Clinical trials: Pulmonary Ventilation Function
ARDS
Ultra-Low Tidal Volume Mechanical Ventilation in ARDS Through ECMO
Primary Research Question for the Full ULTIMATE Randomized Clinical Trial (RCT): What is the effect of ultra-protective ventilation facilitated by extracorporeal membrane oxygenation (ECMO) versus best current conventional…
- Trial name
- ULTIMATE (NCT04832789)
- Testing
- Venovenous ECMO
- Where
- 11 sites in United States, Canada
- Volunteers
- 72 people
- Sponsor
- University of Toronto
Respiratory Failure, Atelectasis
Low Tidal MEChanical Ventilation Against NO Ventilation During Cardiopulmonary Bypass Heart Surgery
BACKGROUND. Postoperative pulmonary complications are a leading cause of morbidity and mortality after cardiac surgery. To this date, there are no recommendations regarding mechanical ventilation associated with cardiopulmonary…
- Conditions
- Respiratory Failure, Atelectasis, Pneumonia, Pneumothorax
- Trial name
- MECANO (NCT03098524)
- Testing
- Low tidal volume ventilation (LTV arm), No ventilation (noV arm), Lung recruitment manoeuver
- Where
- France
- Volunteers
- 1,502 people
- Sponsor
- CMC Ambroise Paré
Obstructive Sleep Apnea (OSA)
Post-extubation Boussignac CPAP System in Adults With Moderate to Severe Obstructive Sleep Apnea
The purpose of this study is to assess the efficacy of the Boussignac positive airway pressure system (a mask) applied immediately following post-operative extubation in improving lung function in patients with obstructive sleep…
- Trial name
- NCT01877928
- Testing
- Boussignac CPAP device, standard CPAP
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- Queen's University
Pregnancy Related
Response of Pulmonary Functions to Deep Breathing Exercise in Twin Pregnancy
this study is to investigate the response of pulmonary function to deep breathing exercise in twin pregnancy
- Trial name
- NCT06031220
- Testing
- deep breathing exercise inform of diaphragmatic and costal breathing
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Badr University
Respiratory Distress Syndrome, Ventilation Therapy; Complications
Changes in Lung Aeration and Inspiratory Effort With and Without Awake Prone
The investigators aimed to investigate the ventilation homogeneity and transpulmonary pressure during treatments of High-flow nasal cannula(HFNC) and (CPAP) on supine and prone position for COVID-19 or non-COVID-19 patients with…
- Trial name
- NCT05719103
- Testing
- With and Without Awake Prone Positioning
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Shanghai Zhongshan Hospital
Intensive Care
Bedside Measurement of Ventilation With or Without a One-way Valve During Lung Lavage
Surveillance of the lungs for bacteria is routinely undertaken in artificially ventilated patients as these individuals are at high risk of developing pneumonia.
- Trial name
- NCT01143961
- Testing
- CSC100 - Verso airway access adapter CareFusion
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Cardiff and Vale University Health Board
Mesothelioma, Lung Neoplasms
Chest Wall Motion Analysis in Disease
Breathing movements, called chest wall motion, are very complex. The investigators are studying how movement of the abdomen, ribs and diaphragm contribute to breathing and how this differs with different diseases in the chest.
- Conditions
- Mesothelioma, Lung Neoplasms, Surgery, Cystic Fibrosis
- Trial name
- CWM (NCT02958683)
- Testing
- Chest wall motion analysis
- Where
- United Kingdom
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Heart of England NHS Trust
COPD, Dyspnea
Deventilation Dyspnea in COPD Patients Using NIV
Non-invasive ventilation (NIV) has shown to be an effective therapy for patients with Chronic Obstructive Pulmonary Disease (COPD) with Chronic Hypercapnic Respiratory Failure (CHRF).
- Conditions
- COPD, Dyspnea, Mechanical Ventilation Complication
- Trial name
- NCT03503123
- Testing
- Monitoring physiology with Electrical Impedance Tomography, Electromyography and transcutaneous carbon dioxide measurements.
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- University Medical Center Groningen
COPD (Chronic Obstructive Pulmonary Disease)
HFNC Versus NIV in Hypercapneic COPD Patients
Aim: To compare gas exchange trends, clinical outcomes, and tolerability between HFNC and NIV in COPD patients with mild-to-moderate hypercapnic respiratory failure.
- Trial name
- NCT07854210
- Testing
- high flow nasal cannula, non invasive ventilation
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Mohammed Shehta
Chronic Obstructive Pulmonary Disease
HomeVent ( Connect) Registry: EU COPD Home NIV Registry
The prevalence of chronic respiratory disease, including chronic obstructive pulmonary disease (COPD), is increasing in industrialized countries.
- Trial name
- HOmeVent (NCT02811588)
- Testing
- Non-invasive ventilation
- Where
- 4 sites in Germany
- Volunteers
- 169 people
- Sponsor
- ResMed
Acute Respiratory Failure
Physiological Effects of a New Interface on Lung Ventilation and Gas Distribution
Hypoxemic Acute Respiratory Failure (hARF) is a common reason of admission to Intensive Care. Different modalities can be used to administer oxygen, which is the first supportive treatment in these patients.
- Trial name
- NCT04619641
- Testing
- High Flow Nasal Cannula (HFNC), Continuous Positive Airway Pressure (CPAP)
- Volunteers
- 15 people
- Sponsor
- University Magna Graecia
Acute Respiratory Failure (ARF)
Lung Recruitment Assessed by 2D/3D-EIT and R/I Ratio in Acute Respiratory Failure Patients With Mechanical Ventilation
The purpose of this observational study is to assess the differences and consistency in evaluating lung recruitment potential between the recruitment-to-inflation ratio (R/I ratio) and three-dimensional electrical impedance…
- Trial name
- NCT07379242
- Testing
- The lung recruitment potential assessed and PEEP titration by ventilator and 2D/3D EIT
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking Union Medical College Hospital
Asthma
VENTURI (VENTilation Using Respiratory Imaging)
The purpose of the study is to enroll participants with uncontrolled asthma to evaluate the large and small airways and drug delivery utilizing two study drugs: Beclometasone dipropionate/Formoterol fumarate…
- Trial name
- VENTURI (NCT07282886)
- Testing
- Beclomethasone Dipropionate/Formoterol Fumarate/Glycopyrrolate pMDI, Fluticasone Furoate/Umeclidinium/Vilanterol 100 MCG/1 ACTUATION-62.5 MCG/1 ACTUATION-25 MCG/1 ACTUATION Inhalation Powder
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Alabama at Birmingham
Respiratory Tract Disease, Kidney Transplantation
Evaluation of the Respiratory Function in Renal Transplanted Children
Objectives: While a respiratory abnormality was found in 50% of pediatric renal transplant recipients in a study conducted in Belgium and the Netherlands in 2008, the respiratory status of transplanted children in France remains…
- Conditions
- Respiratory Tract Disease, Kidney Transplantation, Pediatric
- Trial name
- SPIROKID (NCT03571542)
- Testing
- pulmonary function
- Where
- 5 sites in France
- Volunteers
- 385 people
- Sponsor
- Nantes University Hospital
Respiratory Distress Syndrome, Adult, Ventilator-Induced Lung Injury
Asynchrony During Mechanical Ventilation in Patients With Acute Respiratory Distress Syndrome
Asynchrony during mechanical ventilation has been poorly described in patients suffering from acute respiratory distress syndrome.
- Trial name
- NCT02732041
- Where
- 5 sites in Argentina
- Volunteers
- 103 people
- Sponsor
- Centro de Educación Medica e Investigaciones Clínicas Norberto Quirno
Chronic Obstructive Pulmonary Disease, Chronic Respiratory Hypercapnic Failure
A Study to Investigate the Effects of Heated Humidification During Non-Invasive Ventilation
Noninvasive ventilation (NIV) is a form of ventilation delivered by a mask and is an important mode of treatment in patients with both acute and chronic respiratory (breathing) failure.
- Conditions
- Chronic Obstructive Pulmonary Disease, Chronic Respiratory Hypercapnic Failure, Neuromuscular Disease, Obesity Hypoventilation Syndrome
- Trial name
- NCT01372072
- Testing
- non-invasive ventilation heated humidification (Fisher-Paykel MR810 and MR850 humidifiers)
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Lung Neoplasms, Emphysema
Computed Tomography Assessment of Regional Ventilation (CURVE)
This study uses CT scans to assess airflow in the lung, the scan is quick, cheap and painless. The information from the scan may help doctors tell which patients are suitable to have surgery to cure early stage lung cancer.
- Conditions
- Lung Neoplasms, Emphysema, Lung Diseases, Interstitial, Pulmonary Disease, Chronic Obstructive
- Trial name
- CURVE (NCT02879773)
- Testing
- CTPVe
- Where
- United Kingdom
- Volunteers
- 131 people
- Sponsor
- Heart of England NHS Trust
Invasive Mechanical Ventilation, Ventilator-Induced Lung Injury
Effects of Large Tidal Volumes Despite Minimal Inspiratory Support in Spontaneously Ventilated Intubated Resuscitation Patients. Pathophysiological Exploratory Study.
Some ICU ventilated patients might present with large tidal volume despite very low or inexistant presser support. Patient-Self Inflicted Lung Injury (P-SILI) might appear related with large alveolar stretch an distension.
- Conditions
- Invasive Mechanical Ventilation, Ventilator-Induced Lung Injury, Patient-Self Inflicted Lung Injury, Encephalopathy
- Trial name
- InLarge (NCT05056961)
- Testing
- Multiparametric mesurements
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Clermont-Ferrand
Asthma
The Effect of Pranayama Breathing Technique on Asthma Control, Pulmonary Function and Quality of Life
Most of the asthma patients prefer complementary and integrative applications as they continue to experience asthma symptoms despite pharmacological treatment.
- Trial name
- NCT04110951
- Testing
- Pranayama Breathing Technique, Relaxation technique
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- TC Erciyes University
ARDS, COVID19
Evaluation of Airway Pressure Release Ventilation in COVID-19 ARDS
The 2020 pandemic of the coronavirus (SARS-CoV2) has lead to an increase in ARDS cases requiring invasive mechanical ventilation in the ICU (Intensive Care Unit).
- Trial name
- APRV-COVID19 (NCT04386369)
- Testing
- Airway pressure release ventilation
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Central Hospital, Nancy, France