Clinical trials: Pulmonary-Related Conditions
Pulmonary Hypertension, Chronic Kidney Disease
Association Between Biomarkers and Kidney Function Decline in Pulmonary Hypertension
The objective of this study is to examine the association between urinary and plasma biomarkers and change in estimated glomerular filtration rate (eGFR) among patients with pulmonary hypertension (PH).
- Trial name
- NCT06409624
- Testing
- No intervention is planned as part of the study
- Where
- 2 sites in Germany
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Giessen
Respiratory Syncytial Virus (RSV) Infection, Acute Lower Respiratory Tract Infections
Assessing the Burden of Respiratory Syncytial Virus (RSV)
This study examines the impact of Respiratory Syncytial Virus (RSV) on people of all ages, from infants to the elderly. It uses hospital records collected between January 2018 and December 2024 to understand: How often does RSV…
- Conditions
- Respiratory Syncytial Virus (RSV) Infection, Acute Lower Respiratory Tract Infections, Bronchiolitis, Pneumonia
- Trial name
- NCT07015255
- Where
- United Arab Emirates
- Volunteers
- 1,500 people
- Sponsor
- Abu Dhabi Health Services Company
Pulmonary Disease, Chronic Obstructive
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Dose-Response Relationship of Multiple Doses of GSK2269557 Administered as a Dry Powder to Chronic Obstructive Pulmonary Disease (COPD) Patients
This is a randomised, double-blind, placebo controlled, parallel group study to evaluate the safety, tolerability, pharmacokinetics and dose response of multiple doses of GSK2269557 administered as a dry powder in COPD subjects.
- Trial name
- NCT02130635
- Testing
- GSK2269557 100 MCG, GSK2269557 500 MCG
- Where
- 2 sites in Germany
- Volunteers
- 64 people
- Sponsor
- GlaxoSmithKline
Non Definite IPF, Interstitial Lung Diseases
Pathological Comparisons of Surgical Open Lung Biopsies and Cryobiopsies in Non-IPF ILD
Pathological comparisons of surgical open lung biopsies and cryobiopsies in non-IPF ILD. Patients with non-IPF ILD eligible for an open lung biopsy will undergo cryobiopsy in the same time.
- Trial name
- CryoPID (NCT02763540)
- Testing
- Lung cryobiopsy
- Where
- 2 sites in France, Italy
- Volunteers
- 21 people
- Sponsor
- University Hospital, Montpellier
Systemic Sclerosis, Scleroderma
A Study to Evaluate the Safety and Tolerability of Oral Ixazomib in Scleroderma-related Lung Disease Patients
The purpose of this research study is to learn about the effects of the medication ixazomib in participants with scleroderma/systemic sclerosis including its safety and tolerability, its effects on skin, lungs and other organs…
- Conditions
- Systemic Sclerosis, Scleroderma, Diffuse Systemic Sclerosis, Diffuse Scleroderma
- Trial name
- NCT04837131
- Testing
- Ixazomib
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Michael M. Pham
Respiration Disorders
Randomized Study of Propofol Versus Fentanyl and Midazolam in Pediatric Patients Requiring Mechanical Ventilation and Sedation Therapy
OBJECTIVES: I. Assess the degree of amnesia afforded by study sedatives relative to the patient's intensive care unit experiences. II.
- Trial name
- NCT00004424
- Testing
- fentanyl, Midazolam, propofol
- Volunteers
- 120 people
- Sponsor
- FDA Office of Orphan Products Development
Acute Coronary Syndromes (ACS), Pneumonia
Analysis of Growth Differentiation Factor 15 (GDF-15), Mid Regional proAdrenomedullin (MR proADM), and Persepsin Levels in Patient in Acute Coronary Syndrome Patients With Pneumonia, With or Without Influenza Vaccination
The goal of this observational study is to analyze the relationship between various biomarkers (GDF-15, MR proADM, and Presepsin) in patients with Acute Coronary Syndrome (ACS) who also have Pneumonia and Chronic Obstructive…
- Conditions
- Acute Coronary Syndromes (ACS), Pneumonia, COPD (Chronic Obstructive Pulmonary Disease)
- Trial name
- NCT07604103
- Testing
- Vaxigrip, antibiotic treatments, percutaneus coronary intervention
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- University of Brawijaya
COPD
Respiratory Muscle Fatigue and Lower Extremity Muscle Oxygenation
In our study, changes in vastus lateralis muscle oxygenation will be evaluated with the Moxy device, a functional infrared oxygen measurement device, during the inspiratory muscle fatigue protocol in COPD cases and the healthy…
- Trial name
- NCT06217276
- Testing
- Respiratory muscle fatigue protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Chronic Obstructive Pulmonary Disease
Integrated Care Program for Chronic Obstructive Pulmonary Disease
Integrated eHealth is an innovative, proactive approach to the management of patients with chronic cardiopulmonary disease. Our overall goal is to improve the health of patients by integrating guideline-based education, remote…
- Trial name
- NCT01045213
- Testing
- Integrated Care
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Colorado, Denver
Pulmonary Disease, Chronic Obstructive
The London COPD Exacerbation Cohort
The London COPD exacerbation (EXCEL) cohort builds on an established cohort started in 1995 and designed to study COPD exacerbations and their impact on health-status and disease progression.
- Trial name
- EXCEL_Cohort (NCT02755974)
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Imperial College London
Chronic Obstructive Pulmonary Disease
Expression of SLC25A48 in Chronic Obstructive Pulmonary Disease
This study aims to investigate the expression level of SLC25A48, a mitochondrial choline transporter, in peripheral blood mononuclear cells of patients with chronic obstructive pulmonary disease, and to analyze its correlation…
- Trial name
- NCT07474220
- Where
- 2 sites in Taiwan
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Fu Jen Catholic University
Cytomegalovirus Infections, Cytomegalovirus Retinitis
A Comparison of HIV-Infected Patients With and Without Opportunistic (AIDS-Related) Infection
The purpose of this study is to understand how changes in the immune system of HIV-infected patients affect their risk for 3 serious infections: Pneumocystis carinii pneumonia (PCP), cytomegalovirus (CMV) retinitis, or CMV organ…
- Conditions
- Cytomegalovirus Infections, Cytomegalovirus Retinitis, Pneumonia, Pneumocystis Carinii, HIV Infections
- Trial name
- NCT00005572
- Where
- 16 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Chronic Obstructive Pulmonary Disease, Emphysema
Clinical & Systems Medicine Investigations of Smoking-related Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease (COPD) is an increasing global health problem, which primarily increases among the female population.
- Conditions
- Chronic Obstructive Pulmonary Disease, Emphysema, Chronic Bronchitis, Chronic Airways Obstruction
- Trial name
- COSMIC (NCT02627872)
- Where
- Sweden
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Telomere Disease
Low-Dose Danazol for the Treatment of Telomere Related Diseases
Background: DNA is a structure in the body. It contains data about how the body develops and works. Telomeres are found on the end of chromosomes in DNA.
- Trial name
- NCT03312400
- Testing
- Danazol
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cystic Fibrosis, Constipation
Assessing Tenapanor as a Treatment of CF-related Constipation.
Tenapanor is the newest FDA-approved drug for IBS with constipation (IBS-C). This study seeks to understand tenapanor as a treatment for cystic fibrosis-related constipation (CFrC) in CF patients.
- Trial name
- NCT06810167
- Testing
- Tenapanor
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Massachusetts General Hospital
Sleep Hygiene, Sarcopenia
Sleep Hygiene, Sarcopenia, and Cognitive Function in Respiratory Disease
We aim to clarify the relationship between sleep hygiene and the onset of sarcopenia or cognitive dysfunction using sleep time, arousal, and sleep quality as indicators in COPD or IPF patients, and clarify the effects of sleep…
- Conditions
- Sleep Hygiene, Sarcopenia, Cognitive Function, COPD
- Trial name
- NCT05193136
- Where
- Japan
- Volunteers
- 120 people
- Sponsor
- National Hospital Organization Minami Kyoto Hospital
Coronary Disease, Myocardial Infarction
Chronical Illness-related Limitations of the Ability to Cope With Rising Temperatures: an Observational Study
The CLIMATE Observational Study examines to what extent chronically ill patients experience adverse health effects because of heat and whether the patients' specific efforts, somatosensory amplification, self-efficacy, health…
- Conditions
- Coronary Disease, Myocardial Infarction, Heart Failure, Arrhythmias, Cardiac
- Trial name
- CLIMATE (NCT05961163)
- Where
- Germany
- Volunteers
- 61 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Chronic Obstructive Pulmonary Disease
Arm Training in Patients With Chronic Obstructive Pulmonary Disease
Patients with chronic lung disease often report shortness of breath when they use their arms for simple activities of daily living such as dressing, lifting, shaving, bathing and brushing their hair and teeth.
- Trial name
- NCT00657293
- Testing
- Arm training program
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- West Park Healthcare Centre
COPD
Brisk Walk on Chronic Obstructive Pulmonary Disease
To determine the effects of 30 min brisk walk on Pulmonary Functions on COPD patients To determine the effects of 30 min brisk walk on Health related Health-related quality of life (HRLQ) on Chronic obstructive pulmonary disease…
- Trial name
- NCT05052047
- Testing
- Brisk Walking Group, Conventional Breathing Exercise Group
- Where
- Pakistan
- Volunteers
- 74 people
- Sponsor
- Riphah International University
Nosocomial Infections
Multi-center Observational Study to Evaluate Epidemiology and Resistance Patterns of Common ICU-Infections (MOSER)
Most literature on ICU infections and the resistant patterns comes from the western literature. This data may not truly reflect the incidence, epidemiology and resistance patterns in developing countries such as India.
- Trial name
- MOSER (NCT01346735)
- Testing
- No intervention
- Where
- India
- Volunteers
- 381 people
- Sponsor
- Indian Society of Critical Care Medicine