Clinical trials: Pulmonary Ventilation Function
Chronic Obstructive Pulmonary Disease
Long-term Effects of Non-invasive Ventilation in Hypercapnic Chronic Obstructive Pulmonary Disease (COPD) Patients
In this multicenter study the comparison of the mass flow distribution and redistribution versus the relative blood flow per lobe (as a surrogate for Ventilation/ Perfusion (V/Q) matching) with functional respiratory imaging…
- Trial name
- NCT01592656
- Testing
- Functional Respiratory Imaging, Lung compliance measurement, Non-invasive ventilation (Respironics)
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 40 people
- Sponsor
- FLUIDDA nv
Ventilator-Induced Lung Injury, Mechanical Ventilation Complication
A New Ultrasonographic Tool to Assess Regional Pulmonary Strain
This study is designed to assess the feasibility of the measurement of local pleural strain at 4 different anatomical sites. The secondary objectives of the study are: To assess intra- and inter-observer variability in the…
- Trial name
- NCT03092557
- Testing
- Determination of local pleural strain
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
PMV
Abdominal Weight Training Assisted by Cough Assist Machine on Lung Function
The patients with prolonged mechanical ventilation (PMV) have the risk of ineffective coughing and infection due to diaphragm weakness, making it more difficult to wean.
- Trial name
- NCT05295381
- Testing
- cough machine (CM), abdominal weight training (AWT)
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Liu Shih Feng
COPD - Chronic Obstructive Pulmonary Disease, Forward Head Posture
Combined Posture Correction and Resistive Respiratory Muscles Training in COPD With FHP
Chronic obstructive pulmonary disease (COPD) is characterized by persistent respiratory symptoms and airflow limitation, often exacerbated by postural abnormalities such as forward head posture (FHP).
- Trial name
- NCT07293429
- Testing
- Resistive inspiratory muscles training, Resistive expiratory muscles training:, Combined resistive inspiratory and expiratory muscles training
- Where
- Pakistan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Obesity
Effects of Senobi Breathing Exercises in Obese Women
Previous studies have been done just in studying the relationship between breathing technique and obesity and described how it proved helpful in decreasing body fat.
- Trial name
- NCT05323500
- Testing
- Senobi breathing exercises
- Where
- 2 sites in Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Pneumonia, Invasive Mechanical Ventilation
Ultrasound Evaluation of Respiratory Muscles During Mechanical Ventilation Weaning in ICU Patients
Patients with pneumonia who require invasive mechanical ventilation in the intensive care unit (ICU) often experience difficulties during the process of being separated from the breathing machine (weaning).
- Conditions
- Pneumonia, Invasive Mechanical Ventilation, Weaning From Mechanical Ventilation in Care Unit, Respiratory Muscle Dysfunction
- Trial name
- NCT07405567
- Testing
- No intervention (observational study)
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Bursa Sevket Yilmaz Training and Research Hospital
COVID-19
Effects of Unsupervised Inspiratory Muscle Training on Ventilation Variability in Post-covid-19 Patients.
Dysfunctional breathing and persistent hypocapnia can be associated with many of the symptoms experienced by patients such as dyspnea, fatigue, chest pain and palpitations.
- Trial name
- NCT06362499
- Testing
- Experimental Group
- Where
- 2 sites in Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio Grande do Norte
Pulmonary Disease, Chronic Obstructive, Hypercapnia
Sleep and Daytime Use of Humidified Nasal High-flow Oxygen in COPD Outpatients
Humidified Nasal High-flow with Oxygen (HNHF-O2) therapy has been reported to have acute beneficial effects in patients with hypoxemic respiratory failure who have been hospitalized.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Hypercapnia, Hypoxia
- Trial name
- NCT03221387
- Testing
- Humidified nasal high flow with oxygen
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Temple University
Thoracic Surgery, One-lung Ventilation
CT-Guided vs Conventional DLT Sizing in Thoracic Surgery
This is a prospective, randomized, single-blinded controlled trial designed to compare CT-guided versus conventional methods for selecting double-lumen tube (DLT) size in patients undergoing thoracic surgery requiring one-lung…
- Trial name
- CTDLT-SIZE (NCT07575763)
- Testing
- CT-Guided Group (Intervention), Conventional Group (Control)
- Where
- Jordan
- Volunteers
- 100 people
- Sponsor
- King Hussein Cancer Center
Obstructive Sleep Apnea
Effect of Different Exercise Modalities Training in Patients With Obstructive Sleep Apnea.
The objective of this study was to compare different exercise modalities (moderate continuous intensity training, high intensity interval training, and inspiratory muscle training) on Apnea-Hypopnea index and oxidative stress in…
- Trial name
- NCT06087900
- Testing
- Moderate continuous training (MICT), High intensity interval training (HIIT), Inspiratory muscle training (IMT)
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Chulalongkorn University
Right Ventricular Dysfunction
Right Ventricular Contractility Reserve Following Repair of Tetralogy of Fallot
Background: Residual pulmonary regurgitation following repair of tetralogy of Fallot, in particular the use of a transannular patch, has been shown to correlate with the development of right ventricular dysfunction.
- Trial name
- TOF-Cond (NCT00557934)
- Testing
- dobutamine
- Where
- Germany
- Volunteers
- 16 people
- Sponsor
- University Hospital Tuebingen
Chronic Obstructive Pulmonary Disease
Bronchodilator Test in Mechanical Ventilated Chronic Obstructive Pulmonary Disease Patients
Investigators developed a test to assess the bronchodilator effects in mechanically ventilated chronic obstructive pulmonary disease patients by comparing the change of airway resistance.
- Trial name
- NCT02218398
- Testing
- Albuterol
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Beijing Chao Yang Hospital
Respiratory Distress Syndrome, Newborn
Ventilatory Management of the Preterm Neonate in the Delivery Room
The purpose of this study is to evaluate sustained lung inflation followed by early nCPAP as delivery room ventilatory management for preterm neonates at risk of respiratory distress syndrome in reducing their need for mechanical…
- Trial name
- NCT01255826
- Testing
- Resuscitation of preterm neonates by sustained lung inflation through T piece device followed by CPAP, Resuscitation of preterm neonates by intermittent bag and mask ventilation using self inflating bag.
- Where
- Egypt
- Volunteers
- 112 people
- Sponsor
- Ain Shams University
Lung Diseases, Obstructive, Postoperative Complications
Preoperative Diagnostic Tests for Pulmonary Risk Assessment in COPD
This prospective study intends to investigate the incidence of postoperative pulmonary complications (PPC) or in-hospital mortality in patients with COPD or at risk for COPD undergoing high-risk noncardiac major surgery and to…
- Trial name
- PredicT (NCT02566343)
- Where
- Germany
- Volunteers
- 365 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Severe Infections Pneumonia With Invasive Ventilation in PICU
RAPid SOlution for Diagnosis of Respiratory Infection in Pediatric Intensive Care Unit
In patients with infectious pneumonitis, the FILMARRAY® Pneumonia Plus Panel technique (multiplex PCR) on a respiratory sample makes it possible to identify the responsible pathogen and its resistance to antibiotics in less than…
- Trial name
- RAPSODI (NCT04773704)
- Testing
- FILMARRAY® Pneumonia Plus Panel technique
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cystic Fibrosis
19F MRI to Evaluate Regional Ventilation in Healthy Subjects and Subjects With Cystic Fibrosis
An open label non-randomized study enrolling up to 20 healthy participants and up to 30 participants with cystic fibrosis to establish a healthy versus disease comparison.
- Trial name
- NCT03489590
- Testing
- PFP
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
ARDS, Ventilator-Induced Lung Injury
Assisted or Controlled Ventilation in Ards (Ascovent)
The present pilot randomized controlled clinical trial will test the hypothesis that in patients with ARDS, fixing ventilator settings to the conventional protective ventilatory strategy (VT 6 ml/kg ideal body weight and Pplat ≤…
- Conditions
- ARDS, Ventilator-Induced Lung Injury, Mechanical Ventilation Complication, Inflammatory Response
- Trial name
- ASCOVENT (NCT03245684)
- Testing
- assessment of inflammatory response during PSV
- Volunteers
- 40 people
- Sponsor
- University of Roma La Sapienza
Mechanical Ventilation, Acute Respiratory Distress Syndrome
ART-3 Pilot - Driving Pressure Limited Ventilation for Patients Without ARDS (ART3pilot)
This is a multicenter randomized controlled pilot trial to investigate the feasibility of a driving pressure limited mechanical ventilation strategy compared to a conventional strategy in patients without acute respiratory…
- Trial name
- ART-3pilot (NCT02376647)
- Testing
- Driving pressure limited ventilation, Conventional ventilation
- Where
- Brazil
- Sponsor
- Hospital do Coracao
Chronic Obstructive Pulmonary Disease
Effects of Active Cycle of Breathing Technique With and Without Acapella on Airway Clearance
We are conducting this study to check the effects of active cycle of breathing technique with or without acapella on airway clearance, dyspnea and pulmonary function test in COPD patients.
- Trial name
- NCT05618847
- Testing
- Acapella,ACBTS, ACBTs
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- Riphah International University
Lung Disease, Hypoxemia
Inhaled Nitric Oxide in Neonates With Elevated A-a DO2 Gradients Not Requiring Mechanical Ventilation
The purpose of this pilot study is to evaluate whether administration of nitric oxide (NO)gas by oxygen hood at 20 ppm significantly increases PaO2, as compared to placebo gas (oxygen), within one hour of initiation and with no…
- Conditions
- Lung Disease, Hypoxemia, Respiratory Acidosis
- Trial name
- NCT00041548
- Testing
- nitric oxide for inhalation, Oxygen
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Mallinckrodt