Clinical trials: Pulmonary-cardiovascular Imaging
Coronary Artery Disease, Heart Failure
Stress Echo 2020 - The International Stress Echo Study
Background: Stress echocardiography (SE) has an established role in evidence-based guidelines, but recently the breadth and variety of applications has extended well beyond coronary artery disease (CAD).
- Conditions
- Coronary Artery Disease, Heart Failure, Hypertrophic Cardiomyopathy, Aortic Valve Disease
- Trial name
- SE2020 (NCT03049995)
- Testing
- Left ventricular contractile reserve SE, B-lines SE, Left ventricular outflow tract gradient SE
- Where
- Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Fatebenefratelli Hospital
Cardiovascular Diseases, Multi-omics
Dongzong Cardiovascular Bio-imaging Registry Study
The DAILY project is a large-scale, multicenter, prospective initiative designed to establish a comprehensive bio-imaging database that integrates multidimensional data, including living environments, psychosocial and cognitive…
- Conditions
- Cardiovascular Diseases, Multi-omics, Living Environments, Pulmonary-cardiovascular Imaging
- Trial name
- DAILY (NCT06894095)
- Where
- 3 sites in China
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- Jinling Hospital, China
Atrial Fibrillation, COVID-19
Positron Emission Tomography (PET) Imaging of Thrombosis
The purpose of the study is to evaluate a new radiotracer called 64Cu-FBP8 for PET-MR imaging of thrombosis. The tracer has the potential of detecting thrombosis anywhere in the body, for instance in the left atrial appendage of…
- Conditions
- Atrial Fibrillation, COVID-19, Cancer, Thrombosis
- Trial name
- NCT03830320
- Testing
- [64Cu]FBP8, PET/MR, Blood Collection
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Cardiovascular Diseases
Clinical and Imaging Biomarkers Associated With Plasma ad Cellular Determinants of Cardiovascular Disease at the Time of COVID 19
Acute and chronic cardiovascular complications of pneumonia are common and result from various mechanisms, including relative ischemia, systemic inflammation, and pathogen-mediated injury.
- Trial name
- CARDIOCOVID (NCT05745753)
- Testing
- sample blood
- Where
- Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Chest Pain, Acute Coronary Syndrome
Diagnostic Accuracy of Multislice CT Angiography for Acute Chest Pain
The ACUTE CT trial is designed to test whether the assessment of chest structures by high-resolution multislice computed tomography (CT) provides equivalent diagnostic accuracy for patient with acute chest pain or other potential…
- Conditions
- Chest Pain, Acute Coronary Syndrome, Pulmonary Embolism, Aortic Dissection
- Trial name
- ACUTE CT (NCT00855231)
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of Washington
Hemiparesis, Ischemic Stroke
Functional Magnetic Resonance Imaging (fMRI) and Robot-Assisted Practice of Activities of Daily Living
The investigators will study motor recovery after robot-assisted therapy after stroke. A small clinical trial will be conducted to quantify the central nervous system changes associated with robotic or standard training, and…
- Conditions
- Hemiparesis, Ischemic Stroke, Chronic
- Trial name
- NCT00878085
- Testing
- Robot Therapy Device, Occupational Therapy
- Where
- 2 sites in United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Enhancement of Aorta and Pulmonary Artery, Radiation Exposure
The Best Parameters for Imaging Agent Injection and Scanning Methods in Computed Tomography Angiography
Background: The contrast time-enhancement profiles of pulmonary artery (PA) and the aorta differ by using computed tomography (CT) angiography.
- Trial name
- NCT04832633
- Testing
- Different contrast media injection methods
- Where
- Taiwan
- Volunteers
- 101 people
- Sponsor
- Mackay Memorial Hospital
Pulmonary Arterial Hypertension
Evaluation of Pulmonary Perfusion Heterogeneity and Compliance in Patients With Pulmonary Hypertension Using Positron Emission Tomography Imaging
The purpose of the study is to find out how the blood flow changes in the lungs of people with pulmonary hypertension compared to healthy individuals without pulmonary hypertension.
- Trial name
- NCT01461343
- Testing
- CT imaging, functional PET imaging
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Magnetic Resonance Imaging, Tetralogy of Fallot
4D Velocity Mapping of the Heart in rTOF Patients
MRI with 4D flow permits to assess the hemodynamic parameters in a parent vessel and its branches inside the same sequence.
- Trial name
- CARDIOFLUX (NCT02980614)
- Testing
- 4D flow imaging
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Heart Disease Congenital, Ventricular Septal Defect
Improving Care for Children With Congenital Heart Disease.
Establish a cardiovascular biomarker profile to help screening for congenital heart disease in infants and children as well as use non-invasive cardiac imaging in combination with such profiling to better predict the need for…
- Conditions
- Heart Disease Congenital, Ventricular Septal Defect, Atrial Septal Defect, Patent Ductus Arteriosus
- Trial name
- NCT04667455
- Testing
- Biomarker analysis at enrolment, Biomarker analyses throughout the study
- Where
- Sweden
- Volunteers
- 313 people, healthy volunteers welcome
- Sponsor
- Lund University Hospital
Obesity, Respiratory Insufficiency
Open Lung Strategy in Critically Ill Morbid Obese Patients
The goal of this interventional crossover study in morbidly obese intubated and mechanically ventilated patients is to describe the respiratory mechanics and the heart-lung interaction at titrated positive end-expiratory pressure…
- Conditions
- Obesity, Respiratory Insufficiency, Right-Sided Heart Failure, Pulmonary Atelectasis
- Trial name
- NCT02503241
- Testing
- PEEP INCREMENTAL, PEEP DECREMENTAL
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Massachusetts General Hospital
Pulmonary Arterial Hypertension
PET Image in PAH Patients
Pulmonary arterial hypertension (PAH) is mortal disease affecting the blood vessels of the lung. Despite its morbid prognosis, PAH is often misdiagnosed or ignored, with an average time of 44 months between onset of symptoms to…
- Trial name
- NCT05452889
- Testing
- 18F-FGLN PET Imaging, (18F)FPGLU
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Stephen Y. Chan
Pulmonary Hypertension
Phase-II Study of the Use of PulmoBind for Molecular Imaging of Pulmonary Hypertension
Pulmonary hypertension or elevation of the pressure in the pulmonary vessels, results from various clinical conditions. It may be idiopathic (of unknown cause) or associated with numerous diseases including cardiovascular and…
- Trial name
- PB-02 (NCT02216279)
- Testing
- PulmoBind
- Where
- 3 sites in Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Montreal Heart Institute
Tetralogy of Fallot
Cardiac Function Under Stress for Early Detection of the Right Ventricular Insufficiency After Repair of Tetralogy of Fallot
Summary: The investigators aim to identify markers of right ventricular dysfunction in patients with severe pulmonary regurgitation following repair of Tetralogy of Fallot, that allow prediction of the optimal timing of the…
- Trial name
- NCT00564993
- Testing
- Dobutamin
- Where
- 11 sites in Germany
- Volunteers
- 53 people
- Sponsor
- Competence Network for Congenital Heart Defects
Coronary Artery Disease, Acute Cerebrovascular Accident
Incidence of Acute Cerebrovascular Events Using Either Minimized or Standard Cardiopulmonary Bypass Circuit
The prospective, randomized, two centre study investigates acute cerebrovascular events during extracorporal circulation and the early post operative outcome when using either the minimized cardiopulmonary bypass circuit…
- Conditions
- Coronary Artery Disease, Acute Cerebrovascular Accident, Intracranial Embolism, Embolism, Air
- Trial name
- ROCsafeTM (NCT00862160)
- Testing
- ROCsafeTM
- Where
- 2 sites in Germany
- Volunteers
- 64 people
- Sponsor
- Hannover Medical School
SARS-CoV Infection, Covid19
Study of HEarT DiseAse and ImmuNiTy After COVID-19 in Ireland
SETANTA study will investigate the incidence of cardiac abnormalities as assessed by cardiac magnetic resonance imaging in unselected patients after acute SARS-CoV-2 infection and correlation with immunological response and…
- Conditions
- SARS-CoV Infection, Covid19, Cardiomyopathies
- Trial name
- SETANTA (NCT04823182)
- Testing
- Cardiovascular Magnetic Resonance Imaging
- Where
- Ireland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cardiovascular Research Institute Dublin
Pulmonary Disease, Pulmonary Hypertension
Natural History Study of Biomarkers in Pulmonary Arterial Hypertension
Background: High blood pressure in the lungs, known as pulmonary arterial hypertension (PAH), is a rare disorder. Some people have disease-associated PAH and some have PAH from an unknown cause.
- Trial name
- NCT01730092
- Where
- United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Heart Septal Defects, Atrial
Bosentan for Mild Pulmonary Vascular Disease in Asd Patients.
Volume overload due to left-to-right shunting in patients with atrial septal defect type secundum causes pulmonary vascular disease over a long period of time.
- Trial name
- BOMPA (NCT01218607)
- Testing
- Bosentan
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
COVID-19, Coronary Artery Disease
Radiological Imaging in Patients Tested for COVID-19
It has become apparent that patients with co-morbidities have an increased risk of mortality from coronarvirus disease 2019 (COVID-19).
- Conditions
- COVID-19, Coronary Artery Disease, Cardiovascular Diseases
- Trial name
- NCT05188443
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- University of Edinburgh
Pulmonary Hypertension, Magnetic Resonance Imaging
4D-flow Cardiac MRI to Assess Pulmonary Arterial Pressure in Pulmonary Hypertension
Due to radiation exposure and low but real risk of morbidity and mortality associated with right heart catheterization, non-invasive procedures to estimate mPAP are desired for the diagnosis of PH or to monitor treatment…
- Conditions
- Pulmonary Hypertension, Magnetic Resonance Imaging, Pulmonary Arterial Pressure, Right Heart Catheterization
- Trial name
- HTPFLUW (NCT05103189)
- Testing
- 4D-flow sequence
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens