard test.
- Conditions
- Lung Diseases, Ultrasonography, Fiberoptic Bronchoscopy, One Lung Ventilation
- Trial name
- NCT03314519
- Testing
- Lung ultrasonography by experienced anaesthesiologist, Fiberoptic bronchoscopy for double lumen tube's position
- Where
- Thailand
- Volunteers
- 200 people
- Sponsor
- Mahidol University
Single Lung Ventilation, Thoracic Surgery
Double-lumen Tubes (DLT) - Health Economic Study
The aim of this study is to make a health economic evaluation comparing novice physicians use of VivaSight double-lumen tube and a conventional double-lumen tube for single-lung ventilation during thoracic surgery at a teaching…
- Conditions
- Single Lung Ventilation, Thoracic Surgery, Anesthesia, Cost-effectiveness
- Trial name
- NCT03817879
- Testing
- VivaSight double-lumen tube for single-lung ventilation, Conventional double-lument tube for single-lung ventilation
- Where
- Denmark
- Volunteers
- 70 people
- Sponsor
- Ambu A/S
Mechanical Ventilation, Single-lung Ventilation
Assessment of the Capability of PulmoVista 500 to Continuously Monitor Changes of Ventilation Over Time
The results of this study will help to define the capability and reliability of PulmoVista 500 to detect changes in both global and regional ventilation.
- Conditions
- Mechanical Ventilation, Single-lung Ventilation, ARDS, ALI - Acute Lung Injury
- Trial name
- NCT03076983
- Testing
- Lung Monitoring with EIT device (PulmoVista 500)
- Where
- 3 sites in Germany
- Volunteers
- 80 people
- Sponsor
- Drägerwerk AG & Co. KGaA
One-Lung Ventilation
Estimating Blood Concentrations of Anaesthetics During One-Lung Ventilation (OLV)
The aims of the study is to determine if end-tidal concentrations of the anaesthetic gases isoflurane and sevoflurane as measured by a standard gas monitor are related to the blood levels during one-lung ventilation.
- Trial name
- NCT02821455
- Testing
- Lung Surgery with One-Lung Ventilation
- Where
- United Kingdom
- Volunteers
- 19 people
- Sponsor
- University of Edinburgh
Pulmonary Ventilation, Capnography
Non-invasive Tidal Volume Monitoring Using the Linshom Respiratory Monitoring Device
Many post-operative complications arise from patients who breathe inadequately. Inadequate respiration, whether the result of surgery or the anesthesia, causes a decrease in blood oxygen saturation and an increase in carbon…
- Trial name
- NCT03279458
- Testing
- Linshom Respiratory Monitoring Device
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Mississippi Medical Center
Ventilation, Breathing
Pilot Evaluation Comparing Regional Distribution of Ventilation During Lung Expansion Therapy
The primary purpose of this study is to determine if there is a significant difference in regional distribution of ventilation when comparing eupneic tidal ventilation with Incentive Spirometry (I.S.) and EzPAP® lung expansion…
- Conditions
- Ventilation, Breathing, Atelectasis
- Trial name
- NCT03083379
- Testing
- Volumetric Incentive Spirometry, EzPAP® POSITIVE AIRWAY PRESSURE
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Acute Lung Injury, Acute Respiratory Distress Syndrome
Airway Pressure Release Ventilation in Acute Lung Injury
The purpose of this study is to compare airway pressure release ventilation (APRV) to conventional mechanical ventilation (MV) in patients with acute lung injury (ALI) to determine if APRV can reduce agitation, delirium, and…
- Conditions
- Acute Lung Injury, Acute Respiratory Distress Syndrome, Mechanical Ventilation
- Trial name
- NCT00750204
- Testing
- APRV, Conventional MV
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Johns Hopkins University
Video-assisted Thoracoscopic Surgery, Lung Isolation Device
Lung Collapse With Bronchial Blocker
Lung isolation is frequently used during thoracic surgery. Two techniques are principally used: the double lumen tube (DLT) and the bronchial blocker (BB).
- Conditions
- Video-assisted Thoracoscopic Surgery, Lung Isolation Device, One-lung Ventilation, Double Lumen Endotracheal Tube
- Trial name
- NCT01615263
- Testing
- Lung isolation device
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Laval University