Clinical trials: Pulp Necrosis
Regenerative Endodontics in Traumatized Immature Teeth
Regenerative Treatment of Traumatized Immature Permanent Incisors With Pulp Necrosis
Endodontic management of traumatized immature permanent teeth with pulp necrosis is both a clinical challenge for the dental practitioners and a public health care problem.
- Trial name
- NCT04000854
- Testing
- Calcium hydroxide (Calacept)
- Where
- Sweden
- Volunteers
- 180 people
- Sponsor
- Karolinska Institutet
Apical Periodontitis, Necrotic Pulps
A Comparative Evaluation of the Degree of Pain and MMP-9 Expression Following Instrumentation of Necrotic Pulps With Apical Periodontitis in One or Two Visits
This randomized clinical trial compares postoperative pain and MMP-9 levels after root canal treatment of necrotic teeth with apical periodontitis, using either single-visit or two-visit instrumentation.
- Conditions
- Apical Periodontitis, Necrotic Pulps, Single Rooted Teeth
- Trial name
- NCT07101003
- Testing
- single visit instrumentation, multiple visit instrumentation
- Volunteers
- 28 people
- Sponsor
- Marwa Hisham Mohamed Salah Eldin
Necrotic Pulp, Post Operative Pain
Effect of Vachellia Nilotica Versus Sodium Hypochlorite as Root Canal Irrigant on Postoperative Pain and Bacterial Load Reduction in Mandibular Premolar Teeth With Necrotic Pulp
The aim of this study is to assess the effect of V. nilotica extract solution versus 2.5% NaOCl on the intensity of postoperative pain and the amount of bacterial load reduction.
- Trial name
- NCT06116214
- Testing
- Vachellia Nelotica, sodium hypochlorite
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pulp Disease, Dental, Pulp Necrosis
Chloramphenicol, Tetracycline, Zinc Oxide and Eugenol Paste (CTZ Paste) for Emergency Dental Treatment in Public Health Settings: A Randomized Trial
The treatment of pulpal diseases in primary teeth represents a significant challenge in public health, particularly in emergency dental care settings, where factors such as limited clinical time, low child cooperation, and…
- Conditions
- Pulp Disease, Dental, Pulp Necrosis, Pulp Therapy in Primary Molars, Primary Teeth
- Trial name
- CTZ- emergency (NCT07542639)
- Testing
- CTZ Paste, ZOE Pulpectomy
- Volunteers
- 110 people
- Sponsor
- University of Sao Paulo
Dental Pulp Necrosis
Effect Of Different Lining Materials in Stepwise Excavation
Deep carious lesions will encounter the dentist with the challenge of selecting a treatment method that could avoid the pulpal exposure and maintain the pulp vitality.Conventional restorative treatments suggest complete removal…
- Trial name
- NCT01730287
- Testing
- Control, Calcium Hydroxide, Mineral Trioxide Aggregate(MTA)
- Where
- Iran
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Azad University of Medical Sciences
Type 2 Diabetes Mellitus (T2DM), Necrotic Pulp
Photodynamic Therapy in Root Canal Treatment of T2DM Patients: Microbiome Analysis Via Next-Gen Sequencing
This clinical study investigates the effectiveness of antimicrobial photodynamic therapy (aPDT) as an additional disinfection method in root canal treatment of patients with Type 2 Diabetes Mellitus (T2DM) who have apical…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Necrotic Pulp, Apical Periodontitis
- Trial name
- NCT06931678
- Testing
- aPDT
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Dental Pulp Diseases, Dental Pulp Necrosis
Non-instrumentation Root Canal Treatment of Primary Molars
This randomized clinical trial intended to evaluate the efficacy of a technique of root canal treatment of deciduous molars with non-instrumentation of root canals and use of a paste containing antibiotics (chloramphenicol and…
- Trial name
- EndoDecide-1 (NCT04942158)
- Testing
- Non-instrumentation technique with use of CTZ paste, Instrumentation technique and filling with Zinc Oxide and Eugenol paste
- Where
- 4 sites in Brazil
- Volunteers
- 180 people
- Sponsor
- University of Sao Paulo
Pulp Necrosis, Apical Periodontitis
The Effect of Different Intra-canal Medications on Postoperative Pain
The aim of this study is to assess the effect of ibuprofen, nitrofurantoin, and calcium hydroxide on postoperative pain after endodontic treatment of necrotic mandibular posterior teeth Research question/hypothesis: In patients…
- Trial name
- NCT07603934
- Testing
- ibuprofen, Nitrofurantoin, Calcium Hydroxide
- Where
- Egypt
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pulp Necroses
Histopathological Evaluation of the Periodontal Ligament Subjected to Laser Ablation.
Laser Ablation therapy (LA) using an 810nm diode laser and Indocyanine Green (ICG) solution, which efficiently absorbs laser energy and increases the effectiveness of tissue removal.
- Trial name
- NCT06173648
- Testing
- Laser and ICG solution.
- Where
- Brazil
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- CAO Group, Inc.
Necrotic Pulp
Comparative Evaluation of the Regenerative Capacity of Two Platelet Concentrates
Injectable platelet-rich fibrin (I-PRF) is a flowable blood concentrate that is entirely natural and allows ease of access and flow within the root canal. It was first developed in 2014 by modifying the centrifugation parameters.
- Trial name
- NCT03698188
- Testing
- Injectable platelet-rich fibrin, Platelet-rich plasma
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Necrotic Pulp
Effect of Moringa Oleifera Leaf Extract on Postoperative Pain and Bacterial Reduction in Mandibular Premolars
The aim of this study is to clinically compare the intensity of post-operative pain and the amount of bacterial reduction after using Moringa oleifera leaf extract solution during chemo-mechanical preparation, versus 2.5% NaOCl…
- Trial name
- NCT05348824
- Testing
- Moringa oleifera leaf, Sodium hypochlorite
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Evaluation of Postoperative Pain and Antimicrobial Efficacy
Evaluation of Postoperative Pain and the Antimicrobial Effect of Super Oxidized Water (Microcyn) and Chlorhexidine When Compared With Sodium Hypochlorite in Teeth With Asymptomatic Necrotic Pulps. A Randomized Clinical Trial
The objective of this study is to evaluate the postoperative pain and antimicrobial efficacy when using super-oxidized water (Microcyn) and 2% Chlorhexidine as irrigating solutions in comparison to 2.5% Sodium hypochlorite in…
- Trial name
- NRS (NCT07852260)
- Testing
- super-oxidized water (Microcyn) irrigating solution, 2% chlorhexidine irrigating solution, 2.5% sodium hypochlorite
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Cairo University
Endodontic Disease
Effect of Different Irrigation Solutions on Postoperative Pain and Lesion Healing
In this study researchers plan to conduct, three different irrigation solutions that are responsible for the release of growth factors necessary for the success of regenerative endodontic treatments will be used.
- Trial name
- NCT06386991
- Testing
- Using ethylenediaminetetraacetic acid (EDTA), citric acid ((MONO/ANH) and etidronic acid (HEBP) to clean root canals during regenerative endodontic treatments
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Periapical Lesion, Apical Periodontitis
Effect of Apical Patency on Periapical Lesion Healing
This non-randomized clinical study aims to evaluate the effect of apical patency during root canal treatment on the healing of periapical lesions in maxillary anterior teeth.
- Conditions
- Periapical Lesion, Apical Periodontitis, Dental Pulp Necroses, Mouth Diseases
- Trial name
- NCT07867314
- Testing
- Apical Patency During Root Canal Treatment, Root Canal Treatment Without Apical Patency
- Where
- Turkey (Türkiye)
- Volunteers
- 113 people
- Sponsor
- Recep Tayyip Erdogan University
Pulp Necroses, Apical Periodontitis
"Postoperative Pain Following Laser-Assisted Root Canal Treatment: A Randomized Clinical Trial"
The aim of this study is to evaluate in vivo the post operative pain after laser root canal treatment in necrotic teeth in an evidence-based clinical trial.
- Conditions
- Pulp Necroses, Apical Periodontitis, Pulp Disease, Dental
- Trial name
- NCT06129643
- Testing
- Conventional group, Dual laser group, Combined group
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Dental Pulp Necrosis, Permanent Incisor Avulsed by Trauma
Revitalization of Immature Permanent Teeth With Necrotic Pulps Using SHED Cells
Revitalization of Young Immature Permanent Teeth With Necrotic Pulps Using Autologous Stem Cells from Human Exfoliated Deciduous Teeth
- Trial name
- NCT01814436
- Testing
- scaffold-free SHED-derived pellet
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Air Force Military Medical University, China
Bacterial Count Reduction in Oval Canal After Rotary Instrumentation With Different Systems, Post-operative Pain After Rotary Instrumentation of Oval Canal With Different Systems
Postoperative Pain and Bacterial Reduction in Oval Canals After Instrumentation With Different Noval Rotary Files Systems
Postoperative pain after endodontic treatment can affect a patient's quality of life. It is reported that debris extrusion after the instrumentation technique can influence postoperative pain.
- Trial name
- NCT07019792
- Testing
- Protaper ultimate, Truanatomy file system, Hyflex EDM
- Where
- Jordan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Dental Pulp Necroses
Single and Two-visit Pulpectomy in Primary Molars
A total of 64 primary molars of 5-8 years old children will be randomly selected from Pediatric dental clinic at Faculty of Dentistry, Mansoura University.
- Trial name
- NCT06071663
- Testing
- Single and two visits pulpectomy
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Pain Postoperative
Apical Patency and Postoperative Pain.
The purpose of this study is to determine whether maintaining an apical patency causes postoperative pain in posterior teeth with necrotic pulp and apical periodontitis.
- Trial name
- NCT02768285
- Testing
- APICAL PATENCY
- Where
- Turkey (Türkiye)
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Isparta Military Hospital
Pulp Necroses
Revascularization of Immature Anterior Necrotic Teeth
The object of this study is to compare the effect of Calcium Hydroxide and Di-antibiotic paste as intracanal disinfectants in the 1st visit of revascularization of necrotic immature permanent anterior teeth.
- Trial name
- NCT03504332
- Testing
- intracanal disinfection in revascularization
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Cairo University